logo
Fiona Phillips spotted for first time in over a year after Alzheimer's diagnosis

Fiona Phillips spotted for first time in over a year after Alzheimer's diagnosis

Daily Record23-05-2025
Fiona Philips was pictured for the first time in over a year as she opened up about her battle with Alzheimer's
Fiona Phillips has been spotted for the first time in over a year, following her decision to step back from public life. The ex-breakfast telly host, 64, was diagnosed with Alzheimer's in 2022 and made her diagnosis public a year later.
She is now preparing to share insights into her health and life post-diagnosis in her forthcoming book, Remember When: My life with Alzheimer's. Fiona has been receiving the support of her husband Martin Frizell, who recently resigned as This Morning boss to dedicate more time to their family.

Martin has assisted her in writing the book, which is set to be published in July. Fiona was last seen in public at the funeral of Kate Garraway's late husband Derek Draper in 2024.

In anticipation of her book's release, Fiona radiated positivity in a new photograph. She is also ready to discuss her gradual memory loss and confusion, along with the early warning signs.
Martin, who has been wedded to Fiona for 26 years, left his ITV role in February to look after Fiona and has also shared his experiences in the book, reports the Mirror.
According to the NHS, Alzheimer's disease is the most prevalent cause of dementia in the UK. Dementia refers to a group of symptoms linked with a continuous decline of brain functioning, affecting memory, thinking skills and other mental abilities.
Although the exact cause of Alzheimer's is still unclear, Fiona has provided insight into her experience with the condition. In her book, she expressed her hope that it would offer a glimpse into what living with Alzheimer's is like, stating: "I hope this book can show people a little about what it is like to live with Alzheimer's.
"How frightening and confusing it is. But also how much life can still bring joy and be valued. And if you or someone you love is in the early stages of Alzheimer's, I hope this book brings you some comfort... you are not alone."

Fiona revealed her diagnosis with early onset dementia in 2023, initially mistaking her symptoms of "brain fog and anxiety" for menopause. She had previously cared for her parents, who also suffered from Alzheimer's.
As a TV presenter, Fiona created documentaries about her family's experience with dementia, including "Mum, Dad, Alzheimer's And Me" in 2009 and "My Family And Alzheimer's" in 2010. She left the TV industry in 2018 due to anxiety, having worked on GMTV from 1993 to 2008 and presented various documentaries and episodes of Panorama.

In November, her husband Martin announced his departure as editor of ITV's This Morning after over a decade in the role. He commented: "Next year I'm expecting my family priorities to change, so I need to free up time for them.
"I love my team at ITV and will miss them, and the thrill of live telly, but it's an always on, 24 hours a day, seven days a week commitment, and I won't be able to do both."
Join the Daily Record WhatsApp community!
Get the latest news sent straight to your messages by joining our WhatsApp community today.
You'll receive daily updates on breaking news as well as the top headlines across Scotland.
No one will be able to see who is signed up and no one can send messages except the Daily Record team.
All you have to do is click here if you're on mobile, select 'Join Community' and you're in!
If you're on a desktop, simply scan the QR code above with your phone and click 'Join Community'.
We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don't like our community, you can check out any time you like.
To leave our community click on the name at the top of your screen and choose 'exit group'.
Fiona had said that she gets three daily injections as part of drug trials at University College Hospital in London.
Her stance was clear when she stated: "I've always spoken out about Alzheimer's whether through a book, a documentary or lobbying prime ministers and now that it's turned up on my doorstep I'm not for stopping.
"It's devastated my family and it's the biggest health and social care challenge we face as a country."
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Two NHS drugs slows and could REVERSE devastating Alzheimer's, ‘exciting' study finds
Two NHS drugs slows and could REVERSE devastating Alzheimer's, ‘exciting' study finds

Scottish Sun

time2 hours ago

  • Scottish Sun

Two NHS drugs slows and could REVERSE devastating Alzheimer's, ‘exciting' study finds

Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) TWO NHS drugs could be combined to treat, and even reverse, the most common form of dementia, scientists claim. A pair of cancer drugs have been identified as a powerful duo that may tackle Alzheimer's disease, after scientists sifted through 1,300 approved medicines. Sign up for Scottish Sun newsletter Sign up 1 Alzheimer's was reversed in mice Credit: Alamy The American team used cutting-edge computer tools to match the gene changes seen in Alzheimer's patients with medicines that reverse those effects. They found that two cancer drugs, both already available on the NHS, reduced brain degeneration in mice with the disease, and even brought back their memory. The study, from the University of California, San Francisco (UCSF), first looked at how Alzheimer's alters the activity of individual brain cells. They then searched for existing drugs that trigger the opposite changes, with the aim of rewiring damaged neurons and brain cells called glia. And when they tested the top two candidates, letrozole and irinotecan, in lab mice, the results were impressive. One theory of how Alzheimer's comes about is that sticky proteins - like amyloid-beta - start clumping together in the brain years before symptoms appear. These toxic clumps block communication between brain cells and trigger inflammation, eventually causing the cells to die. Some scientists believe this buildup is the root cause of Alzheimer's, so clearing it could stop the disease in its tracks. When combined, the cancer drugs not only halted brain cell damage but also undid toxic clumps of proteins, restored memory and reversed the disease's genetic footprint. Prof Marina Sirota, senior author, said: 'We're excited that our computational approach led us to a potential combination therapy for Alzheimer's based on existing FDA-approved medications.' Common painkiller used for back pain ups risk of dementia by 29%, scientists warn She added: 'Alzheimer's disease comes with complex changes to the brain, which has made it tough to study and treat — but our tools opened up the possibility of tackling that complexity directly.' The scientists then trawled through the anonymised medical records of 1.4million over-65s and found those already taking the cancer drugs were less likely to develop Alzheimer's. Dr Yaqiao Li, the study's lead author, said: 'Thanks to all these existing data sources, we went from 1,300 drugs, to 86, to 10, to just five. 'In particular, the rich data collected by all the UC health centres pointed us straight to the most promising drugs. It's kind of like a mock clinical trial.' Letrozole is typically used to treat breast cancer, while irinotecan is prescribed for colon and lung cancer. Both are already used in the UK. 'So exciting' Prof Yadong Huang, co-senior author, said: 'Alzheimer's is likely the result of numerous alterations in many genes and proteins that, together, disrupt brain health. 'This makes it very challenging for drug development - which traditionally produces one drug for a single gene or protein that drives disease.' He added: 'It's so exciting to see the validation of the computational data in a widely used Alzheimer's mouse model.' The breakthrough, published in the journal Cell, could fast-track trials in humans. Prof Sirota said: 'If completely independent data sources, such as single-cell expression data and clinical records, guide us to the same pathways and the same drugs and then resolve Alzheimer's in a genetic model then maybe we're onto something.' She added: 'We're hopeful this can be swiftly translated into a real solution for millions of patients with Alzheimer's.' Alzheimer's causes a relentless decline in cognition, learning, and memory. But decades of research have only produced two FDA-approved drugs, neither of which can meaningfully slow the decline. In the UK, no disease-modifying drugs are currently approved or available. Instead, the UK relies on symptom-managing drugs, such as Donepezil and Rivastigmine.

Could cancer drugs be the future of Alzheimer's treatment?
Could cancer drugs be the future of Alzheimer's treatment?

NBC News

time2 hours ago

  • NBC News

Could cancer drugs be the future of Alzheimer's treatment?

With few treatments available to stop or reverse Alzheimer's disease, scientists have turned to cancer drugs as a potential means of walking back cognitive decline. Alzheimer's cases are rising in the United States and worldwide due to an aging population, but there is no cure for the disease. Attempts to develop new treatments that slow the disease's progress, rather than lessen symptoms, have frequently failed. Only two drugs — the antibody therapies Leqembi and Kisunla — are currently approved by the Food and Drug Administration to slow the progression of early Alzheimer's, and scientists say their benefits are limited. Some pharmaceutical companies have halted or abandoned their Alzheimer's drug development programs because of unsuccessful trials. Others are trying to use existing medications, including popular weight loss drugs, to combat Alzheimer's. With that in mind, researchers at the University of California, San Francisco conducted a broad search for drugs that could be repurposed to treat the condition — in theory, reducing the time in which the drugs could be made available to patients. They scoured a database of more than 1,300 drugs of various classes, including antipsychotics, antibiotics, antifungals and chemotherapy drugs. Then, they looked at how those drugs affected gene expression. Their new study, published Monday in the journal Cell, identified two cancer drugs as the best candidates to lower Alzheimer's risk in patients. When combined, the drugs seemed to slow or reverse Alzheimer's symptoms in mice. One of the drugs is normally used to treat breast cancer, while the other is effective against colon and lung cancer. Alzheimer's disease is associated with significant changes in the way genes are expressed in the brain, leading to the increased production of certain proteins and the decreased production of others. These imbalances may disrupt brain function and contribute to symptoms like memory loss. Fewer than 90 drugs in the researchers' database reversed the expression of signature Alzheimer's-related genes in human brain cells. And five drugs in particular seemed to lower the risk of Alzheimer's in actual patients, based on electronic medical records. The authors ultimately selected two of those drugs, both approved by the FDA to treat cancer, to test in mice. 'We didn't expect cancer drugs to come up' as the most promising, said Marina Sirota, a co-author of the study and interim director of the UCSF Bakar Computational Health Sciences Institute. The authors said the breast cancer drug letrozole seemed to change gene expression in nerve cells. And the colon and lung cancer drug irinotecan seemed to change gene expression in glial cells, which support the nervous system. Alzheimer's can destroy nerve cells and cause glial cells to proliferate, creating inflammation in the brain. In a 2020 study, breast cancer patients who received letrozole were less likely to develop Alzheimer's than patients who did not receive the drug. Colorectal cancer survivors treated with irinotecan also had a decreased Alzheimer's risk, according to a 2021 study. After testing the drugs in mice, the study authors found that the two-drug combo reversed brain degeneration and improved memory in mice that had developed hallmarks of Alzheimer's as they aged. Because results in mice often don't translate to humans, the researchers hope to test the drugs in a clinical trial with Alzheimer's patients. 'Developing a new drug can take hundreds of millions, or even billions, of dollars, on average take more than 10 years. For this repurposed drug, usually it just takes two or three years, and then you can go to the clinical trial and the cost is much, much lower,' said Dr. Yadong Huang, a co-author of the study and professor of neurology at UCSF. 'We still haven't generated or produced any very effective drugs that can really slow dramatically the cognitive decline,' he added. Part of the difficulty in developing drugs for Alzheimer's is the complexity of the disease. Its exact cause is largely unknown. For now, the authors said, it's unclear exactly why the cancer drugs seem to work against Alzheimer's. One theory is that the breast cancer drug blocks the production of estrogen, a hormone that controls the expression of a large number of genes. The colon and lung cancer drug may also block inflammation in the brain by preventing the proliferation of glial cells — though Huang said there are other possibilities. Dr. Melanie McReynolds, an assistant professor of biochemistry at Pennsylvania State University, who was not involved in the study, offered another theory. Her research has suggested that a different type of cancer drug could help treat Alzheimer's by regulating glucose metabolism, the process by which cells make energy. McReynolds said the process is necessary for various brain cells to communicate with each other. 'With aging, with stress, with diseases, that line of communication is disrupted,' she said. McReynolds said the drug combo tested in the new study might reverse metabolic decline — what she called 'the secret for contributing to better outcomes with Alzheimer's.' But assessing how Alzheimer's patients tolerate the combination of cancer drugs will be important. Letrozole can cause hot flashes and irinotecan can cause severe diarrhea. Both drugs can lead to nausea and vomiting. 'These drugs have huge side effects, so you need to always balance and figure out whether those types of side effects would be amenable to somebody with Alzheimer's,' Sirota said. 'It's not that it's a slam dunk.'

I put my daughter on fat jabs aged 11 - it wasn't a difficult decision at all and saved her from the bullies
I put my daughter on fat jabs aged 11 - it wasn't a difficult decision at all and saved her from the bullies

Daily Mail​

time3 hours ago

  • Daily Mail​

I put my daughter on fat jabs aged 11 - it wasn't a difficult decision at all and saved her from the bullies

A woman who put her daughter on weight-loss jabs at the age of 11 has shared her family's experience with the medication. Ashley Hamilton appeared on Monday's instalment of This Morning and revealed to Dermot O'Leary and Alison Hammond via video call from Idaho, America about why her young daughter is on the medication. Both Ashley and her daughter Sophia have taken weight loss jabs to help them with their health. The young girl opened up about her personal experience with her weight and bullying at school that led her to approach her mum for help. She said: 'The bullying was definitely not ideal at all, it was just very hard to deal with because I used to think I was pretty and now I can't look at myself in the mirror without hating myself.' Dermot asked: 'Ashley it's important to stress here because people can probably see a headline, you have always instilled exercise, you've always instilled a good diet and it was just very, very difficult to keep the weight off. The young girl opened up about her personal experience with her weight and bullying at school that led her to approach her mum for help 'How hard was it for you to make that decision for Sophia to take the weight loss jabs?' Ashley admitted it 'wasn't hard at all'. She added: 'When she came to me and asked if this would work for her I told her yes, but we have to get your blood work done and your labs done to make sure there is an underlying problem, because if there was nothing showing right then that is something that we would've said, 'Okay, this is diet and exercise type of thing'. 'But it wasn't hard at all for me to decide that.' The mother shared how she had done research on the medications and went on: 'I knew that if she needed it this is what we were going to do'. When Sophia began to take the jabs, she soon noticed her mum had to remind her 'constantly' to eat. 'And then I started to lose weight and then I started to realise I actually had a lot of inflammation in my face and arms and in my hands... now I can wear normal sizes for my age,' she added. Alison asked Ashley if she had received any backlash for her decision take weight loss injections herself. She admitted: 'A lot of people deal with backlash on social media from people but for me it's actually been more in my real life, dealing with people who I can tell are judging me but it doesn't bother me it's a way for me to educate more people on what the reason is that I started.' Sophia is no longer on the injections and during the conversation, This Morning's resident GP Dr Zoe Williams shared her take. 'The thing to consider, Sophia's a perfect example of this, Sophie already had insulin resistance and her blood work was showing that she had pre-diabetes,' Dr Zoe said. 'What you always have to consider is the risks and potential risks of a medication but weigh that against the risks and potential risks of doing nothing, when you've tried all the sensible things, the exercise, the changes to eating, the psychological approach, for some people like Sophia and her mum it's a genetic thing. 'Your genes predispose you to having problems with your weight..' She added: 'In Sophia's case it seems it's been really helpful for her.'

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store