Europa League line-ups: Viktoria Plzen vs. Lazio
It kicks off at the Stadion Mesta Plzne at 20.00 GMT.
You can follow all the build-up and action as it happens from this game, Roma-Athletic Club and Panathinaikos-Fiorentina on the Liveblog.
The second leg is at the Stadio Olimpico next Thursday evening.
The Aquile topped the table in the league phase and were therefore top seeds in the draw, while they are fresh off a thrilling 2-1 Serie A victory over Milan.
That was sealed with a last-gasp Pedro penalty won by Isaksen, and they both start tonight with Noslin taking over as centre-forward.
Taty Castellanos, Mattia Zaccagni, Elseid Hysaj and Fisayo Dele-Bashiru did not make the trip to Plzen.
Viktoria are not to be under-estimated, as they eliminated Ferencvaros in the play-offs, losing 1-0 away before a 3-0 home victory.
They also beat Real Sociedad, Anderlecht and Dynamo Kyiv in the group phase, drawing 3-3 away to Eintracht Frankfurt.
Christophe Kabongo is out with a knee injury, but they have veteran former Udinese and Watford striker Matej Vydra and impressive creative midfielder Pavel Sulc.
Viktoria Plzen: Jedlicka; Dweh, Markovic, Jemelka; Memic, Kalvach, Cerv, Cadu; Sulc; Vydra, Durosinmi
Lazio: Provedel; Marusic, Gigot, Romagnoli, Tavares; Guendouzi, Rovella; Isaksen, Dia, Pedro; Noslin
Ref: Rumsas (LTU)
Europa League line-ups: Roma vs. Athletic Club
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