Online Slot Sites 2025: Crown Coins Voted Leading Online Slots Casino
Online Slot Sites 2025: Crown Coins Voted Leading Online Slots Casino
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The platform offers bonuses and promotions for special events, including holidays and new game launches. Leaderboard challenges and weekly competitions create competition among bettors, rewarding top players with in-game rewards and additional coins. Seasoned players receive free coins and offers that go beyond just rewards; they make a connection between gamblers and the casino. These promotions and generous bonuses create a gaming environment where every player feels like a winner, even before they begin a gaming session.
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Another reason Crown Coins has been voted the leading online slots casino is its partnerships with key gaming providers. Crown Coins has partnered with top gaming studios to create an engaging gaming library that caters to the needs of all players. Among the partners is Pragmatic Play, which delivers titles such as Sugar Rush and Sweet Bonanza to add more excitement to the gaming library. Games by Microgaming introduce depth through titles such as Fortunium and Immortal Romance. Random number generators are used in each game to ensure that the outcomes are always fair.
Other gaming studios include Booming, Playson, Playtech, Relax Gaming, Ruby Play, Slotmill, and Hacksaw Gaming, contributing through games that offer seamless gameplay and more bonuses. Partnering with these providers ensures that each game delivers creativity and immersive gameplay that matches the current standards in online gaming. Each partner is carefully selected to offer something unique, whether it's stunning graphics, cutting-edge technology, or games that keep the gaming experience engaging. Crown Coins works closely with each software provider to ensure that every gaming option is polished and prioritizes player interests.
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Crown Coins has created a fast and reliable payment system, ensuring bettors can play games without worrying about deposits or payouts. Adding funds and cashing out is smooth and secure, creating excitement from start to end. Players can deposit funds through bank transfer, debit and credit cards, and e-wallets. Crown Coins has simplified the deposit process, enabling gamers to make deposits and start enjoying the games immediately. The casino also ensures that players can enjoy payouts seamlessly.
Each transaction is secured through encryption technology that protects financial and personal information. Additionally, Crown Coins ensures that each transaction is verified and payments are transferred safely. Before withdrawing, players are guided on limits, processing time, and fees. The casino caters to its players' needs through these deposit and withdrawal options. As a result, players can enjoy the gaming library, access payouts, or make deposits hassle-free.
Friendly Customer Support
Crown Coins provides friendly and reliable customer support to ensure every player feels valued. The customer support team creates a seamless user experience that complements the robust gaming library. Players can reach the support team through various channels, including email, the help center, and chat. The chat option enables players to communicate with experienced agents, making it easy to resolve account issues or address payment delays. Email support is used to give detailed responses within 24 hours.
The help center provides players with answers to frequently asked questions and guides them on how to improve their gaming experience. This section is updated regularly to ensure that new changes are reflected. Each agent is trained to assist players, resolve payment issues, and address account security concerns. Users can reach the team around the clock and get answers to problems that affect gameplay. The customer support at Crown Coins provides gamers with the confidence to play games seamlessly, making the casino a trusted gaming destination.
Responsible Gaming
Crown Coins ensures that gaming is fun and safe for all players. The casino promotes responsible gaming through resources that help players control their habits. Gaming should be fun, not a source of income. Monthly, weekly, and daily limits allow casino lovers to control their spending and avoid addiction. Self-exclusion will enable users to step back, review their gaming habits, and seek help if necessary.
Players can also track their spending through account history, allowing them to budget their finances effectively. The casino also provides gamers with educational resources and tools that offer information about the risks of gambling and tips to avoid being addicted. Links to counselling services, such as Gamblers Anonymous and Problem Gambling, ensure that individuals receive professional help if needed. The support team also offers guidance to users experiencing addiction on how to take a break and get help. These tools have made Crown Coins a safe and engaging gaming platform that fosters trust and honesty at every step.
About Crown Coins
Crown Coins is a social casino that offers video poker, table games, and slot games to casino players. The games are designed for fairness and fun, allowing players to enjoy smooth gameplay without spending a dime. Crown Coins has become a leading casino by prioritizing player interests at every step.
Disclaimer: This press release is for informational purposes only and does not constitute gambling advice or a guarantee of outcomes. Crown Coins Casino operates as a social gaming platform with no real-money wagering. Players should play responsibly and only if they are of legal age in their jurisdiction.
Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.
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[Latest] Managed Security Services Market Size Will Attain USD 97.12 Billion by 2032 Growing at 14.44% CAGR - Exclusive Report by Zion Market Research (Global Industry Size, Share, Forecast, Trends Analysis Report)
The global managed security services market size was valued at USD 28.84 billion in 2023 and is expected to surpass USD 97.12 billion by 2032, registering a CAGR of 14.44% during the forecast period (2024- 2032). NEW YORK, USA, Aug. 19, 2025 (GLOBE NEWSWIRE) -- Zion Market Research has published a new research report titled 'Managed Security Services Market By Security (Data Security, Cloud Security, Network Security, and Endpoint Security), By Services (Managed DDoS and Managed Risk & Compliance), By Enterprise (Small & Medium Enterprises and Large Enterprises), By Vertical (BFSI, Defense/Government, Healthcare, IT & Telecom, Manufacturing, and Retail), and By Region - Global and Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, and Forecasts 2024 - 2032' in its research database. 'According to the latest research study, the global managed security services market size was valued at around USD 28.84 billion in 2023. The market is expected to grow at a CAGR of 14.44% and is anticipated to reach a value of USD 97.12 billion by 2032.'Get a Free Sample PDF of this Research Report for more Insights - (A free sample of this report is available upon request; please get in touch with us for more information.) Managed Security Services Market Overview: Managed security services are network security solutions that are outsourced to a service provider. They are also considered as a systematic approach for effectively handling the security requirements of an organization. These services can be carried out in-house as well as can be outsourced to the service provider that supervises network services & information system security services of other firms. Various functions of managed security services include effective management of firewalls & intrusion detection systems and round-the-clock monitoring of these systems. Apart from this, managed security services also help in monitoring patch management, system updates, security audits, and security assessments along with effectively responding to contingencies. Report Scope: Report Attribute Report Details Market Size in 2023 USD 28.84 Billion Market Forecast in 2032 USD 97.12 Billion Growth Rate CAGR of 14.44% Base Year 2023 Forecast Years 2024- 2032 Key Companies Covered Rapid 7, Fujitsu, AT&T, Verizon, BAE Systems Inc., Cisco Systems, Palo Alto Networks, Check Point Software Technologies, Fortinet Inc., IBM, Wipro, and Others. Segments Covered By Security, By Services, By Enterprise, By Vertical, and By Region Regions Covered North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa Customization Scope Avail customized purchase options to meet your exact research Purchase a Copy of the Report | Quick Delivery Available - Key Insights from Primary Research As per the analysis, the managed security services market share is likely to grow at a CAGR of around 14.44% between 2024 and 2032. The managed security services market size was worth around $28.84 billion in 2023 and is estimated to hit approximately $97.12 billion by 2032. Due to a variety of driving factors, the market is predicted to rise at a significant rate. Based on security, the data security segment is growing at a high rate and is projected to dominate the global market. On the basis of services, the managed DDoS segment is projected to swipe the largest market share. In terms of enterprise, large enterprise segment is likely to grow at a significant rate over the forecast period. Based on vertical, the BFSI segment is predicted to contribute majorly towards the global industry share in the ensuing years. On the basis of region, the Asia-Pacific is expected to dominate the global market during the forecast period. Managed Security Services Market: Growth Drivers An increase in cyber terrorism activities can help the global market register exponential growth over the forecast period The growing complexity of cyber threats is anticipated to propel the expansion of the global managed security services market. Escalating the need for security monitoring and operations associated with the strict execution of security technology will scale up the growth of the global market. Furthermore, managed security solutions include a slew of features enabling firms to effectively manage & protect digital assets from various kinds of cyber terrorism. Reportedly, managed security services include beneficial features such as rapid threat response, threat hunting abilities, 24/7 threat identification, device encryption, remote wipes, and app management for improving security & compliance management. Browse the full 'Managed Security Services Market By Security (Data Security, Cloud Security, Network Security, and Endpoint Security), By Services (Managed DDoS and Managed Risk & Compliance), By Enterprise (Small & Medium Enterprises and Large Enterprises), By Vertical (BFSI, Defense/Government, Healthcare, IT & Telecom, Manufacturing, and Retail), and By Region - Global and Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data, and Forecasts 2024 - 2032' Report at Managed Security Services Market: Segmentation The global managed security services market is divided into security, services, enterprise, vertical, and region. Based on security terms, the managed security services market is divided into data security, cloud security, network security, and endpoint security segments. The data security segment held the largest market share in 2023 and is expected to grow at a significant rate over the forecast period due to the use of data security in IT companies and various other large & small firms to reduce the risk of theft and trespassing, along with enhancing access control to the staff. In terms of services, the global managed security services industry is split into managed DDoS and managed risk & compliance segments. The managed DDoS segment is growing at a high rate and is projected to dominate the global market. On the basis of enterprise, the global managed security services market is segmented into small & medium enterprises and large enterprises segments. The large enterprises segment holds the largest share in 2023, is anticipated to make notable contributions towards the global market proceeds over the assessment timeframe. By vertical, the global managed security services industry is bifurcated into BFSI, defense/government, healthcare, IT & telecom, manufacturing, and retail segments. Moreover, the BFSI segment, which accumulated about 57% of the global industry share in 2023, is expected to make lucrative contributions towards the global industry revenue over the expected timespan. Why does Asia Pacific outperform other regions in the global managed security services market? North America is expected to dominate the global market North America, which accounted for nearly 65% of the global managed security services market earnings in 2023, is anticipated to establish a numero one position in the global market in the years to come. Moreover, the market expansion in North America in the next couple of years can be a result of a humongous demand for outsourcing solutions from a spectrum of tech firms. Furthermore, the huge demand for cloud computing, data security, and network security will augment the regional market surge. The Asia-Pacific managed security services industry is anticipated to register the fastest CAGR in the forecast timespan. The progression of the industry in APAC can be ascribed to the rise in the need for outsourcing managed security solutions from vendors. Furthermore, lack of availability of skilled cyber staff in developing economies of Asia can further accelerate the growth of the industry in the Asia-Pacific. Request For Customization on This Report as Per Your Requirements - Managed Security Services Market: Competitive Landscape The report contains qualitative and quantitative research on the global managed security services market, as well as detailed insights and development strategies employed by the leading competitors. Some of the main players in the global managed security services market include; Rapid 7 Fujitsu AT&T Verizon BAE Systems Inc. Cisco Systems Palo Alto Networks Check Point Software Technologies Fortinet Inc. IBM Wipro. The global managed security services market is segmented as follows: By Security Data Security Cloud Security Network Security Endpoint Security By Services Managed DDoS Managed Risk & Compliance By Enterprise Small & Medium Enterprises Large Enterprises By Vertical BFSI Defense/Government Healthcare IT & Telecom Manufacturing Retail By Region North America The U.S. Canada Europe France The UK Spain Germany Italy Rest of Europe Asia Pacific China Japan India Southeast Asia Rest of Southeast Asia The Middle East & Africa GCC South Africa Rest of the Middle East & Africa Latin America Brazil Argentina Rest of Latin America Request Free Brochure of the Global Managed Security Services Market @ Key Questions Answered in This Report: What are managed security services? Which key factors will influence managed security services market growth over 2024-2032? What will be the value of the managed security services market during 2024-2032? What will be the CAGR value of the managed security services market during 2024-2032? Which region will contribute notably towards the managed security services market value? Which are the major players leveraging the managed security services market growth? What can be expected from the global managed security services market report? 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Aptose Reports Early Data Demonstrating Tuspetinib Improves Standard of Care Treatment Across Diverse Populations of Newly Diagnosed AML in Phase 1/2 TUSCANY Trial
Addition of Tuspetinib (TUS) to Venetoclax (VEN) and Azacitidine (AZA) is being developed as safe and mutation agnostic frontline therapy for AML Addition of TUS to VEN+AZA improves response rates; 100% CR/CRh at 80 mg and 120 mg Addition of TUS to VEN+AZA improves MRD-negativity rates; 78% among responders 100% CR/CRh in FLT3 wildtype AML, representing 70% of AML population 100% CR/CRh and MRD-negativity rates in TP53, RAS and FLT3-ITD mutated AML Broad spectrum activity and excellent safety profile continue at 120 mg dose to date SAN DIEGO and TORONTO, Aug. 18, 2025 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. ('Aptose' or the 'Company') (OTC: APTOF, TSX: APS), a clinical-stage precision oncology company developing the tuspetinib (TUS)-based triple drug frontline therapy to treat patients with newly diagnosed AML, today provided a data update from the Phase 1/2 TUSCANY trial in newly diagnosed AML. The trial was initiated in December 2024, and the growing body of positive data includes the recently completed third cohort of 120 mg TUS in the TUS+VEN+AZA triplet therapy. Data to date from ten (10) patients across all three cohorts, 40 mg, 80 mg or 120 mg TUS dose in TUS+VEN+AZA, support the use of TUS with standard of care treatment across all AML populations, including those carrying mutations that are the most difficult to treat and those with mutated and unmutated (wildtype) FLT3 genes. The TUS+VEN+AZA triplet is being developed as a safe and well-tolerated mutation agnostic frontline therapy to treat large, mutationally diverse populations of newly diagnosed AML patients who are ineligible to receive induction chemotherapy. At the 120 mg TUS dose level in combination with VEN+AZA, as with the prior reported 40 mg and 80 mg TUS dose cohorts, no significant safety concerns or dose limiting toxicities (DLTs) have been observed in the TUSCANY trial, including no prolonged myelosuppression in Cycle 1 of subjects in remission, no reports of drug-related QTc prolongation or differentiation syndrome (DS), and no treatment-related deaths. Nine out of ten dosed patients remain on study across all dose cohorts and enrollment is being advanced to the 160 mg TUS dose level following the Cohort Safety Review Committee (CSRC) meeting. 'We already have data from three different TUS dose levels in the TUSCANY trial, and the data continue to strengthen at higher doses of TUS and over time. We are building a strong case for TUS+VEN+AZA as a triplet frontline therapy of choice to address a broad AML population, including subgroups with the most adverse of mutations,' said William G. Rice, Ph.D., Chairman, President and Chief Executive Officer of Aptose. Data highlights: Comparison of CR/CRh1 Response rates2-5: VEN+AZA2 TUS+VEN+AZA All subjects 65% 90% (9/10) NPM1-mutant 67% 100% (2/2) FLT3-ITD 61% 100% (2/2) TP53-mutant 52% 100% (2/2) Comparison of MRD-negativity6 rates among All Subjects and among CR/CRh Responders3: VEN+AZA2,3 TUS+VEN+AZA Among All Subjects 23.4% 70% (7/10) Among CR/CRh Responders 40.9% 78% (7/9) Comparison of MRD-negativity rates among more difficult-to-treat Patient Subpopulations defined as Lower Benefit (TP53-mutated) and Intermediate Benefit (FLT3-ITD or RAS-mutated) relative to VEN+AZA5: VEN+AZA3,5 TUS+VEN+AZA Intermediate Benefit 27.9% 100% (3/3) Lower Benefit 14.5% 100% (2/2) TUS+VEN+AZA - CR/CRh and MRD-negativity rates among Subjects with Adverse Mutations: TP53, FLT3-ITD, RAS mutations: Achieved CR/CRh and MRD-negativity 100% (5/5) 'As illustrated in the data highlights, the addition of TUS to VEN+AZA appears to boost response rates and MRD-negativity while maintaining favorable safety and tolerability,' said Rafael Bejar, M.D., Ph.D., Chief Medical Officer of Aptose, 'and the 100% CR/CRh and 100% MRD-negativity rates among the five biallelic TP53-mutant, FLT3-ITD, and RAS-mutant AML cases are exciting to see, as this can correlate with longer overall survival. We have observed a trend towards achieving CRs more quickly at the higher dose levels, so we are keen to see the activity as we advance into the 160 mg TUS dose cohort.' Key messages: Addition of TUS to VEN+AZA demonstrates excellent CR/CRh rates 100% CR/CRh among all subjects treated at 80 mg and 120 mg TUS dose levels Appear to be achieving CR earlier with 120 mg TUS than with 40 mg or 80 mg Addition of TUS to VEN+AZA demonstrates excellent MRD-negativity rates MRD-negativity in 7 of 9 (78%) already achieved in patients who responded to therapy Expect patient survival to be extended with continued long-term treatment Excellent safety and well tolerated with no dose-limiting toxicities (No DLT) at completed dose levels Broad-spectrum activity including patients with adverse TP53, RAS and FLT3-ITD mutations No loss of MRD-negativity observed to date, including in one patient with over 7 months of follow up MRD-negativity and remissions continue to mature over time on therapy No relapses reported to date and no treatment related deaths The only non-responder was a patient at the initial TUS dose level (40 mg) that did not achieve TUS exposures previously associated with response Additional data are included in the new Aptose corporate presentation here. TUSCANY: TUS+VEN+AZA Triplet Phase 1/2 Study The tuspetinib-based TUS+VEN+AZA triplet therapy is being advanced in the TUSCANY Phase 1/2 trial with the goal of creating an improved frontline therapy for newly diagnosed AML patients that is active across diverse AML populations, durable, and well tolerated. The TUSCANY triplet Phase 1/2 study, being conducted at 10 leading U.S. clinical sites by elite clinical investigators, is designed to test various doses and schedules of TUS in combination with standard dosing of AZA and VEN for patients with AML who are ineligible to receive induction chemotherapy. A convenient, once daily oral agent, TUS is being administered in 28-day cycles. Multiple U.S. sites are enrolling in the TUSCANY trial with anticipated enrollment of 18-24 patients by late 2025. Data will be released as it becomes available. More information on the TUSCANY Phase 1/2 study can be found on (here). About Aptose Aptose Biosciences is a clinical-stage biotechnology company committed to developing precision medicines addressing unmet medical needs in oncology, with an initial focus on hematology. The Company's lead clinical-stage, oral kinase inhibitor tuspetinib (TUS) has demonstrated activity as a monotherapy and in combination therapy in patients with relapsed or refractory acute myeloid leukemia (AML) and is being developed as a frontline triplet therapy in newly diagnosed AML. For more information, please visit Forward Looking Statements This press release may contain forward-looking statements within the meaning of Canadian and U.S. securities laws, including, but not limited to, statements relating to the therapeutic potential and safety profile of tuspetinib (including the triplet therapy) and its clinical development, the anticipated enrollment rate in the TUSCANY trial and the timing thereof, as well as statements relating to the Company's plans, objectives, expectations and intentions and other statements including words such as 'continue', 'expect', 'intend', 'will', 'should', 'would', 'may', and other similar expressions. Such statements reflect our current views with respect to future events and are subject to risks and uncertainties and are necessarily based upon a number of estimates and assumptions that, while considered reasonable by us are inherently subject to significant business, economic, competitive, political and social uncertainties and contingencies. Many factors could cause our actual results, performance or achievements to be materially different from any future results, performance or achievements described in this press release. Such factors could include, among others: our ability to obtain the capital required for research and operations and to continue as a going concern; the inherent risks in early stage drug development including demonstrating efficacy; development time/cost and the regulatory approval process; the progress of our clinical trials; our ability to find and enter into agreements with potential partners; our ability to attract and retain key personnel; changing market conditions; inability of new manufacturers to produce acceptable batches of GMP in sufficient quantities; unexpected manufacturing defects; and other risks detailed from time-to-time in our ongoing quarterly filings, annual information forms, annual reports and annual filings with Canadian securities regulators and the United States Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should the assumptions set out in the section entitled 'Risk Factors' in our filings with Canadian securities regulators and the United States Securities and Exchange Commission underlying those forward-looking statements prove incorrect, actual results may vary materially from those described herein. These forward-looking statements are made as of the date of this press release and we do not intend, and do not assume any obligation, to update these forward-looking statements, except as required by law. We cannot assure you that such statements will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking statements due to the inherent uncertainty therein. For further information, please contact: Aptose Biosciences PietropaoloCorporate Communications & Investor Relations201-923-2049spietropaolo@ 1 Complete Response / Complete Response with Partial Hematological Recovery2 DiNardo et al. New England Journal of Medicine, August 2020; Volume 383(7):617-629.3 Pratz et al. Journal of Clinical Oncology, December 2021; Volume 40 (8):855-865.4 Othman et. al. Blood Neoplasia; September 2024; Volume 1 (3):1-11.5 Döhner et. al. Blood. 2024 November 21;144(21):2211-2222.6 MRD-negative indicates that the amount of Measurable Residual Disease, as assessed by central flow cytometry, is such that the proportion of leukemic cells in a bone marrow sample falls below <0.1%Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
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The Apache Software Foundation Announces Apache Ozone 2.0.0
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