Debiopharm to Reveal Insights From Their ADC, DDR Inhibitor, and Antibody Conjugation Technology Research at the 2025 AACR Conference in Chicago
LAUSANNE, Switzerland--(BUSINESS WIRE)--Debiopharm (www.debiopharm.com), a privately-owned, Swiss-based biopharmaceutical company aiming to establish tomorrow's standard-of-care to cure cancer and infectious diseases and develop new antibody linker technologies, will release promising new data for two of its pipeline products at the 2025 Annual American Association for Cancer Research (AACR) meeting in Chicago, Illinois. Furthermore, a joint poster presentation with Oncodesign Services (www.oncodesign-services.com) will highlight the applicability of its antibody conjugation technology, AbYlink™, in the preparation of conjugates for use in non-invasive preclinical imaging.
Comprehensive preclinical results will be presented for Debio 1562M, a next-generation Antibody-Drug Conjugate (ADC) targeting the cell surface glycoprotein CD37 soon to undergo first-in-human evaluation. Two preclinical data releases will be included in the poster display sessions for Debio 0123, a selective WEE1 kinase inhibitor disrupting the DNA-damage response (DDR) of cancer cells. The first data release shows how Debio 0123 can be used in combination with the PKMYT1 inhibitor lunresertib as a promising therapeutic strategy in ovarian and breast cancer. The company will also unveil new impactful findings stemming from its collaboration with Genialis, showing how machine learning has the potential to enhance the ability to predict responders to Debio 0123, thus further advancing the understanding and application of WEE1 biology and response to inhibitors.
Additionally, in the framework of a licensing agreement and a collaborative endeavor to support innovative research, Debiopharm and Oncodesign Services will present promising new data illustrating how AbYlink™ conjugation technology can facilitate the production of conjugates for use in preclinical research in cancer treatment.
'The pre-clinical results to be released during the AACR are laying a solid foundation for future research,' explained Angela Zubel, Chief Development Officer, Debiopharm. 'The two drug research approaches of ADCs and DDR inhibition are harnessing novel modalities and targets with the potential to outsmart hard-to-treat liquid and solid tumors, revolutionizing patient outcomes. Our AbYlink™ technology demonstrates great potential in the context of antibody radio conjugates against cancer and shows promise for broader use and wider applications.'
Poster Session Title: Artificial Intelligence and Machine Learning for Therapeutic Election and Discovery
AACR 2025
Poster Presentation
Debiopharm compound
Title
Presenter
-Mon, April 28 th
-Poster display: 2:00-5:00pm
-Abstract #3659
-Poster Section: 45
-Poster Board #: 21
Debio 0123
Biology-driven, machine learning-based development of a biomarker to predict response to WEE1 inhibitor Debio 0123
Kristian Urh, Genialis
Expand
Poster Session Title: Radiation Treatment Combinations for Tumors, Normal Tissue
About DNA-Damage Repair (DDR)
When cells have damaged DNA, they need to undergo a repair process called DDR to be able to survive. Cancer cells rely a lot on DDR as they divide and grow uncontrollably. Inhibition of DDR, particularly in combination with other anticancer agents, prevents cancer cells from repairing their DNA, which ultimately activates a self-destruction program in cancer cells. DDR inhibitors such as Debio 0123, a WEE1 inhibitor from Debiopharm, are being tested in clinical and preclinical studies.
Debiopharm's ADC portfolio
We're developing fit-for-purpose antibody drug conjugates through a tailored 'Trifecta' approach: strategic target selection, innovative Multilink™ linker technology and smart payload choices. Our broad and balanced portfolio of 1st-in-class and best-in-class ADCs includes Debio 0633 (undisclosed target), Debio 1562M, a CD37-targeted ADC for the treatment of acute myeloid leukemia (AML) Myelodysplastic syndromes (MDS), Debio 0532, an HER3-targeted ADC for solid tumors, as well as other ADCs for undisclosed targets including a proprietary bispecific ADC. Key partnerships also comprise options to in-licence bispecific antibodies targeting HER2-HER3 and HER3-EGFR along with other antibodies for undisclosed targets. To allow both high DAR and high stability, our ADCs are designed with our innovative proprietary Multilink™ linker technology. We're leveraging key collaborations and our in-house capabilities including ADC conjugation, optimization, PK/PD, toxicology, translational medicine, clinical development and supply chain to produce novel ADCs that respond to the high unmet needs of cancer patients.
About AbYlink™
AbYlink™ is a versatile and rapid regio-selective chemical conjugation technology for use to prepare diagnostic or therapeutic conjugates. This one step method results in stable conjugation at defined and invariable sites on the Fc domain of an antibody or the like, with no impact on antigen-binding regions. It enables a seamless and reproducible conjugation of payloads (e.g. a chelator for radiolabeling, a fluorescent dye or a drug) to antibodies or ADCs. The universal applicability of the technology has been demonstrated for various antibody isotypes and payloads.
Debiopharm's commitment to cancer patients
Debiopharm develops innovative therapies that target high unmet medical needs in oncology and infectious diseases. Bridging the gap between disruptive discovery products and real-world patient reach, we identify high-potential assets and technologies for in- licensing, clinically demonstrate their safety and efficacy, and then select pharmaceutical commercialization partners to maximize patient access globally.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
19 minutes ago
- Yahoo
2 Michigan Hooters abruptly close. Are any left after latest closures?
Hooters is near the end of an era in Michigan — abrupt closures this week have left just one location open in the state. The sports bar and grill chain closed more than 30 locations across multiple states Wednesday, June 4, including two in Michigan, USA TODAY reported. The restaurants in Flint and Taylor were among the closings. A Saginaw location is Michigan's last one remaining restaurant. The move comes several months after the restaurant chain filed for bankruptcy in late March 2025, though it had said no locations would close at the time. Here's what to know. In Michigan, the Flint and Taylor Hooters closed June 4, USA TODAY reported, leaving just one Hooters location open in the state. The restaurant chain, known for its chicken wings and servers wearing orange shorts and low-cut tank tops, began in 1983 and expanded to 29 countries before its decline, closing numerous locations in recent years. The following Hooters in other states also closed, per USA TODAY: Sanford, Florida Orlando, Florida - Kirkman Road Kissimmee, Florida - Osceola Parkway Melbourne, Florida Atlanta, Georgia - Downtown Douglasville, Georgia Gwinnett, Georgia Valdosta, Georgia Greenwood, Indiana Rockford, Illinois Newport, Kentucky St. Louis, Missouri - Downtown Charlotte, North Carolina - South Boulevard Columbia, South Carolina Rock Hill, South Carolina Murfreesboro, Tennessee Memphis, Tennessee - Downtown Nashville, Tennessee - Harding Place Grapevine, Texas Houston, Texas San Marcos, Texas Hooters said in a statement to USA TODAY that the closed stores were company owned and called the closures a "difficult decision." "Hooters will be well-positioned to continue our iconic legacy under a pure franchise business model," the company said. "We are committed to supporting our impacted team members throughout this process and are incredibly grateful to our valued customers for their loyalty and dedication to the Hooters brand." The company did not respond to a followup inquiry on a list of closed locations or when employees were notified of the closures. There were 305 Hooters locations, including 151 owned and operated by the company itself and a separate 154 operated by franchisees. The company has been closing locations suddenly since at least 2024. The company filed for bankruptcy in late March 2025 amid financial challenges. The Atlanta-based restaurant chain was then $376 million in debt and looking to sell 151 of its corporate-owned restaurants to a buyer group comprised of two existing Hooters franchises. At the time, no locations were expected to close and Hooters said it would "continue providing customers with the guest-obsessed hospitality experience and delicious food they have come to expect over the past 40 years." The closures leave one Hooters open in Michigan, at 5538 Bay Road in Saginaw. USA TODAY contributed. Contact Jenna Prestininzi: jprestininzi@ This article originally appeared on Detroit Free Press: What to know as Hooters locations close in Michigan
Yahoo
21 minutes ago
- Yahoo
Why Navitas Semiconductor Rocketed 164% in May
Navitas is a small-cap semiconductor stock with declining revenues and operating losses. However, the company was named as a partner for Nvidia's upcoming Kyber data center power infrastructure. Navitas took the opportunity of a higher stock price to raise cash via equity sales, bolstering its balance sheet. 10 stocks we like better than Navitas Semiconductor › Shares of Navitas Semiconductor (NASDAQ: NVTS) rocketed 164.2% in May, according to data from S&P Global Market Intelligence. Entering the month, Navitas has been a small designer of gallium nitride (GaN) and silicon carbide (SiC) chip designs. These niche chips had primarily targeted electric vehicles and electrified infrastructure. But given the recent downturns in these markets, Navitas had seen its revenue go into reverse and its bottom line continuing to lose money. But in mid-May, Nvidia named Navitas as a key partner for Nvidia's upcoming Kyber data center infrastructure, which will be a new architecture to support Rubin-based sever racks beginning in 2027. While other power chip providers were also named, the fact that Navitas was so small, at just $350 million or so market cap at the time of the announcement, caused a massive rally in the stock. Navitas then used the opportunity to sell stock and bolster its balance sheet, extending its runway, likely until the 2027 time frame. As Nvidia explained in a May 20 blog post, the current 54 V DC power distribution systems in today's data centers will push up against their physical limits as AI server racks go to needing 200 kilowatts to power next-generation AI chips. To counter this, Nvidia is developing a ground-up redesign of data centers to an 800 V HVDC power architecture. Nvidia also noted that it was collaborating with a number of power chip and infrastructure companies early on as it develops the new data center power infrastructure, which Nvidia plans to unveil in 2027 for its upcoming Rubin-based systems. The following day, Navitas published its own blog post explaining how the new 800 V architecture will use both Navitas' SiC chips in the power room of data centers, which convert AC grid power to DC power for the data center, and then GaN-based power converters at the server rack level. The day of the blogs, May 21, Navitas rocketed 150% higher, before retreating. But then the following week, Navitas disclosed it had exhausted its $50 million equity at-the-market sales facility, and that it had filed for a new $50 million facility. Normally, when a company notes it has and will dilute shareholders, the stock goes down. But since Navitas' stock had gone up so much, investors viewed the capital raise as a positive, in that it fortified Navitas' balance sheet to bridge more of the time gap between now and 2027. While the prospect of a small company partnering up with Nvidia is highly tantalizing, there weren't any financial terms disclosed in the announcements. That makes sense, as the platform isn't even fully developed yet, and revenues from the venture aren't likely to come before 2027. So it's hard to say right now if Navitas has moved too far, too fast. Still, last month's cash raise will bolster Navitas' balance sheet, giving it more time to build out its platform in anticipation of the 2027 Kyber rollout. Before you buy stock in Navitas Semiconductor, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Navitas Semiconductor wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $668,538!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $869,841!* Now, it's worth noting Stock Advisor's total average return is 789% — a market-crushing outperformance compared to 172% for the S&P 500. Don't miss out on the latest top 10 list, available when you join . See the 10 stocks » *Stock Advisor returns as of June 2, 2025 Billy Duberstein and/or his clients have no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Nvidia. The Motley Fool has a disclosure policy. Why Navitas Semiconductor Rocketed 164% in May was originally published by The Motley Fool
Yahoo
24 minutes ago
- Yahoo
New owner of Portsmouth events venue once went to school there
Giovanni Donatelli used to walk the halls of Portsmouth Catholic High School as a young boy. Now, almost four decades later, Donatelli is the new owner of the renovated and renamed building, Cambridge Hall. An entrepreneur who moved to the U.S. in 1982, Donatelli is the founder and CEO of The Language Group, a Virginia Beach-based translation service company established in 1999. His company employs 70 fulltime employees and 600 linguists skilled in 225 languages. The Language Group also has a secondary office in Hamburg, Germany. In early April, Donatelli purchased the building at auction for $660,000. There was also a separate transaction totaling $25,000 to buy the intellectual property rights for the business, including the event hall, website, furniture, artwork and baby grand piano. William J. 'Billy' Summs Sr., auctioneer with Atlantic Asset Management Group, said Donatelli was the perfect buyer. The Italianate-style building was transformed into a wedding and event venue in 2022 by Ed O'Neil, an insurance agent with New York Life in Norfolk. Donatelli plans to reopen it this summer as an event hall to host family and company functions. An immigrant from the east coast of Italy, he said he identifies as a local boy from Portsmouth and cherishes the building. 'I stood where my locker used to be and you can see where the desks used to sit,' he said. 'I can almost see myself sitting in the classrooms again.' Armed with ideas, Donatelli said he will continue to operate it as a rental event hall for now — including employee functions for his business — but he is also thinking about using part of the more than 6,000 square feet for nonprofits. Overjoyed with the amount of care the two most recent owners put into the building following years of neglect, Donatelli, a resident of Virginia Beach, said it's now up to him to be a proper steward of it. 'I would love to have a reunion to celebrate the different classes that graduated from there — back in their own building,' he said. 'And I'd like to make a wall to honor the school with a copy of all the yearbooks.' Situated at the corner of London and Washington streets in Old Towne Portsmouth since 1892, the structure was originally St. Paul's Academy for Boys, then St. Paul's Catholic High School before it became Portsmouth Catholic High School in 1964. The Donatelli family's journey to Hampton Roads began in the late 1970s when his father, Otero, a tailor in his native land, was recruited by Morris Rapoport, late patriarch and founder of The Quality Shops. 'They couldn't find anyone in the U.S. so they extended their search and found my father,' Donatelli said. Rapoport sponsored the family's visas and after 6 years they applied for their citizenship. Donatelli's mother, Grace is known throughout Hampton Roads for her seamstress skills. Donatelli and his younger brother, Sandro began their schooling at the now defunct Shea Terrace Elementary where he fondly remembers they learned to speak English. His love of languages only grew from that experience. When Donatelli was in seventh grade, he started his studies at Portsmouth Catholic. An altar boy in Italy, Donatelli said he continued his faithful service to the church every Sunday, serving mass at St. Paul's Catholic Church adjacent to the school. 'I used to play right there and fly my kite on North Street in the parking lot,' Donatelli said. 'It's my home; even though I'm an immigrant, I really grew up in Portsmouth.' Portsmouth Catholic shuttered in 1991 and Donatelli graduated from Churchland High School the following year. 'It feels right; the sentimental connection is there, and it's really special that I was able to do this,' he said. 'It's really nice to feel like I can offer something back to the community by buying my old schoolhouse.' Sandra J. Pennecke, 757-652-5836,
