Trump signs order aiming to cut some U.S. drug prices to match lower ones abroad

Business Mayor

12-05-2025

President Donald Trump on Monday revived a controversial policy that aims to slash drug costs by tying the prices of some medicine in the U.S. to the significantly lower ones abroad.
Trump signed an executive order including several different actions to renew that effort, known as the 'most favored nation' policy. He did not refer to specific nations, but signaled that he would target other developed countries because 'there are some countries that need some additional help, and that's fine.'
'Basically, what we're doing is equalizing,' Trump said during a press event on Monday. 'We are going to pay the lowest price there is in the world. We will get whoever is paying the lowest price, that's the price that we're going to get.'
White House officials did not disclose which medications the order will apply to, but said it will impact the commercial market as well as Medicare and Medicaid. They said Monday's announcement will be broader than a similar policy that Trump tried to push during his first term, which only applied to Medicare Part B drugs.
Officials added that the administration will have a particular focus on drugs that have the 'largest disparities and largest expenditures,' which could include popular weight loss and diabetes treatments called GLP-1 drugs.
It's unclear how effective the policy will be at lowering costs for patients. In a social media post on Monday, Trump claimed drug prices will be cut by '59%, PLUS!'
But Trump during the press event claimed drug prices may fall even more, between 59% and 80%, or 'I guess even 90%.'
Some Wall Street analysts and other experts also questioned whether the policy can be implemented.
In a note on Monday, JPMorgan analysts called the policy 'challenging to practically implement' because it would likely require congressional approval and could run into legal hurdles.
It is Trump's latest effort to try to rein in U.S. prescription drug prices, which are two to three times higher on average than those in other developed nations – and up to 10 times more than in certain countries, according to the Rand Corp., a public policy think tank.
In a statement on Monday, the pharmaceutical industry's biggest lobbying group, PhRMA, lauded Trump for taking aim at other nations 'not paying their fair share.'
Still, PhRMA's CEO Stephen Ubl said 'importing foreign prices from socialist countries would be a bad deal for American patients and workers' because it would hurt the industry's ability to bring them new treatments. Some experts have said the order could face challenges from the pharmaceutical industry in court. Read More Generic platinum chemotherapy shortages did not increase deaths
Despite the order, shares of U.S. drugmakers rose Monday. Merck 's stock added more than 4%, while Pfizer and Amgen climbed more than 2%
AARP, which advocates for older Americans, thanked Trump for issuing the order in a statement on Monday.
'For too long, big drug companies have been ripping off America's seniors—charging the highest prices in the world for lifesaving prescriptions, padding their profits at the expense of American lives, and forcing older adults to skip medications they can't afford,' AARP's chief advocacy and engagement officer Nancy LeaMond said in the statement. How Trump's drug pricing order will work
President Donald Trump, joined by Health and Human Services Secretary Robert F. Kennedy Jr., speaks during a press conference in the Roosevelt Room of the White House on May 12, 2025, in Washington, DC.
Andrew Harnik | Getty Images
Part of the order takes aim at nations abroad, which have more power to negotiate down drug prices with pharmaceutical companies.
'Starting today, the United States will no longer subsidize the health care of foreign countries, which is what we were doing,' Trump said, adding the U.S. 'will no longer tolerate profiteering and price gouging from Big Pharma.'
He added that 'it was really the countries that forced Big Pharma to do things that, frankly, I'm not sure they really felt comfortable doing.'
The order directs the Office of the U.S. Trade Representative and the Department of Commerce to crack down on 'unreasonable and discriminatory policies' in foreign countries that 'suppress' drug prices abroad, the officials said.
'We are going to be working to make sure that countries aren't being unfair in their negotiations with pharmaceutical companies, right?' one official said. Drugmakers are 'constantly complaining' about being put 'in an untenable situation when in these negotiations' because those companies typically have to broker drug discounts with entire countries, the official added.
Unlike the U.S., several foreign countries offer universal health coverage where the government is the sole payer, giving it significant leverage to negotiate or set drug prices.
White House officials said they expect drugmakers to provide discounts across the board to 'reciprocate' the actions the Trump administration is taking to address prices abroad.
Trump's order also directs the secretary of the Department of Health and Human Services to establish a pathway for U.S. patients to buy their drugs directly from manufacturers at most favored nation prices, bypassing middlemen.
'We're going to cut out the middlemen and facilitate the direct sale of drugs at the most favorite nation price, directly to the American citizen,' Trump said.
Within 30 days, the secretary will also have to set clear targets for price reductions across all markets in the U.S., according to the officials. That will open up a round of negotiations between HHS and the pharmaceutical industry, officials said, not providing exact details on the nature of those talks.
If 'adequate progress' is not made toward those price targets, HHS Secretary Robert F. Kennedy Jr. will impose the most favored nation pricing on drugs through rulemaking.
The order also directs the Food and Drug Administration to consider expanding imports from other developed nations beyond Canada. Trump signed a separate executive order in April directing the FDA to improve the process by which states can apply to import lower-cost drugs from Canada, among other actions intended to lower drug prices.
Monday's order also directs the Department of Justice and Federal Trade Commission to aggressively enforce 'anti-competitive actions' that keep prices high in the U.S.
The Department of Commerce will also consider export restrictions that 'fuel and enable that low pricing abroad.' The effects on patients, companies
Drugmakers have argued that the most favored nation policy would hurt their profits and ultimately, their ability to research and develop new medicines.
White House officials contended that pharmaceutical companies will continue to make money after the price cuts if they realize that the U.S. 'alone is not going to pay for innovation' and if they increase prices abroad to get additional revenue there.
Drugmakers 'should pursue deals where they get financially rewarded commensurate the value that they are providing to other nations, health systems,' one official said.
'Other countries should pay research and development, too. It's for their benefit,' Trump added on Monday.
The industry also lobbied against similar Trump plans during his first term. He tried to push the policy through in the final months of that term, but a federal judge halted the effort following a lawsuit from the pharmaceutical industry. The Biden administration then rescinded that policy. Read More Understanding metabolites underlying eye development
White House officials initially pressed congressional Republicans to include a most favored nation provision in the major reconciliation bill they plan to pass in the coming months, but the policy would have specifically targeted Medicaid drug costs, Politico reported earlier this month. Several GOP members opposed that measure.
The industry's largest trade group, PhRMA, estimated that Trump's Medicaid proposal could cost drugmakers as much as $1 trillion over a decade.
Some health policy experts have said a most favored nation drug policy may not be effective at lowering medication costs.
For example, USC experts said the policy 'can't undo the basic economics of the global drug marketplace,' where 70% of pharmaceutical profits worldwide come from the U.S.
'Facing a choice between deep cuts in their U.S. pricing or the loss of weakly profitable overseas markets, we can expect many firms to pull out from overseas markets at their earliest opportunity,' experts said in a report in April.
That will leave Americans paying the same amount for medications, drugmakers with lower profits and future generations of patients with less innovation, they said.
'In sum, everyone loses,' the experts said.
Even if the drug industry pushes back on Trump's executive order in court, his administration still has another tool to push down drug prices: Medicare drug price negotiations.
It's a key provision of the Inflation Reduction Act that gives Medicare the power to negotiate certain prescription drug prices with manufacturers for the first time in history.
Trump last month proposed a change to that policy that drugmakers have long sought. Lawmakers on both sides of the aisle could be receptive to the idea, which proposes changing rules that differentiate between small-molecule drugs and biologic medicines.
Trump last week said he plans to announce tariffs on medicines imported into the U.S. within the next two weeks. Those planned levies aim to boost domestic drug manufacturing.
Drugmakers, including Eli Lilly and Pfizer , are pushing back on those potential duties. Some companies have questioned whether the tariffs are necessary, given that several of them have already announced new U.S. manufacturing and research and development investments since Trump took office.
Still, Trump last week doubled down on efforts to reshore drug manufacturing. He signed an executive order that streamlines the path for drugmakers to build new production sites.