Blood test may predict rapid brain decline in Alzheimer's patients
A common blood test can flag early Alzheimer's disease patients who are four times more likely to experience rapid brain decline, a new study says. Photo by Adobe Stock/HealthDay News
A common blood test can flag early Alzheimer's disease patients who are four times more likely to experience rapid brain decline, a new study says.
The test -- the triglyceride-glucose (TyG) index -- assesses a person's level of insulin resistance and can estimate their risk of developing Type 2 diabetes.
But the test also can help determine which people newly diagnosed with Alzheimer's might experience a faster decline in brain function, researchers reported at the European Academy of Neurology's annual meeting.
"Once mild cognitive impairment is diagnosed, families always ask how fast it will progress," lead investigator Dr. Bianca Gumina, a neurology resident at the University of Brescia's Brain Health Center in Italy, said in a news release.
"Our data show that a simple metabolic marker available in every hospital laboratory can help identify more vulnerable subjects who may be suitable candidates for targeted therapy or specific intervention strategies," she added.
Insulin resistance has been linked to the onset of Alzheimer's, but its role in how quickly the disease progresses has received less attention, researchers said in background notes.
For the study, researchers reviewed medical records for 315 non-diabetic patients in cognitive decline, including 200 with confirmed Alzheimer's disease.
All underwent the TyG index blood test and were followed for three years.
The third of Alzheimer's patients with the highest levels of insulin resistance had a quadrupled risk of faster cognitive decline, when compared to those with the least insulin resistance, results show.
"We were surprised to see the effect only in the Alzheimer's spectrum and not in other neurodegenerative diseases," Gumina noted. "It suggests a disease-specific vulnerability to metabolic stress during the prodromal window, when interventions may still change the trajectory."
Insulin resistance is believed to advance Alzheimer's by impeding blood sugar uptake to neurons, promoting accumulation of toxic beta amyloid proteins, disrupting the blood-brain barrier and fueling inflammation, researchers said.
This study found that high TyG-assessed insulin resistance was indeed associated with disruption to the blood-brain barrier, researchers said.
However, insulin resistance did not appear to interact with a person's genetic risk for Alzheimer's, indicating that these are separate risk factors that might operate independently.
Researchers now are investigating whether TyG levels track with imaging scans of Alzheimer's, as combining the two could aid earlier detection.
"If targeting metabolism can delay progression, we will have a readily modifiable target that works alongside emerging disease-modifying drugs," Gumina said.
She presented her findings Monday at the EAN meeting in Helsinki.
Findings presented at medical meetings should be considered preliminary until published in a peer-reviewed journal.
More information
The University of Washington has more on insulin resistance and Alzheimer's disease.
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Blood test may predict rapid brain decline in Alzheimer's patients
A common blood test can flag early Alzheimer's disease patients who are four times more likely to experience rapid brain decline, a new study says. Photo by Adobe Stock/HealthDay News A common blood test can flag early Alzheimer's disease patients who are four times more likely to experience rapid brain decline, a new study says. The test -- the triglyceride-glucose (TyG) index -- assesses a person's level of insulin resistance and can estimate their risk of developing Type 2 diabetes. But the test also can help determine which people newly diagnosed with Alzheimer's might experience a faster decline in brain function, researchers reported at the European Academy of Neurology's annual meeting. "Once mild cognitive impairment is diagnosed, families always ask how fast it will progress," lead investigator Dr. Bianca Gumina, a neurology resident at the University of Brescia's Brain Health Center in Italy, said in a news release. "Our data show that a simple metabolic marker available in every hospital laboratory can help identify more vulnerable subjects who may be suitable candidates for targeted therapy or specific intervention strategies," she added. Insulin resistance has been linked to the onset of Alzheimer's, but its role in how quickly the disease progresses has received less attention, researchers said in background notes. For the study, researchers reviewed medical records for 315 non-diabetic patients in cognitive decline, including 200 with confirmed Alzheimer's disease. All underwent the TyG index blood test and were followed for three years. The third of Alzheimer's patients with the highest levels of insulin resistance had a quadrupled risk of faster cognitive decline, when compared to those with the least insulin resistance, results show. "We were surprised to see the effect only in the Alzheimer's spectrum and not in other neurodegenerative diseases," Gumina noted. "It suggests a disease-specific vulnerability to metabolic stress during the prodromal window, when interventions may still change the trajectory." Insulin resistance is believed to advance Alzheimer's by impeding blood sugar uptake to neurons, promoting accumulation of toxic beta amyloid proteins, disrupting the blood-brain barrier and fueling inflammation, researchers said. This study found that high TyG-assessed insulin resistance was indeed associated with disruption to the blood-brain barrier, researchers said. However, insulin resistance did not appear to interact with a person's genetic risk for Alzheimer's, indicating that these are separate risk factors that might operate independently. Researchers now are investigating whether TyG levels track with imaging scans of Alzheimer's, as combining the two could aid earlier detection. "If targeting metabolism can delay progression, we will have a readily modifiable target that works alongside emerging disease-modifying drugs," Gumina said. She presented her findings Monday at the EAN meeting in Helsinki. Findings presented at medical meetings should be considered preliminary until published in a peer-reviewed journal. More information The University of Washington has more on insulin resistance and Alzheimer's disease. Copyright © 2025 HealthDay. All rights reserved.
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[220+ Pages Latest Report] According to a market research study published by Custom Market Insights, the demand analysis of Global Alzheimer's Drug Market size & share revenue was valued at approximately USD 5.64 Billion in 2024 and is expected to reach USD 6.41 Billion in 2025 and is expected to reach around USD 19.3 Billion by 2034, at a CAGR of 13.03% between 2025 and 2034. The key market players listed in the report with their sales, revenues and strategies are Eli Lilly and Co., Biogen Inc., Roche Holding AG, AstraZeneca PLC, Novartis AG, Johnson & Johnson, Pfizer Inc., Merck & Co. Inc., Bayer AG, Amgen Inc., Sanofi S.A., AbbVie Inc., Takeda Pharmaceutical Company Limited, Lundbeck A/S, Otsuka Pharmaceutical Co. Ltd., H. Lundbeck A/S, Acadia Pharmaceuticals Inc., Alzheon Inc., Cassava Sciences Inc., Green Valley Pharmaceutical Inc, and others. Austin, TX, USA, June 23, 2025 (GLOBE NEWSWIRE) -- Custom Market Insights has published a new research report titled 'Alzheimer's Drug Market Size, Trends and Insights By Type of Drug (Disease-Modifying Therapies (DMTs), Symptomatic Therapies), By Application (Amyloid-Targeting Agents, Tau-Targeting Agents, Cholinesterase Inhibitors, NMDA Antagonists, Other Agents), By End User (Hospitals, Clinics, Home Care Settings), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2025–2034' in its research database. 'According to the latest research study, the demand of the global Alzheimer's Drug Market size & share was valued at approximately USD 5.64 Billion in 2024 and is expected to reach USD 6.41 Billion in 2025 and is expected to reach a value of around USD 19.3 Billion by 2034, at a compound annual growth rate (CAGR) of about 13.03% during the forecast period 2025 to 2034.' Click Here to Access a Free Sample Report of the Global Alzheimer's Drug Market @ Alzheimer's Drug Market Overview As per the industry experts at CMI, the market for Alzheimer's Drugs includes the ageing global population, rising awareness about the disease, and advancements in disease-modifying therapies (DMTs). Increased investments in research and demand for effective treatments further fuel the market growth, thus offering opportunities for pharmaceutical firms. Alzheimer's Drug Market Growth Factors and Dynamics Aging Population: The global aging population is a growth driver for the Alzheimer's drug market. With an ever-growing proportion of elderly individuals, the disease is becoming more and more prevalent. This demographic shift, especially in North America, Europe, and Asia-Pacific, is triggering the demand for innovative therapies. Alzheimer's disease primarily affects individuals aged 65 and above, and as the elderly population grows, it will significantly expand the patient base. The more serious implications of this trend include an immediate need for effective disease-modifying therapies, which presents a possible opportunity in the coming years. Thus, the rise in Alzheimer's cases combined with an aging population offers an opportunity for substantial growth in the market. Trends Influencing Research and Development: Advancements in mechanisms in research for Alzheimer's disease are accelerating the development of new and more effective therapies. Key discoveries about drugs that target amyloid, therapies based on tau, and genetic research are paving the way for treatments that can change the course of the disease. The improved understanding of Alzheimer's pathology has led to the ability to direct drug compounds against the underlying disease instead of merely alleviating symptoms. Large-scale clinical trials, supported by significant investments from both private and government sectors, will drive significant growth in R&D over the next few years by introducing new treatment options. Elevated Investments and Awareness in Healthcare: Increasing recognition of Alzheimer's disease as a growing healthcare challenge has, of course, led to increasing investment in research, treatment, and supportive services. Governments, healthcare organizations, and the private sector are spending more money developing better ways to treat people. There is also a greater commitment to addressing Alzheimer's disease expressed in policy changes, increased funding for clinical trials, and public health initiatives aimed at early diagnosis and intervention. The rise in awareness concerning the said Alzheimer's disease will also make it possible for healthcare providers and patients to seek and adopt new treatments more widely, thus feeding market demand. Request a Customized Copy of the Alzheimer's Drug Market Report @ High Treatment Costs and Accessibility Issues: The advanced Alzheimer's drug market deals with the high costs of disease-modifying therapy, which are some of the biggest challenges to disease-modifying therapies (DMTs). Annual treatment costs for amyloid-targeting agents, especially Aducanumab, are at a rate of over $50,000. Such prices may deny access to new treatments, mostly in the setting of the developing world healthcare systems or where insurance coverage is scant. While new therapies play their part in modifying the disease, affordability or cost will remain a major dynamic in the adoption rate. Combined with the necessity for frequent diagnostic imaging, high treatment costs will probably prevent the market from expanding access to all patient populations. Approval Delays and Regulatory Hurdles: Regulatory processes define the drug market for Alzheimer's because any drug needs to go through extensive clinical trials and approval procedures before its market entry. Regulatory authorities, such as the FDA and EMA, are becoming more cautious due to the complexity of treatments and the risks associated with new therapies for Alzheimer's. Concerns about side effects, including brain swelling associated with amyloid-targeting agents, often lead to extended approval times and heightened safety concerns. These regulatory dynamics will often end up delaying entry into the market for promising treatments, which in turn slows down market growth and the availability of new drugs. Market Fragmentation and Competitive Landscape: The Alzheimer's drug market is said to be highly fragmented, with more and more entrants coming in to offer competition for developing therapeutic options. While major companies like Eli Lilly, Biogen, and Roche have established themselves as market leaders with therapies targeting amyloid, they face competition from small biotechnology firms that are focusing on unique targets such as tau proteins and other mechanisms of Alzheimer's disease. Competition here, however, generates innovation but also creates difficulties in differentiating products. The plethora of divergent mechanisms and efficacy profiles would confuse, among other things, healthcare providers and patients, making it harder for individual therapies to capture the market. Report Scope Feature of the Report Details Market Size in 2025 USD 6.41 Billion Projected Market Size in 2034 USD 19.3 Billion Market Size in 2024 USD 5.64 Billion CAGR Growth Rate 13.03% CAGR Base Year 2024 Forecast Period 2025-2034 Key Segment By Type of Drug, Application, End User and Region Report Coverage Revenue Estimation and Forecast, Company Profile, Competitive Landscape, Growth Factors and Recent Trends Regional Scope North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America Buying Options Request tailored purchasing options to fulfil your requirements for research. (A free sample of the Alzheimer's Drug report is available upon request; please contact us for more information.) Our Free Sample Report Consists of the following: The updated report for 2024 includes an Introduction, an Overview, and an in-depth industry analysis. We have included the COVID-19 Pandemic Outbreak Impact Analysis in the package. About 220+ Pages Research Report (Including Recent Research) Provide detailed chapter-by-chapter guidance on the Request. Updated Regional Analysis with a Graphical Representation of Size, Share, and Trends for the Year 2025 Includes We have updated the tables and figures. The most recent version of the report includes the Top Market Players, their Business Strategies, Sales Volume, and Revenue Analysis Custom Market Insights (CMI) research methodology (Please note that the sample of the Alzheimer's Drug report has been modified to include the COVID-19 impact study prior to delivery.) Request a Customized Copy of the Alzheimer's Drug Market Report @ Alzheimer's Drug Market SWOT Analysis Strengths: The Alzheimer's drug market is now almost purely dependent on huge R&D investments directed toward disease-modifying therapies. Breakthrough therapies in the shape of amyloid-targeting drugs have gained so much attention. However, the tremendous global aging population plays a significant role in market growth because these individuals will certainly require treatment for Alzheimer's disease. More regulatory developments are leaning toward the faster approval of therapies with encouraging promise. Growing awareness and concern over Alzheimer's as a public health issue have facilitated research funding, clearing the path toward advanced treatment options. Weaknesses: The cost of new treatments, like Aducanumab, is a major weakness in the Alzheimer's drug market; they cannot be reached. This cost acts as a barrier to introducing it more widely in health economies with a limited budget. Also, the existence of safety issues related to the newer modalities, like brain swelling or bleeding, limits the number of patients eligible for the treatment. While many advances have been made, the treatments remain essentially symptomatic or limited in effect, leading to reluctance on the part of both patients and healthcare providers to use these therapies. Opportunities: The increasing number of Alzheimer's disease diagnoses presents significant opportunities for the Alzheimer's drug market. The demand for innovative treatments rises with an increasing patient population. Another opportunity is offered by advances in the area of personalized medicine and genetic therapies, with the prospect of tailoring therapies to individual patients. Research on Alzheimer's disease is receiving an increasing amount of funding, and increasing awareness of this disease presents additional growth opportunities. There also arise major opportunities for developing low-cost therapies, with better access to healthcare infrastructure in developing markets, such as those in the Asia-Pacific region and Latin America. Threats: Regulatory obstacles to the approval of new therapies pose the primary threat to entry into the Alzheimer's drug market. Strict rules for clinical trials make it hard for new drugs to enter the market and raise concerns about the safety of drugs in the later trial stages, especially those aimed at amyloid. High costs of treatment represent another challenge, especially for patients in low-income areas or those lacking comprehensive health insurance coverage. The development of several treatments could fragment the market, leading to increased competition and making it difficult for individual therapies to take hold. Another factor impeding market growth is the regulatory backlash against new drugs based on safety issues. Request a Customized Copy of the Alzheimer's Drug Market Report @ Key questions answered in this report: What is the size of the Alzheimer's Drug market and what is its expected growth rate? What are the primary driving factors that push the Alzheimer's Drug market forward? What are the Alzheimer's Drug Industry's top companies? What are the different categories that the Alzheimer's Drug Market caters to? What will be the fastest-growing segment or region? In the value chain, what role do essential players play? What is the procedure for getting a free copy of the Alzheimer's drug market sample and company profiles? Key Offerings: Market Share, Size & Forecast by Revenue | 2025−2034 Market Dynamics – Growth Drivers, Restraints, Investment Opportunities, and Leading Trends Market Segmentation – A detailed analysis by Types of Services, by End-User Services, and by regions Competitive Landscape – Top Key Vendors and Other Prominent Vendors Buy this Premium Alzheimer's Drug Research Report | Fast Delivery Available - [220+ Pages] @ Alzheimer's Drug Market Regional Analysis The Alzheimer's drug market is segmented into various regions, including North America, Europe, Asia-Pacific, and LAMEA. Here is a brief overview of each region: North America: North America, especially the United States, accounts for the largest portion of the Alzheimer's drug market as a result of the aging population, extensive health care expenditure, and all the research and development activities going on. Major pharmaceutical companies like Eli Lilly, Biogen, and Johnson & Johnson are present in the country and are at the forefront of developing DMTs for Alzheimer's disease. Moreover, the North American region boasts well-established healthcare infrastructures that will facilitate the adoption of new therapies. The rapid uptake of drugs targeting amyloid, like Aducanumab, reflects the growing consumer demand for innovative treatments. The economic accessibility of these treatments is narrowing down for the older population. The high cost of these therapies, combined with growing concerns about affordability and healthcare access, presents significant challenges to their widespread use. North America has emerged as the largest and fastest-growing market in terms of increasing demand for new treatments and the rising number of Alzheimer's patients. Europe: The continent of Europe will play a significant role in the development of Alzheimer's drugs worldwide as it benefits from sound healthcare systems, high prevalence of the disease, and major research funding. Countries such as Germany, the United Kingdom, and France all boast solid healthcare access and traditional treatment and new approval streams. The authorizing of new indications for many novel therapies has even been possible in Europe, in particular by the European Medicines Agency (EMA), which recently cleared Leqembi and Aducanumab. Asia-Pacific: The market for Alzheimer's drugs in the Asia-Pacific region is, according to analysts, the most rapidly growing. The stupendous aging populations in Japan, China, and India play their part. In addition to the anticipated improvements from infrastructure and government programs, the region is enhancing its healthcare access. Given that Japan is one of the oldest populations in the world, it serves as a great opportunity market for drugs for Alzheimer's patients-such as those at the early stage of their disease. Thus, the developing awareness of Alzheimer's disease will also increase the application of diagnostic technologies regarding necromancy, and the need for advancing therapies to change the course of the disease is increasing. The fact that increasingly expensive alternatives to treatment are becoming more widely prescribed is unlikely to prevent use. LAMEA (Latin America, the Middle East, and Africa): Latin America, the Middle East, and Africa (LAMEA) have unique market dynamics. For example, among the Latin American countries, Brazil and Mexico are likely to experience increased demand for Alzheimer's treatments because of their aging populations and growing awareness regarding the disease. However, it has also been limited by the economic situation and the commonly inaccessible aspects of healthcare or budget constraints. The increased incidences of Alzheimer's are creating a need for more treatment options in the Middle East, such as in the UAE and Saudi Arabia, but high costs of drugs remain a major hurdle. Unfortunately, Africa faces the same issues, specifically a lack of population-wide tools for facilitating diagnosis and healthcare infrastructure. Request a Customized Copy of the Alzheimer's Drug Market Report @ (We customized your report to meet your specific research requirements. Inquire with our sales team about customizing your report.) Still, Looking for More Information? Do you want data for inclusion in magazines, case studies, research papers, or media? Email Directly Here with Detail Information: support@ Browse the full 'Alzheimer's Drug Market Size, Trends and Insights By Type of Drug (Disease-Modifying Therapies (DMTs), Symptomatic Therapies), By Application (Amyloid-Targeting Agents, Tau-Targeting Agents, Cholinesterase Inhibitors, NMDA Antagonists, Other Agents), By End User (Hospitals, Clinics, Home Care Settings), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2025–2034' Report at Leading Players: Eli Lilly and Co. Biogen Inc. Roche Holding AG AstraZeneca PLC Novartis AG Johnson & Johnson Pfizer Inc. Merck & Co. Inc. Bayer AG Amgen Inc. Sanofi S.A. AbbVie Inc. Takeda Pharmaceutical Company Limited Lundbeck A/S Otsuka Pharmaceutical Co. Ltd. Lundbeck A/S Acadia Pharmaceuticals Inc. Alzheon Inc. Cassava Sciences Inc. Green Valley Pharmaceutical Inc. 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Who Are the Global Key Players in This Alzheimer's Drug Market? What are the company profiles, product information, and contact details for these key players? What Was the Global Market Status of the Alzheimer's Drug Market? What Was the Capacity, Production Value, Cost and PROFIT of the Alzheimer's Drug Market? What Is the Current Market Status of the Alzheimer's Drug Industry? What's Market Competition in This Industry, Both Company and Country Wise? What's the Market Analysis of Alzheimer's Drug Market by Considering Applications and Types? What Are Projections of the Global Alzheimer's Drug Industry Considering Capacity, Production, and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply, and Consumption? What about imports and exports? What Is Alzheimer's Drug Market Chain Analysis by Upstream Raw Materials and Downstream Industry? What Is the Economic Impact On Alzheimer's Drug Industry? What are Global Macroeconomic Environment Analysis Results? What Are Global Macroeconomic Environment Development Trends? What Are Market Dynamics of Alzheimer's Drug Market? What Are Challenges and Opportunities? What Should Be Entry Strategies, Countermeasures to Economic Impact, and Marketing Channels for Alzheimer's Drug Industry? Click Here to Access a Free Sample Report of the Global Alzheimer's Drug Market @ Reasons to Purchase Alzheimer's Drug Market Report Alzheimer's Drug Market Report provides qualitative and quantitative analysis of the market based on segmentation involving economic and non-economic factors. Alzheimer's Drug Market report outlines market value (USD) data for each segment and sub-segment. This report indicates the region and segment expected to witness the fastest growth and dominate the market. Alzheimer's Drug Market Analysis by geography highlights the consumption of the product/service in the region and indicates the factors affecting the market within each region. The competitive landscape incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled. The report includes extensive company profiles, which include company overviews, insights, product benchmarking, and SWOT analyses for the major market players. The Industry's current and future market outlook concerning recent developments (which involve growth opportunities and drivers as well as challenges and restraints of both emerging and developed regions. Alzheimer's Drug Market Includes in-depth market analysis from various perspectives through Porter's five forces analysis and offers context for the market through Value Chain. Reasons for the Research Report The study provides a thorough overview of the global Alzheimer's Drug market. Compare your performance to that of the market as a whole. Aim to maintain competitiveness while innovations from established leaders drive market growth. Buy this Premium Alzheimer's Drug Research Report | Fast Delivery Available - [220+ Pages] @ What does the report include? Drivers, restrictions, and opportunities are among the qualitative elements covered in the worldwide Alzheimer's Drug market analysis. The report covers the competitive environment of current and potential participants in the Alzheimer's Drug market, along with those companies' strategic product development ambitions. According to the component, application, and industry vertical, this study analyzes the market qualitatively and quantitatively. Additionally, the report offers comparable data for the important regions. The report provides actual market sizes and forecasts for each segment mentioned above. Who should buy this report? Participants and stakeholders worldwide Alzheimer's Drug market should find this report useful. The research will be useful to all market participants in the Alzheimer's Drug industry. Managers in the Alzheimer's Drug sector are interested in publishing up-to-date and projected data about the worldwide Alzheimer's Drug market. Governmental agencies, regulatory bodies, decision-makers, and organizations want to invest in Alzheimer's Drug products' market trends. Market insights are sought for by analysts, researchers, educators, strategy managers, and government organizations to develop plans. Request a Customized Copy of the Alzheimer's Drug Market Report @ About Custom Market Insights: Custom Market Insights is a market research and advisory company delivering business insights and market research reports to large, small, and medium-scale enterprises. 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