Padres at Giants prediction: Odds, expert picks, starting pitchers, betting trends, and stats for June 5
It's Thursday, June 5 and the Padres (35-25) are in San Francisco to take on the Giants (34-28). Dylan Cease is slated to take the mound for San Diego against Robbie Ray for San Francisco.
The Padres had their three-game winning streak snapped in a 6-5 loss to the Giants yesterday. San Diego took the first meeting, so this will be the rubber match between the two featuring two of the best pitchers they have to offer.
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Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Padres at Giants
Date: Thursday, June 5, 2025
Time: 3:45PM EST
Site: Oracle Park
City: San Francisco, CA
Network/Streaming: SDPA, NBCSBA
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Padres at the Giants
The latest odds as of Thursday:
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Moneyline: Padres (+106), Giants (-126)
Spread: Giants -1.5
Total: 7.0 runs
Probable starting pitchers for Padres at Giants
Pitching matchup for June 5, 2025: Dylan Cease vs. Robbie Ray
Padres: Dylan Cease, (1-4, 4.67 ERA)
Last outing: 4.2 Innings Pitched, 3 Earned Runs Allowed, 7 Hits Allowed, 1 Walk, and 6 Strikeouts Giants: Robbie Ray, (7-1, 2.43 ERA)
Last outing: 7.0 Innings Pitched, 1 Earned Run Allowed, 2 Hits Allowed, 3 Walks, and 9 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Expert picks & predictions for tonight's game between the Padres and the Giants
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
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Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Thursday's game between the Padres and the Giants:
Moneyline: NBC Sports Bet is recommending a play on the San Francisco Giants on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the San Diego Padres at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 7.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Padres at Giants
The Giants have won 12 of their last 20 home games
The Under is 4-1 in the Giants' last 5 games
The Giants are 10-2 in Ray's 12 starts, but 1-2 in the last three games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
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