Mathieu van der Poel pulls out of Tour de France with pneumonia
The versatile Dutchman, who wore the yellow jersey and won a stage during the opening week of the race, experienced 'symptoms of a common cold over the past few days,' his Alpecin-Deceuninck team said a few hours before Stage 16.
Van der Poel's condition worsened 'significantly' during Monday's second rest day and was taken to an hospital in the southern city of Narbonne with a fever for further examinations.
'Medical tests revealed that Mathieu is suffering from pneumonia,' the team said. 'In consultation with the medical staff, it was decided that he can no longer continue the race. His health is the top priority, and rest and recovery are now essential.'
Van der Poel will now rest for a week before further medical examinations determine the next steps in his recovery, his team added.
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13 minutes ago
- Yahoo
Ipsen announces changes to its Executive Committee
PARIS, FRANCE, 23 July 2025 - Ipsen (Euronext: IPN; ADR: IPSEY), a global specialty care biopharmaceutical company, today announced the following changes to its Executive Committee: Mari Scheiffele is appointed to EVP, Chief Product Officer Andreas Gerber is appointed to EVP, Head of International Caroline Sitbon is appointed to EVP, General Counsel Mari, Andreas and Caroline will report to Ipsen's Chief Executive Officer, David Loew, beginning September 1, 2025. After 4 years successfully leading the commercial operations for the International Region at Ipsen, Mari Scheiffele will now lead all medicines in Oncology and Rare Disease at Ipsen. In the new role, Mari will focus on driving product development and pipeline innovation for new medicines and lead globally, brands and life cycle management. Mari succeeds Bartek Bednarz who will now lead the newly created Asia, Pacific & China region at Ipsen. Andreas Gerber joins Ipsen from Johnson & Johnson where he most recently served as Worldwide Vice-president and Head of the Oncology Franchise. In his new role as Head of International, Andreas will lead Ipsen's operations in all geographies excluding North America. Andreas's extensive business acumen and commercial operations experience will support driving growth in Ipsen's three therapeutic areas: Oncology, Rare Disease and Neuroscience across the International region. Andreas succeeds Mari Scheiffele. Finally, Caroline Sitbon has been promoted to the role of Ipsen's General Counsel. Caroline joined the company from GSK in 2024 as Senior Vice President, Legal Affairs. In her new role, Caroline will lead legal and business ethics and will also serve as the Board of Directors' General Secretary. Caroline succeeds François Garnier who will be retiring after a very successful career, including his tenure as Ipsen's General Counsel and General Secretary to the Board of Directors. 'These three appointments bring additional highly qualified global leaders to our executive leadership team and I'm delighted that they represent a combination of internal promotions and new leaders that have joined Ipsen,' said David Loew, Chief Executive Officer. 'After personally working with both Mari and Caroline throughout their tenure at Ipsen, I have been impressed by their leadership, business insights and innovative mindsets. Each of these leaders, in their respective fields, have strongly contributed and partnered with Executive Leadership Team members to the ongoing transformation that we have been successfully driving at Ipsen. I am also very pleased to welcome Andreas to Ipsen. Over the last few years, I have observed his accomplishments and am convinced that his leadership and capacity to inspire our teams to execute and deliver on our strategy will be instrumental in our continuous growth trajectory in those respective markets. These additions also now represent a gender-balanced Executive Committee at Ipsen. I would also like to warmly thank François Garnier who had a long and distinguished career at Ipsen, making a big impact on the development of our company.' Mari Scheiffele said, 'I am honored to step into the role of Chief Product Officer at such an exciting time for our company. I am committed to driving innovation, fostering a culture of excellence, and continuing to work with our teams to deliver impact for our customers and patients.' Andreas Gerber said, 'I am thrilled to join Ipsen to lead the International Region and to work, together, with a world-class team to make a real impact on patients' everyday lives. I am looking forward to driving our innovative medicines across the portfolio to create access and adoption for patients and customers worldwide and to realize the full potential of our transformative therapies.' Caroline Sitbon added, 'It is an honor to take the General Counsel and General Secretary role and be part of this dynamic and fast-growing organization committed to advancing science for patients and consumers. I am very excited to have the opportunity to lead a highly qualified team that ensures our commitment to remain unwavering in compliance and integrity'. ABOUT IPSEN We are a global biopharmaceutical company with a focus on bringing transformative medicines to patients in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Our pipeline is fueled by internal and external innovation and supported by nearly 100 years of development experience and global hubs in the U.S., France and the U.K. Our teams in more than 40 countries and our partnerships around the world enable us to bring medicines to patients in more than 80 countries. Ipsen is listed in Paris (Euronext: IPN) and in the U.S. through a Sponsored Level I American Depositary Receipt program (ADR: IPSEY). For more information, visit IPSEN CONTACTS InvestorsKhalid Deojee +33 6 66 01 95 26 MediaSally Bain +1 857 32 00 517Anne Liontas +33 6 69 09 12 96 Disclaimers and/or Forward-Looking StatementsThe forward-looking statements, objectives and targets contained herein are based on Ipsen's management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect Ipsen's future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words 'believes', 'anticipates' and 'expects' and similar expressions are intended to identify forward-looking statements, including Ipsen's expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external-growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by Ipsen. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising medicine in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. Ipsen must face or might face competition from generic medicine that might translate into a loss of market share. Furthermore, the research and development process involves several stages each of which involves the substantial risk that Ipsen may fail to achieve its objectives and be forced to abandon its efforts with regards to a medicine in which it has invested significant sums. Therefore, Ipsen cannot be certain that favorable results obtained during preclinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the medicine concerned. There can be no guarantees a medicine will receive the necessary regulatory approvals or that the medicine will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation; global trends toward healthcare cost containment; technological advances, new medicine and patents attained by competitors; challenges inherent in new-medicine development, including obtaining regulatory approval; Ipsen's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Ipsen's patents and other protections for innovative medicines; and the exposure to litigation, including patent litigation, and/or regulatory actions. Ipsen also depends on third parties to develop and market some of its medicines which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to Ipsen's activities and financial results. Ipsen cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of Ipsen's partners could generate lower revenues than expected. Such situations could have a negative impact on Ipsen's business, financial position or performance. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsen's business is subject to the risk factors outlined in its registration documents filed with the French Autorité des Marchés Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to Ipsen's latest Universal Registration Document, available on Attachment Ipsen PR_ELT Changes_23072025Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
an hour ago
- Yahoo
What is the greatest save you've ever seen live?
This coming Sunday, the winners of the Women's European Championship will be crowned, but perhaps the most iconic moment of the tournament has already been and gone. It's wasn't a goal nor a celebration, but instead the breathtaking, gravity-defying save pulled off Germany's Ann-Katrin Berger that kept her team alive in their quarter-final encounter with France. It was spectacular enough on a TV screen but imagine seeing it in the flesh. Inspired by Berger's moment of brilliance and the feeling of wonder it evoked, we asked our writers to take a trip down memory lane and wax lyrical about the best goalkeeper saves they've been privileged enough to see live. Enjoy this list and make sure to share the greatest save you've ever seen in person in the comments section below. Now, let's start with the save that inspired this collection of treasured stops… Ann-Katrin Berger, July 2025, Germany 1-1 France AET, Euro 2025 The existential urge that arises when an athlete executes some other-worldly feat is to go full rankings mode. Get out of the pantheon of (insert similar moments here) work backwards and write accordingly. That didn't happen in St. Jakob-Park after 105 minutes during Germany's Euro 2025 quarter-final win against France. It just simply didn't. And that's because what Ann-Katrin Berger did is simply unquantifiable and unrankable. Did you see her left arm? The way it effectively abandons its socket and sinews? The way she torqued and adjusted her body mid-scramble/leap? All while being completely and utterly beaten by the ball's arc, its headstart towards her goal? And yet somehow there's power to propel herself upwards despite falling explicitly backwards? But I want to go back to her arm because all the freeze frames of her save call to mind not any goalkeeper but Odell Beckham Jr. Specifically, 2014 OBJ for the New York Giants against the Dallas Cowboys, the one-handed catch that launched a million others. That is what we are talking about here: a save that is not really a save but a piece of transcendent sporting artistry that very few, if that, are capable of executing in these masses of bones and muscles we call human bodies. Megan Feringa Jordan Pickford, May 2022, Everton 1-0 Chelsea, Premier League Stuck perilously in the bottom three at the business end of the season, the arrival of European champions Chelsea at Goodison Park was daunting for Frank Lampard's side. Nevertheless, Everton managed to get ahead with Richarlison's goal and held on thereafter thanks to a performance by Jordan Pickford that beggared belief. There were many remarkable stops, including one at point-blank range with his face, but the finest of them all was from Cesar Azpilicueta. Pickford dived to his right to try to keep out a Mason Mount shot and the ball struck one post before zipping across goal, hitting the other upright and pinballing out to the waiting Chelsea captain. The Everton keeper had the awareness to crane his neck after his dive, following the trajectory of the ball along the line and realising it had stayed in play. So in a split second, despite regaining his feet in a slightly awkward position that left him facing the crowd not the play, he sprinted across goal in time to be in position to stop Azpilicueta's shot. It was an eight-yard dash that probably saved his team from a slow march to relegation. Greg O'Keeffe Nigel Martyn, Leeds United 1-1 Everton, April 2004, Premier League 'Nigel, give us a goal…' sang the Leeds United fans towards their former hero in the Everton goal. It was meant in jest, even though Leeds' predicament at the time during the 2003-04 Premier League season was deadly serious. Just three years after reaching the Champions League semi-finals, United were heading for relegation. Back-to-back wins in early April had brought renewed hope of survival but, still, only another three points against Everton would do if there was to be a great escape. Hence the half-tongue-in-cheek plea to a now 37-year-old Nigel Martyn, sold by a skint Leeds the previous summer. The fans could have saved their voices, as the veteran went on to produce a truly stunning individual display to earn Everton a 1-1 draw. His best save came after a miscued clearance had found James Milner. The teenager's curled shot was going in all the way until Martyn thrust a big hand skywards to tip the ball wide. Leeds never recovered, losing their next four games to drop out of the top flight, destined not to return for another 16 years. Martyn, though, rightly remains hugely popular at Elland Road, his name invariably at the very top of any polls to decide their best ever goalkeeper. Richard Sutcliffe Mary Earps, Spain 1-0 England, August 2023, World Cup final It's the World Cup final. Spain, who are trained from infancy in the art of collectively zip-wiring the ball around you, have a penalty. They are already 1-0 up. It is 69 minutes into the second half and their No 10, Jenni Hermoso, is standing over the ball. This is going in. Until it's not. Step up, Mary Earps, the 'queen of stops'. Look, this wasn't the best penalty but it was one great save. Earps clamped onto the ball low to her left like it was a car Hermoso had parked in the wrong place — but the bigger moment came next. England's goalkeeper jumped up and swore like mad. She stuck her tongue out which, along with the industrial language, felt like a rallying cry that boosted a nation and restored belief with 20 minutes to play. England ultimately lost the final but that sweary save will live on in our hearts forever. Caoimhe O'Neill Petr Cech, Chelsea 2-1 Liverpool, May 2012, FA Cup final This was not just a superb stop to light up an ordinary game. It was on the big occasion — a major cup final being played at Wembley against a bitter rival. It also ensured Chelsea would lift a trophy. Chelsea seemed to be cruising to another FA Cup triumph in 2012 when they went 2-0 up early in the second half only for Liverpool substitute Andy Carroll to get a goal back in the 64th minute. Carroll looked certain to equalise with eight minutes to go. He was picked out by Luis Suarez unmarked at the back post, just four yards out. The striker headed the ball with all his might and from my vantage point in the press box — and basically everyone else's inside the stadium that day — it looked a certain goal. However, Petr Cech dived to his right and somehow clawed the ball away, even though it was already behind him, before all of it crossed the line. To add to the drama, the ball came off the underside of the crossbar and was then cleared to safety by Branislav Ivanovic. Carroll and Suarez had already begun their celebrations and could not believe Cech had denied them. They were not the only ones. Simon Johnson Joe Hart, Manchester United 1-0 Manchester City, November 2008, Premier League It's not usually the marker of a brilliant save, but the most impressive part of Hart's heroic stop in the dying moments of the Manchester Derby back in 2008 was the pace that he showed to get there. City had been here before — a goal down to their arch-rivals thanks to Wayne Rooney's opener — but few could have anticipated just how close they would come to both nicking a point, and conceding a second, in added on time. With minutes to go, Joe Hart came up for a corner, and could only watch as Richard Dunne swivelled and stabbed a volleyed effort towards goal, blocked on the line by Patrice Evra and hacked away by John O'Shea. The goalkeeper stayed up for the resulting free kick but was caught miles out of his goal as a terrible back-pass gave Ryan Giggs and Rooney a clear run at City's open goal. Giggs didn't seem to fancy his chances from range, laying it off for Rooney to cut inside and blast it goalwards from all of 45 yards. But Hart, somehow, made up the ground, punching the ball just wide of the post at full-stretch before clattering into the net. In the end, it was another dismal derby defeat for City, but the sheer absurdity of the situation — watching in horror as the ball sailed towards the unguarded net, a flash of bright green shooting across the pitch to save it — makes it a game I'll struggle to forget. Thom Harris Guillermo Ochoa, Mexico 0-0 Poland, November 2022, World Cup Mexico entered the 2022 World Cup in turmoil. The country had turned against Argentine manager Gerardo 'Tata' Martino and there was little hope that the CONCACAF giants would progress from Group C that featured Poland, Argentina and Saudi Arabia. But Mexico still had Guillermo 'Memo' Ochoa in goal. He had been spectacular for Mexico at the 2014 and 2018 World Cup finals. His acrobatic reflex saves became part of World Cup lore, often saving Mexico from elimination. But could he do it again in Qatar, during his fifth World Cup at the age of 37? We found out rather quickly. In Mexico's opening group-stage match against Poland at Doha's Stadium 974, Ochoa danced on his line as he stared down Polish striker Robert Lewandowski. The match was scoreless when Poland were awarded a penalty in the 56th minute, in a match that had all the makings of a 1-0 affair. A Lewandowski conversion would surely have demoralised a Mexican side that was already under fire back home but the Poland great had struggled to score for his country on the biggest stage. Ochoa, on the other hand, relished the limelight. When Ochoa dove to his left and blocked Lewandowski's penalty, the roar inside the stadium was deafening. Ochoa had done it again. It was another masterclass from a World Cup legend. Mexico later crashed out in the group stage, proving that hope is futile, but Ochoa's class is timeless. Video for UK readers Video for U.S. readers Felipe Cardenas Phallon Tullis-Joyce, Manchester City 0-2 Manchester United, April 2025, FA Cup Goalkeepers are often peppered with balls from different angles, high to low, left to right, in training. The aim of the game is to get your body from a lying position to standing as quickly as possible. But rarely do you see such reactions in matches. In last year's FA Cup Manchester derby semi-final, Yui Hasegawa hit a beauty of a free kick right on the edge of the penalty arc. Manchester United's Phallon Tullis-Joyce did so well to dive to the right and get a firm hand on the shot to tip the ball onto the bar, but she was down on the ground. The rebound fell right in front of City's Lily Murphy. Surely she would score but up popped the USWNT goalkeeper in a flash. Somehow, she had the balance and strength to stick her left leg out and clear Murphy's header. United's No 1, usually so calm and measured, pumped her arms and let out a roar. 'LET'S GO!!!' United won 2-0, sending them through to their third consecutive FA Cup final. Charlotte Harpur Jimmy Walker, Swindon Town 1-1 Walsall, December 1999, First Division It was almost the end of a century and, for Walsall, it was an age of possibility. They were back in the second tier of English football for the first time in over a decade and only the fourth time in their history and, having upset all of the odds in the previous season to beat big-spending Manchester City and win promotion alongside even-bigger-spending Fulham, a team made up largely of other clubs' cast-offs was making a decent fist of batting to stay there. Collecting something from Swindon, who began the day bottom, was vital for a Walsall team two places and two points above them and, after a young midfielder called Michael Carrick (whatever happened to him?) had scored for Swindon to cancel out Darren Wrack's opener for Walsall, Jimmy Walker clinched the visitors a point in dramatic fashion in stoppage time. Grainy YouTube footage does not do it justice. As Iffy Onuora fired in a shot from a rebound off the frame of the goal, Walker already looked beaten, the ball seemingly past him, yet somehow he managed to react and claw it away. Walsall ended up relegated on the final day of the season but the fight to avoid the drop was epic and Walker's role in it helped cement his legend at Bescot. This young reporter from a weekly newspaper, given the chance to cover a club he had watched from the terraces a couple of years earlier, has never forgotten that moment. Steve Madeley Mike Maignan, Republic of Ireland 0-1 France, March 2023, World Cup qualifier These days, heroic failure rather than tangible results is the steady feed that fuels Republic of Ireland fans, nine years on since they last tasted the delicacies of major tournament football. All the usual ingredients were on show when then-world champions France came to Dublin in March 2023 for a European Championship qualifier. A resolute defensive display, undone by a moment of quality — this time a long-range Benjamin Pavard strike — followed by an earnest yet limited effort to equalise. But when awarded a last-minute corner, murmurings of belief echoed around the Aviva Stadium. This turned to cacophonous expectation when Nathan Collins connected perfectly with Josh Cullen's whipped delivery, powerfully guiding it towards the top right corner from just outside the six-yard box. Then a clawing hand appeared. Mike Maignan, with body and fingertips fully outstretched, legs splayed mid-air, reached behind his body to miraculously keep out the Irish captain's effort. 'I thought I had done everything,' said Collins post-match. He had, but Maignan's lightning reflexes meant it was yet another gut-wrenching, last-gasp rug-pull for the Irish faithful. Conor O'Neill Matz Sels, Nottingham Forest 0-1 Liverpool, March 2204, Premier League Last season, Matz Sels conjured up a truly remarkable save to keep out Brighton & Hove Albion's Danny Welbeck, when he dived full length to get the slightest of touches to a shot that was bound for the top corner, steering it onto the crossbar. But the Nottingham Forest keeper had pulled off an even better one during the 2023-24 campaign. When Darwin Nunez connected powerfully with a corner, his header already looked to be beyond Sels' reach, but he somehow stretched out a hand with remarkable speed and strength to swat it away from goal, right on the line, before gathering the ball into his grasp. The fact that the ball also seemed to take a deflection off Murillo only made his effort even harder to read — and the save all the more impressive. Sels has been the most influential keeper at Forest since Brice Samba, who produced penalty shootout heroics against Sheffield United in the Championship play-off semi-final as the club plotted a course to promotion in 2022. Paul Taylor This article originally appeared in The Athletic. Premier League, Soccer, Women's Soccer, Women's Euros 2025 The Athletic Media Company
Medscape
an hour ago
- Medscape
Sexual Health in MS Is Overlooked; Here's How to Change That
Summer — often associated with desire and lightness — can also bring renewed attention to the vulnerabilities of intimate life, especially for people with chronic illnesses. Among them, patients with multiple sclerosis (MS) frequently experience sexual dysfunction, a topic still too rarely addressed in routine care. In an interview with MediQuality , a Medscape Network platform, Arnaud Zeler, MD, French physician and sexologist, offered insights into the impact of MS on sexual health and outlines how healthcare professionals can better support their patients in this area. MS affects far more than motor or cognitive function — it also significantly impairs sexual wellbeing. Studies estimate that 40%-80% of men and 50%-70% of women with MS experience some form of sexual dysfunction. 'Because of its central neurological involvement, MS can cause a wide range of sexual dysfunctions,' said Zeler, noting that symptoms vary by sex, lesion location, and disease stage. In women, common issues include reduced vaginal lubrication, diminished clitoral and erogenous sensitivity, difficulty achieving orgasm, and frequent dyspareunia. For men, erectile dysfunction — ranging from partial to complete — is most frequently reported, along with ejaculatory problems and decreased genital sensation. 'In both sexes, hypoactive sexual desire and chronic fatigue often diminish libido and hinder sexual activity,' Zeler added. Beyond the Bedroom These dysfunctions can have profound personal and relational consequences. 'They affect sexual health, self-esteem, and intimate relationships — leading to frustration, guilt, and lower overall quality of life,' he said. International surveys, including those from the Multiple Sclerosis International Federation, consistently emphasize the importance of sexual wellbeing in quality of life assessments. Yet the issue remains taboo. 'Most clinical encounters do not address sexuality — this is acknowledged by both patients and clinicians,' Zeler said. On the patient side, modesty, fear of stigma, or assumptions that sexual problems are secondary to other MS symptoms may prevent disclosure. Only 22.4% of women with MS report sexual issues to a healthcare provider. Clinicians, too, face barriers: limited time, lack of training in sexual health, personal discomfort, or uncertainty about how to broach the topic. 'Outside of specialized MS clinics, only 18.75% of physicians raise these issues. This reciprocal silence leads to underdiagnosis and inadequate management of sexual dysfunction, further complicating the patient's care journey,' Zeler warned. Practical Solutions That these challenges are often overlooked is particularly regrettable, given that effective interventions exist and targeted management is possible. 'Several therapeutic options are available,' said Zeler. 'For erectile dysfunction, phosphodiesterase type 5 inhibitors such as sildenafil or tadalafil are often effective first-line treatments.' For women experiencing vaginal dryness, water- or silicone-based lubricants are essential, and regular use of vaginal moisturizers can improve comfort and tissue health. Managing associated symptoms like spasticity and pain can further support sexual function. This may involve pharmacologic approaches — including muscle relaxants, analgesics, and neuropathic pain medications — as well as nonpharmacologic therapies like physiotherapy, physical therapy, or osteopathy. Fatigue, one of the most common and debilitating symptoms of MS, also requires targeted management as it significantly limits sexual activity. In parallel with medical treatment, sexological counseling is a key component of care. 'Support can include practical advice and individualized adjustments — such as modifying sexual positions to reduce discomfort, scheduling intimacy during times of lower fatigue, or exploring noncoital expressions of intimacy and pleasure like touch, massage, and erotic play,' Zeler explained. A Holistic Approach to Intimacy Addressing sexual health in MS is not ancillary — it's integral to comprehensive patient care. Zeler encourages healthcare providers to take the lead: Open the conversation, normalize the topic, and incorporate sexual wellbeing into routine evaluations. Doing so not only validates patients' experiences but may also enhance overall treatment outcomes and quality of life.
