Red Sox at Astros prediction: Odds, expert picks, starting pitchers, betting trends, and stats for August 12
Dustin May is slated to take the mound for Boston against Spencer Arrighetti for Houston.
Game 1 of this series saw the Astros jump out to a 7-2 lead and hold on late for a 7-6 win. Chas McCormick smacked his first home run of the season and Ramon Urias hit his first since being traded to Houston to pace the attack. Alex Bregman went yard for the Sox in his first game back in Space City.
Lets dive into Game 2 of the matchup and find a sweat or two.
We've got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.
Game details & how to watch Red Sox at Astros
Date: Tuesday, August 12, 2025
Time: 8:10PM EST
Site: Minute Maid Park
City: Houston, TX
Network/Streaming: NESN, SCHN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Red Sox at the Astros
The latest odds as of Tuesday:
Moneyline: Red Sox (+100), Astros (-120)
Spread: Astros -1.5
Total: 8.0 runs
Probable starting pitchers for Red Sox at Astros
Pitching matchup for August 12, 2025: Dustin May vs. Spencer Arrighetti
Red Sox: Dustin May (6-8, 4.85 ERA)Last outing: August 6 vs, Kansas City - 7.36 ERA, 3 Earned Runs Allowed, 6 Hits Allowed, 1 Walks, and 4 Strikeouts
Astros: Spencer Arrighetti (1-2, 7.43 ERA)Last outing: August 6 at Miami - 12.27 ERA, 5 Earned Runs Allowed, 11 Hits Allowed, 1 Walks, and 5 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Top betting trends & insights to know ahead of Red Sox at Astros
The Red Sox have won 4 of their last 5 series
The Over is 8-1-1 for the Astros' last 5 games at home and the Red Sox's last 5 on the road combined
The Astros have covered the Run Line in 3 straight home games
Each of the starting pitchers lasted just 3.2 innings in their last start
Carlos Correa has now hit safely in 9 straight games (16-37)
Cam Smith is 3-7 in his last 2 games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight's game between the Red Sox and the Astros
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday's game between the Red Sox and the Astros:
Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Boston Red Sox at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
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