Metastatic Colorectal Cancer Market Poised for Expansion Across the 7MM During the Forecast Period (2025-2034) as Breakthrough Therapies Gain Traction
LAS VEGAS, April 23, 2025 /PRNewswire/ — Colorectal cancer (CRC) ranks as the third most prevalent cancer, with metastasis being the leading cause of mortality among affected patients. The liver and peritoneum are the most frequent sites of distant spread. For most individuals, metastatic CRC (mCRC) remains largely incurable, with common metastatic locations including the liver, lungs, lymph nodes, and peritoneum.
Seen in approximately 45% CRC patients, KRAS mutations significantly influence the prognosis and treatment outcomes. These mutations are associated with a more aggressive disease course, resistance to chemotherapy and targeted therapies, and overall poorer survival rates.
In 2024, the incidence of metastatic colorectal cancer was around 294K cases across the seven major markets, with the United States reporting the highest incidence. This number is expected to rise by 2034. Surgical intervention is the mainstay for resectable CRC, while unresectable cases are typically managed with chemotherapy, radiotherapy, and immunotherapy. These conventional therapies, however, often lack specificity and can harm healthy cells, leading to additional health complications.
The treatment paradigm for mCRC involves multiple lines of therapy. First-line (1L) metastatic colorectal cancer treatments include combination chemotherapy regimens such as FOLFOX, FOLFIRI, and CAPEOX, alongside anti-angiogenic agents and targeted therapies like VECTIBIX and ERBITUX, with or without chemotherapy. KEYTRUDA and BRAFTOVI (in combination with ERBITUX and mFOLFOX6) are also approved for use in the first line. In the second-line (2L) setting, treatment options expand to include OPDIVO (± YERVOY), JEMPERLI, TUKYSA (± Trastuzumab), LONSURF (± Bevacizumab), and KRAZATI plus ERBITUX. For third-line (3L) therapy, specific agents such as STIVARGA and FRUZAQLA are utilized.
Learn more about the metastatic colorectal cancer treatment landscape @ Metastatic Colorectal Cancer Drugs Market
FRUZAQLA (fruquintinib) is a once-daily oral capsule developed by Takeda Pharmaceuticals. It is a kinase inhibitor approved for adult patients with metastatic colorectal cancer who have previously been treated with chemotherapy regimens including fluoropyrimidine, oxaliplatin, and irinotecan, as well as anti-VEGF therapy and, for RAS wild-type patients, anti-EGFR therapy. FRUZAQLA works by selectively targeting and inhibiting VEGFR-1, -2, and -3, thereby disrupting VEGF-driven blood vessel formation and tumor growth.
The FDA approved FRUZAQLA for previously treated mCRC in November 2023, followed by the European Commission in June 2024, and Japan in September 2024—marking it as the first new targeted therapy for mCRC in more than ten years in the Japanese market.
OPDIVO QVANTIG (nivolumab and hyaluronidase-nvhy) is indicated for adult patients with MSI-H or dMMR mCRC that has progressed after prior treatment with fluoropyrimidine, oxaliplatin, and irinotecan. It can be used as a standalone treatment or following prior combination therapy with intravenous nivolumab and ipilimumab. This drug works by blocking the PD-1 receptor, preventing its interaction with PD-L1 and PD-L2 to boost immune system activity against cancer cells.
In December 2024, the FDA approved OPDIVO QVANTIG as a subcutaneous injection for mCRC, making it the first PD-1 inhibitor available in this form. This new route of administration offers quicker treatment delivery—just 3 to 5 minutes—compared to the traditional 30-minute intravenous infusion of OPDIVO.
To know more about metastatic colorectal cancer treatments, visit @ Metastatic Colorectal Cancer Aggressive Treatment
Despite several advancements, the metastatic colorectal cancer drug market remains highly competitive, with significant unmet needs for durable and long-term treatment responses. Ongoing research into investigational agents like amivantamab, zanzalintinib, and vactosertib highlights the push for more effective, resistance-targeting, and tumor microenvironment-modifying therapies, signaling a dynamic and evolving future for mCRC treatment.
Key companies such as Johnson & Johnson Innovative Medicine, Shanghai Henlius Biotech, Inspirna, Treos Bio, Cardiff Oncology, Agenus, Leap Therapeutics, Arcus Biosciences, Enterome, Tizona Therapeutics, Innovative Cellular Therapeutics, and others are currently active in the metastatic colorectal cancer drug market.
Discover which therapies are expected to grab major metastatic colorectal cancer drug market share @ Metastatic Colorectal Cancer Market Report
Amivantamab is a bispecific antibody designed to target specific genetic alterations, especially EGFR exon 20 insertion mutations. Its dual mechanism focuses on inhibiting both the Epidermal Growth Factor Receptor (EGFR) and the MET receptor—two key players in cancer cell growth and survival. By binding to these receptors, amivantamab interferes with their signaling pathways, helping to overcome resistance that tumors often develop to other treatments.
This dual targeting not only suppresses tumor cell growth but also enhances the body's immune response, leading to greater cancer cell destruction. The drug is currently in Phase III clinical trials for treating metastatic colorectal cancer (mCRC).
Zanzalintinib (XL-092) is a third-generation oral tyrosine kinase inhibitor that blocks several cancer-related receptor tyrosine kinases, including VEGF receptors, MET, AXL, and MER. These kinases play a role in normal cell function as well as pathological processes like cancer development, metastasis, angiogenesis, and resistance to therapies such as immune checkpoint inhibitors. Developed by Exelixis, Zanzalintinib builds on the company's experience with cabozantinib, aiming to improve attributes like pharmacokinetic half-life. It is also in Phase III clinical trials for mCRC.
DKN-01 is a humanized monoclonal antibody that targets the DKK1 protein and is being developed for treating esophagogastric, gynecologic, and colorectal cancers. Initial findings from Part A of the DeFianCe trial were shared at the 2024 ASCO Gastrointestinal Cancers Symposium. Enrollment for Part B of the DeFianCe trial (NCT05480306) concluded in September 2024. This Phase II, randomized, open-label, controlled study is assessing DKN-01 in combination with bevacizumab and chemotherapy as a second-line treatment for advanced colorectal cancer in patients previously treated with one systemic therapy. The study enrolled 188 patients, with early results anticipated by mid-2025.
Discover more about drugs for metastatic colorectal cancer in development @ Metastatic Colorectal Cancer Clinical Trials
The anticipated launch of these emerging metastatic colorectal cancer treatments are poised to transform the market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the metastatic colorectal cancer market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
DelveInsight estimates that the market size for metastatic colorectal cancer in the 7MM is expected to grow from USD 13 billion in 2024 with a significant CAGR by 2034. This growth is fueled by advancements in precision medicine, including targeted therapies and immunotherapies, which have shown promise in improving patient outcomes.
DelveInsight's latest published market report titled as Metastatic Colorectal Cancer Market Insight, Epidemiology, and Market Forecast – 2034 will help you to discover which market leader is going to capture the largest market share. The report provides comprehensive insights into the metastatic colorectal cancer country-specific treatment guidelines, patient pool analysis, and epidemiology forecast to help understand the key opportunities and assess the market's underlying potential. The metastatic colorectal cancer market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM, segmented into:
Total Incident Cases of CRC
Gender-specific Cases of CRC
Age-specific Cases of CRC
Tumor Location-specific Cases of CRC
Stage-specific Cases of CRC
Total Incident Cases of mCRC
Mutation Type-specific Cases of mCRC
Total Treated Cases of mCRC by Line of Therapy
The report provides an edge while developing business strategies by understanding trends shaping and driving the 7MM metastatic colorectal cancer market. Highlights include:
10-year Forecast
7MM Analysis
Epidemiology-based Market Forecasting
Historical and Forecasted Market Analysis upto 2034
Emerging Drug Market Uptake
Peak Sales Analysis
Key Cross Competition Analysis
Industry Expert's Opinion
Access and Reimbursement
Download this metastatic colorectal cancer market report to assess the epidemiology forecasts, understand the patient journeys, know KOLs' opinions about the upcoming treatment paradigms, and determine the factors contributing to the shift in the metastatic colorectal cancer market. Also, stay abreast of the mitigating factors to improve your market position in the metastatic colorectal cancer therapeutic space.
Related Reports
Metastatic Colorectal Cancer Pipeline
Metastatic Colorectal Cancer Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key metastatic colorectal cancer companies, including Shanghai Henlius Biotech, Eisai Inc., Treos Bio, AUM Biosciences, Leap Therapeutics, Inc., Hoffmann-La Roche, Replimune, Qilu Pharmaceutical, Lutris Pharma, Ipsen, Bold Therapeutics, Pacylex Pharmaceuticals, FivepHusion, SystImmune, Inspirna, Inc., Sapience Therapeutics, Exelixis, Daiichi Sankyo, Hutchmed, Merus N.V., REVOLUTION Medicines, Pure Tech Health, Medicenna Therapeutics, Inc., Verastem Inc., Next Cure Inc., Isofol Medical, Zentalis Pharmaceuticals, Oncoinvent, KaryoPharm Therapeutics, Aadi Biosciences, among others.
Metastatic Colorectal Cancer Market
Metastatic Colorectal Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key metastatic colorectal cancer companies, including Johnson & Johnson Innovative Medicine, Shanghai Henlius Biotech, Inspirna, Treos Bio, Cardiff Oncology, Agenus, Leap Therapeutics, Arcus Biosciences, Enterome, Tizona Therapeutics, Innovative Cellular Therapeutics, among others.
Colorectal Cancer Market
Colorectal Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key colorectal cancer companies, including Mirati Therapeutics, Exelixis, Enterome, Arcus Biosciences, Lyell Immunopharma, AstraZeneca, Novartis Pharmaceuticals, Surgimab, Numab Therapeutics, SOTIO Biotech, Amgen, Sichuan Baili Pharmaceutical, Qilu Pharmaceutical, Bristol-Myers Squibb, NGM Biopharmaceuticals, Takeda, PureTech, Pfizer, Kezar Life Sciences, Salubris Biotherapeutics, among others.
Colorectal Cancer Pipeline
Colorectal Cancer Pipeline Insight – 2025 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key colorectal cancer companies, including Exelixis, Mirati Therapeutics, Merck Sharp & Dohme LLC, Daiichi Sankyo Company, Inspirna, Lyell Immunopharma, Genentech, Cantargia AB, Arcus Biosciences, Inc, Neogap Therapeutics AB, Criterium, Inc, Daiichi Sankyo, Inc, Bristol-Myers Squibb, Celyad Oncology SA, Pfizer, Akeso, Menarini Group, Elpiscience (Suzhou) Biopharma, Ltd., BeyondBio Inc., Shanghai Henlius Biotech, Rottapharm Biotech, Innovative Cellular Therapeutics Inc., BioNTech SE, among others.
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.
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The GnRH inhibitor market is shifting toward more convenient, patient-focused treatments, driven by oral therapies such as ORGOVYX and YSELTY. As the pipeline continues to grow and indications expand, this drug class is poised for broader clinical use and is likely to play a key role in the future of hormonal suppression in oncology and women's health. LAS VEGAS, Aug. 13, 2025 /PRNewswire/ — DelveInsight's GnRH Receptor Antagonists Market Size, Target Population, Competitive Landscape & Market Forecast report includes a comprehensive understanding of current treatment practices, addressable patient population, which includes top indications such as Endometriosis, fibroids, prostate cancer, and others. The selected indications are based on approved therapies and ongoing pipeline activity. The report also provides insights into the emerging GnRH receptor antagonists, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM. Key Takeaways from the GnRH Receptor Antagonists Market Report As per DelveInsight's analysis, the total market size of GnRH receptor antagonists in the 7MM is expected to surge significantly by 2034. The report provides the total potential number of patients in the indications, such as Endometriosis, fibroids, prostate cancer, and others. Leading GnRH receptor antagonist companies, such as Debiopharm, Tiumbio, Antev, and others, are developing novel GnRH Receptor Antagonists that can be available in the GnRH receptor antagonist market in the coming years. Some of the key GnRH receptor antagonists in the pipeline include Debio 4326, Merigolix (TU2670), Teverelix, and others. In May 2025, TiumBio and Daewon Pharmaceutical completed Phase II clinical trial of 'Merigolix (TU2670/DW4902)' for Uterine Fibroids with positive results. In March 2025, Kissei initiated the Phase III Clinical Trial for the GnRH Antagonist 'Linzagolix' indicated for Endometriosis in Japan. 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Key indications for GnRH receptor antagonists include prostate cancer, endometriosis, uterine fibroids, and assisted reproductive technologies (ART). One of the significant drivers of market expansion is the growing prevalence of hormone-sensitive cancers, particularly prostate cancer in men and endometriosis or uterine fibroids in women. The increasing demand for therapies with improved safety profiles and faster onset of action has created a favorable environment for GnRH antagonists. Moreover, recent product launches such as RELUGOLIX (marketed as ORGOVYX for prostate cancer and MYFEMBREE for uterine fibroids) and ELAGOLIX (marketed as ORILISSA for endometriosis and ORIAHNN for fibroids) have gained regulatory approvals and demonstrated commercial success, further validating the therapeutic potential of this class. Additionally, the market is benefiting from a broader shift towards oral therapies. 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As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the GnRH receptor antagonists market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth. To know more about GnRH receptor antagonists clinical trials, visit @ GnRH Receptor Antagonists Treatment GnRH Receptor Antagonists Overview GnRH antagonists mark a notable improvement in androgen deprivation therapy (ADT) for treating hormone-sensitive prostate cancer. These drugs function by directly inhibiting GnRH receptors in the pituitary gland, which quickly suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a rapid drop in testosterone levels. This direct mechanism avoids the initial testosterone surge, or 'flare', that is often seen with other forms of ADT. 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GnRH Receptor Antagonists Epidemiology Segmentation The GnRH receptor antagonists market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM, segmented into: Total Cases in Selected Indications for GnRH Receptor Antagonist Total Eligible Patient Pool for GnRH Receptor Antagonist in Selected Indications Total Treated Cases in Selected Indications for GnRH Receptor Antagonist GnRH Receptor Antagonists Report Metrics Details Study Period 2020–2034 GnRH Receptor Antagonists Report Coverage 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] Key Indications Covered in the Report Endometriosis, fibroids, prostate cancer, and others Key GnRH Receptor Antagonist Companies Debiopharm, Tiumbio, Antev, Ferring Pharmaceuticals, Sumitomo Pharma, Theramex, Kissei, and others Key GnRH Receptor Antagonists Debio 4326, Merigolix (TU2670), Teverelix, FIRMAGON, ORGOVYX, YSELTY, and others Scope of the GnRH Receptor Antagonists Market Report GnRH Receptor Antagonists Therapeutic Assessment: GnRH Receptor Antagonists' current marketed and emerging therapies GnRH Receptor Antagonists Market Dynamics: Conjoint Analysis of Emerging GnRH Receptor Antagonists Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies Unmet Needs, KOL's views, Analyst's views, GnRH Receptor Antagonists Market Access and Reimbursement Discover more about GnRH receptor antagonists in development @ GnRH Receptor Antagonists Clinical Trials Table of Contents 1 Key Insights 2 Report Introduction 3 Executive Summary of GnRH Receptor Antagonist 4 Key Events 5 Epidemiology and Market Forecast Methodology 6 GnRH Receptor Antagonist Market Overview at a Glance in the 7MM 6.1 Market Share (%) Distribution by Therapies in 2024 6.2 Market Share (%) Distribution by Therapies in 2034 6.3 Market Share (%) Distribution by Indications in 2024 6. Market Share (%) Distribution by Indications in 2034 7 GnRH Receptor Antagonist: Background and Overview 7.1 Introduction 7.2 Treatment 8 Target Patient Pool 8.1 Key Findings 8.2 Assumptions and Rationale: 7MM 8.3 Epidemiology Scenario in the 7MM 8.4 Total Cases in Selected Indications for GnRH Receptor Antagonist in the 7MM 8.5 Total Eligible Patient Pool for GnRH receptor antagonist in Selected Indications in the 7MM 8.6 Total Treated Cases in Selected Indications for GnRH Receptor Antagonist in the 7MM 9 Marketed Therapies 9.1 Key Competitors 9.2 FIRMAGON (degarelix): FERRING PHARMACEUTICALS 9.2.1 Product Description 9.2.2 Regulatory milestones 9.2.3 Other developmental activities 9.2.4 Clinical development 9.2.5 Safety and efficacy 9.3 ORGOVYX (relugolix): Sumitomo Pharma List to be continued in the report 10 Emerging Therapies 10.1 Key Competitors 10.2 Debio 4326: Debiopharm 10.2.1 Product Description 10.2.2 Other developmental activities 10.2.3 Clinical development 10.2.4 Safety and efficacy 10.2.5 Analyst Views 10.3 Teverelix: Antev List to be continued in the report 11 GnRH Receptor Antagonist: Seven Major Market Analysis 11.1 Key Findings 11.2 Market Outlook 11.3 Conjoint Analysis 11.4 Key Market Forecast Assumptions 11.4.1 Cost Assumptions and Rebates 11.4.2 Pricing Trends 11.4.3 Analogue Assessment 11.4.4 Launch Year and Therapy Uptakes 11.5 Total Market Size of GnRH receptor antagonist in the 7MM 11.6 Market Size of GnRH Receptor Antagonist by Indication in the 7MM 11.7 Market Size of GnRH Receptor Antagonist by Therapies in the 7MM 11.8. 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