Cardinals at White Sox prediction: Odds, expert picks, starting pitchers, trends, and stats for June 17

NBC Sports

3 hours ago

Its Tuesday, June 17 and the Cardinals (37-35) are in Chicago to begin a series against the White Sox (23-49).
Matthew Liberatore is slated to take the mound for St. Louis against Shane Smith for Chicago.
To put it mildly, these teams are struggling. The Sox have lost five in a row and the Cards have lost seven of their last eight. Chicago is now 22.5 games behind Detroit in the American League Central while St. Louis has fallen seven games back of the Cubs in the National League Central.
Lets dive into the series opener and find a sweat or two.
We've got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Cardinals at White Sox
Date: Tuesday, June 17, 2025
Time: 7:40PM EST
Site: Rate Field
City: Chicago, IL
Network/Streaming: FDSNMW, CHSN
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Cardinals at the White Sox
The latest odds as of Tuesday:
Moneyline: Cardinals (-154), White Sox (+129)
Spread: Cardinals -1.5
Total: 8.0 runs
Probable starting pitchers for Cardinals at White Sox
Pitching matchup for June 17, 2025: Matthew Liberatore vs. Shane Smith
Cardinals: Matthew Liberatore (3-6, 4.17 ERA)
Last outing: 6/11 vs. Toronto - 5IP, 5ER, 9H, 1BB, 4KsWhite Sox: Shane Smith (3-3, 2.37 ERA)
Last outing: 6/10 at Houston - 6IP, 1ER, 7H, 2BB, 4Ks
Cardinals: Matthew Liberatore (3-6, 4.17 ERA)
Last outing: 6/11 vs. Toronto - 5IP, 5ER, 9H, 1BB, 4Ks
White Sox: Shane Smith (3-3, 2.37 ERA)
Last outing: 6/10 at Houston - 6IP, 1ER, 7H, 2BB, 4Ks
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Top betting trends & insights to know ahead of Cardinals at White Sox
The White Sox have lost 5 games in a row
The Over is 12-8 in the Cardinals' last 10 games on the road and the White Sox's last 10 at home combined
The White Sox are showing a profit of 2.40 units on the Run Line in their last 5 games at Rate Field
Miguel Vargas is riding a 5-game hitting streak (7-24)
Nolan Arenado has at least 1 hit in his last 6 games (8-23)
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Expert picks & predictions for tonight's game between the Cardinals and the White Sox
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday's game between the Cardinals and the White Sox:
Moneyline: NBC Sports Bet is recommending a play on the St. Louis Cardinals on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Chicago White Sox at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC
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Jay Croucher (@croucherJD)
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Brad Thomas (@MrBradThomas)