This common prescription drug could reduce deaths by sepsis, study finds
Critically ill patients with sepsis who are given statins may be more likely to survive, new research suggests.
Researchers set out to explore whether the cholesterol-busting drugs may bring additional benefits for patients.
The new study examined information on sepsis patients who received statins during a stint in intensive care and compared it with patients in a similar situation who did not receive statins.
Some 14.3 per cent of 6,000 sepsis patients who were given statins died within 28 days.
This is compared with 23.4 per cent of 6,000 patients who did not receive statin therapy.
The research team from China said that this equates to a 39 per cent reduced risk of death within a month.
The research, based on data from thousands of patients at a hospital in Israel between 2008 and 2019, also found that 7.4 per cent of statin patients died while in the intensive care unit compared with 13.6 per cent of those who did not receive statins.
And during their overall hospital stay, some 11.5 per cent of sepsis patients who were given statins died, compared with 19.1 per cent of sepsis patients who did not take statins.
However, it appeared that those who were not prescribed statins had a slightly shorter hospital stay compared with those who did receive them – an average of eight days compared with almost 10 days.
'We found that statin users exhibited decreased 28-day all-cause mortality,' the authors wrote in the journal Frontiers in Immunology.
Sepsis is a life-threatening reaction to an infection that occurs when the immune system overreacts and starts to damage the body's tissues and organs.
In the UK, 245,000 people are affected by sepsis every year.
UK sepsis experts said that 'anything which might reduce the burden of a condition which claims one in five lives worldwide needs to be rigorously explored' as they called for larger trials to confirm the findings.
Statins are known as cholesterol-busting drugs because they can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood.
But experts said that they also have other benefits, including reducing inflammation and antibacterial effects.
The research team called for larger trials to confirm their findings.
'Our large, matched cohort study found that treatment with statins was associated with a 39 per cent lower death rate for critically ill patients with sepsis, when measured over 28 days after hospital admission,' said Dr Caifeng Li, the study's corresponding author and an associate professor at Tianjin Medical University General Hospital in China.
'These results strongly suggest that statins may provide a protective effect and improve clinical outcomes for patients with sepsis.'
Commenting on the study, Dr Ron Daniels, founder and chief executive of the UK Sepsis Trust, said: 'It has been known for some time that the anti-inflammatory properties of statins confer a survival benefit on those who take them if they develop sepsis.
'Whilst previous studies have failed to show a similar survival benefit in treating people with sepsis with statins, this new study supports calls for a large, multi-country, randomised control trial.
'Anything which might reduce the burden of a condition which claims one in five lives worldwide needs to be rigorously explored.'
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BBC News
2 hours ago
- BBC News
How groundwater pumping is causing cities to sink at 'worrying speed'
Cities around the world are sinking at 'worrying speed' Animation enabled Twenty-two years ago, when Erna stood outside her house, 'the windows were as high as my chest'. Now they're knee-height. As their home has sunk, she and her family have had to cope with frequent flooding. In the most extreme cases 'we used canoes - the water kept coming in and swamped the ground floor', she says. Erna lives in the Indonesian capital Jakarta - one of the fastest-sinking cities in the world. Her home is in one of the worst-affected areas, the north of the city, and is now much lower than the road. The 37-year-old grew up here and remembers playing in nearby streets and praying in the mosque - that is now long gone, permanently underwater, as is the old port. The walls of her home, built in the 1970s, are cracked, and you can see where thick layers of concrete have been added to the floor to try to restore it to ground level - about 10 times since it was built, and a metre thick in some places. The house is still subsiding, and Erna can't afford to move. Erna and her mother, Soni, have had to raise the floors in their home many times This is one of dozens of coastal regions that are sinking at a worrying speed, according to a study by Nanyang Technological University (NTU) in Singapore. The team studied subsidence in and around 48 coastal cities in Asia, Africa, Europe and the Americas. These are places that are particularly vulnerable to a combination of rising sea levels, which are mainly driven by climate change, and sinking land. Based on the study and population data from the United Nations, the BBC estimates that nearly 76 million people live in parts of these cities that subsided, on average, at least 1cm per year between 2014 and 2020. The impact on their lives can be huge - for example in Tianjin in north-east China, 3,000 people were evacuated from high-rise apartment buildings in 2023, after subsidence left large cracks in nearby streets. All 48 urban areas in the NTU study are shown in this globe. The most extreme cases of subsidence were seen in Tianjin, which has undergone rapid industrial and infrastructural development this century. The worst-hit parts of the city sank up to 18.7cm per year between 2014 and 2020. Select a city below to see how much it is sinking by. A map will display the most subsiding areas in that city in green, with details of factors contributing to subsidence. The subsidence rate is measured from a reference point in each city, which scientists assume is more stable than others - you can read more on the methodology at the end of this article. Abidjan, Côte d'Ivoire Ahmedabad, India Alexandria, Egypt Bangkok, Thailand Barcelona, Spain Buenos Aires, Argentina Chennai, India Chittagong, Bangladesh Choose a city Dalian, China Dar es Salaam, Tanzania Dhaka, Bangladesh Dongguan, China Foshan, China Fukuoka, Japan Guangzhou, China Hangzhou, China Ho Chi Minh City, Vietnam Hong Kong, China Houston, United States Istanbul, Türkiye Jakarta, Indonesia Karachi, Pakistan Kolkata, India Lagos, Nigeria Lima, Peru London, United Kingdom Los Angeles, United States Luanda, Angola Manila, Philippines Miami, United States Mumbai, India Nagoya, Japan Nanjing, China New York, United States Osaka, Japan Philadelphia, United States Qingdao, China Rio de Janeiro, Brazil Seoul, South Korea Shanghai, China Singapore, Singapore St Petersburg, Russia Surat, India Suzhou, China Tianjin, China Tokyo, Japan Washington DC, United States Yangon, Myanmar A 3d model viewer showing land subsidence in the selected city Observed subsidence per year (cm) 0 0 Please wait, a three-dimensional map is currently loading... Tap and move to rotate, pinch to zoom Fastest observed sinking Reference point Landmark Avenida 4 de , Fevereiro Ilha da Cazanga 0 -3.3 Observed subsidence per year (cm) Barrio Padre , Mugica Casa Rosada Observed subsidence per year (cm) 0 -1.5 Sandwip Para Chittagong Port Observed subsidence per year (cm) 0 -9.8 Basundhara , Residential , Area Bangladesh , National Museum Observed subsidence per year (cm) 0 -3.6 Rio das Pedras Christ the , Redeemer 0 -6.3 Observed subsidence per year (cm) Dalian Jinzhou , Bay , International , Airport Hongji Grand , Stage Observed subsidence per year (cm) 0 -16.4 Dongguan , Central Square Nongyuwei 0 -6.5 Observed subsidence per year (cm) Baofeng Temple Beijiaozhen 0 -6.3 Observed subsidence per year (cm) Nansha District The Canton , Tower 0 -6.8 Observed subsidence per year (cm) Central , Xiaoshan , district Lingyin Temple 0 -3.4 Observed subsidence per year (cm) Yongning , Subdistrict Nanjing City , Wall 0 -2.5 Observed subsidence per year (cm) Yinghai , Subdistrict, , Jiaozhou City Qingdao Railway , Station 0 -8 Observed subsidence per year (cm) Yingbin , Expressway Shanghai Tower 0 -10.3 Observed subsidence per year (cm) Classical , Gardens of , Suzhou North-west , Wujiang 0 -4.8 Observed subsidence per year (cm) 0 -18.7 Observed subsidence per year (cm) Bohai Bay Guwenhua Street East Abobo , district St Paul's , Cathedral Observed subsidence per year (cm) 0 -5.1 Adh Dheraa Al , Bahri Lighthouse of , Alexandria Observed subsidence per year (cm) 0 -2.7 Tuen Mun Vitoria Peak 0 -10.6 Observed subsidence per year (cm) Sidi Saiyyed , Mosque Piplaj Observed subsidence per year (cm) 0 -5.1 Tharamani Kapaleeshwarar , Temple Observed subsidence per year (cm) 0 -3.7 Bhatpara Victoria , Memorial 0 -2.8 Observed subsidence per year (cm) Gateway of , India Area near , King's Circle , station, , Matunga East 0 -5.9 Observed subsidence per year (cm) Karanj Surat Diamond , Bourse 0 -6.7 Observed subsidence per year (cm) Penjaringan National , Monument 0 -11.6 Observed subsidence per year (cm) Mochimaru, , Asakura , district Fukuoka Tower Observed subsidence per year (cm) 0 -5.7 Minato ward Atsuta-jingu , Shrine 0 -1.5 Observed subsidence per year (cm) East Konohana , ward Osaka Castle 0 -7.8 Observed subsidence per year (cm) Central , Breakwater, , Koto ward Tokyo Skytree 0 -2.4 Observed subsidence per year (cm) South Dagon , Township Shwedagon , Pagoda 0 -7.5 Observed subsidence per year (cm) City Hall Orange Island 0 -13.1 Observed subsidence per year (cm) Landhi Town Mazar-E-Quaid 0 -15.7 Observed subsidence per year (cm) Ancón district Lima Main , Square 0 -2.4 Observed subsidence per year (cm) Manila Bay Fort Santiago 0 -5.7 Observed subsidence per year (cm) Lakhta Winter Palace 0 -2.9 Observed subsidence per year (cm) Changi Bay Merlion Park 0 -4.6 Observed subsidence per year (cm) Area near , Sinjeong subway , station, , Yangcheon , District Blue House 0 -2 Observed subsidence per year (cm) Sagrada Familia Zona Franca Observed subsidence per year (cm) 0 -7 Kigamboni , district Askari Monument Observed subsidence per year (cm) 0 -3 Democracy , Monument Lam Phakchi, , Nong Chok Observed subsidence per year (cm) 0 -4.1 Istanbul , Airport Hagia Sophia 0 -13.2 Observed subsidence per year (cm) Big Ben South Upminster 0 -4 Observed subsidence per year (cm) Central , Southwest Sam Houston , Park 0 -11 Observed subsidence per year (cm) Hollywood Sign Coastal San , Pedro 0 -2.5 Observed subsidence per year (cm) Freedom Tower Coconut Grove 0 -2.2 Observed subsidence per year (cm) Breezy Point Central Park 0 -3 Observed subsidence per year (cm) Holmesburg Independence , Hall 0 -2.3 Observed subsidence per year (cm) South-west , Washington Memorial , Lincoln 0 -2.2 Observed subsidence per year (cm) East Nhà Bè Independence , Palace 0 -9.5 Observed subsidence per year (cm) Choose another city An animated line break showing building slowly sinking The perils of groundwater pumping Many factors can contribute to subsidence, including building, mining, tectonic shifts, earthquakes, and natural soil consolidation - where soil is pressed closer and becomes more dense over time. But 'one of the most common causes is groundwater extraction', explains the lead researcher on the NTU study, Cheryl Tay. It has had a major impact in half of the 48 coastal cities identified in the study. Groundwater is found beneath the Earth's surface in cracks and spaces in sand, soil and rock. It makes up about half of the water used for domestic purposes - including drinking - around the world. It's also essential for irrigating crops. But as cities grow, freshwater supplies come under strain. Households and industries in some places drill their own wells or boreholes and extract too much - as in Jakarta. Extracting excessive amounts of water in this way over extended periods of time compresses the soil, eventually causing the surface - and everything built on it - to sink or subside. 'A lot of the sinking cities are in Asia or South-East Asia,' says Ms Tay. 'That is likely because the demand for water is much higher there with very fast-growing populations and a lot of development. 'That could lead to higher rates of groundwater extraction and then this could snowball… This means that flooding will be more frequent, intense, and prolonged in the future,' she adds, explaining there could also be 'salt water intrusion that can affect agricultural land and the quality of drinking water'. Some types of ground are affected more than others and Ms Tay believes the risks are especially acute for the many coastal cities built on low-lying deltas - where rivers divide before flowing into the sea. This includes places such as Jakarta, Bangkok, Ho Chi Minh City, and Shanghai. Almost half of Jakarta now sits below sea level. Its location on swampy land where 13 rivers flow into the ocean makes it particularly vulnerable. The combination of land sinking and sea levels rising accelerates the 'relative sea level rise', says Ms Tay. 'There are two components: the land moving down and the water moving up.' Flooding in Jakarta leaves residential and business districts underwater Indonesia's meteorological agency has said that 'the flood cycle, which used to occur every five years, could become more frequent' in Jakarta as 'the overall trend of extreme rainfall is increasing in Indonesia, in line with rising surface temperatures and greenhouse gas concentrations'. Over the past decade, dozens have died in floods in the city and at least 280,000 people have had to leave their homes until the water receded. With parts of Jakarta now 4m lower than they were in 1970, Indonesia decided to build a new capital city - Nusantara - on a different island, Borneo, more than 1,200km (750 miles) away. It is further from the coast and will rely on a huge dam and reservoir to store river and rainwater. The plan is to purify and distribute water to all homes and offices in the new capital, eliminating the need to extract groundwater. However, the new city is controversial and development has slowed. There has been criticism of the $34bn price tag and its environmental impact on one of the most biodiverse places on the planet. Buildings in Ebute Metta, Lagos, where Rukkayat lives, are sinking - the white dotted line shows the highlighted structure's original position Five of the cities studied by NTU are in Africa, including Lagos in Nigeria. Last year, flooding affected more than 275,000 people there. Twenty-eight-year-old Rukkayat moved to Ebute Metta, in the east of the city, three years ago in search of work and a better life. But she could only afford to rent a house in a sinking area - one of the locations identified in the NTU report. 'It's hard to live in a place where it gets easily flooded if downpours or storms hit the city,' she says. 'I have to scoop water out of the corridor.' The walls of the house are cracked, the floor is damp and the roof leaks - a common situation in sinking areas, experts say. Both Lagos and Jakarta are facing rapid urbanisation and growing populations with more than half unable to access piped water, turning instead to pumping groundwater themselves. An animated line break showing water flowing under landmarks The bowl effect As many coastal cities deal with the combination of subsiding land and rising seas, they are looking for solutions - but these can sometimes contribute to other problems. Some, including Jakarta, Alexandria in Egypt and Ho Chi Minh City in Vietnam have built dykes, walls and sand barriers along their coastlines to try to prevent flooding from the sea. A seawall was built to stop seawater swamping homes in North Jakarta Alexandria has built concrete breakwaters to protect the city from the sea But as walls get higher and bigger, a 'bowl effect' can be created, says Prof Pietro Teatini of the University of Padova in Italy, potentially trapping rain and river water in areas and preventing it from flowing back into the sea. This can contribute to flooding. So, to drain excess water, Jakarta and Ho Chi Minh City are among those that have built pumping stations. However, this does not address the causes of subsidence or flooding. How Tokyo solved the problem When Tokyo found parts of its city were subsiding, it took a different approach and decided to tackle the root of the problem. The sinking slowed significantly in the 1970s after Tokyo imposed strict regulations on groundwater pumping. It also built a water supply management system, which scientists argue is the most efficient way to stop subsidence. The NTU study found that today the city is much more stable, although a few small areas have sunk by between 0.01 and 2.4cm per year between 2014 and 2020. So, how does Tokyo's system work? Almost all of Tokyo's water comes from forests and rivers controlled by two big dams outside the city. The water is purified in 10 plants and sent to a supply centre. The centre regulates the volume and pressure of the water. The centre distributes the water to homes and industries via pipes designed to resist earthquake damage. Despite the effectiveness of Tokyo's system, scientists are sceptical it can be applied widely given the high build and maintenance costs, says Prof Miguel Esteban of Waseda University in Japan. Nonetheless, he adds, some Asian cities still look at Tokyo's approach as a model. Taipei, for example, reduced groundwater extraction in the 1970s which, in turn, helped to slow down its subsidence rates. Many other cities - including Houston, Bangkok and London - also carefully regulate groundwater pumping to ensure it is neither too low nor too high. Some cities have tried different methods. Shanghai, for instance, has applied 'water injection, which works very well', says Prof Teatini. It injected purified water from the Yangtze River into the ground through wells that had previously been used to extract groundwater. Others, such as Chongqing in China and San Salvador in El Salvador, have adopted the principles of sponge cities. Instead of simply using non-porous concrete and asphalt in areas such as pavements, a sponge city makes use of surfaces that are designed to absorb water naturally, such as soil, grass and trees. The construction of parks, wetlands and green spaces is prioritised, along with lakes and ponds where water can be diverted and stored during the rainy season. The roof of this building on the edge of Chongqing is designed to absorb water and help manage heavy rainfall A residential complex in Berlin has been designed with areas to store and absorb water This may offer a 'more viable and sustainable solution, it costs only a tenth of building dams', says Prof Manoochehr Shirzaei of Virginia Tech University. But critics say that it is hard to add these features to existing developments and often they are not installed on a large enough scale to make a big difference. And behind any investment, there needs to be long-term political commitment, says Prof Shirzaei. 'Land subsidence emerges gradually over time, so to deal with that, we have to take difficult decisions which remain in place for decades,' he says, even if pumping restrictions are initially unpopular with voters who rely on wells and boreholes for water. Without change, experts warn there will be more people like Erna, fighting a losing battle as their homes gradually slip away. A note on methodology For its study the NTU chose coastal urban agglomerations within 50km (30 miles) of the coast, with a population of at least five million in 2020. It analysed satellite images, comparing data from 2014 to 2020 to estimate subsidence rates. The subsidence rate is measured from a reference point in each city, which scientists assume is more stable than others. However, if the reference point is also sinking or rising, other parts of the city might be sinking faster or slower than the measurements suggest. This could affect the BBC estimates of how many people are affected. The subsidence rates used here should therefore be seen as a relative measure, helping to identify which areas are likely more affected than others. A line break showing a wave
Daily Mail
4 hours ago
- Daily Mail
Statins almost halve the risk of death in patients critically ill with sepsis
Taking statins can improve the chances of surviving sepsis by 40 per cent, a trial has found. Sepsis can occur when the body's immune system overreacts to an infection and attacks its own organs. It is notoriously difficult to spot because the telltale symptoms, such as a fever and muscle pain, can be easily mistaken for signs of a common cold or other infection. Statins lower cholesterol to prevent heart attacks and strokes and are taken by around 5 million adults in the UK. But experts say they have other benefits, including reducing inflammation and fighting bacteria that can ultimately lead to sepsis. The study compared survival rates of sepsis patients given statins and those who were not during a hospital stay. It found the pills reduced the risk of death for those critically ill with the condition by 39 per cent. The study compared survival rates of sepsis patients given statins and those who were not during a hospital stay. It found the pills reduced the risk of death for those critically ill with the condition by 39 per cent (file image) In intensive care, 14.3 per cent of 6,000 sepsis patients given statins died within 28 days, compared with 23.4 per cent of 6,000 patients who were not. For those no longer in a critical condition, 11 per cent given statins died compared to 19 per cent who were not. Dr Caifeng Li, of Tianjin Medical University General Hospital in China and the study's author said: 'These results suggest that statins may provide a protective effect and improve clinical outcomes for patients with sepsis.' Researchers believe the drugs may help with sepsis by helping to combat bacteria directly, reducing the toll infection takes on the body. Earlier this year another study found the pills could also slash dementia risk – even in patients who don't have high cholesterol. The sepsis study, published in the journal Frontiers in Immunology, was based on data from thousands of patients at an Israeli hospital over a decade. Dr Ron Daniels, founder and chief executive of the UK Sepsis Trust, said: 'This study supports calls for a large, multi-country, randomised control trial. 'Anything which might reduce the burden of a condition which claims one in five lives worldwide needs to be rigorously explored.' Sepsis is known as the 'silent killer'. For every hour of delay in treatment, a patient's chance of dying increases 8 per cent. If caught early, it can be treated with antibiotics and fluids. Symptoms include slurred speech or confusion, shivering or muscle pain, passing no urine in a day, severe breathlessness and mottled or discoloured skin. Blood test to spot Alzheimer's early A Blood test for Alzheimer's can accurately detect the disease early, a study suggests. The test was 95 per cent accurate in identifying people with memory problems. It also scored 82 per cent for specificity, which means it was highly accurate in ruling out people without dementia. The study, published in the journal Alzheimer's and Dementia, found proteins amyloid beta 42/40 and p-tau217 in blood plasma can be examined to diagnose the condition. The study was carried out on more than 500 people in an outpatient memory clinic. The blood test has already been approved by the Food and Drug Administration regulator in the US.
The Independent
7 hours ago
- The Independent
New coronavirus discovered in China ‘only small step' from infecting humans
A new coronavirus discovered in China is only a small step from mutating and causing another global pandemic, experts have warned. Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 – which caused millions of deaths – and may have more potential for jumping between species. US researchers fear that HKU5-CoV-2, found in China, in February, could also infect humans, leading to a widespread outbreak. The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses, which includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome. The team from Washington State University looked at how the new pathogen interacts with human cells. They found that a small change in the virus's spike protein could allow it to attach to human ACE2 cells in people's throats, mouths and noses. HKU5-CoV-2 can infect and replicate inside human cells in both the airways and gut. According to the World Health Organisation, about 35 per cent of people infected with Middle East Respiratory Syndrome die. Since 2012, some 27 countries have reported cases, leading to 858 known deaths due to the infection, which spread from camels. But when HKU5 was discovered in February, scientists warned against exaggerating the risks because it does not enter human cells as readily as Sars-CoV-2, which caused Covid-19. HKU5 was first detected in bats by scientists from the Chinese laboratory where some say Covid originated in 2019. Prof Michael Letko, a virologist who co-led the study, said: 'HKU5 viruses in particular really hadn't been looked at much, but our study shows how these viruses infect cells. 'What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans.' When Covid-19 emerged it was widely blamed on markets in China where different breeds of wild animal are kept caged and often slaughtered close to other animals. Meat is sold at the open-air stalls. Critics said the markets were the perfect breeding ground for new zoonotic diseases – those that spread to humans – to emerge. The scientists, whose experiments studied how the new pathogen interacts with human cells, believe the virus would have to carry certain mutations if it were to infect humans. 'These viruses are closely related to MERS, so we have to be concerned if they ever infect humans,' Prof Letko said. 'While there's no evidence they've crossed into people yet, the potential is there and that makes them worth watching.'
