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The Guardian
an hour ago
- The Guardian
Rebel Wilson: ‘I always wanted to be like Judi Dench. But people like laughing at me'
What's been the most fun you've had on set? FrNthOldPitch Perfect, because it felt like theatre camp. We came together in Baton Rouge, Louisiana. It was like college: hanging out with my friends, having fun, not really acting. For four weeks we were in boot camp, where we'd dance and do conditioning in the mornings – so sit-ups, stretching and learning the choreography. In the afternoons, we'd learn our 10-part harmonies and go into the recording studio. Sometimes we were really dorky and said: on Friday we're all going to wear the same colour T-shirts, just to be like a squad. You've worked with Sir Derek Jacobi twice – in Juliet & Romeo, and the upcoming Tinsel Town. How was he? Derekj2210It was pretty cool to be in scenes with him. Even though we weren't doing the iambic pentameter, it was interesting to watch how the language fell off his tongue. We were filming in this medieval Italian church. It was zero degrees, but he was so easygoing: always telling stories, with this fun grandpa vibe. He's one of the most amazing Shakespearean actors ever: in his 80s, still crushing every line. I kept wanting to get selfies with him, because he really is one of the greats. I felt the same when I worked with Dame Judi Dench on Cats. When I started acting, I always wanted to be like Dame Judi, because I thought I was going to be a serious actor. It just turned out that people like laughing at me. She's like your grandma, in that you just want to hold her hand, and help her. She's also got a wicked sense of humour: she'd be throwing out jokes and cursing, which I thought was hilarious. There have been a few times I've had to pinch myself. I had to do a boot camp with Sir Ian McKellen for Cats; at one point we were crawling around on the floor, pretending to lick each other. It was so funny. What is it like being a guest on the Graham Norton Show? I enjoyed your rap and the way you took your heels off. VegansRuleThePlanetGraham Norton is such a master of the talkshow. Other talkshows can be a bit of a struggle, but with him, it really is just like having a chat. I did the rap because I was telling the story of when I was 11, I had a rap group with my sister, which was probably the most uncool thing ever, seeing as we were two white girls from Sydney. I took my shoes off because I'm terrible at doing anything in high heels. I do try to wear them to be classy on the night-time talkshows, but I'm terrible at moving in heels: I move like a shuffling wombat. You won $250,000 for charity on the US version of Who Wants to Be a Millionaire? Does this mean you're not such a Rebel Without a Cause? vammypWe had a great cause: the money sponsored a school in Tanzania, and helped put 40 kids through college. Some have already graduated. The medical students still send me video updates every six months. It's surreal that going on a gameshow for half an hour resulted in putting 40 kids through college in Africa. My heart rate was pumping because I wanted to win as much money for charity as I could. You think: oh my God, please don't be an idiot. I play a lot of dumb, stupid characters, but in real life, I do have two degrees – in theatre and performance studies, and law. I have a charitable connection to Africa because when I was 18, I did a gap year, and travelled from South Africa to Malawi, Mozambique and Zimbabwe. When I got to Mozambique, I got malaria really badly. We didn't have time to put up the mosquito nets and I woke up with my face covered in mosquito bites. Two weeks later, I was in hospital because it was a really bad strain. I don't know whether it was the disease or the drugs, but I was hallucinating really badly, and I hallucinated that I won an Academy Award. It was so visceral and real that I came out of hospital and said: 'Hey everyone, I think I'm going to become an actor now.' The South Africans were like: 'Ah, no, Rebel. The malaria has demented your brain.' My parents were pushing me into law school, so I did law by day and acting by night. Has your positive body transformation led to different scripts coming your way? BradLopez22In the movie I just shot in the UK, Tinsel Town, I play the love interest to Kiefer Sutherland, which is probably not at all the kind of role you'd think I'd get cast as. There was a tendency to think: she's no longer Fat Amy [from Pitch Perfect], so she can't play those characters any more. There was a little bit of: also, is she still funny? I've just been offered the lead in a horror movie. So it's not just comedies, musicals and romcoms. It's good to surprise people. Did I have a Greggs? [Sutherland is an outspoken fan, so Greggs sent a van to the set]. Yes. I enjoyed a sausage roll. Greggs gifted Kiefer and I a £50 VIP voucher, which I still have. You get four sausage rolls for the price of three as well. That's a lot of sausage rolls. Pitch Perfect: The Reunion ...? Any plans for a fourth instalment? writeronthestormOh God, I hope so. We hear rumours all the time. I know Universal is developing some scripts. The fanbase for Pitch Perfect is so awesome and keeps growing as younger people are introduced to it. So, hopefully – there's a huge desire for another movie. Marmite or Vegemite? TopTrampI'm actually a weird Australian: I don't eat Vegemite or Marmite. I don't know why. I just don't like the look of it. If I was putting something on toast, I'd put Nutella. What role challenged you most? HamesJoyceI did a very small movie called The Almond and the Seahorse, which we filmed up in Liverpool and north Wales, about traumatic brain injury. Because it was such an intense subject, you had to go from zero to 100 emotionally within the same scene. I was like: how am I gonna do this? But it turned out really well, and challenged me a lot more than roles like Fat Amy where I get to sing, dance and be goofy. Juliet & Romeo will screen in selected UK cinemas for one night only on 11 June
The Guardian
an hour ago
- The Guardian
Millions in west do not know they have aggressive fatty liver disease, study says
More than 15 million people in the US, UK, Germany and France do not know they have the most aggressive form of fatty liver disease, according to research. Metabolic dysfunction-associated steatotic liver disease (MASLD) – the formal name for non-alcoholic fatty liver disease – occurs in people who drink no or minimal amounts of alcohol whose liver contains more than 5% fat. Around two-thirds of patients with type 2 diabetes are thought to have the condition, which is also associated with obesity, heart and circulatory disease. Around 5% of adults globally have the most aggressive form of MASLD. Metabolic dysfunction-associated steatohepatitis (MASH) causes fibrosis (scarring) and can lead to cirrhosis and is linked to greater risk of cardiovascular disease, chronic kidney disease and liver cancer. But the vast majority of people do not know they have the condition. An international group of researchers examined prevalence and diagnosis of aggressive fatty liver disease in the US, UK, Germany and France. The researchers found that just under 3% of people in the UK, France and Germany, and 4% of those in the US have MASH, but diagnosis rates were below 18%. That means about 20 million people in the US, UK, Germany and France are living with MASH but only 2.5 million people have a diagnosis, leaving more than three-quarters – about 16.7 million people – unaware they have the condition. The report, published in the Lancet Regional Health Europe and presented at an the meeting of the global thinktank on steatotic liver disease in Barcelona, Spain on Thursday, calls for a doubling in diagnosis rates from 2022 levels. Traditionally, MASH was diagnosed through biopsy, but now non-invasive methods, such as blood tests, ultrasound and MRI scans can be used. As a result, everyone with type 2 diabetes; obesity combined with one or more other risk factors; and those with persistently high liver enzymes should be screened for MASH, the researchers conclude. Dr Jeffrey Lazarus, the lead author of the paper and a professor of global health in New York and Barcelona, said: 'Undiagnosed MASH costs economies billions of pounds in lost productivity and poor health. Unless diagnosis rates are doubled, alongside similar increases in treatment and care, direct health costs alone are predicted to triple over the next 20 years.' Responding to the findings, Emmanouil Tsochatzis, a professor of hepatology at UCL and a consultant hepatologist at the Royal Free hospital, said: 'More than 15 million people across the US and Europe have the deadliest form of fatty liver disease – and don't know it. Without faster diagnosis and access to treatment, the human and economic toll will skyrocket.' The research has also prompted renewed calls for weight loss jabs to be used to treat MASH. Dr Paul Brennan, a co-author of the Lancet paper and a hepatologist at NHS Tayside, said: 'GLP-1s (including Wegovy and Mounjaro) offer the potential to resynchronise our metabolism, by introducing feelings of satiety – fullness – and delaying the time the stomach takes to empty. These effects often result in reduced calorie intake, and improvements in how the liver handles nutrients as a result of weight loss, thus reducing scar tissue formation in the liver.' Michael Betel, the president of the Fatty Liver Alliance, said: 'Too many people living with type 2 diabetes or obesity are never tested for MASH until it's too late. We need a huge increase in liver health assessments in patients living with these diseases, alongside lifestyle changes and for some, when appropriate, weight loss drugs to reduce blood sugar and appetite. While weight loss drugs weren't created to treat liver disease, trials suggest they could benefit multiple metabolic-related conditions, and improve our liver health.' Separately a study published on Wednesday found that the diabetes drug dapagliflozin, which reduces blood sugar levels, can also reduce fat levels and fibrosis in the liver.
The Guardian
an hour ago
- The Guardian
New York City Democratic mayoral primary debate: five key takeaways
In the first debate of the New York City Democratic mayoral primary, nine candidates took the stage and fielded questions on housing, affordability, crime, policing, public safety, political regrets and how each candidate would handle the Trump administration if elected. The candidates included former New York governor Andrew Cuomo; democratic socialist Zohran Mamdani; the New York City council speaker, Adrienne Adams; the current New York City comptroller, Brad Lander; former comptroller Scott Stringer; former Bronx assemblyman Michael Blake; state senators Zellnor Myrie and Jessica Ramos; and former hedge fund manager Whitney Tilson. The current mayor, Eric Adams, was not present on Wednesday as he is running for re-election as an independent candidate, although he ran as a Democrat in 2021. A few takeaways from the debate: Throughout the debate, former New York governor Andrew Cuomo, the current frontrunner in the race, was grilled on his record by his Democratic rivals. Cuomo spent much of the night sparring with progressive state assemblyman Zohran Mamdani, who is polling second. Mamdani accused Cuomo of being beholden to wealthy donors and corporate interests, saying Cuomo prioritized the '1%, the billionaires and the profitable corporations', over 'working-class New Yorkers'. Cuomo dismissed the 33-year-old as inexperienced, calling Mamdani 'very good on Twitter and with videos' but saying he was someone who 'produces nothing'. 'He's been in government 27 minutes, he passed three bills, that's all he's done,' Cuomo said. 'He has no experience with Washington, no experience with New York City.' Trump came up several times, as the candidates agreed the next mayor must be ready to stand up to his administration if elected mayor, though they differed on who was best equipped to do so. 'I know how to deal with Donald Trump because I've dealt with him before,' Cuomo said, citing his experience as New York governor. Mamdani warned that 'President Trump will target whomever is the next mayor of this city' and said that is 'important that we have a mayor who will fight back and that is what I will do'. 'I am Donald Trump's worst nightmare as a progressive Muslim immigrant who actually fights for the things that I believe in,' Mamdani added. 'And the difference between myself and Andrew Cuomo is that my campaign is not funded by the very billionaires who put Donald Trump in DC.' Cuomo fired back, saying that 'Donald Trump would go through Mr Mamdani like a hot knife through butter'. 'He would be Trump's delight,' Cuomo added. Mamdani countered: 'It's true that I don't have experience with corrupt Trump billionaires that are funding my campaign. I don't have experience with party politics and insider consultants. I do have experience, however, with winning $450m in debt relief for thousands of working-class taxi drivers and actually delivering for working-class people.' Adrienne Adams, the speaker of the New York city council, said she would take legal action against Trump when necessary. Asked how they would respond if the Trump administration ordered city-run hospitals to stop providing care to undocumented patients or risk losing millions in federal funding, all candidates voiced strong opposition to Trump's recent crackdown on immigration in general. 'You cannot give in to Mr Trump and his demands,' Cuomo said. 'If you give in to him, he is a bully, I know him well, if you give in to him today, you will be giving him your lunch money for the rest of your life.' 'You have to fight him and the way you fight him is not by suing him,' the former governor said. 'We need a national coalition, which we can put together of like-minded states and cities that will oppose these actions and then we're going to have to eventually beat him politically in Congress.' Whitney Tilson said that if Trump were to act 'illegally to try and blackmail us, you have to sue to restore that funding', adding that he was 'appalled by what Trump is doing to terrorize immigrant communities' and would 'fight him tooth and nail'. Mamdani said that New York City was 'under attack by an authoritarian Trump administration'. 'The way that we fight back is ensure that our local institutions continue to provide the services to each and every New Yorker,' he said. 'We will tell those institutions that we will provide that funding and we will get that funding by taxing the 1% and the wealthiest corporations.' Pressed about his administration's handling of nursing home deaths during the Covid-19 pandemic – a 2021 report by the New York attorney general found that his office undercounted thousands of deaths of state nursing home residents – Cuomo defended his record, claiming the numbers were not, in fact, undercounted. He also denied the sexual harassment allegations against him that led to his resignation. 'I said at the time that if I offended anyone it was unintentional but I apologize and I say that today,' he said. Asked about their biggest political regret, city council speaker Adrienne Adams took a swipe at the current mayor. 'My biggest regret is believing that Eric Adams would be a good mayor for all New Yorkers,' she said. The city's comptroller, Brad Lander, said that he regretted not pushing 'for more housing in his Brooklyn district when he was a city council member'. Mandani used the moment to target Cuomo once more, saying that 'as a Democrat, one of my regrets is having trusted the leaders within our own party, leaders like Andrew Cuomo'. Cuomo, on the other hand, said his biggest regret was 'the state of the Democratic party', which prompted backlash from other candidates on stage. 'No personal regrets?' asked Adrienne Adams. 'No regrets when it comes to cutting Medicaid or healthcare? No regrets when it comes to slow-walking PPE and vaccinations in the season of Covid to Black and brown communities? Really, no regrets?' Cuomo said her claims were 'not accurate', adding: 'Medicaid went up under me. I pushed President Trump to give us everything he had, leading the way during Covid.' The moderators asked the candidates how much they pay in rent or mortgage in New York City. Adams said she owned her home and that it was paid off; Mamdani said he pays $2,300 a month in rent for a rent-stabilized apartment in Astoria. Blake said he spends about $1,800 for a home that he owns, while Myrie said his rent-stabilized apartment was $1,300 a month and Ramos said her rent was $2,500 a month. Lander said his mortgage was $3,300 a month. Cuomo said that he pays $7,800 a month, while Tilson said that he owned his home and paid about $5,000 per month in maintenance fees and taxes. Stringer said he pays $6,400.
