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Skye Bioscience Demonstrates Over 30% Weight Loss with Nimacimab and Tirzepatide Combination in Preclinical Model

Skye Bioscience Demonstrates Over 30% Weight Loss with Nimacimab and Tirzepatide Combination in Preclinical Model

Yahoo15-04-2025

Nimacimab shows comparable weight loss to monlunabant and tirzepatide alone, and an additive effect in combination with tirzepatide, in diet-induced obesity model
New data demonstrates superior potency of nimacimab's differentiated and favorable mechanism of inhibition versus monlunabant
Nimacimab Phase 2a CBeyond™ top-line randomized data expected late Q3/early Q4 2025
SAN DIEGO, April 15, 2025 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) ('Skye'), a clinical-stage biotechnology company focused on unlocking new therapeutic pathways for obesity and other metabolic health disorders, today announced new preclinical data for its novel CB1 antibody, nimacimab. In a murine diet-induced obesity (DIO) model, after 25 days of treatment, results demonstrated:
Greater than 30% weight loss when nimacimab was combined with the dual GLP-1/GIP agonist, tirzepatide
Nimacimab alone demonstrated 23.5% weight loss, comparable to monlunabant and tirzepatide alone.
'This new preclinical study highlights that a truly peripherally-restricted CB1 inhibitor—nimacimab—effectively drives weight loss in a DIO model. Nimacimab compared favorably to and provided significant additive weight loss when combined with GLP-1-targeted drugs like tirzepatide,' said Punit Dhillon, CEO of Skye. 'Using higher doses, this study builds on our previous preclinical DIO data in human CB1 knock-in mice that showed significant dose-dependent weight loss. Biomarker analyses demonstrated that nimacimab-driven weight loss was associated with beneficial changes in key hormones, glycemic control, and inflammatory markers.
'Skye believes nimacimab shows potential both as a monotherapy and in combination with a GLP-1 targeted drug to address unmet needs in obesity with the potential to change weight loss standards of care. Initial data from Skye's Phase 2a study in obesity is expected in late Q3/early Q4 2025.'
Mr. Dhillon added, 'The second key finding of this animal study is that Skye's highly-peripherally restricted nimacimab drives efficacy similar to a less-peripherally restricted CB1 inhibitor, monlunabant, in a DIO model. These in vivo data continue to support our belief that our differentiated antibody approach can potentially provide meaningful efficacy without the challenge current small molecule CB1 inhibitors face—brain exposure that can cause unwanted neuropsychiatric side effects.'
Figure 1 - DIO model to interrogate combination of nimacimab and tirzepatideNew In Vitro Data Characterizes Differentiated Potency Characteristics
Skye also shared new in vitro potency data demonstrating that nimacimab's non-competitive allosteric binding to CB1 provides for a differentiated and potentially advantageous mechanism of inhibition versus small molecules like monlunabant, which must compete with CB1 agonists. In this study, potency of nimacimab and monlunabant were assessed against two concentrations of the CB1 agonist CP55940. The first condition evaluated potency of each drug with a lower concentration of CP55940 (50nM or EC80), while the second condition evaluated potency against an elevated concentration of CP55940 (2000nM or 40X EC80). These two conditions serve as a model of a physiological versus a pathological state where conditions such as obesity can promote an increase in the CB1 ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and thus competition for the CB1 receptor. These data demonstrated that while nimacimab's potency remained relatively stable, the activity of monlunabant when challenged with a higher concentration of a CB1 agonist was significantly impacted.
Dr. Chris Twitty, Chief Scientific Officer of Skye, said, 'These data demonstrate for the first time how nimacimab's allosteric binding to the CB1 receptor is differentiated from the small molecules which bind to the receptor's active orthosteric site. We know that in a disease state such as obesity, the CB1 receptor as well as its natural ligands, AEA and 2-AG, are upregulated. In this diseased state, there may be significant competition for the active binding site. In our in vitro experiment we aimed to recreate this potential situation. The biological impact of these data suggests that when there is significant competition for CB1 binding, the activity of small molecules like monlunabant can be significantly impacted. Clinically this could result in impacting the relationship between pharmacodynamics and pharmacokinetics of the drug, ultimately requiring more of the small molecule to overcome the competition. Alternatively, nimacimab does not compete for the same site as the natural ligands, and our data show that as a result of this allosteric binding, the potency is minimally impacted regardless of the concentration of competing molecules.'
'In the context of CB1 inhibition, we aim to realize the weight loss and metabolic benefits of this mechanism without the neuropsychiatric side effects seen with small molecule drugs. In our estimation, the potential of superior potency of nimacimab in this disease state may offer the widest possible therapeutic window among CB1 inhibitors.'
Figure 2 - Comparison of potency between monlunabant* and nimacimab*** Monlunabant's potency dropped significantly at high agonist levels due to direct competition for the receptor's orthosteric site.** Nimacimab's potency was preserved due to its allosteric binding mechanism that avoids direct competition.
About Skye Bioscience
Skye is focused on unlocking new therapeutic pathways for metabolic health through the development of next-generation molecules that modulate G-protein coupled receptors. Skye's strategy leverages biologic targets with substantial human proof of mechanism for the development of first-in-class therapeutics with clinical and commercial differentiation. Skye is conducting a Phase 2 clinical trial (ClinicalTrials.gov: NCT06577090) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1. This study is also assessing the combination of nimacimab and a GLP-1R agonist (Wegovy®). For more information, please visit: www.skyebioscience.com. Connect with us on X and LinkedIn.
CONTACTSInvestor Relationsir@skyebioscience.com(858) 410-0266
LifeSci Advisors, Mike Moyermmoyer@lifesciadvisors.com(617) 308-4306
Media InquiriesLifeSci Communications, Michael Fitzhughmfitzhugh@lifescicomms.com(628) 234-3889
FORWARD LOOKING STATEMENTS
This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, forward-looking statements can be identified by terminology including 'anticipated,' 'plans,' 'goal,' 'focus,' 'aims,' 'intends,' 'believes,' 'can,' 'could,' 'challenge,' 'predictable,' 'will,' 'would,' 'may' or the negative of these terms or other comparable terminology. These forward looking statements include, but are not limited to: (i) statements regarding the superior safety and tolerability profile of nimacimab relative to other small molecule CB1 inhibitors, (ii) statements relating to any expectations regarding the efficacy and therapeutic potential of nimacimab as a monotherapy or in combination with a GLP-1 targeted drug, including expectations based on preclinical DIO models, (iii) statements regarding nimacimab's potential to change weight loss standards of care, (iv) statements regarding superior potency of nimacimab to other small molecule CB1 inhibitors based on nimacimab's mechanism of action and (v) statements regarding the timing of receipt of final data from Skye's Phase 2 obesity study of nimacimab. Such statements and other statements in this press release that are not descriptions of historical facts are forward-looking statements that are based on management's current expectations and assumptions and are subject to risks and uncertainties. If such risks or uncertainties materialize or such assumptions prove incorrect, our business, operating results, financial condition, and stock price could be materially negatively affected. We operate in a rapidly changing environment, and new risks emerge from time to time. As a result, it is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements the Company may make. Risks and uncertainties that may cause actual results to differ materially include, among others, our capital resources, uncertainty regarding the results of future testing and development efforts and other risks that are described in the Company's periodic filings with the Securities and Exchange Commission, including in the 'Risk Factors' section of Skye's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q. Except as expressly required by law, Skye disclaims any intent or obligation to update these forward-looking statements.
Photos accompanying this announcement are available at
https://www.globenewswire.com/NewsRoom/AttachmentNg/97a10bc7-3e79-4fbc-9275-d0929f35c403
https://www.globenewswire.com/NewsRoom/AttachmentNg/acfb12e0-c08e-4700-b340-bc19d8a8a712

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Virtual Prepaid Card Market Segmentation Categories Analyzed: The virtual prepaid card market is segmented into key categories, including general-purpose cards, gift cards, entertainment and gaming cards, teen and campus cards, business and administrative expense cards, payroll cards, meal cards, travel forex cards, transit and toll cards, social security and other government benefit program cards, fuel cards, utilities, and other miscellaneous categories. Performance Evaluation: For each category, the report assesses transaction value, providing insights into the adoption and usage patterns of virtual prepaid cards across different consumer segments. Consumer Usage Trends Age Groups: Identifying usage patterns across different age demographics. Income Levels: Analyzing how income brackets influence prepaid card adoption and usage. Gender: Examining differences in usage trends between genders. Key Attributes: Report Attribute Details No. of Pages 159 Forecast Period 2025 - 2029 Estimated Market Value (USD) in 2025 $7.17 Billion Forecasted Market Value (USD) by 2029 $9.96 Billion Compound Annual Growth Rate 8.5% Regions Covered Sweden ScopeSweden Prepaid Payment Instrument Market Size and Forecast Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Market Share Analysis by Prepaid Card vs. Digital Wallet Sweden Digital Wallet Market Size and Forecast Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Market Share Analysis by Key Segments Sweden Digital Wallet Market Size and Forecast by Key Segments Retail Shopping (Value, Volume, Avg. Value) Travel (Value, Volume, Avg. Value) Restaurant (Value, Volume, Avg. Value) Entertainment and Gaming (Value, Volume, Avg. Value) Recharge and Bill Payment (Value, Volume, Avg. Value) Sweden Digital Wallet Retail Spend Dynamics Food and Grocery - Transaction Value Health and Beauty Products - Transaction Value Apparel and Foot Wear - Transaction Value Books, Music and Video - Transaction Value Consumer Electronics - Transaction Value Pharmacy and Wellness - Transaction Value Gas Stations - Transaction Value Restaurants & Bars - Transaction Value Toys, Kids, and Baby Products - Transaction Value Services - Transaction Value Others - Transaction Value Sweden Prepaid Card Industry Market Attractiveness Load Value Trend Analysis Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Number of Cards Market Share Analysis by Functional Attributes - Open Loop vs. Closed Loop Market Share Analysis by Prepaid Card Categories Sweden Open Loop Prepaid Card Future Growth Dynamics Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Number of Cards Sweden Closed Loop Prepaid Card Future Growth Dynamics Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Number of Cards Sweden Prepaid Card Consumer Usage Trends By Age Group By Income Group By Gender Sweden Prepaid Card Retail Spend Dynamics Food and Grocery - Transaction Value Health and Beauty Products - Transaction Value Apparel and Foot Wear - Transaction Value Books, Music and Video - Transaction Value Consumer Electronics - Transaction Value Pharmacy and Wellness - Transaction Value Gas Stations - Transaction Value Restaurants & Bars - Transaction Value Toys, Kids, and Baby Products - Transaction Value Services - Transaction Value Others - Transaction Value Sweden General Purpose Prepaid Card Market Size and ForecastSweden Gift Card Market Size and ForecastGift Card Market Size and Forecast by Functional Attribute By Open Loop Gift Card By Closed Loop Gift Card Gift Card Market Size and Forecast by Consumer Segments By Retail Consumer Segment By Corporate Consumer Segment Gift Card Market Share Analysis by Retail Categories Gift Card Market Share Analysis by Gifting Occasion Gift Card Market Share Analysis by Purchase Location Sweden Entertainment and Gaming Prepaid Card Market Size and ForecastSweden Teen and Campus Prepaid Card Market Size and ForecastTeen and Campus Prepaid Card Market Size and Forecast by Functional Attribute By Open Loop Teen and Campus Prepaid Card By Closed Loop Teen and Campus Prepaid Card Sweden Business and Administrative Expense Prepaid Card Market Size and ForecastBusiness and Administrative Expense Prepaid Card Market Size and Forecast by Consumer Segments By Small Scale Business Segment By Mid-Tier Business Segment By Enterprise Business Segment By Government Segment Sweden Payroll Prepaid Card Market Size and ForecastPayroll Prepaid Card Market Size and Forecast by Consumer Segments By Small Scale Business Segment By Mid-Tier Business Segment By Enterprise Business Segment By Government Segment Sweden Meal Prepaid Card Market Size and ForecastMeal Prepaid Card Market Size and Forecast by Consumer Segments By Small Scale Business Segment By Mid-Tier Business Segment By Enterprise Business Segment By Government Segment Sweden Travel Forex Prepaid Card Market Size and ForecastTravel Forex Prepaid Card Market Size and Forecast by Consumer Segments By Retail By Small Scale Business Segment By Mid-Tier Business Segment By Enterprise Business Segment By Government Segment Sweden Transit and Tolls Prepaid Card Market Size and ForecastSweden Social Security and Other Government Benefit Programs Prepaid Card Market Size and ForecastSweden Fuel Prepaid Cards Market Size and ForecastSweden Utilities, and Other Prepaid Cards Market Size and ForecastSweden Virtual Prepaid Card Industry Market Attractiveness Transaction Value Trend Analysis Transaction Volume Trend Analysis Average Value per Transaction Market Share Analysis by Key Virtual Prepaid Card Categories Sweden Virtual Prepaid Card Market Size by Key Categories General Purpose Prepaid Card - Transaction Value Gift Card - Transaction Value Entertainment and Gaming Prepaid Card - Transaction Value Teen and Campus Prepaid Card - Transaction Value Business and Administrative Expense Prepaid Card - Transaction Value Payroll Prepaid Card - Transaction Value Meal Prepaid Card - Transaction Value Travel Forex Prepaid Card - Transaction Value Transit and Tolls Prepaid Card - Transaction Value Social Security and Other Government Benefit Programs Prepaid Card - Transaction Value Fuel Prepaid Cards - Transaction Value Utilities, and Other Prepaid Cards - Transaction Value For more information about this report visit About is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Attachment Swedish Prepaid Card and Digital Wallet Market CONTACT: CONTACT: Laura Wood,Senior Press Manager press@ For E.S.T Office Hours Call 1-917-300-0470 For U.S./ CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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