Lyndra Therapeutics appoints Adam Sayer new CEO and president
Sayer, who will also join the company's board of directors, brings experience from his previous role as chief transformation officer at Envision Healthcare.
With an understanding of the healthcare ecosystem, Sayer's expertise in strategy, transformation and payer negotiations is expected to be pivotal in progressing the company's programmes, particularly oral weekly risperidone (LYN-005).
This long-acting therapeutic is a key focus for the company as it strives to enhance patient experience by offering less frequent dosing.
The pivotal safety trial for LYN-005 is scheduled to begin in the first half of 2025.
Adam stated: 'I am excited to join Lyndra at this pivotal moment for the company. Lyndra's LYNX platform technology has demonstrated remarkable potential to transform oral medicine delivery and make a meaningful impact on patient outcomes, and I look forward to leading this talented team as we bring the first-ever long-acting oral medicines to market.'
Under the stewardship of Jessica Ballinger, outgoing CEO and president, the company completed a pivotal efficacy study for LYN-005.
Lyndra Therapeutics board executive chair and co-founder Amy Schulman stated: 'We are grateful for Jess's contributions and overall dedication to our mission. Now, under Adam's leadership and with his focus on business execution, we are poised to achieve our goals and fundamentally change how oral medicines are delivered.'
The company recently entered a strategic partnership with Thermo Fisher Scientific, focusing on commercial manufacturing and clinical research on a global scale.
Lyndra's LYNX drug delivery platform is tailored to deliver treatments for a week or more in one oral dose. The platform's flexibility and potential have been showcased through clinical proof-of-concept studies across 25 active pharmaceutical ingredients and five therapeutic areas.
"Lyndra Therapeutics appoints Adam Sayer new CEO and president" was originally created and published by Pharmaceutical Technology, a GlobalData owned brand.
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NBC Sports
4 days ago
- NBC Sports
WNBA Trade Deadline winners and losers roundtable
The WNBA trade deadline passed at 3 p.m. ET on Thursday, closing out one of the most active deadline's in recent memory. The reason for this? In previous years, 12 teams for eight playoff spots meant that teams had ample chances to try to squeeze into those final couple of spots. Teams that probably should have folded their playoff chances and became sellers didn't because they still believed could go on a late season playoff push. Also, it was often difficult for certain trades to go through because the WNBA operates on a hard salary cap rather than a softer one, which is the status quo in other professional leagues. Three years ago the Phoenix Mercury were trying to trade Skylar Diggins after there were tensions between her, Diana Taurasi and their head coach at the time, Vanessa Nygaard. Trading Diggins never went through because the math didn't work and general managers around the WNBA didn't manage their caps as intentionally as they do now in 2025. This season, however, trades were much more intentional with clear buyers and sellers. Franchises like the Dallas Wings and Washington Mystics embraced their roles as sellers stacking their assets for the future, especially leading up to a 2026 free agency period where around 80 percent of the WNBA will be unrestricted free agents. While this year's deadline resulted in four different trades, including one that came in late June, it still didn't match the typical excitement that often comes on deadline day in the NBA or MLB. This could change as soon as next season. The current iteration of the Collective Bargaining Agreement expires on October 31 and a well-reported goal of the players association is to bargain for a softer salary cap. How much did the sellers like the Mystics and the Wings accomplish their goals? And what about teams like the Minnesota Lynx and Seattle Storm who were clearly buying at the deadline? 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But now, Edwards heads back to Connecticut, where she enjoyed major success and earned plenty of fans as a UConn Husky, to potentially start in the frontcourt for a Sun team playing the rest of this season without many expectations from a wins and losses standpoint. She may have a chance to log heavy minutes in a stress-free environment, giving her a chance to get her career back on track. Jackie Powell: Diamond Miller is going to get a huge opportunity to play minutes on a Dallas team that has a lot of young talent. Miller has been through the ringer when it came to injuries, missing around half of her sophomore season in 2024. But another challenge Miller had to endure playing for the Lynx was her playing time. She lost her starting role to the more experienced Bridget Carlton after she had begun her WNBA career averaging over 12 points per game during her rookie season in 2023. Lynx head coach and president of basketball operations Cheryl Reeve alluded to the Lynx having a longer developmental timeline for Miller than Miller herself wanted in her career. Miller wanted to contribute and playing in Dallas will allow her to do that immediately with much lower stakes. Miller provided a spark every time she came off the bench for the Lynx. She shot over 50 percent from three in 26 total attempts, but Reeve didn't have enough trust in her yet to allow her to play freely in critical situations. 'I think… most of us came from places where we've felt undervalued,' Miller told reporters prior to her first game for the Wings this past Tuesday night. 'Now it's time where we can expand our game so it's really exciting.' To be clear, Miller is thankful for her time in Minnesota as she learned what excellent looks and sounds like. 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And while the Mystics shipped off a young player with potential in Edwards, there was a logjam in the frontcourt, and her exodus brought back a future first-round pick, as did the Sykes trade. Powell: Respect is due for how clear the Mystics' vision is. This is a franchise that aims to build through some of the most pro-ready draft classes the league has ever seen. There are some teams, namely the Chicago Sky and Los Angeles Sparks that chose not to take advantage of the circumstances that the Mystics have. As a result the Sky are 11th place and they won't have control over what will be a 2026 lottery pick due to a pre-draft trade they made this year to make sure they could draft Hailey Van Lith. And the Sparks are clawing tooth and nail to get into one of the last two playoff spots. But just because the Mystics' vision is clear, doesn't mean they've hit a home run on all of their moves. Edwards is a talent who could have become part of the Mystics young core, but because of the Mystics' poor roster construction she ended up in an unfavorable spot in the rotation leading to a trade request. Did no one want Stefanie Dolson instead around the league? That's for sure possible. But also, the inexperience of Mystics' front office came back to bite them earlier this season when they missed the deadline to pick up 22 year-old point guard Jade Melbourne's option, extending her rookie scale deal through 2026. As a rebuilding franchise that should have control over as many young players as possible, this was a missed opportunity. So while this vision is clear, it's far from flawless. Which team do you believe is the biggest threat to the current favorite, Minnesota, to win the title? Johnson: It's New York, under the assumption that their frontcourt will return to full strength well ahead of the playoffs. Not having Breanna Stewart, Nyara Sabally and Kennedy Burke due to injury is huge, as it's left the Liberty light on frontcourt depth. Adding Emma Meeseman to the fold was a significant move, as she was the best player not in the WNBA at the time of her signing. Meeseman's offensive versatility will be a major asset for Sandy Brondello, especially as the veteran forward continues to get more comfortable with her new teammates and the system. Plus, they still have Sabrina Ionescu and Natasha Cloud on the perimeter. Huff: Like Raphielle said, New York is Minnesota's biggest threat, if healthy. The Liberty were off to a similarly fast start to the season as the Lynx were before Jonquel Jones' ankle injury jumpstarted a series of injuries to follow for the Liberty, who are very banged up at the time of this writing. Health provided, in addition to the acquisition of Meeseman, there's a real argument to be made that the defending champions have a better roster than they did a season ago. That being said, the injuries are a concern and good health come postseason is far from guaranteed. Powell: I have two answers. The obvious one is the New York Liberty which both Raphielle and Cole alluded to. But what about the Atlanta Dream, a team that's currently third in the standings and third in net rating behind the Lynx and the Liberty. The Lynx have struggled with the Dream's size this season as Alanna Smith has had to take the brunt of guarding the Dream's large and strong centers in Brittney Griner and Brionna Jones. To be clear Smith deals with this mismatch when she guards Jonquel Jones in New York, but in Atlanta there are two players of that stature that she really has to worry about. In two games played against the Dream this season, the Lynx have a net rating of zero, and their defensive and offensive ratings are both at 107.7. The Lynx's base defensive rating of 95.4 drops by over 12% when they play against the Dream. While Carrington will be able to contain Allisha Gray and Rhyne Howard when she returns better than Kayla McBride previously could, I still question how much the mismatch in the front court will matter for the Lynx. Although if the standings remain the same by the final day of the regular season, the Lynx might get lucky and might not have to face the Dream in the postseason at all. Do you believe the Connecticut Sun should have gone 'all-in' on a rebuild by being more active at the deadline? Johnson: I'm somewhat surprised that the Sun did not look to move another of their veterans, either for a young prospect to evaluate for the rest of the season or in exchange for added draft capital. Then again, maybe the fact that nearly 80 percent of the league's players will be free agents after this season factored into Connecticut not doing more before the trade deadline. Adding Edwards via trade was a good move, but Connecticut not looking to move another post to free up minutes for the 2024 first-round pick was somewhat confusing. If there's anything to watch down the stretch for Rachid Meziane's team, it's the playing time that Edwards and rookies Leïla Lacan, Saniya Rivers and Aneesah Morrow receive (Rayah Marshall can be included, but she's been out of the rotation on most nights). This isn't going to be a playoff team, so the focus should be on evaluating those young players. Huff: Yes, considering the Sun's spot in the standings at this point in the season. With the worst record in the league and the playoffs likely unrealistic, the starting roles that Connecticut's veteran players occupy are preventing the young players from receiving important developmental reps; this potentially becomes even more of a hindrance with Aaliyah Edwards in town and needing minutes. Marina Mabrey and Tina Charles are a couple of veterans slated to become unrestricted free agents after this season, which will provide the Sun even more cap space to be active in free agency this upcoming offseason. Perhaps they are waiting until then to go 'all in.' Powell: To be clear the Sun were forced to rebuild unlike the Mystics who leaned more into it after changing hands once they fired Mike and Eric Thibault. The writing had been on the wall for so long that the late 2010s and early 2020s Sun coached by Curt Miller and then Stephanie White was going to come to a dramatic end. That success wasn't going to be continued mostly because the Sun franchise arguably has the least player friendly facilities in the league and is located in the most middle of nowhere place in Uncasville, Connecticut. The Sun as they stand aren't a place for free agents as they once were. There are many reasons as to why the Sun weren't more active, but the most obvious one is the current battle for the franchise itself. There is an ownership group in Boston willing to put up $325 Million for the franchise and move it to Boston. The proposal, however, hasn't been accepted by the board of governors and multiple reports suggest that the league could force the Sun to sell to a buyer of the league's choosing rather than Connecticut's. There are also other questions about how much trade value 37-year-old Tina Charles and recently-hurt guard Marina Mabrey had. Jacy Sheldon, who they did trade, is a very good rotation two-way guard and she will balance out a Mystics roster that was never balanced. 2026 will present a blank slate for many WNBA teams, and that includes the Connecticut Sun. Between the Lynx and the Storm, who improves more as a result of the moves they made at the deadline? Johnson: While Seattle adding Sykes may have addressed a slightly more pressing need, adding a defender of Carrington's caliber is why Minnesota receives the nod for me. The Lynx were able to go small at times on Tuesday, playing three wings with Bridget Carleton shifting down due to Alanna Smith being in foul trouble. And the move worked, with Minnesota making its run and going on to beat the Storm in Seattle. It isn't difficult to envision lineups where it's Napheesa Collier serving as the five once she returns from her sprained ankle. Minnesota has been the best team all season, and the Carrington additions should make them even better, especially once Collier returns. Huff: I somewhat alluded to this in an earlier response, but I'll rephrase it here: I think the Lynx entered and exited the trade deadline as an A+ team, while the Storm upgraded from probably a B-level team to something greater. Alysha Clark's role had diminished throughout the season and she wasn't consistently playing meaningful minutes by the end of her second stint in Seattle. Now, the Storm gets deeper with the addition of Sykes and gains another defender, but one with real game-changing ability on the offensive end and player capable of closing games. Between their starting five, the rookie Dominique Malonga, and now Sykes, Seattle has a very strong seven-player rotation. Powell: I agree with Cole on this one. The Storm improved more because they added a better all around player, but I'm not sure how much adding Sykes is going to help them make a deep playoff run and make it into the WNBA Finals. Basketball is about math and I agree with Nekias Duncan at Bleacher Report when he says that the Sykes trade 'reinforces' who the Storm are rather than " solves what they aren't'. While Sykes has improved her three-point clip over the years, she's still not the perimeter spacing threat that the Storm need in order to put more pressure on defenses. To be clear, I saw the fit for Sykes much more in Minnesota. The Lynx didn't just need another perimeter defender, but they needed someone who can reliably create offense in high pressure situations when offensive actions get blown up by excellent defenses presumably in the postseason. Napheesa Collier is the Lynx's only consistent creator of offense in clutch and crunch time situations. She can be handed the basketball and can make something happen with it. While there's some argument to be made that Courtney Williams and Kayla McBride have the potential to take on those types of responsibilities, Sykes has been excellent at drawing contact and getting to the line, which regardless of officiating, the Lynx struggled to do in situations when it mattered most. As of now the Lynx are 11th in the league when it comes to free throws attempted per game.
Yahoo
01-08-2025
- Yahoo
WNBA trade deadline: 3 trade scenarios for playoff contenders looking to make a push
The WNBA trade deadline less than a week away, on August 7. While the WNBA isn't known for a flurry of deadline day trades like we saw in MLB on Thursday, there have been some impactful midseason trades. The biggest was in 2015, when Sylvia Fowles sat while being under contract with the Chicago Sky until she was traded to Minnesota. She went on to become a key part of the Lynx's championship win that season and was named Finals MVP. Those are the kind of trades general managers dream of making. But this year is particularly interesting, as nearly every non-rookie contract ends after this season because of the impending CBA expiration. Will general managers be more likely to make risky trades because of their concerns about how the future CBA will affect their teams? Or will it make them more conservative for the same reason? WNBA trade rules are fairly cut and dry. With the help of Her Hoop Stats, here are the basics of WNBA trades: Any player can be traded, and contracts do not need to be equal for trades to happen. Cash considerations are not a part of WNBA trades for that reason. The team picking up a player is on the hook for the rest of her salary from the time she's traded. Draft picks can be traded, and the 2026 draft order already includes several trades. Not every team will be active at the trade deadline, as some teams don't have the salary cap room to make changes. The Liberty don't have much cap space — $119,000, per Her Hoop Stats, but that was before they signed Belgian superstar Emma Meesseman. The top team in the league, Minnesota, is also unlikely to make a huge move; they have a chemistry that has led them to a record of 23-5, and only $43,494 in cap space. Atlanta is salary cap-prohibited, and Indiana has a full roster at 12. The Fever have been active on the free-agent market this season with their injury issues, and signed Chloe Bibby to a rest of the season contract on Friday. Now, let's get to the trades that could make sense: Dallas' DiJonai Carrington to Golden State for a second-round draft pick Kayla Thornton had been enjoying a breakout season in Golden State, making it to her first All-Star Game, but her season ended with a knee injury on July 25. To make it into the playoffs in the franchise's first season, the Valkyries will need to continue to focus on defense. The Wings' Dijonai Carrington is relentless on that end of the floor, and could make an immediate impact at Golden State. She's dealt with ongoing injuries, so a second-round pick could be fair compensation as the Wings are likely looking forward to the team they will build around Paige Bueckers. Plus, Golden State has plenty of cap space (about $300,000) to absorb the trade this way. Chicago's Rebecca Allen to Seattle for Alysha Clark and a draft pick Seattle's defense is incredible, and with Gabby Williams, Ezi Magbegor and Dominique Malonga on patrol, it will only get better. But on offense? Seattle is ranked ninth in the league in points per game (80.7) and 3-pointers made per game (7.4). Currently ranked fourth in the WNBA at 16-11, the team is hoping to follow Nneka Ogwumike and Skylar Diggins to a title. But they could use a shooter, and Chicago's Rebecca Allen could be a good fit. She is a plug-and-play type, as she's played for four different teams over the past four seasons. To be able to afford Allen, Alysha Clark's giant contract ($185,000) will need to be moved. Clark and a draft pick to build up the Sky in the future could make the trade worthwhile for Chicago. Los Angeles' Azurá Stevens to Washington Mystics for Aaliyah Edwards and a second-round draft pick One of the pleasant surprises of the 2025 season is how well the young Mystics team has played. Led by rookie All-Stars Sonia Citron and Kiki Iriafen, the team is well-positioned to make a postseason push in Sydney Johnson's first season as head coach (they're 13-14, currently 9th in the league). But they could use some veteran leadership and depth in the frontcourt. The Sparks' Azurá Stevens (14.7 points, 8.6 rebounds, 1.9 assists per game) could provide both, and with Cameron Brink healthy again, she's needed more in Washington than in Los Angeles. Aaliyah Edwards has been eclipsed by the Mystics' rookies and could find a new start in LA.
