AbbVie and Genmab's Promising Phase 3 Study for DLBCL Treatment
Elevate Your Investing Strategy:
Take advantage of TipRanks Premium at 50% off! Unlock powerful investing tools, advanced data, and expert analyst insights to help you invest with confidence.
AbbVie and Genmab are conducting a Phase 3 clinical study to evaluate the safety and efficacy of epcoritamab plus lenalidomide compared to rituximab plus gemcitabine and oxaliplatin in treating relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL). This study is significant as it explores new treatment options for this aggressive form of cancer, potentially improving patient outcomes.
The study involves three treatment arms: one receiving subcutaneous injections of epcoritamab plus oral lenalidomide, another receiving intravenous rituximab plus gemcitabine and oxaliplatin, and a third receiving only epcoritamab. The goal is to determine which treatment is most effective in managing DLBCL.
This randomized, open-label study follows a parallel intervention model with no masking. Its primary purpose is treatment, aiming to enroll around 360 participants across 165 global sites.
The study began on August 13, 2024, with an estimated completion date yet to be announced. The last update was submitted on August 4, 2025, indicating ongoing progress.
For investors, this study could impact AbbVie and Genmab's stock performance, especially if the results show promising outcomes. The competitive landscape in oncology treatments is fierce, and successful trials can lead to significant market advantages.
The study is ongoing, with further details available on the ClinicalTrials portal.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Globe and Mail
3 hours ago
- Globe and Mail
3 Key Takeaways from the Q2 Earnings Season
As we head into the final phase of the Q2 earnings season, we can say with complete confidence that the overall earnings picture remains strong and resilient. Even more importantly, the outlook for the current and coming quarters has clearly started improving, with the favorable revisions trend particularly notable for the Tech sector. While we still have a few key Tech sector players among the 9% of S&P 500 members that are still to report results, the primary focus of the still-to-come reports will be on the retail space. We have a couple of retail-centric companies, such as Advanced Auto Parts AAP and Birkenstock BIRK, on deck to report this week, but the bulk of the sector results will start coming out the following week. Here are the three key takeaways from the Q2 earnings season. First, we saw an above-average proportion of companies beat Q2 EPS and revenue estimates, with the beats percentage particularly notable on the revenues side. Through Friday, August 8 th, we have seen Q2 results from 455 S&P 500 members, or 91% of the index's total membership. Total earnings for these companies are up +11.6% from the same period last year on +5.9% revenue growth, with 80.4% beating EPS estimates and 79.1% beating revenue estimates. This is a notably better performance relative to what we have seen from this group of index members in other recent periods, as the comparison charts below show. The comparison charts below show the Q2 earnings revenue growth pace for the 455 index members that have already reported results. As you can see above, the revenue performance is particularly notable. Second, we are on track for a new all-time quarterly record for the aggregate Q2 earnings total for the S&P 500 index, surpassing the previous record set in 2024 Q4. Looking at Q2 as a whole, combining the actual results from the 455 index members that have reported already with estimates for the still-to-come 45 companies, total S&P 500 earnings are expected to be up +12.1% from the same period last year on +6.2% higher revenues. The Q2 earnings growth rate improves to +13.9% when the Energy sector's drag is removed from the results and weakens to +8.5% when the Tech sector's substantial contribution is excluded from the aggregate numbers. The aggregate dollar total for Q2 is a new all-time quarterly record, as the chart below shows. As you can see above, aggregate earnings are on track to reach $582 billion, up from $556.2 billion in the preceding period, $519.3 billion in the year-earlier quarter, and the previous record of $573.6 billion in 2024 Q4. Third, the revisions trend has turned positive, with the trend particularly notable for the Tech sector. For the current period (2025 Q3), the expectation today is for earnings growth of +5.1% for the S&P 500 index on +5.6% higher revenues. The chart below shows how Q3 earnings growth expectations have evolved in recent weeks. You can also see above how Q3 estimates have evolved since the start of July. Since the start of July, Q3 estimates have increased for 6 of the 16 Zacks sectors, with the biggest gains for the Tech, Finance, Energy, and Retail sectors. On the negative side, Q3 estimates have declined for the remaining 10 sectors since the start of the period, with the biggest declines for the Medical, Transportation, Basic Materials, Construction, and Auto sectors. For the Tech sector, Q3 earnings are currently expected to be up +10.4% from the same period last year on +11.5% higher revenues. The chart below shows how the sector's Q3 earnings growth expectations have evolved since the quarter got underway. The Earnings Big Picture The chart below shows current Q2 earnings and revenue growth expectations in the context of the preceding four quarters and the coming four quarters. The chart below shows the overall earnings picture on a calendar-year basis. In terms of S&P 500 index 'EPS', these growth rates approximate to $257.35 for 2025 and $289.35 for 2026. The chart below shows how these calendar year 2025 earnings growth expectations have evolved since the start of Q2. As you can see below, estimates fell sharply at the start of the quarter, which coincided with the tariff announcements, but have started going back up lately. Quantum Computing Stocks Set To Soar Artificial intelligence has already reshaped the investment landscape, and its convergence with quantum computing could lead to the most significant wealth-building opportunities of our time. Today, you have a chance to position your portfolio at the forefront of this technological revolution. In our urgent special report, Beyond AI: The Quantum Leap in Computing Power, you'll discover the little-known stocks we believe will win the quantum computing race and deliver massive gains to early investors. Access the Report Free Now >> Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Advance Auto Parts, Inc. (AAP): Free Stock Analysis Report Birkenstock Holding PLC (BIRK): Free Stock Analysis Report
Globe and Mail
4 hours ago
- Globe and Mail
C3 AI Restructures Sales and Services Organizations to Accelerate Growth
C3 AI (NYSE: AI), the Enterprise AI application software company, in the course of Q1, has restructured its global sales and services organization, including new leadership. That restructuring is now complete. New leadership includes: Rob Schilling joins C3 AI as EVP and Chief Commercial Officer, responsible for all Sales, customer-facing teams, and Alliances, effective June 16, 2025. Schilling is a seasoned enterprise application sales leader. His prior experience includes SVP, ERP, Oracle, responsible for a billion-dollar cloud application business; GVP, Nokia Software; CEO, SpaceTime; SVP, SAP Americas; Chief Customer Officer, SAP Japan; and SVP of Sales at Siebel Systems. He brings almost a quarter century of senior enterprise sales leadership to lead the C3 AI go-to-market effort globally. John Kitchingman joins C3 AI as General Manager, EMEA, effective June 30, 2025. He previously served as SVP, Global Customer Engagement at Dassault Systèmes and VP and Global Sales Leader, IBM Global Services. Jeff Cosseboom joins C3 AI as Group Vice President, North America East Sales. He brings over three decades of enterprise sales experience as Chief Revenue Officer, Palladin Technologies; Area VP, Salesforce-Vlocity; VP, SAP; and GVP, Siebel Systems/Oracle. Lars Farnstrom joins C3 AI as Group Vice President, Nordics. He is also an exceptionally experienced technology leader, including as CEO, VP, Nordics, C3 AI; CEO, Raw Lab; VP, Sales Northern Europe, C3 AI; and Group Director, CRM, Siebel Systems. Alex Amato, Group Vice President of Customer Services and an executive with C3 AI for nine years, has been promoted to assume responsibility for all professional services and customer service operations, reporting to Rob Schilling. In the course of Q1, he has restructured the services organization to ensure a consistent and universal focus on rapid and significant value realization for all C3 AI engagements. 'The good news is we have completely restructured the sales and services organization, including new and highly experienced leadership across the board to ensure a return to accelerating growth and increased customer success at C3 AI. The bad news is that sales results in Q1 were completely unacceptable. Having given this a lot of thought, I attribute this to two factors. One: It is clear that in the short term, the reorganization with new leadership had a disruptive effect. Two: As we have previously announced, I have had a number of health issues in the past six months including multiple hospitalizations and vision impairment. Unfortunately, dealing with these health issues prevented me from participating in the sales process as actively as I have in the past. With the benefit of hindsight, it is now apparent that my active participation in the sales process may have had a greater impact than I previously thought. That being said, as we enter Q2, we have new leadership in place, a restructuring completed, an extraordinarily large market opportunity, a superlative product offering, and exceptional levels of customer satisfaction, and I am confident the company is positioned to accelerate going forward,' said Thomas M. Siebel, Chairman and CEO, C3 AI. 'I am pleased to also report that, but for vision impairment, my health has improved dramatically. I am feeling strong and am fully engaged. As you also know, we are actively engaged in an executive search for a successor CEO at C3 AI and are moving expeditiously to identify some excellent candidates in short order.' Use of Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. The words 'continue,' 'may,' 'would,' 'will' and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding our market opportunity, our sales and customer opportunity pipeline, the results of restructuring our sales and services organizations, the success of our new sales leadership structure, customer satisfaction, the outcome of our search for a new Chief Executive Officer, and our business strategies, plans, and objectives for future operations. We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. These forward-looking statements are subject to a number of risks and uncertainties, including our history of losses and ability to achieve and maintain profitability in the future, our historic dependence on a limited number of existing customers that account for a substantial portion of our revenue, our ability to attract new customers and retain existing customers, market awareness and acceptance of enterprise AI solutions in general and our products in particular, the length and unpredictability of our sales cycles and the time and expense required for our sales efforts. Some of these risks are described in greater detail in our filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the fiscal year ended April 30, 2025, and other filings and reports we make the Securities and Exchange Commissions from time to time, including our Quarterly Report on Form 10-Q that will be filed for the fiscal quarter ended July 31, 2025, although new and unanticipated risks may arise. Certain of the future events and trends discussed in this press release may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance, achievements, or events and circumstances reflected in the forward-looking statements will occur. Except to the extent required by law, we do not undertake to update any of these forward-looking statements after the date of this press release to conform these statements to actual results or revised expectations. About Inc. C3 AI is the Enterprise AI application software company. C3 AI delivers a family of fully integrated products including the C3 Agentic AI Platform, an end-to-end platform for developing, deploying, and operating enterprise AI applications, C3 AI applications, a portfolio of industry-specific SaaS enterprise AI applications that enable the digital transformation of organizations globally, and C3 Generative AI, a suite of domain-specific generative AI offerings for the enterprise.
Globe and Mail
6 hours ago
- Globe and Mail
3 No-Brainer Artificial Intelligence (AI) Stocks to Buy Now and Hold Forever
Key Points The biggest winners from the AI revolution will all have durable competitive advantages. Despite strong operating results, these stocks still look like great values amid the AI stock boom. With long-term potential gains from AI, you can buy them now and hold them forever. 10 stocks we like better than Amazon › Excitement around artificial intelligence (AI) and its potential impact on businesses has led to soaring stock prices for many of the biggest tech companies. Nvidia, for example, has seen its stock price grow more than tenfold since the release of ChatGPT in late 2022, now topping $4 trillion in market cap. Some investors may feel like they've missed the boat and they're too late to buy AI stocks at a good price. It's important to consider that today's AI winners might not be the biggest companies to benefit from advancements in artificial intelligence over the long run. Finding a company that's making excellent progress right now with sustainable long-term competitive advantages could end up being an even better stock to own when the dust settles. Where to invest $1,000 right now? Our analyst team just revealed what they believe are the 10 best stocks to buy right now. Continue » These three companies are all well positioned to benefit from the continued growth and advancement in artificial intelligence. Their stocks are all attractive at today's prices, too, which means you can buy them now and hold them forever. 1. Amazon Amazon (NASDAQ: AMZN) is home to the largest public cloud computing platform in the world, Amazon Web Services, or AWS. The segment generated $116.4 billion over the last 12 months, roughly 50% larger than its next-closest competitor, Microsoft 's Azure. Some have expressed concern about AWS for a few reasons. First, it was caught flat-footed as the generative AI opportunity was getting off the ground. That led it to cede market share to Microsoft and others who were earlier to invest in the space. However, it quickly course corrected, releasing its Bedrock platform, and it's seeing triple-digit growth in AI services. As such, it's been able to maintain most of its market share in a rapidly growing market (even though overall revenue growth has slowed to the high-teens). The second reason is that AWS saw a significant decline in operating margin in the second quarter. Management explained half of that decline was due to the timing of stock-based compensation. The rest is explained by Amazon's significant investments in capacity, as it notes the business remains capacity constrained. Over time, investors should see margin tick back up. It's worth noting AWS still commands higher margins than its smaller competitors. Meanwhile, the rest of Amazon looks strong. Its retail operations are seeing improved margins quarter after quarter, thanks in part to a strong advertising business. The international segment is notably on its way to becoming a meaningful contributor to operating income after years of investment. The stock fell following the release of its second-quarter earnings based on a disappointing outlook. But the long-term potential for Amazon, particularly in AWS, remains strong. The pullback in price looks like an opportunity for long-term investors to buy this AI leader. 2. Salesforce Salesforce (NYSE: CRM) provides a suite of software often found at the center of many enterprises' operations. The company has seen very good results with its growing set of cloud-based software solutions, but the standout recently has been its Data Cloud offering. Data Cloud provides a single platform to aggregate all of a company's data to create actionable insights from a single source. Data Cloud recurring revenue grew to $1 billion in Salesforce's most recent quarter, up 120% year over year. It's seeing strong attachment, with 60 of its top 100 deals including Data Cloud in the contract. And the most recent product built on top of Data Cloud, Agentforce, is seeing very strong adoption. Agentforce allows businesses to build AI agents that can execute tasks or provide customer service with minimal human intervention. The key to building successful AI agents is access to pertinent data, which is exactly what Data Cloud brings to the table. Management says it's made 8,000 deals with Agentforce since its launch last fall, representing $100 million in revenue. That makes it Salesforce's fastest-growing product ever. Considering Salesforce's software suite is entrenched in the operations of so many enterprises, it's in a prime position to benefit from growing spend on artificial intelligence, particularly through Data Cloud. It's unlikely to lose that position. In fact, its expanding suite of software tools only serves to increase the switching costs for a company. With shares trading for just 22 times forward earnings estimates, Salesforce looks like a great buy at today's price. 3. Meta Platforms Meta Platforms (NASDAQ: META) may be the biggest investor in artificial intelligence in the world. It's on track to spend between $66 billion and $72 billion on capital expenditures, and it's only building compute power for itself (unlike the other hyperscalers, who serve cloud customers). There's a good reason Meta is spending more than everyone else on artificial intelligence; it could be the biggest beneficiary of all generative AI has to offer. Signs of that are already coming through. In the second quarter, Meta's ad prices climbed 9% year over year and impressions grew 11%. CEO Mark Zuckerberg notes a significant portion of that improvement came from its AI-recommendation model. Additionally, time spent on Facebook and Instagram increased 5% and 6%, respectively, thanks to bigger AI models. But the future is bright, too. Meta's generative AI tools for ad creative are seeing strong adoption. Zuckerberg notes "a meaningful... [percentage] of our ad revenue now... [comes] from campaigns using one of our Generative AI features." Long term, Meta is working on an AI agent that can develop and test ad creatives autonomously. Meta's AI chatbot now boasts over 1 billion users, creating an additional channel for monetization over the long run. Meta only recently started putting ads in WhatsApp and Threads, which should provide additional ad revenue as advertising on Meta grows increasingly easier thanks to generative AI capabilities. Meta's seeing excellent financial results from the growing adoption of its advertising platform and increased engagement from its users. Revenue climbed 22% last quarter and operating income grew an impressive 38%. Meta's growing depreciation expense will likely weigh on earnings going forward as long as it continues to ramp up spending, but if it continues to produce top-line growth like last quarter, that's easily digestible. If you back out the depreciation expense using EBITDA, Meta shares trade for an attractive price with enterprise value around 16 times forward EBITDA estimates. Even on a more traditional forward P/E valuation, Meta shares look to be well worth the 27 times multiple you'll have to pay for the stock today. Should you invest $1,000 in Amazon right now? Before you buy stock in Amazon, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Amazon wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $636,563!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $1,108,033!* Now, it's worth noting Stock Advisor's total average return is 1,047% — a market-crushing outperformance compared to 181% for the S&P 500. Don't miss out on the latest top 10 list, available when you join Stock Advisor. See the 10 stocks » *Stock Advisor returns as of August 4, 2025
