REVEAL GENOMICS and Ona Therapeutics Join Forces to Advance Next-generation Cancer Treatment
REVEAL GENOMICS and Ona Therapeutics today announced a strategic collaboration aimed at accelerating the clinical development of ONA-255, a next-generation ADC designed to enhance the precision and efficacy of cancer treatment across multiple tumor types.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20250414211014/en/
ONA-255 is positioned to be a first-in-class molecule against a novel ADC target present in multiple, prevalent solid tumor types. Ona has privileged insight of the target as a hallmark of molecular adaptation in advanced diseases and its unique function as a universal driver of resistance to various therapies. ONA-255 is an ADC tailor-made to match the design of the molecule to the extraordinary biology of the target to deliver exceptionally potent drug against recalcitrant tumors, especially resistant clones for deeper and more durable responses.
At the heart of this collaboration is Dr. Aleix Prat, Co-Founder and Chief Scientific Officer of REVEAL GENOMICS. A globally recognized expert in precision oncology and drug development, Dr. Prat played a key role in identifying the ONA-255 drug target and generating, in collaboration with Ona Therapeutics and Dr. Roger Gomis, the critical preclinical data necessary for its clinical advancement. He also serves as the head of Ona Therapeutics' advisory board.
As a leader in genomic innovation, REVEAL GENOMICS will conduct a comprehensive molecular analysis of tumor and blood samples from the ONA-255 phase 1-2 clinical trial as part of this strategic collaboration. Leveraging proprietary technologies and advanced computational algorithms, the company will decode key molecular and genomic biomarkers to reveal insights into tumor biology, the immune microenvironment, and response mechanisms to ONA-255. This pioneering work will help define patient populations, identify predictive biomarkers, and deepen the understanding of ONA-255's mechanism of action—accelerating its clinical development and opening new therapeutic avenues.
To advance this partnership, Ona Therapeutics—working in collaboration with the U.S. subsidiary of REVEAL GENOMICS—has been awarded a grant from CDTI ( Centro para el Desarrollo Tecnológico y la Innovación ), a public entity under the Spanish Ministry of Science, Innovation, and Universities that promotes technological innovation and development. The grant is funded by the Plan de Recuperación, Transformación y Resiliencia – Funded by the European Union NextGenerationEU.
Valerie Vanhooren, Co-Founder and CEO of Ona Therapeutics, added, " ADCs have transformed cancer treatment; however, the technology has been applied to a limited number of tumor targets. These limitations restrict the number of patients who can benefit from treatments and highlight the critical need to identify new broadly expressed tumor targets. Ona's tailor-designed ADCs have the potential to define new treatment paradigms and patient populations, resulting in a clear benefit for patients with cancer. This partnership with REVEAL GENOMICS combines Ona's ADC experience with cutting-edge diagnosticswith the goal to transform the treatment landscape for aggressive solid tumors.'
Patricia Villagrasa, Co-Founder and CEO of REVEAL GENOMICS, stated, " Ona Therapeutics is at the forefront of developing next-generation cancer therapies. This collaboration marks a key milestone in combining advanced diagnostics with innovative treatments, reinforcing the strategic value of integrating biomarker science early in drug development. It also underscores REVEAL GENOMICS's leadership in driving biomarker strategy and our commitment to shaping new business models that bring precision oncology closer to patients.'
Dr. Aleix Prat commented, "
For further information visit: http://www.reveal-genomics.com
For further information visit: https://ona-therapeutics.com/
View source version on businesswire.com:https://www.businesswire.com/news/home/20250414211014/en/
Further information: Adriana Herrera,[email protected]
KEYWORD: EUROPE SPAIN UNITED STATES NORTH AMERICA
INDUSTRY KEYWORD: SCIENCE OTHER SCIENCE BIOTECHNOLOGY RESEARCH ONCOLOGY HEALTH CLINICAL TRIALS OTHER HEALTH
SOURCE: REVEAL GENOMICS
Copyright Business Wire 2025.
PUB: 04/14/2025 08:05 AM/DISC: 04/14/2025 08:06 AM
http://www.businesswire.com/news/home/20250414211014/en
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