What is glioblastoma, the aggressive brain cancer singer Michael Bolton was diagnosed with

Time of India

30-04-2025

Iconic singer and two-time Grammy-award winner,
, known for timeless hits like 'When a Man Loves a Woman' and 'How Am I Supposed to Live Without You?', recently opened up on his battle with
glioblastoma
, a rare and aggressive form of
brain cancer
.
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Diagnosed in December 2023, the 72-year-old artist has since undergone multiple surgeries and intensive treatment, and now credits the experience with giving him a 'heightened sense of appreciation' for life. While his short-term memory, speech and mobility have been affected by his treatments, his spirit remains intact. 'Succumbing to the challenge is not an option. You're really quickly drawn into a duel. I guess that's the way you find out what you're made of," Bolton told PEOPLE in an interview.
It all began when a troubling symptom led Bolton and his family to seek medical attention, something his daughter Taryn, later described as 'super weird.' Bolton was out bowling with his kids - daughters Taryn, Holly and Isa and grandkids - River, Olivia, Amelia, Jack, Dylan and Grayson, when he bowled out of turn, then he did it again, and again. Another red flag was noticed when the singer fell out of his chair to the left, which is very unusual.
"He's super athletic, and he doesn't drink,' says Taryn. 'So he fell, and we were like, 'What just happened?''
Doctors quickly discovered a
brain tumor
that required immediate emergency surgery. The tumor was successfully removed in its entirety. This outcome occurs in only about 30–40% of glioblastoma cases, according to Dr. Ingo Mellinghoff of Memorial Sloan Kettering Cancer Center.
Bolton shared in his diagnosis on his official Facebook page that a brain tumor had been discovered 'which required immediate surgery'.
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A second brain surgery was then performed just weeks later due to an infection, and Bolton subsequently underwent rounds of radiation and chemotherapy. His most recent MRI in April 2025 came back clear. This is quite a positive as the disease carries a 90% recurrence rate, according to the Glioblastoma Foundation.
What is Glioblastoma?
Glioblastoma is an aggressive cancer that originates in the brain or spinal cord, specifically from cells called
astrocytes
that support nerve cells.
It can happen at any age but is more commonly seen in older adults. The disease progresses rapidly and can destroy healthy brain tissue, making it especially dangerous.
Common symptoms include persistent headaches (often worse in the morning), nausea, vomiting, memory loss, confusion, personality changes, vision problems, speech difficulties, and seizures. The tumor can impact coordination, mobility, and even basic functions like speaking or sensation.
Glioblastoma begins when the DNA of brain or spinal cord cells mutates. These mutations cause the cells to grow uncontrollably and evade death, eventually forming a mass, the tumor that invades and damages surrounding tissues. While there is no known cure, treatment like surgery, radiation, and chemotherapy may slow its progression and help manage symptoms.
In the months following his diagnosis and treatment, Bolton has shared simple but satisfying moments with his three daughters and six grandchildren.
Together, they have found joy in simple routines like family trivia nights, golf games, and quiet moments at home in Westport, Connecticut, where Bolton has lived for more than 30 years.
Despite lingering effects on his speech, memory, and mobility, Bolton hasn't lost his fighting spirit or his voice. 'He was in recovery in the hospital room singing within minutes,' recalls his daughter Holly. That same voice, which has sold over 75 million records and earned him two Grammy Awards, continues to be a source of strength and comfort.
'I want to keep going. I feel there's still a lot to do on the fight side,' he says. 'I got a title for a song: 'Ain't Going Down Without a Fight.' '
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