Integrated DNA Technologies Announces Translational CRISPR Portfolio Expansion with Product Innovation Updates
'IDT's rich history, deep expertise, and ability to manufacture bespoke products at the highest quality uniquely positions us to consistently innovate on our CRISPR portfolio and support customers at every stage of their gene editing journey'
Share
Tailored gRNAs to Accelerate CRISPR Discoveries
As researchers advance from discovery to clinical applications, the demand for higher purity in CRISPR reagents increases. To meet this need, IDT's chemically synthesized gRNAs are now available for online ordering in a range of modification and purity options. With high purity ideal for translational applications such as gene editing in primary cells and in vivo models, IDT's high-performance liquid chromatography (HPLC)-purified gRNAs are orderable in 2 nmol and 10 nmol yields with larger quantities available by request and ship in as little as 12 business days. Formats include CRISPR-Cas9 gRNA and Custom Alt-R™ CRISPR gRNA. 2' Fluoro, 2' O-Methyl, and other modifications can be added to increase stability and specificity with IDT's custom gRNA tool.
Supporting Scientists with Regulatory Filings and Ensuring Safety of Therapeutic Candidates
CRISPR-based genome editing allows for targeted editing at specific sites in the genome, but there is potential risk that off-target edits at other locations can occur. To enable scientists to understand where these off-target edits might happen and assess how they might impact safety early in the therapeutic development process, IDT launched UNCOVERseq, off-target nomination services which uses an enhanced GUIDE-seq™ methodology to identify off-target sites for its customers. When paired with IDT's award-winning off-target confirmation services, rhAmpSeq™ CRISPR Analysis System, CRISPR pioneers can confidently accelerate their path to the clinic by obtaining a deeper understanding of editing risks.
The custom safety services provided in baby KJ's treatment helped launch UNCOVERseq and represent a major step forward in ensuring the safety of CRISPR-based therapies.
Enhancing Safety, Quality and Efficiency: IDT's Growing Pipeline and Future Collaborations
Future IDT launches, planned for late 2025, include complementary offerings such as the Alt-R HDR Enhancer Protein, which is designed specifically for therapeutic applications, and manufactured by Aldevron, to meet rigorous quality standards. The HDR Enhancer Protein improves HDR efficiency in difficult-to-edit cells, and maintains safety and cell health. IDT, in collaboration with Aldevron, will also be launching a novel Cas9 mRNA to support early discovery to clinical stage customers. IDT has been a long-time provider of CRISPR gRNA libraries for screening applications and will unveil a new design tool later this year for efficient ordering of custom, configured libraries.
'IDT's rich history, deep expertise, and ability to manufacture bespoke products at the highest quality uniquely positions us to consistently innovate on our CRISPR portfolio and support customers at every stage of their gene editing journey,' said Sandy Ottensmann, VP/GM, Gene Writing & Editing at IDT. 'On the heels of the world's first personalized CRISPR-based therapy, we're honored to bring more CRISPR tools that will enable researchers to make important discoveries, like the one designed for baby KJ, and progress science forward.'
Learn more about IDT's CRISPR portfolio here.
About IDT
Building from a strong foundation of innovation, expertise, and reliability, Integrated DNA Technologies (IDT) has evolved from an oligo manufacturer to a leading genomics provider. We work shoulder-to-shoulder with scientific and global health partners to enable genomics breakthroughs at scale. Our vision of enabling researchers to rapidly move from the lab to life-changing advances reflects our ongoing commitment to a healthier, brighter future for all.
IDT is proud to be part of Danaher, a global science and technology leader. Together we combine our capabilities to accelerate the real-life impact of tomorrow's science and technology to improve human health.
For more information about IDT, visit www.idtdna.com and follow the company on LinkedIn, X, Facebook, YouTube, and Instagram.
Disclaimer: RUO — For research use only. Not for use in diagnostic procedures. Unless otherwise agreed to in writing, IDT does not intend these products to be used in clinical applications and does not warrant their fitness or suitability for any clinical diagnostic use. Purchaser is solely responsible for all decisions regarding the use of these products and any associated regulatory or legal obligations.
Disclaimer: CGMP refers to products manufactured under ICHQ7; IDT engineering runs and CGMP gRNA are for development and investigational use only. The performance characteristics of this product have not been established. This product is not intended to be used as final drug product. The purchaser is solely responsible for all decisions regarding the intended use of the product and any associated legal or regulatory obligations.
GUIDE-seq™ is owned by Maxcyte®, Inc.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Newsweek
7 hours ago
- Newsweek
MrBeast Makes Astronomer Joke After Gwyneth Paltrow Video
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. MrBeast, who was recently named the top content creator in the world by Forbes, has reacted to one of the year's most viral stories, the Astronomer Coldplay "kiss-cam scandal." In a post on X, formerly Twitter, MrBeast responded to the company's recent marketing video, which featured Gwyneth Paltrow. Newsweek has reached out to a representative for MrBeast via email for comment. Why It Matters MrBeast's social media post comes after a split-second clip of Astronomer CEO Andy Byron and his colleague Kristin Cabot was shared on social media and promptly broke the internet. The video, first shared by instaagraace on TikTok, has been viewed over 128 million times as of time of writing. Left, MrBeast speaks onstage during YouTube Brandcast 2025 at David Geffen Hall in New York City on May 14, 2025. Right, Gwyneth Paltrow attends the 2025 Breakthrough Prize Ceremony at Barker Hangar in Santa Monica,... Left, MrBeast speaks onstage during YouTube Brandcast 2025 at David Geffen Hall in New York City on May 14, 2025. Right, Gwyneth Paltrow attends the 2025 Breakthrough Prize Ceremony at Barker Hangar in Santa Monica, California, on April 5, 2025. More Taylor Hill/FilmMagic/for YouTube In the clip, the jumbotron lands on the pair and they promptly sprang apart. Coldplay's lead singer Chris Martin, says: "Either they're having an affair or they're just really shy." The pair were later identified as Byron, CEO of the tech firm Astronomer, and Cabot, the company's head of Human Resources. Both have now resigned. What To Know On July 26, Astronomer shared a light-hearted marketing video which capitalizes on the attention that has been brought to the company since the now infamous Coldplay canoodling. The video features Paltrow, Martin's Oscar-winning ex-wife, as a "very temporary spokesperson." MrBeast, real name Jimmy Donaldson, responded to this on X. In a post that has been viewed over 230,000 times, he wrote, "Can I be CEO." Astronomer's board of directors have announced that they will start a formal search for their new chief executive. Company co-founder Pete DeJoy has taken over as interim CEO. He said on Monday that Astronomer has faced an "unusual and surreal" amount of attention in recent days. Astronomer is a New York-based company that helps companies develop, grow, and analyze products using artificial intelligence. MrBeast, whose YouTube channel boasts over 416 million subscribers, is the owner of multiple companies, including Feastables and MrBeast Burger. He has previously shared posts on social media expressing interest in buying the social media platform X from Elon Musk. In June, as part of their list of Top Content Creators, Forbes reported that MrBeast had earnings of $85 million. Back in 2022, Forbes reported the 27-year-old could become the world's "first YouTuber billionaire," reporting at the time that he had a net worth of $500 million. What People Are Saying An Astronomer spokesperson previously told Newsweek in a statement: "Astronomer is committed to the values and culture that have guided us since our founding. Our leaders are expected to set the standard in both conduct and accountability, and recently, that standard was not met." What's Next The search for Astronomer's new CEO is ongoing.
Time Business News
9 hours ago
- Time Business News
BrainSim-X Launches Developer Platform for Neural Simulation Data
BrainSim-X announced the launch of a developer access program that allows researchers and app developers to integrate brain simulation data into their applications. More information about the platform is available at their official website . The Bangalore-based research initiative said the platform will focus on medical applications, particularly epilepsy research and neurological treatment development. Unlike typical API services, BrainSim-X requires developers to submit applications explaining their intended use cases before gaining access to the platform. Interested developers can request API credentials through their secure portal. The approval process takes approximately one week, with the organization reviewing each application to ensure it aligns with their medical research focus. One developer who has used the platform for three months described it as providing detailed neural activity data that requires significant technical expertise to implement properly. A detailed account of this developer's experience can be found in their comprehensive review . 'The platform generates large amounts of data that require powerful computing resources,' the developer said. 'It's designed for serious medical research rather than general app development.' The organization provides documentation and support for developers working on brain-computer interfaces, neuroscience research projects, and medical applications. Their research findings are available for review in published papers. Real-time data access became available recently, allowing developers to integrate live neural simulation feeds into their applications. The platform is intended for researchers studying brain activity patterns, testing neurological treatments, and developing diagnostic tools. BrainSim-X operates the service through a secure API that provides access to neural simulation data generated by their brain modeling platform. Technical requirements include high-memory computing systems capable of processing large neural datasets. Additional technical insights about the platform's capabilities can be found in this technical analysis . The research initiative says the developer program represents part of their commitment to making brain simulation technology accessible to the global research community. Applications are evaluated based on their potential contribution to medical research and neurological treatment development. BrainSim-X has not disclosed revenue generated from the developer platform, stating that funds support ongoing research activities. The organization expects demand for the platform to grow as more researchers learn about neural simulation applications in medical research. Future platform updates will include enhanced simulation capabilities and additional tools for analyzing neural activity patterns. BrainSim-X says the developer program differentiates it from commercial AI companies by focusing on open research collaboration rather than proprietary technology development. The platform supports research into cognitive enhancement, educational technology, and advanced diagnostic systems. Developers interested in accessing the platform must demonstrate relevant research experience and explain how they plan to use neural simulation data in their projects. BrainSim-X provides training resources to help developers understand neuroscience concepts necessary for effectively using the platform. The organization says it will continue expanding the developer program while maintaining focus on medical and scientific applications. Related Resources TIME BUSINESS NEWS
Buzz Feed
21 hours ago
- Buzz Feed
These Fitness Items Can Help Improve Your Bone Density
You're probably familiar with many of the benefits of regular exercise, when done properly. From building muscle to boosting your energy and even helping your brain function better, there's no shortage of reasons to work up a sweat. But there's another great benefit you might not think about as much: You could be improving your bone density through exercise, according to experts. 'Bone density refers to how strong and solid your bones are,' Dr. Raphael Longobardi, New Jersey-based orthopedic surgeon told us. He serves with the RWJBarnabas Health Medical Group and specializes in sports medicine, frequently identifying ways to strengthen the body. 'The amount of mineral content in our bones helps them maintain their strength and resistance to fractures. Maintaining bone density is an incredibly important preventative for reducing the risk of conditions like osteoporosis or fractures. This is especially true as we age.'There are also risk factors for certain groups, according to Kai-Yu Ho, a physical therapist and professor of physical therapy at University of Nevada in Las Vegas. Ho said bone density is important to look after 'especially in postmenopausal women, as estrogen loss speeds up bone weakening.' So, if you're concerned about your bone density, how can exercise help? If you haven't been looking after your bone health, now's the time: Based on the experts' advice, we rounded up some small and easy fitness items you can use to help improve your bone density and reduce your risk of fractures. A set of resistance bands with different resistance levels All three experts we spoke to recommended resistance bands as one of the most effective pieces of exercise equipment that can help increase bone density through resistance training. Ho said bands are "useful for beginners and those with limited mobility," while Longobardi explained, "They apply resistance that stimulates bone growth through stress."We like this five-pack because all five bands are the same length, but each one has a different resistance level, from extra-light to extra-heavy. "It's important to begin with lighter resistance, gradually increasing in intensity to prevent injuries," Longobardi said, advice that Ho bands are made with a durable, elastic fabric that comes in a bunch of colors. You can use the bands for squats, lunges and other review: "These are high quality resistance bands. They have a slight texture to them which holds them in place while using them. Purchased after recommended by my physical therapist. Variety of resistance bands in the pack which makes it easy to make exercises easier or harder!" —Austin NicholsGet them from Amazon for $19.97. A weighted vest to increase bone density while walking According to Ho, "Weighted vests increase bone-loading stimulus, especially during walking or bodyweight exercises." To properly use a weighted vest for walking to help with bone density or osteoporosis, Medical News Today suggests trying out a vest without weights first, then adding the lowest possible amount and slowly increasing that amount over time. (It's generally recommended that you start with no more than 10% of your body weight, but always check with your physician first.)To do this, you may be best off with an adjustable vest like this one by Zelus, so you can change the weight. The vest comes in three sizes and two colors, with six removable weights on each vest. The vest is designed to evenly distribute the load, and the neoprene material is strong and comfortable. The vest is also equipped with reflective strips for visibility and a pocket to hold your keys, phone and other essentials. Promising review: "My workout program includes a daily walk/run. I have osteoporosis in my spine and I'd been looking for a weight vest to wear during my walks to possibly help rebuild bone density. I really like this vest because the straps are adjustable; there're pockets in the front to hold keys, tissue, etc.; it doesn't ride up or rub when I'm running; and the weights are easy to add and remove. The vest had a noticeable chemical smell when I first took it out the box, but the smell quickly dissipated after the vest sat out a couple days. All in all, it's great value for the money!" —E. R. RogersGet it from Amazon for $39.99+. A mini stair stepper to help you get in some weight-bearing exercise Improving your bone density can be as simple as getting your steps in. Who knew? "Other weight-bearing exercises such as walking, stair climbing, and aerobics also contribute to bone health," Longobardi said. "Activities such as these cause your bones to bear your body weight against gravity, and this contributes to increasing bone mass and preventing osteoporosis in the future." Sellmeyer also suggested stair climbing as part of her recommended 30 minutes of impact exercise a day. If you don't live in a building with stairs or near a set of stairs you can use, a mini stair stepper like this one can provide an easy and convenient way to do these exercises without having to leave the house or make room for large equipment. This stepper has a loading capacity of 300 pounds and weighs just 16 pounds itself, so you can move it around the house as shown in the pictures here. The silent cushioning pad will keep the machine from making too much noise, and the height of the steps can be adjusted depending on your workout needs. You can even use it sitting down, as one reviewer can attest it from Amazon for $47.49+ (available in three colors). Or a walking pad to get even more steps in throughout the day Again, Longobardi and Sellmeyer both recommended walking for impact exercise. One other exercise you can try, according to Sellmeyer, is "tandem walking," where you walk "in a straight line with one foot directly in front of the other" to train your balance and reduce falls (and therefore, your risk of fracturing bones). Like the stair stepper, a walking pad can come in handy if you have less time to go outside for a walk or less space for something like a treadmill that can't be easily stowed away when not in pick is this one by Akluer. You can adjust the incline up to 5%, and the LED display lets you see important stats like distance and speed. The running belt is anti-slip with shock absorbers for a comfortable walk. And when you're done, tuck away the pad under a bed or sofa with ease using the built-in transport it from Amazon for $99.99+ (available in seven styles). A pair of comfortable, supportive shoes Whether or not you buy fancy equipment for your workouts, what you'll always want is a good pair of shoes. "Supportive footwear [is] essential for impact activities like jumping and jogging to prevent joint stress," Ho said, adding that proper footwear can help you avoid it comes to supportive and comfy shoes, we're Hoka fans here, and the Bondi 9s are podiastrist-recommended, to boot. Their plush cushioning and supportive construction have made them a cult favorite for the brand. You can get them in a bunch of colorways and men's sizes 7–16, as well as women's sizes 4– them from Nordstrom for $170 in men's or for $175 in women's. A foam balance pad for balance training Sellmeyer recommended some simple balance exercises, including "standing on each leg for 30 seconds two to three times each day, [and] doing the same standing on a foam balance pad which is more difficult." Foam balance pads have an unstable surface, so using them can help your balance and like this one made by ProsourceFit, which comes in two sizes and has a near-perfect 4.8-star rating with more than 14,000 reviews. The lightweight pad weighs just 12 ounces so you can carry it wherever, and use it for Sellmeyer's recommended balance exercises as well as lunges, squats, planks and more. That's in addition to other uses around the house, like as a knee pad for gardening, a foot pad for underneath your desk and more. Talk about versatility. The pad is available in five colors and two review: "Functions exactly as advertised. great for balance and core work. this pad has the perfect amount of "give" to work those areas. also the small waves on the surface help to prevent sliding on hard wood floors." —Mary it from Amazon for $21.06+. A pair of adjustable dumbbells for weight training Both Ho and Longobardi named adjustable dumbbells as a beneficial equipment option for resistance training. Why adjustable? "While free weights and resistance bands can help stimulate bone growth, it's important to begin with lighter resistance, gradually increasing in intensity to prevent injuries," Longobardi added that adjustable equipment is more suitable for long-term use as you slowly up the intensity of your workouts. In other words, adjustable dumbbells involve taking on a higher cost upfront, but you'll save money later by not having to purchase new dumbbells so pick is this set from Lifepro, which comes in four weight ranges. You just use the sliders to increase or decrease the weight. The dumbbells have a non-slip handle and safety locking mechanism, as well as a storage rack that comes included so you can keep these secure and out of the way. Get them from Amazon for $111.97+. Or this single adjustable dumbbell If you'd rather start off with one instead of a pair, Target sells a single adjustable dumbbell from their All In Motion brand. This plastic and steel dumbbell goes up to 25 pounds and comes with a similar storage tray. Promising review: "These are really nice (I bought 2)! I am a beginner with strength training, so I like that these are compact and easy to adjust the weight. Took me a minute to figure out how to use it (didn't realize the explanation was printed on the actually dumbbells lol) and when I first picked them up one of the plates fell out but luckily I was sitting on the floor. All in all an excellent product and makes me feel confident using weights!" —TeeinteeGet it from Target for $100. A pickleball paddle set for beginners Pickleball has become "America's fastest-growing sport" over the past couple of years, and it can also help improve your bone density, according to Sellmeyer, who suggested the activity as one type of impact exercise. This is also a great way to work out with family or friends for something a little more exciting than a typical walk or weightlifting starter set from Recess Pickleball includes two durable fiberglass paddles with sweat-proof handles and three balls. The brand offers tons of color and pattern options, including the fun "Dog Day" doodles shown here, as well as sets with paddle cases, a gym bag and up to eight it from Amazon for $88.
