
Scientists Uncover World's Most Bitter Tasting Thing Ever
The mushroom is widely available in Britain, and despite being extremely bitter, it is not toxic. The researchers extracted three compounds from the mushroom and studied their effect on human taste receptors.
This tree-growing mushroom has a compound that is so potent that an individual would be able to taste a single gram of the substance dissolved in 106 bathtubs of water. Named oligoporin D, this chemical activates specialised bitter receptors in our mouths which also help detect natural poisons.
Study's implications
The study results, published in the Journal of Agricultural and Food Chemistry may help scientists research how humans evolved to be able to detect bitter tastes and why. Notably, bitter is one of the five basic taste sensations humans have, alongside sweet, sour, salty and savoury, also called "umami".
"Our results contribute to expanding our knowledge of the molecular diversity and mode of action of natural bitter compounds," said lead researcher Dr Maik Behrens.
"In the long term, insights in this area could enable new applications in food and health research, for example in the development of sensorially appealing foods that positively influence digestion and satiety."
Prior to the German study, most of the research had centred around how flowering plants can have a bitter taste. However, fewer studies had been done looking at fungi such as mushrooms.
Studies show that sensors for bitter substances are also found in the stomach, intestines, heart and lungs apart from the mouth.
Previous studies have indicated that sensors for bitter substances are not only found in the mouth but also in the stomach, intestines, heart and lungs. Researchers stated that closely analysing compounds derived from fungi like oligoporin D could be key to understanding our complex relationship with bitterness.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


The Hindu
14 hours ago
- The Hindu
All you need to know about: CLOVES Syndrome
CLOVES Syndrome, in which the letters stand for: Congenital; Lipomatous; Overgrowth; Vascular malformations ; Epidermal nevi and Spinal/skeletal anomalies/Scoliosis, is very a rare condition, with only about 200 cases or less are believed to have been reported worldwide. Here is all you need to know about it. What is CLOVES syndrome? CLOVES Syndrome is a rare genetic disorder. Researchers believe it is caused by mutations in a gene called PIK3CA. According to the National Cancer Institute, U.S., this gene makes one of the proteins in an enzyme called PI3K, which is involved in many important functions in a cell. 'Mutations (changes) in the PIK3CA gene may cause the PI3K enzyme to become overactive, which may cause cancer cells to grow. PIK3CA gene mutations have been found in many types of cancer, including cancers of the breast, lung, ovary, stomach, brain, colon, and rectum. They have also been found in some genetic conditions,' the website states. CLOVES Syndrome is an overgrowth disorder, part of a larger group of similar disorders called PIK3CA-related overgrowth spectrum or PROS. When was it first discovered? The U.S.-based non-profit National Organisation for Rare Disorders (NORD) states that CLOVES syndrome was described independently by [Julie C.] Sapp and colleagues in 2007 and [Ahmad I.] Alomari in 2009, making it a relatively new classification. The website however notes that a case report by the German physician Hermann Friedberg, 'gigantism of the right lower limb' published in 1867 is probably the first known written account of CLOVES syndrome. Who is at risk? The mutations in the PIK3CA gene are believed to occur spontaneously in the womb. CLOVES syndrome is not hereditary and cannot be passed on. At present, there are no known risk factors. As per the NORD, it is believed that mutations in the gene result in two sets of cells in the body (one set with the mutation and one set without) and the mutated cells lead to the formation of abnormal tissue. It also states that CLOVES syndrome affects males and females equally regardless of their race or ethnicity. What are the signs and symptoms of CLOVES syndrome? Babies are born with this condition. Symptoms can range from mild to severe and may vary from child to child. Symptoms include: soft masses of fatty tissue on the abdomen, back, sides and buttocks; vascular or blood vessel anomalies such as dilated veins that may be seen in the chest, arms and legs and that may pose a risk of blood clots; large and wide hands or feet, with large gaps between fingers and toes; 'port wine stain' birthmarks; spinal problems such as scoliosis or a tethered cord; kidney problems; skin abnormalities such as raised bumps, and sometimes, intestinal problems and asymmetry in growth. How is CLOVES syndrome diagnosed? Doctors may diagnose CLOVES syndrome with a detailed physical examination, medical history and through various imaging tests such as MRIs, CT scans, ultrasounds and X-rays. A confirmation of the diagnosis can be made with molecular genetic testing for the mutation. Not all patients with CLOVES syndrome will have all the signs, and some signs may be subtle. Detailed, expert medical examinations are necessary. With the condition being so rare however, many healthcare providers are often not aware of it. Children with CLOVES syndrome are often misdiagnosed as having other syndromes. How is CLOVES syndrome treated? There is no cure as yet for CLOVES syndrome. However, with the right diagnosis, healthcare providers can help patients manage symptoms. Treating CLOVES syndrome usually involves a multidisciplinary team of specialists. Treatment options may include: drugs, to suppress the immune system and slow growth of abnormal vessels; sclerotherapy, which helps reduce the size of vascular malformations; embolisation, a minimally invasive procedure that blocks blood vessels and debaulking surgery to help remove overgrown tissue. Other orthopaedic or neuro surgeries may be required too. Rehabilitation therapies may also be prescribed. What is the scenario in India? A few cases of CLOVES syndrome have been documented in India. In 2019, Vikram K. Mahajan et al, wrote in the Indian Dermatology Journal Online of a three-year-old boy believed to have the syndrome. Another case of an eight-year-old boy was described by Pallavi Hegde et al in the Indian Journal of Paediatric Dermatology in 2022. Yet another case, of a 10-month-old boy was described by Ankur Singhal et al in the Indian Journal of Postgraduate Dermatology in 2024. The paper noted, 'CLOVES syndrome is exceptionally rare, and research in this area is predominantly limited to a scant body of published literature... We are presenting this case to contribute to medical literature by providing a comprehensive account on CLOVES syndrome.'

Time of India
14 hours ago
- Time of India
Russia Earthquake Triggers 2nd Volcano After 450 Years
A volcano in Russia's remote Kamchatka region has erupted for the first time in 450 years, just days after one of the most powerful earthquakes ever recorded rocked the area. The Krasheninnikov volcano sent a massive plume of ash 6,000 metres into the sky, triggering aviation alerts and raising fears of further seismic activity. Now, a new magnitude 6.7 quake has hit Russia's Kuril Islands, according to German and Pacific seismic authorities. Though no tsunami warning was issued, the tremors have raised fresh concerns about escalating geological instability in the Pacific Ring of Fire. Read More


India.com
a day ago
- India.com
Worlds Oldest Baby? Boy Born To Ohio Couple From Embryo Frozen Over 30 Years Ago
In a remarkable and heartwarming event, a baby boy was born from an embryo that was frozen over 30 years ago. The child was born to Lindsey and Tim Pierce, a couple from Ohio, United States, on Saturday. The embryo, preserved since the early 1990s, marks an impressive milestone for reproductive medicine. According to a BBC report, this is believed to be the longest an embryo has been frozen before leading to a successful live birth. The rare case highlights the remarkable achievement and advancement in fertility science. Adoption Of 30-Year-Old Embryo Lindsey and Tim Pierce had been trying to have a child for seven years before deciding to adopt a frozen embryo. The BBC further reported, the embryo was created in 1994 through IVF by Linda Archerd (62). She and her then-husband had created four embryos, one of which led to the birth of their daughter, now 30 years old. The remaining three embryos were frozen and stored for decades, one of which has now resulted in the birth of Lindsey and Tim's baby boy. Linda separated from her husband; however, she wanted to be involved with the baby that would be born from her embryos. Thus, she kept the embryos in storage until she found a Christian embryo adoption agency. According to the BBC, Linda told MIT Technology Review that she wanted her embryos to be adopted by a Caucasian married and Christian couple from the US. The baby boy has been named Thaddeus Daniel Pierce. The birth of Thaddeus could bring hope to countless families seeking alternative paths to parenthood. Significance of IVF Treatment The IVF treatment has, for a long time, made the dreams of many people of becoming parents come true. Speaking of the treatment's procedure, according to an ANI report, the In-vitro fertilization means that eggs are taken from the ovaries and fertilized with sperm outside of the body in an IVF centre lab. Meanwhile, as per IANS, scientists in the UK used a three-person IVF technique to bring to life eight children and spared them from genetic mitochondrial disease. The infants, four girls and four boys, including one set of identical twins, were born using DNA from three people.