Evolysse Smart Hydration Redefined with Advanced HA Fusion Technology
Skin hydration is more than just applying water or a basic moisturizer. The skin's outermost layer, the stratum corneum, relies on a delicate balance of water and lipids to maintain elasticity, suppleness, and protection. When this balance is disrupted, skin becomes dry, flaky, and prone to premature aging.
Hyaluronic Acid (HA) is a naturally occurring molecule in the skin known for its exceptional water-retention capabilities. A single gram of HA can hold up to 1,000 times its weight in water, making it a hydration powerhouse. However, not all HA is created equal. Traditional HA molecules vary in size, affecting their penetration and efficacy.
Most skincare products use standard HA, which: Only provides surface-level hydration
Evaporates quickly without locking in moisture
Fails to address deeper skin layers
This is where Evolysse's Advanced HA Fusion Technology comes into play.
What is Evolysse proprietary Advanced HA Fusion Technology is a multi-dimensional approach to hydration, combining: Multi-Molecular Weight HA – A blend of high, medium, and low-weight HA molecules ensures hydration penetrates every layer of the skin. High-weight HA forms a protective moisture barrier on the surface.
Medium-weight HA hydrates the mid-layers for plumpness.
Low-weight HA penetrates deeply to stimulate collagen and long-term hydration. Smart Delivery System – Encapsulated HA ensures controlled release, providing 24-hour hydration without the need for reapplication. Bio-Fermented HA – Sustainably sourced and bio-fermented for higher purity and enhanced skin compatibility. Feature Traditional HA Products Evolysse Smart Hydration Hydration Depth Surface-level only Multi-layered (deep, mid, surface) Duration Short-term (few hours) Long-lasting (24-hour release) Technology Standard HA Advanced HA Fusion + Smart Delivery Skin Benefits Temporary plumping Enhanced barrier, collagen support
This intelligent system ensures that skin remains hydrated, resilient, and youthful throughout the day.
Unlike traditional moisturizers that simply coat the skin's surface, Evolysse provides deep, continuous hydration at the cellular level, helping to prevent transepidermal water loss (TEWL).
Evolysse strengthens the skin's natural lipid barrier, offering protection against environmental stressors such as pollution and UV exposure.
Well-hydrated skin appears plumper, reducing the visibility of fine lines. The low-weight HA in Evolysse also stimulates collagen production for long-term anti-aging benefits.
With consistent use, skin becomes more elastic and resilient, combating sagging and dullness.
Whether you have dry, oily, combination, or sensitive skin, Evolysse's pH-balanced, non-comedogenic formula ensures optimal hydration without irritation.
Traditional skincare takes a passive approach—adding moisture only when dryness is noticeable. In contrast, smart hydration, like that in Evolysse, is proactive, responding to the skin's needs in real time for continuous, adaptive care.
The future of skincare lies in personalized hydration. Imagine a system where: Smart sensors detect skin's hydration levels
AI adjusts HA delivery based on environmental conditions
Custom-blended serums are created for individual needs
Evolysse is at the forefront of this movement, paving the way for next-gen skincare innovations.
Formulated with bio-fermented HA and housed in eco-conscious packaging, Evolysse supports the global move toward green beauty—delivering high performance without compromising the planet.
Start with a gentle cleanser to remove impurities. Dispense 2-3 drops onto fingertips.
Gently press onto face and neck.
Allow absorption before layering other products.
For maximum benefits, follow with a moisturizer or sunscreen. Morning & Night for optimal hydration.
Under Makeup for a smooth, plump base.
Evolysse Smart Hydration isn't just another skincare product—it represents a new era in skin wellness. Powered by Advanced HA Fusion Technology, it offers smarter, deeper, and longer-lasting hydration than conventional approaches.
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Cosmopolitan
04-08-2025
- Cosmopolitan
Evolysse Hyaluronic Acid Filler Review
It's not every day a new injectable hits the beauty market, so when I first heard about Evolysse, a new type of filler from Evolus (the makers of Jeuveau, a popular type of Botox), my ears immediately perked then my skin perked up, itching to give it a try. Yes, Evolysse is a filler. The dreaded f-word. But it promises to lead the way in rebranding the way social media has conditioned us to view filler in recent months (that it's bad, unnatural, and that it will leave your face looking puffy if overdone in just the slightest) thanks to a new technology that preserves the molecular structure of hyaluronic acid so it looks smooth and natural once injected. Intrigued? I was too—and was fortunate enough to get an early sneak peek of the newest FDA-approved injectable to see how it compares to the tried-and-true injectables currently on the market. I'm here to give my honest thoughts after trying it, and help set the record straight on where this injectable fits into your cosmetic treatment routine. Evolysse is a hyaluronic acid injectable. Hyaluronic acid is a molecule that's naturally occurring in our bodies that, when injected underneath the skin, can smooth out imperfections, add volume to areas of the face, and augment features such as the lips, chin, and jawline. You know how your hyaluronic acid serum makes your skin all plump, bouncy, and firm? When injected properly, hyaluronic fillers basically create that same effect but for the long term. Hyaluronic acid fillers have been around since the early aughts, but Evolysse is the first real technological innovation in the space in the last decade, says Julie K. Karen, MD, a board-certified dermatologist in New York, NY. "It's a new group of hyaluronic acid fillers that seeks to restore volume and smooth out the lower face in a very natural and smooth way because of the innovative technology by which they're developed,' explains Dr. Karen. Said innovative technology is called Cold-X Technology. It's what sets Evolysse apart from other hyaluronic acid-injectables on the market, and it helps protect the natural structure of the hyaluronic acid molecule. I'm going to get a little sciencey here, but the gist is that hyaluronic acid molecules are sensitive to warmer temperatures when manufactured for aesthetic use, though all current ones on the market are produced in this manner. When hyaluronic acid-injectables are made at very warm temperatures, it 'denatures the hyaluronic acid,' effectively causing it to break down into shorter fragments, which are then crosslinked to reconnect them for use. 'By processing the Evolysse line at cold, near-freezing temperatures, they preserve the natural structure of hyaluronic acid. This leads to a more natural-looking result, mimicking the actual existence of hyaluronic acid in the skin,' says Dr. Karen. This process also leads to more natural tissue integration and less swelling when the product is injected into the skin. Right now, Evolysse is FDA-approved to smooth dynamic smile lines and laugh lines in the lower face, though, depending on your provider's expertise, it can be injected off-label into other areas to volumize, smooth, or augment. Currently, the Evolysse line has two different types of filler in the U.S. market: Form and Smooth. 'Evolysse Smooth is softer and more pliable, making it suitable for more superficial lines like those around the mouth, like perioral lines, marionette lines, nasolabial folds,' says Connie Yang, MD, a board-certified dermatologist in New York, NY. 'I have injected Smooth in the lips and seen a beautiful, soft result,' says Dr. Yang. Evolysse Form, on the other hand, is firmer, more robust, and gel-like, making it 'suitable for deeper folds and areas needing more volume (like cheeks, jawline, etc.). It provides more structure and contour, which is great for areas that need more volume restoration and support,' she further explains. This all being said, Dr. Yang says the family of injectables 'are quite versatile and can be used at different depths to address a wide variety of concerns on the face.' Aside from the fact that it smooths dynamic smile lines and laugh lines, augments, and restores volume to areas of the face, Evolysse doesn't cause the lumps and bumps that can potentially form post-injection. 'One of the adverse effects of hyaluronic acid fillers is sometimes delayed onset of nodules, the little lumps, bumps, or granulomas around where the filler is placed,' explains Dr. Karen. By using Cold-X Technology and maintaining the natural form of hyaluronic acid by not having to crosslink it as much, 'they are finding both in the initial pivotal study, and then in practice, there is basically a nonexistent rate of nodules. That's not to say it can't happen, but in their initial study, no delayed onset nodules formed,' Dr. Karen adds. As of now, according to that same study, Evolysse is shown to last for one year. It's important to note that the length of the study lasted only for 12 months, and that it's been reported that fillers can remain detectable in the face years longer than initially thought, so it's reasonable to infer that Evolysse lasts just as long as other hyaluronic acid-based injectables on the market in the long term. Anyone experiencing volume loss, particularly around the lower face, and who wants a natural look is a great candidate. Dr. Karen says both Smooth and Form are great for a highly mobile area, such as the mouth (you're chewing, talking, smiling, etc), because of how natural and delicate the product is. 'If you put something that is too lumpy or clumpy in that area, it may not give you the best result,' she says. Dr. Karen adds that there's really no one who isn't a good candidate, unless someone has major volume loss where their end-game aesthetics goals are not realistic from the use of injectables. As a beauty editor and self-proclaimed aesthetics guinea pig, I wanted to try Evolysse to fill in some areas of slight volume loss around my mouth that were bugging me. I visited Dr. Karen's office for my Evolysse treatment. After having numbing cream applied to my areas of concern in my lower face and sitting with it for about 10 minutes, Dr. Karen assessed my face, choosing to use Evolysse Form on me. She injected a little bit of Evolysse Form between my upper lip and cheek, the nasolabial fold, and the melolabial fold, or what people call the marionette. She also placed a little in the pre-jowl sulcus, which is that slight divot that people get at the lateral aspect of their chin, along the jawline. Thanks to the numbing cream, the experience was only very mildly uncomfortable. The whole thing took less than thirty minutes, and I saw the results of the product immediately. Though very subtle, the skin around my lower face looked smoother and slightly plumper. The immediate results are what Dr. Yang loves about the injectable. 'What's unique about Evolysse is that you can treat to correction, meaning what you see after injection is about what you can expect in the long run. With Cold-X Technology, these fillers do not swell as much as other HAs on the market, which can be a good thing depending on your treatment goals." Depending on your location, provider, and number of syringes needed, the cost may vary, but the price of Evolysse is comparable to other brands of hyaluronic acid-injectables. You can expect to pay around $900 to $1,500 for a syringe, but even this range may vary. For reference, Dr. Karen does not usually inject more than a syringe or two at a time during an appointment. While I certainly love the results from my Evolysse appointment and find them to be super natural, it ultimately does not look like I've had filler, which is arguably the whole point. Provided you go to an experienced injector, you Evolysse can definitely refresh your face without making you look overfilled or puffy. I also loved that the effects were instant—so when I left my appointment, I immediately felt good about my results. All in all, Evolysse is another great option to choose from if you're interested in fillers. Taryn is a beauty writer and editor in digital media with more than 10 years of experience. She has covered the newest and most innovative skincare and beauty products, aesthetic treatments, and plastic surgery trends. Her stories touch on everything from the best products to treat hyperpigmentation to why fat grafting is the better alternative to filler. In addition to Cosmopolitan, she currently contributes to Allure, InStyle, PS (formerly POPSUGAR), Marie Claire, The Zoe Report, and Bustle. In addition to her writing, Taryn directs, produces, and writes short films that have appeared at numerous film festivals around the country. Whenever she has a free moment, you can find her hopping around New York City with her Maltese pup, Bryn, and probably daydreaming about being at the beach. Follow her on Instagram for the latest.
Time Business News
13-06-2025
- Time Business News
Evolysse Smart Hydration Redefined with Advanced HA Fusion Technology
In the ever-evolving world of skincare, hydration remains a cornerstone of healthy, radiant skin. However, traditional moisturizers often fall short in delivering deep, long-lasting hydration. Enter Evolysse Smart Hydration, a revolutionary skincare innovation powered by Advanced HA Fusion Technology. With increasing environmental stressors, pollution, and lifestyle factors impacting skin health, What is Evolysse demand for intelligent hydration solutions has never been higher. Evolysse combines science and nature to create a breakthrough formula that hydrates and enhances the skin's natural barrier, ensuring lasting moisture retention and a youthful glow. Skin hydration is more than just applying water or a basic moisturizer. The skin's outermost layer, the stratum corneum, relies on a delicate balance of water and lipids to maintain elasticity, suppleness, and protection. When this balance is disrupted, skin becomes dry, flaky, and prone to premature aging. Hyaluronic Acid (HA) is a naturally occurring molecule in the skin known for its exceptional water-retention capabilities. A single gram of HA can hold up to 1,000 times its weight in water, making it a hydration powerhouse. However, not all HA is created equal. Traditional HA molecules vary in size, affecting their penetration and efficacy. Most skincare products use standard HA, which: Only provides surface-level hydration Evaporates quickly without locking in moisture Fails to address deeper skin layers This is where Evolysse's Advanced HA Fusion Technology comes into play. What is Evolysse proprietary Advanced HA Fusion Technology is a multi-dimensional approach to hydration, combining: Multi-Molecular Weight HA – A blend of high, medium, and low-weight HA molecules ensures hydration penetrates every layer of the skin. High-weight HA forms a protective moisture barrier on the surface. Medium-weight HA hydrates the mid-layers for plumpness. Low-weight HA penetrates deeply to stimulate collagen and long-term hydration. Smart Delivery System – Encapsulated HA ensures controlled release, providing 24-hour hydration without the need for reapplication. Bio-Fermented HA – Sustainably sourced and bio-fermented for higher purity and enhanced skin compatibility. Feature Traditional HA Products Evolysse Smart Hydration Hydration Depth Surface-level only Multi-layered (deep, mid, surface) Duration Short-term (few hours) Long-lasting (24-hour release) Technology Standard HA Advanced HA Fusion + Smart Delivery Skin Benefits Temporary plumping Enhanced barrier, collagen support This intelligent system ensures that skin remains hydrated, resilient, and youthful throughout the day. Unlike traditional moisturizers that simply coat the skin's surface, Evolysse provides deep, continuous hydration at the cellular level, helping to prevent transepidermal water loss (TEWL). Evolysse strengthens the skin's natural lipid barrier, offering protection against environmental stressors such as pollution and UV exposure. Well-hydrated skin appears plumper, reducing the visibility of fine lines. The low-weight HA in Evolysse also stimulates collagen production for long-term anti-aging benefits. With consistent use, skin becomes more elastic and resilient, combating sagging and dullness. Whether you have dry, oily, combination, or sensitive skin, Evolysse's pH-balanced, non-comedogenic formula ensures optimal hydration without irritation. Traditional skincare takes a passive approach—adding moisture only when dryness is noticeable. In contrast, smart hydration, like that in Evolysse, is proactive, responding to the skin's needs in real time for continuous, adaptive care. The future of skincare lies in personalized hydration. Imagine a system where: Smart sensors detect skin's hydration levels AI adjusts HA delivery based on environmental conditions Custom-blended serums are created for individual needs Evolysse is at the forefront of this movement, paving the way for next-gen skincare innovations. Formulated with bio-fermented HA and housed in eco-conscious packaging, Evolysse supports the global move toward green beauty—delivering high performance without compromising the planet. Start with a gentle cleanser to remove impurities. Dispense 2-3 drops onto fingertips. Gently press onto face and neck. Allow absorption before layering other products. For maximum benefits, follow with a moisturizer or sunscreen. Morning & Night for optimal hydration. Under Makeup for a smooth, plump base. Evolysse Smart Hydration isn't just another skincare product—it represents a new era in skin wellness. Powered by Advanced HA Fusion Technology, it offers smarter, deeper, and longer-lasting hydration than conventional approaches. TIME BUSINESS NEWS
Yahoo
16-04-2025
- Yahoo
Evolus Announces Commercial Launch of Evolysse™
NEWPORT BEACH, Calif., April 16, 2025--(BUSINESS WIRE)--Evolus, Inc. (NASDAQ: EOLS), a performance beauty company with a focus on building an aesthetic portfolio, today announced the commercial launch date for Evolysse™ Form and Evolysse™ Smooth injectable hyaluronic acid (HA) gels, the first two products in the Evolysse™ collection, scheduled for Friday, April 18th. To support the introduction, Evolus will initiate a comprehensive educational rollout beginning with a national Evolus Academy webcast for healthcare practitioners on April 18th with several thousand attendees expected to participate. Ahead of the webcast, the company has already begun an early experience program by sending product to over 1,000 key accounts, including key opinion leaders (KOLs), clinical investigators, and leading practices. This approach enables providers to explore the performance and versatility of Evolysse™ injectable HA gels for the correction of dynamic facial wrinkles and folds, such as nasolabial folds, which will accelerate comfort, confidence, and integration of the products into clinical practice. The Evolysse™ collection marks the company's second commercial aesthetics product, following the successful launch of Jeuveau® in 2019. Since its launch, Jeuveau® has become the fastest-growing neurotoxin in the U.S. for four consecutive years and has now captured over 14% of the U.S. market and penetrated over 50% of aesthetic clinics. With over 15,000 purchasing accounts, Evolysse™ will launch into an established customer base who will gain access to Evolysse™ Form and Evolysse™ Smooth, helping to drive immediate and impactful momentum in the U.S. injectable HA market. "With the introduction of Evolysse™, we are bringing together the fastest growing toxin in the category with the first new innovation in HA technology in over a decade," said David Moatazedi, President and Chief Executive Officer of Evolus. "This is more than a product launch, it is the introduction of differentiated injectable HA gels that are grounded in clinical science and designed to meet the evolving needs of consumers seeking natural-looking results. By pairing this innovative Cold-X™ technology with the commercial strength we've built with Jeuveau®, we are well-positioned to expand our leadership with a differentiated injectable portfolio." Dr. John Fezza, MD, an award-winning oculofacial plastic surgeon, commented, "With over 30 years of experience in the aesthetics industry, I'm excited to integrate Evolysse™ into my practice. These products represent the next generation of injectable HA gels, scientifically driven, delivering natural-looking results, and backed by a strong safety profile. Evolysse™ provides a new level of confidence when treating patients who are concerned about looking overdone or unnatural. It's exactly what my patients have been asking for." Representing the first breakthrough in HA technology in over a decade, Evolysse™ utilizes innovative Cold-X™ technology by Symatese which is designed to better preserve the natural structure of the HA molecule for long-lasting, natural-looking results. Evolysse™ Form and Evolysse™ Smooth address moderate to severe dynamic facial wrinkles and facial folds that may develop over time for many reasons, including the natural aging process or following weight loss. In a head-to-head clinical study against Restylane®-L, both Evolysse™ Form and Evolysse™ Smooth met the 6-month primary endpoint of non-inferiority1, with the confidence intervals and corresponding p-values (<0.001) demonstrating statistical superiority1. Additionally, Evolysse™ Form demonstrated statistically significant differences2 compared to Restylane®-L at all measured timepoints throughout the 12-month study period. Evolysse™ Smooth showed statistically significant differences2 at 6 and 9 months, despite 20% more Restylane®-L being used3. In the head-to-head clinical study versus Restylane®-L, the safety profile of Evolysse™ Form and Evolysse™ Smooth was similar to the control. About Evolus, Inc. Evolus (NASDAQ: EOLS) is a global performance beauty company redefining the aesthetic injectable market for the next generation of beauty consumers through its unique, customer-centric business model and innovative digital platform. Our mission is to become a global leader in aesthetics anchored by our flagship products: Jeuveau® (prabotulinumtoxinA-xvfs), the first and only neurotoxin dedicated exclusively to aesthetics, and Evolysse™, a collection of unique injectable hyaluronic acid (HA) gels. Visit us at and follow us on LinkedIn, X, Instagram or Facebook. 1 Based on the primary endpoint analysis for Evolysse™ Form (95% CI [-0.500, -0.032]) and Evolysse™ Smooth (95% CI [-0.416, -0.019]) 2 Based on Wrinkle Severity Rating Scale (WSRS) Live Investigator Assessments (p < 0.05) 3 In the clinical study, the mean injection volume for optimal correction was 1.0 mL for Evolysse™ Smooth versus 1.2 mL for Restylane®-L Jeuveau® and Nuceiva® are registered trademarks and Evolysse™ is a trademark of Evolus, is a trademark of Symatese Group is a trademark of Galderma S.A. View source version on Contacts Evolus Contacts: Investors: Nareg SagherianVice President, Head of Global Investor Relations and Corporate CommunicationsTel: 248-202-9267Email: ir@ Media:Email: media@
