logo
Sandia Labs help complete new gravity bomb a year ahead of schedule

Sandia Labs help complete new gravity bomb a year ahead of schedule

Yahoo21 hours ago

ALBUQUERQUE, N.M. (KRQE) — Sandia National Labs is marking a major milestone for the US nuclear security enterprise, and they're doing so earlier than expected. The first production unit of the B61-13 is officially complete about a year ahead of schedule.
Story continues below
New Mexico News Insiders: The Crew Behind Swift Water & Arroyo Rescues
Film: These productions were filmed at Rail Yards. Have you seen them?
Trending: New video shows fight before teen was shot and killed in Albuquerque
News: VIDEO: Canoeing accident in northern NM leads to dramatic rescue operation
Sandia says they served as the lead system integrator and the design agency for the unit's non-nuclear components. Scientists say the newly completed bomb that relies on gravity to reach its target comes with increased yield compared to its previous version.
In May, Department of Energy Secretary Chris Wright 'diamond stamped' the B61-13, signifying the unit's readiness for deployment to the US nuclear stockpile.
Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Sandia Labs help complete new gravity bomb a year ahead of schedule
Sandia Labs help complete new gravity bomb a year ahead of schedule

Yahoo

time21 hours ago

  • Yahoo

Sandia Labs help complete new gravity bomb a year ahead of schedule

ALBUQUERQUE, N.M. (KRQE) — Sandia National Labs is marking a major milestone for the US nuclear security enterprise, and they're doing so earlier than expected. The first production unit of the B61-13 is officially complete about a year ahead of schedule. Story continues below New Mexico News Insiders: The Crew Behind Swift Water & Arroyo Rescues Film: These productions were filmed at Rail Yards. Have you seen them? Trending: New video shows fight before teen was shot and killed in Albuquerque News: VIDEO: Canoeing accident in northern NM leads to dramatic rescue operation Sandia says they served as the lead system integrator and the design agency for the unit's non-nuclear components. Scientists say the newly completed bomb that relies on gravity to reach its target comes with increased yield compared to its previous version. In May, Department of Energy Secretary Chris Wright 'diamond stamped' the B61-13, signifying the unit's readiness for deployment to the US nuclear stockpile. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Zai Lab Presents New Preclinical Data for ZL-1503, an IL-13/IL-31R Bispecific Antibody for the Treatment of Atopic Dermatitis, at EAACI Congress 2025
Zai Lab Presents New Preclinical Data for ZL-1503, an IL-13/IL-31R Bispecific Antibody for the Treatment of Atopic Dermatitis, at EAACI Congress 2025

Yahoo

time5 days ago

  • Yahoo

Zai Lab Presents New Preclinical Data for ZL-1503, an IL-13/IL-31R Bispecific Antibody for the Treatment of Atopic Dermatitis, at EAACI Congress 2025

-Data highlights potential of ZL-1503 as a promising treatment for moderate-to-severe atopic dermatitis and other IL-13 and IL-31-driven diseases -Favorable preclinical safety profile, prolonged half-life and durable suppression of both inflammatory and pruritogenic pathways support advancement of ZL-1503 to IND-enabling studies -Zai Lab plans to file an IND for ZL-1503 for moderate-to-severe atopic dermatitis by the end of 2025 SHANGHAI & CAMBRIDGE, Mass., June 13, 2025--(BUSINESS WIRE)--Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) today announced new data from its preclinical study of ZL-1503, the Company's promising IL-13/IL-31R bispecific antibody, demonstrating its ability to simultaneously suppress the inflammatory and pruritogenic (itch-causing) pathways in atopic dermatitis (AD). The findings, featured during a poster presentation at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025 in Glasgow, Scotland, highlight the potential of ZL-1503 as a novel treatment option for moderate-to-severe AD. Medications that inhibit IL-4/IL-13 signaling have markedly improved the therapeutic landscape for AD. Certain AD symptoms are mediated by IL-31; however, they are only partially alleviated by IL-4/IL-13 inhibition. As a result, many patients experience slow and modest clinical responses to currently available medications. ZL-1503 was evaluated in a pilot preclinical study in non-human primates to assess its long-term effects on IL-31-mediated scratching and IL-13-induced signaling (pSTAT6). Key study results presented at the EAACI Congress 2025 include: An intravenous single dose of ZL-1503 (10 mg/kg, iv) completely inhibited IL-13-mediated pSTAT6 and IL-31-induced scratching for at least 76 days in all preclinical subjects. Two out of three subjects exhibited prolonged IL-13-mediated pSTAT6 inhibition for over 118 days, and one out of three subjects sustained IL-31-induced scratching inhibition for over 133 days. Pharmacokinetic (PK) analysis of serum samples collected during the study revealed that ZL-1503 exhibited slow clearance, correlating closely pharmacodynamic (PD) responses, demonstrating strong PK/PD relationships in blocking IL-13 and IL-31 pathways in the preclinical model. ZL-1503 was well tolerated following weekly IV dosing up to 150 mg/kg. Additionally, in vitro studies showed that binding to one target did not affect ZL-1503's blocking effects on the other target. Details regarding the ZL-1503 poster presentation at EAACI Congress 2025 are as follows: Title: ZL-1503: A Bispecific Antibody Targeting Inflammatory and Pruritogenic Pathways with a Prolonged Serum Half-life and Sustained Activity in Non-human Primates Presenter: Linda Liu, Ph.D., Senior Vice President, Biologics Discovery, Zai LabSession Title: Thematic Poster Session 18 (TPS18), Biologicals 01Date/Time: Friday, June 13, 2025, from 12:00 - 13:00 BSTAbstract Number and Location: n°000625 & Poster Prefix D1.365, Poster Zone About Zai Lab Zai Lab is an innovative, research-based, commercial-stage biopharmaceutical company based in China and the United States. We are focused on discovering, developing, and commercializing innovative products that address medical conditions with significant unmet needs in the areas of oncology, immunology, neuroscience, and infectious disease. Our goal is to leverage our competencies and resources to positively impact human health worldwide. For additional information about Zai Lab, please visit or follow us at Zai Lab Forward-Looking Statements This press release contains forward-looking statements relating to our future expectations, plans, and prospects, including, without limitation, statements regarding product candidates in our pipeline including ZL-1503 and related preclinical studies; the potential benefits of ZL-1503; and the potential treatment of atopic dermatitis and other diseases involving the IL-13 and IL-31 pathways. All statements, other than statements of historical fact, included in this press release are forward-looking statements, and can be identified by words such as "aim," "anticipate," "believe," "could," "estimate," "expect," "forecast," "goal," "intend," "may," "plan," "possible," "potential," "will," "would," and other similar expressions. Such statements constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are not statements of historical fact or guarantees or assurances of future performance. Forward-looking statements are based on our expectations and assumptions as of the date of this press release and are subject to inherent uncertainties, risks, and changes in circumstances that may differ materially from those contemplated by the forward-looking statements. We may not actually achieve the plans, carry out the intentions, or meet the expectations or projections disclosed in our forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including but not limited to (1) our ability to successfully commercialize and generate revenue from our approved products, (2) our ability to obtain funding for our operations and business initiatives, (3) the results of our clinical and pre-clinical development of our product candidates, (4) the content and timing of decisions made by the relevant regulatory authorities regarding regulatory approvals of our product candidates, (5) risks related to doing business in China, and (6) other factors identified in our most recent annual and quarterly reports and in other reports we have filed with the U.S. Securities and Exchange Commission (SEC). We anticipate that subsequent events and developments will cause our expectations and assumptions to change, and we undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, except as may be required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release. Our SEC filings can be found on our website at and the SEC's website at View source version on Contacts Investor Relations: Christine Chiou / Lina Zhang+1 (917) 886-6929 / +86 136 8257 / Media: Shaun Maccoun / Xiaoyu Chen+1 (857) 270-8854 / +86 185 0015 / Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Space and tech celebration in Nob Hill hopes to inspire the future of STEM
Space and tech celebration in Nob Hill hopes to inspire the future of STEM

Yahoo

time5 days ago

  • Yahoo

Space and tech celebration in Nob Hill hopes to inspire the future of STEM

ALBUQUERQUE, N.M. (KRQE) – Tapping into curiosity and hoping to make New Mexico's next great scientists. A special event from New Mexico's STEM-leaders on Thursday is giving kids hands-on experience in what may be their future career. Story continues below Investigation: Politicians sink $13M in closed New Mexico tourist attraction Space: LIST: 5 places to go stargazing in New Mexico News: Videos show man in dumpster getting dumped into waste truck in Albuquerque Trending: Albuquerque City Council votes down 'RENT' ordinance 'This is a way to kind of open their eyes to what's out there,' said Ronda Harmon, STEM Academy Director at the Air Force Research Lab. They're planting the seed and hoping to fuel New Mexico's future. Dozens of kids learning about how they can been engineers or analysts not just years from today, but right now. At a special event called 'Atomic 66,' dozens of kids got hands on with robots, building simple circuits, and even simulating rocket launches. 'Students often make decisions about what they're going to be when they grow up. Like in the middle school, grade levels. And if they're making that choice without knowing what all their options are, then they're making a very limited choice,' shared Harmon. This week long workshop directly puts kids in the driver's seat, making them aware of the many opportunities there are in stem-related fields. 'We have all kinds of jobs in New Mexico that kids can plug into, and I don't think they know that, right? So this is kind of that awareness, not only about what careers are available, but also about what skills it takes to do those careers,' continued Harmon. Home to an off-site air force research lab and other tech-focused businesses, the Q Station on Central says it hopes to nurture critical thinking for the next generation, 'Sometimes kids think, 'that's too hard, I can't do that. I don't know anything about it.' But once you start to dabble and explore and say, 'what happens if I do this? What happens if I do that?' Then you're like, 'oh, this is really cool. This is fun for me,'' said Harmon. The 'Atomic 66' event has tech talks and another youth-focused stem event happening on Friday. Click here to learn more. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store