AstraZeneca announces results from MATTERHORN Phase III trial of IMFINZI
Positive results from the MATTERHORN Phase III trial showed perioperative treatment with AstraZeneca's (AZN) IMFINZI in combination with standard-of-care FLOT chemotherapy demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of event-free survival, EFS, versus chemotherapy alone. Patients were treated with neoadjuvant IMFINZI in combination with chemotherapy before surgery, followed by adjuvant IMFINZI in combination with chemotherapy, then IMFINZI monotherapy. The trial evaluated this regimen versus perioperative chemotherapy alone for patients with resectable, early-stage and locally advanced gastric and gastroesophageal junction, GEJ, cancers. In a planned interim analysis, patients treated with the IMFINZI-based perioperative regimen showed a 29% reduction in the risk of disease progression, recurrence or death versus chemotherapy alone. Estimated median EFS was not yet reached for the IMFINZI arm versus 32.8 months for the comparator arm. For the secondary endpoint of overall survival, a strong trend was observed in favor of the IMFINZI-based perioperative regimen. The trial will continue to follow OS, which will be formally assessed at the final analysis.
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Get Starting Point A guide through the most important stories of the morning, delivered Monday through Friday. Enter Email Sign Up Emails seeking comment were left Tuesday with Habba's office and the Homeland Security Department, where Patel works. Advertisement The episode outside the Delaney Hall federal immigration detention center has had dramatic fallout. It began on May 9 when Baraka tried to join three Democratic members of Congress — Rob Menendez, LaMonica McIver and Bonnie Watson Coleman — who went to the facility for an oversight tour, something authorized under federal law. Baraka, an outspoken critic of Trump's immigration crackdown and the detention center, was denied entry. Video from the event showed him walking from the facility side of the fence to the street side, where other people had been protesting, and then uniformed officials came to arrest him. As they did, people could be heard in the video saying to protect the mayor. The video shows a crowd forming and pushing as officials led off a handcuffed Baraka. Advertisement He was initially charged with trespass, but Habba dropped that charge and charged McIver with two counts of assaulting officers stemming from her role in the skirmish at the facility's gate. McIver decried the charges and signaled she plans to fight them. A preliminary hearing is scheduled later this month. Delaney Hall, a 1,000-bed facility, opened earlier this year as a federal immigration detention facility. Florida-based Geo Group Inc., which owns and operates the property, was awarded a 15-year contract valued at $1 billion in February. The announcement was part of the president's plans to sharply increase detention beds nationwide from a budget of about 41,000 beds this year. Baraka sued Geo soon after that deal was announced. Then, on May 23, the Trump Justice Department filed a suit against Newark and three other New Jersey cities over their so-called sanctuary policies. There is no legal definition for sanctuary city policies, but they generally limit cooperation by local law enforcement with federal immigration officers. New Jersey's attorney general has a statewide directive in place prohibiting local police from collaborating in federal civil immigration matters. The policies are aimed at barring cooperation on civil enforcement matters, not at blocking cooperation on criminal matters. They specifically carve out exceptions for when Immigration and Customs Enforcement supplies police with a judicial criminal warrant. The Justice Department said, though, the cities won't notify ICE when they've made criminal arrests, according to the suit. It's unclear whether Baraka's role in these fights with the Trump administration is having an effect on his campaign for governor. He's one of six candidates seeking the Democratic nomination in the June 10 election to succeed term-limited Democratic Gov. Phil Murphy. Advertisement In a video ad in the election's final weeks, Baraka has embraced a theme his rivals are also pushing: affordability. He says he'll cut taxes. While some of the images show him standing in front of what appears to be Delaney Hall, he doesn't mention immigration or the arrest specifically, saying: 'I'll keep Trump out of your homes and out of your lives.' Trump has endorsed Jack Ciattarelli, one of several Republicans running in the gubernatorial primary. Ciattarelli has said if he's elected, his first executive order would be to end any sanctuary policies for immigrants in the country illegally.
