logo
Zydus announces plan to acquire US manufacturing units of Agenus Inc

Zydus announces plan to acquire US manufacturing units of Agenus Inc

Indian Express2 days ago

Zydus Lifesciences on Tuesday announced its plan to acquire Agenus Inc's US-based biologics CMC (Chemistry, Manufacturing, and Control) facilities, marking the Gujarat-based firm's entry into the global biologics contract development and manufacturing organisation (CDMO) business.
Agenus Inc. is a clinical-stage immuno-oncology company developing immune therapies, which effectively combat cancer. Zydus, in a statement, said it is set to acquire two biologics manufacturing facilities, located in Emeryville and Berkeley, California, for an upfront consideration of USD 75 million and contingent payment of USD 50 million to be paid over three years, 'subject to achievement of certain revenue milestones'.
With this acquisition, Zydus claims it will become a one-stop solution provider across the entire development spectrum of biologics, right from preclinical to toxicology studies, clinical development and now manufacturing.
Zydus's CDMO business will operate as an independent entity and will house the acquired manufacturing capabilities, according to the statement. Further, Zydus will also become an exclusive contract manufacturer for Agenus and will provide manufacturing services for clinical and commercial supply of two identified Phase-3 ready immuno-oncology products, Botensilimab (BOT) and Balstilimab (BAL). In addition, Zydus will have the first right of negotiation to manufacture any of the future pipeline products developed by Agenus, the statement further read.
Dr Sharvil Patel, Managing Director (MD) of Zydus Lifesciences, said, 'The acquisition will give Zydus a strategic foothold in the US for biologics manufacturing in the global hub for biotech innovation, California. It will enhance our ability to partner with innovation-centric entities, advancing new products and prioritising patient-centric solutions. This move strengthens our long-term biologics vision and positions us to better serve the evolving needs of the global biopharmaceutical industry.'

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Rupee ends higher aided by mild inflows; RBI policy decision in focus
Rupee ends higher aided by mild inflows; RBI policy decision in focus

Economic Times

time28 minutes ago

  • Economic Times

Rupee ends higher aided by mild inflows; RBI policy decision in focus

Tired of too many ads? Remove Ads Tired of too many ads? Remove Ads Popular in Markets 1. Rupee buckles under position unwinding; dollar demand builds The Indian rupee closed modestly stronger on Thursday, lifted by mild dollar inflows as well as positive cues from gains in most Asian peers, while traders awaited the Reserve Bank of India's monetary policy decision on rupee closed at 85.79 against the U.S. dollar, up from its close of 85.90 in the previous the rupee was nearly flat in the first half of the session, it received a slight boost from foreign banks' dollar sales in the latter half, likely on behalf of their custodial clients, a trader at a Mumbai-based bank currencies were mostly stronger on the day as well while the dollar index was hovering little changed at 98.8.U.S. President Donald Trump reiterated his call for the Federal Reserve to lower interest rates after U.S. private payrolls data came in weaker-than-expected on have priced in 56 basis points of rate cuts this year from the Fed, with traders pricing in a 95% chance for easing in September, per LSEG Reserve Bank of India, meanwhile, is widely expected to deliver its third consecutive 25 bps cut on Friday, according to economists polled by Reuters."Our base call is for the RBI to undertake 50 bps more cuts (including June's move) in second half of 2025, taking the terminal rate to 5.5%," DBS Bank said in a note."Beyond this week's likely reduction, we expect the focus to shift towards policy transmission," the note benchmark equity indexes, the BSE Sensex and Nifty 50 closed higher by about 0.5% each, with some gains led by rate-sensitive in the day, the focus will be on the release of U.S. jobless claims data for cues on how uncertainty about trade policies is impacting the world's largest economy.

IRCTC's Ebitda growth rate mirrors pace of a slow-moving train
IRCTC's Ebitda growth rate mirrors pace of a slow-moving train

Mint

time28 minutes ago

  • Mint

IRCTC's Ebitda growth rate mirrors pace of a slow-moving train

Indian Railway Catering and Tourism Corp. Ltd (IRCTC)'s results for the three months ended March (Q4FY25) proved unimpressive versus expectations of a solid quarter due to the Mahakumbh event-related push. Ebitda growth was 6% year-on-year to ₹385 crore, with margin compressing by almost 100 basis points to 30.4%. A basis point is one-hundredth of a percentage point. Recall that IRCTC had offered food service in Aastha Express to Ayodhya in Q4FY24 during the consecration ceremony of the Ram temple. Thus, there was hope that it would be done for Mahakumbh special trains, too. In the Q4FY25 earnings call, the management clarified that these trains operated without catering facilities because the government's aim was to accommodate more passengers to Mahakumbh and also clear the subsequent rush from there. The outcome: IRCTC's catering revenue was unchanged year-on-year at ₹529 crore. The segment's profitability improvement isn't impressive either, as the base quarter had an abnormally low margin. Sequentially, the margin was flat at 12%. Also Read: KEC is making amends to repair margin, allay debt concerns IRCTC's mainstay business remains internet ticketing, contributing about 75% of its total FY25 Ebit. The segment has two revenue streams of convenience fee (simply put, the online ticket booking charges) and non-convenience fee from advertising and ancillary services for buying food, travel insurance, etc. Convenience fee grew 9% year-on-year as online ticket booking volume increased by 10%. While volume growth is not a problem, the concern here is about the 7% quarter-on-quarter fall in average fee per ticket to ₹18.6. The fee is different for AC and non-AC ticket booking, and also for booking payments made using Unified Payments Interface (UPI) or other modes that include netbanking and cards. The share of UPI-based payments has been steadily climbing up, from 45% in Q1FY25 to 47.7% in Q4FY25, which puts pressure on the average fee per ticket as the convenience fee is lower on payments made using UPI. Bright spot The tourism segment was the only bright spot in the results, which essentially is a packaged tour business offering options for religious and luxurious tours. Tourism Ebit soared by 161% on-year to ₹50 crore with margin almost doubling to 18.1% in Q4FY25. Bharat Gaurav train and Maharaja Express have contributed to the growth. Also Read: PMI: India's services exports bump may lose steam amid global economic gloom For FY25, the two trains clocked revenue of ₹277 crore and ₹92 crore, respectively. While Bharat Gaurav's revenue is higher, its margin is lower at 8% versus 18% of Maharaja Express, as the former operates in the affordable segment and the latter in the luxurious travel category. The management is optimistic that the tourism segment will maintain its upward trajectory, but the segment's past performance has been volatile. Meanwhile, IRCTC is likely to get initial approval from the Reserve Bank of India (RBI) for a payment aggregation license within the next couple of months. However, even after the business starts, it would be tough to make inroads given the wafer-thin margin. The space is already crowded with well-entrenched players such as PhonePe and Razorpay. High valuation As such, the new business initiative is unlikely to change the trajectory of the stock, which is down 15% over the past one year even as the Ebitda CAGR over the last two years to FY25 has been 10%. The decline in the stock is thus indicative of the correction in its rich valuation. Ebitda is short for earnings before interest, taxes, depreciation, and amortisation. Also Read: Ola Electric's new breakeven targets appear more like wishful thinking Bloomberg consensus estimates show Ebitda growth in FY26 could go up to 18%, which appears a tad optimistic. The decline in stock price pushes the enterprise value (EV) (numerator in EV/Ebitda) lower, while optimistic Ebitda estimates push the denominator higher. Despite that, the valuation still remains expensive at EV/Ebitda of 33x based on Bloomberg consensus estimates for FY26.

Most listed new-age startups improve Q4 profitability; Swiggy, Ola lag behind
Most listed new-age startups improve Q4 profitability; Swiggy, Ola lag behind

Economic Times

timean hour ago

  • Economic Times

Most listed new-age startups improve Q4 profitability; Swiggy, Ola lag behind

Out of the 17 new-age companies listed on Indian stock exchanges, 11 reported an improvement in profitability for the January-March quarter, either by expanded profits or narrower losses, in a sign of better operational performance. This group includes Nykaa, Delhivery, BlackBuck, Paytm, Policybazaar, Go Digit, Ather Energy and Ixigo. However, six others saw a deterioration in their bottom lines. These include food and grocery delivery firms Swiggy and Eternal, which ramped up cash burn amid intensifying competition in the fast-growing quick commerce sector. Losses also widened for FirstCry, Mobikwik and Ola Electric. For Ola Electric, the fourth-quarter loss more than doubled to Rs 870 crore even as its operating revenue plummeted 62%. Among the lot of these 17 companies, beauty and fashion retailer Nykaa and Policybazaar parent PB Fintech were the top performers, having posted 24% and 38% year-on-year growth in revenue for the fourth quarter, while also more than doubling their underscored the improvement in margins for these two companies, which went public in 2021, suggesting the momentum could continue. For PB Fintech, Citi Research highlighted a one-percentage-point expansion in contribution margins for the March quarter — which came after three quarters of contraction — in addition to reduced expenses on employee stock option plans as key drivers behind its strong profitability momentum. On Nykaa, brokerage firm JM Financial said strong working capital enhancement ensured that the company had its first year of positive cashflow since Covid, after adjusting for lease liabilities and capital expenditure. 'We believe core BPC (beauty and personal care) will benefit from repeat purchases from customers acquired this year, resulting in sharper margin improvement in the coming years. Nykaa's ability to deliver robust growth in a tepid demand environment along with margin enhancement demonstrates its differentiated market positioning,' the firm said. Beauty retailer Honasa Consumer, the parent of Mamaearth, meanwhile saw its profits falling 15% during the quarter on back of the company's offline restructuring exercise. The company's management indicated that it is now expected to see the positive impact of the rejig. Quick burn The fourth quarter saw increased cash burn for Gurgaon-based Zomato parent Eternal and Bengaluru-headquartered Swiggy in their quick commerce units, Blinkit and Instamart, respectively. This impacted their consolidated earnings, particularly at a time when their largest segment of food delivery is undergoing a slowdown. Going ahead, senior executives of the two companies laid out differing views on how they see profitability. Eternal said Blinkit will aggressively chase market share even if it comes at the cost of near-term profitability. On the other hand, Swiggy group CEO Sriharsha Majety said the operating losses for Instamart peaked by the end of the January-March quarter, and the company expects to 'progressively unwind losses' from here on. Eternal reported a 78% fall in its net profit to Rs 39 crore in the past quarter, while Swiggy's net loss nearly doubled to Rs 1,081 crore.A research note from HSBC Securities said Blinkit lost Rs 2 for every Rs 100 of gross order value (GOV), while Swiggy lost Rs 18. 'Cash burn for Swiggy was even higher than profit losses. In terms of competitive intensity, while the next few months are tactically favourable for Blinkit and Swiggy Instamart, competition may get intense again in the second half of this year and next year (2026),' it said. EV mixed bag For Ola Electric, the March quarter saw not only expanding losses but also a significant fall in revenue as the company went from being the leader in electric two wheeler segment to now falling behind legacy players such as TVS Motor and Bajaj Auto in terms of market at Kotak Institutional Equities, while downgrading their call on Ola Electric's stock to 'sell', said its future 'hinges on scaling up volumes' and a 'successful motorcycle foray', and that the company 'faces executive and credibility challenges'.According to the brokerage firm, the company's performance during the past couple of quarters has been marred by weaker scooter volumes and rising warranty provisions, which have weighed on its profitability. 'Volume trends have been impacted by increased competitive intensity and several quality issues faced by customers,' the analysts added. The company's operating revenue for the March quarter came in at Rs 611 crore – lower than its rival Ather Energy, which posted Rs 676 crore in top line. To be sure, Ather Energy, which went public in May, clocked less than half the scooter volumes compared with la Electric in fiscal 2025. Even though Ola Electric's losses expanded, Ather Energy saw its loss narrowing 17% during the March quarter. Logistics on firm ground New-age logistics firm Delhivery and truck aggregator platform BlackBuck both reported profits for the fourth quarter, compared to losses in the year-ago period. For Delhivery, the profitability in the March quarter meant it posted its first full year of net profit as its core transportation business continued to show improvement in operating efficiencies. BlackBuck, which went public last year, reported a net profit of Rs 280 crore, a major chunk of which was on account of a one-time tax credit. However, even on a pre-tax basis, BlackBuck turned profitable, reporting a Rs 41 crore profit, as it tightened expenses particularly under the heads of employee benefits and interest costs.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store