Multiple injuries after coach fire and crashes
Thames Valley Police confirmed it was called to the A34 southbound, between Abingdon Road and Fiddlers Lane junction, at 19:00 GMT on Friday.
A force spokesperson said they received reports of collisions on the north and southbound carriageways.
They said one person was taken to hospital with non-life-threatening injuries and "a number" of other people had been hurt but their injuries were not thought to be serious.
National Highways East said there had also been a coach fire between the M4 and A4185 Chilton.
Motorists were advised to avoid the area while the road closures were in place. The road has since reopened.
Police have asked anyone with information about the incident to contact 101.
The force spokesperson added: "We thank members of the public for their patience while the road was closed."
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