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Yahoo
an hour ago
- Yahoo
SpaceX launch is delayed after widespread power outage scrubs mission with 45 seconds to spare
A SpaceX rocket launch planned for Tuesday afternoon at Vandenberg Space Force Base was forced to take a rain check after a widespread power outage scrubbed the liftoff, according to a statement from the Federal Aviation Administration. The power outage in the Santa Barbara region disrupted telecommunications at the Los Angeles Air Route Traffic Control Center, creating a "no-go condition for launch," NASA said in post. The control center manages air traffic over 177,000 square miles of airspace including California's coast from L.A. to San Luis Obispo, the Ventura area and into the Pacific for about 200 miles, according to the FAA. The decision came just 45 seconds before the rocket was set to launch, with a SpaceX official calling, "Hold, hold, hold. ... We have aborted launch today due to airspace concerns." "The FAA took this action to ensure the safety of the traveling public," the administration said. The FAA also issued a ground stop at the Santa Barbara Airport on Tuesday due to the outage, the airport said in a statement. Flights were diverted and delayed. Power at the airport hadn't been restored as of about 9:30 p.m. Tuesday, according to a spokesperson, who said that the ground stop would be lifted once power was restored to the area. In addition, the outage disrupted 911 service throughout Santa Barbara County, according to KTLA. As for the SpaceX launch, the rocket and its payloads were still in good shape, NASA said. Aboard the rocket were two twin satellites, a part of NASA's TRACERS mission — Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites. The two satellites will study Earth's magnetosphere by determining how magnetic explosions send solar wind particles into Earth's atmosphere, and how those particles affect space technology and astronauts. The launch was rescheduled to Wednesday at 11:13 a.m., NASA said. It will take place at Space Launch Complex 4 East at Vandenberg. Last month, a SpaceX launch from the same location lighted up the night sky across Southern California. Sign up for Essential California for news, features and recommendations from the L.A. Times and beyond in your inbox six days a week. This story originally appeared in Los Angeles Times. Solve the daily Crossword
Medscape
2 hours ago
- Medscape
How Myeloma Plays Hide and Seek With CAR T Cells
TOPLINE: G protein-coupled receptor, class C, group 5, member D (GPRC5D) loss after chimeric antigen receptor (CAR) T-cell therapy in multiple myeloma (MM) occurs through biallelic genetic inactivation and hypermethylation-driven epigenetic silencing. Among 10 patients who relapsed, eight showed GPRC5D loss, while two had mixed expression. METHODOLOGY: Researchers conducted whole-genome sequencing (WGS) and whole-genome bisulfite sequencing (WGBS) analysis on MM samples from 10 patients who relapsed after GPRC5D CAR T-cell therapy. Analysis included CD138+ MM cells isolated from bone marrow samples with purity exceeding 80%, with tumor samples sequenced at 100× coverage and matched normal samples at 30× coverage. Investigators performed targeted bisulfite sequencing to evaluate methylation status of GPRC5D regulatory regions across seven MM cell lines, with library construction and sequencing conducted by specialized institutes. Patient characteristics included median age of 57.5 years (range, 44-66 years), equal gender distribution, and 90% having high-risk cytogenetic abnormalities. TAKEAWAY: Genetic alterations were identified in three cases: one with homozygous deletion in GPRC5D gene, another with biallelic loss in regulatory regions, and a third with homozygous deletions in both TNFRSF17 and GPRC5D after sequential anti-B-cell maturation antigen and anti-GPRC5D CAR T-cell therapies. Multiple hypermethylation sites were present in transcriptional regulatory elements of GPRC5D gene in five posttreatment MM samples, with no genetic changes detected at GPRC5D locus in seven cases. GPRC5D expression showed inverse correlation with methylation levels in regulatory regions of MM cell lines, with azacitidine treatment inducing GPRC5D messenger RNA and protein expression in hypermethylated MM cell lines. All 10 patients achieved complete response or better as best response with median time to best response of 2.5 months (range, 0.5-15.3 months), though median time to disease progression was 15.9 months (range, 3.0-26.5 months). IN PRACTICE: 'Our findings highlight that biallelic genetic inactivation and hypermethylation-driven epigenetic silencing are key mechanisms contributing to GPRC5D loss and treatment resistance,' wrote the authors of the study. SOURCE: The study was led by Mingshan Niu, Blood Diseases Institute, Xuzhou Medical University in Xuzhou, China. It was published online in Blood. LIMITATIONS: According to the authors, the structural variant deletions on chromosomes may be missed by 100× WGS in patients with a clone size less than 20%. The limit of detection for quantitative polymerase chain reaction ranged from 16 to 50 copies per reaction, indicating sensitivity limitations of these detection methods. Additionally, genetic alterations in the GPRC5D locus could either be acquired after CAR T-cell therapy or selected from preexisting clones, necessitating more sensitive detection methods for dynamic monitoring. DISCLOSURES: The research received support from the National Natural Science Foundation of China (82270181) and the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (21KJA320005). The authors reported having no relevant conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Yahoo
4 hours ago
- Yahoo
SpaceX launch set for tomorrow after widespread power outage scrubs mission at last minute
A SpaceX rocket launch planned for Tuesday afternoon at Vandenberg Space Force Base was forced to take a rain check after a widespread power outage scrubbed the liftoff, according to a statement from the Federal Aviation Administration. The power outage in the Santa Barbara region disrupted telecommunications at the Los Angeles Air Route Traffic Control Center, creating a "no-go condition for launch," the National Aeronautics and Space Association said in post. The control center manages air traffic over 177,000 square miles of airspace including California's coast from L.A. to San Luis Obispo, the Ventura area and into the Pacific for about 200 miles, according to the FAA. The decision came just 45 seconds before the rocket was set to launch, with a SpaceX official calling, "Hold, hold, hold. ... We have aborted launch today due to airspace concerns." "The FAA took this action to ensure the safety of the traveling public," the administration said. The FAA also issued a ground stop at the Santa Barbara Airport on Tuesday due to the outage, the airport said in a statement. Flights were diverted and delayed. Power at the airport hadn't been restored as of about 9:30 p.m. Tuesday, according to a spokesperson, who said that the ground stop would be lifted once power was restored to the area. In addition, the outage disrupted 911 service throughout Santa Barbara County, according to KTLA. As for the SpaceX launch, the rocket and its payloads were still in good shape, NASA said. Aboard the rocket were two twin satellites, a part of NASA's TRACERS mission — Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites. The two satellites will study Earth's magnetosphere by determining how magnetic explosions send solar wind particles into Earth's atmosphere, and how those particles affect space technology and astronauts . The launch was rescheduled to Wednesday at 11:13 a.m., NASA said. It will take place at Space Launch Complex 4 East at Vandenberg. Last month, a SpaceX launch that took off from the same location lit up the night sky across Southern California. Sign up for Essential California for news, features and recommendations from the L.A. Times and beyond in your inbox six days a week. This story originally appeared in Los Angeles Times.
