Nature-Inspired Gel Explains Why This Duck Is Stuck
Hydrogels are soft, jellylike materials used in many fields. In medicine, they can dress wounds and deliver drugs. In agriculture, they can help soil hold more water. But making substances sticky is tough—and underwater, it's even tougher. The glues typically don't hold well under a wet and salty surf.
Nature, however, has a solution. Creatures such as barnacles and mussels naturally produce proteins that let them stick to wet surfaces. Inspired by these adhesive abilities, researchers combed through catalogs of these animals' protein structures to mimic their stickiest features. Then, the scientists incorporated these protein structures into the hydrogels and tested them. After running several experiments, the team fed the results to a machine-learning system so that it could design a hydrogel with even stronger glue. The system came up with three superadhesive designs, composed of different protein structures, which the researchers described this week in Nature.
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Jonathan Barnes, a polymer scientist at Washington University in St. Louis, who was not involved in the study, was impressed by the sheer strength of the enhanced hydrogels. In one experiment, the researchers used one of the gels to glue together pairs of plates made of one of three different materials—ceramic, glass and titanium—in a tank of saline. Each glued pair had a kilogram-mass load suspended below it. The gel held on for more than a year. 'To last for a year is incredible,' Barnes says.
All three of the artificial-intelligence-designed hydrogels showed similar strength in artificial seawater. But one outperformed the others when tested in deionized water, which is devoid of charge and not found in nature. The differences in strength show that some adhesive materials may be more equipped for specific environments than others. 'We are now working to tune this difference and test them in different conditions,' says study co-author Jian Ping Gong, a polymer scientist at Hokkaido University in Japan. 'We also want to improve and [find] other formulations that can work on metal, for example.'
After synthesizing the ultrasticky gels, the scientists took two of them into the field to test their real-world capabilities. The researchers used one gel to seal a hole at the base of a three-meter-long pipe that was filled with tap water to simulate a high-pressure water leak. And they used the other to affix a rubber duck onto a rock to see how well the technology fared in seawater. One day these gels could help researchers develop artificial skin or repair underwater and offshore structures.
'[The study] points to tougher, faster and more reliable wet adhesives—for medical sealing, marine infrastructure and emergency repairs,' says Ximin He, a materials scientist who studies biologically inspired materials at the University of California, Los Angeles, and was not involved in the paper. 'The data‑driven playbook they use could shorten the path from idea to material across many applications that affect daily life.'
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Scientific American
a day ago
- Scientific American
Nature-Inspired Gel Explains Why This Duck Is Stuck
On the shores of a beach in northern Japan, waves pummel a rubber duck stubbornly stuck to a rock. Thanks to a new supersticky hydrogel lining its base, the toy won't budge. Hydrogels are soft, jellylike materials used in many fields. In medicine, they can dress wounds and deliver drugs. In agriculture, they can help soil hold more water. But making substances sticky is tough—and underwater, it's even tougher. The glues typically don't hold well under a wet and salty surf. Nature, however, has a solution. Creatures such as barnacles and mussels naturally produce proteins that let them stick to wet surfaces. Inspired by these adhesive abilities, researchers combed through catalogs of these animals' protein structures to mimic their stickiest features. Then, the scientists incorporated these protein structures into the hydrogels and tested them. After running several experiments, the team fed the results to a machine-learning system so that it could design a hydrogel with even stronger glue. The system came up with three superadhesive designs, composed of different protein structures, which the researchers described this week in Nature. On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. Jonathan Barnes, a polymer scientist at Washington University in St. Louis, who was not involved in the study, was impressed by the sheer strength of the enhanced hydrogels. In one experiment, the researchers used one of the gels to glue together pairs of plates made of one of three different materials—ceramic, glass and titanium—in a tank of saline. Each glued pair had a kilogram-mass load suspended below it. The gel held on for more than a year. 'To last for a year is incredible,' Barnes says. All three of the artificial-intelligence-designed hydrogels showed similar strength in artificial seawater. But one outperformed the others when tested in deionized water, which is devoid of charge and not found in nature. The differences in strength show that some adhesive materials may be more equipped for specific environments than others. 'We are now working to tune this difference and test them in different conditions,' says study co-author Jian Ping Gong, a polymer scientist at Hokkaido University in Japan. 'We also want to improve and [find] other formulations that can work on metal, for example.' After synthesizing the ultrasticky gels, the scientists took two of them into the field to test their real-world capabilities. The researchers used one gel to seal a hole at the base of a three-meter-long pipe that was filled with tap water to simulate a high-pressure water leak. And they used the other to affix a rubber duck onto a rock to see how well the technology fared in seawater. One day these gels could help researchers develop artificial skin or repair underwater and offshore structures. '[The study] points to tougher, faster and more reliable wet adhesives—for medical sealing, marine infrastructure and emergency repairs,' says Ximin He, a materials scientist who studies biologically inspired materials at the University of California, Los Angeles, and was not involved in the paper. 'The data‑driven playbook they use could shorten the path from idea to material across many applications that affect daily life.'
Medscape
a day ago
- Medscape
Aug 08 2025 This Week in Cardiology
Please note that the text below is not a full transcript and has not been copyedited. For more insight and commentary on these stories, subscribe to the This Week in Cardiology podcast , download the Medscape app or subscribe on Apple Podcasts, Spotify, or your preferred podcast provider. This podcast is intended for healthcare professionals only. In This Week's Podcast For the week ending August 8, 2025, John Mandrola, MD, comments on the following topics: Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients. A listener sent me a huge meta-analysis published in the Annals of Internal Medicine comparing catheter and surgical ablation to no ablation in randomized controlled trials (RCTs). I had seen the study but ignored it, but when avid listeners say they are keen to know my thoughts, I relooked at it and will discuss it now. A group at Washington University in St Louis led the study. It was a massive meta-analysis encompassing 63 trials with more than 11,000 patients. There were 39 catheter ablation trials and 24 surgical ablation trials. The goal was to bring together all RCTs in the field to assess the primary outcome of ischemic stroke at more than 30 days. Pause there. Stop and Think. This is weird. Why ischemic stroke after 30 days. What if a stroke happens at day 29? How is that less important than a stroke at 31 days? The authors also looked at secondary outcomes of mortality and heart failure hospitalizations. Six news outlets picked up the study—all with positive headlines. But we need to look deeper. The main results were that: Compared with medical therapy, catheter ablation reduced risks for ischemic stroke after 30 days (relative risk [RR], 0.63 [95% CI, 0.43 - 0.92]), mortality (RR, 0.73 [CI, 0.60 - 0.88]), and heart failure hospitalization (RR, 0.68 [CI, 0.55 - 0.85]). However, catheter ablation increased the RR for ischemic stroke at or before 30 days (6.81 [CI, 1.56 - 29.8]) such that the RRs were 0.77 (CI, 0.55 - 1.09) for any ischemic stroke and 0.77 (CI, 0.57 - 1.05) for all strokes. Surgical ablation reduced the RRs for ischemic stroke (0.54 [CI, 0.34 - 0.86]) and stroke from any cause (0.54 [CI, 0.35 - 0.82]) but had uncertain benefit for other outcomes. Ischemic stroke after 30 days in surgical ablation trials — RR was 0.63 (CI, 0.37 - 1.06); and non-significant for mortality and HHF. This is lacking, right? You want to know total stroke, mortality and HHF numbers. You also want to know absolute risk reductions. So here they are: For catheter ablation: Total stroke had a non-significant 33% relative risk reduction (RR, 0.77 (0.57-1.05) ARR 0.6% fewer per 1000 to 1 per 1000 more cases. Total mortality had a significant 37% relative risk reduction (RR, 0.73 (0.6-0.88); ARR was 16 per 1000 fewer. HHF had a 32% relative risk reduction (RR, 0.68 (0.55-0.85) and the ARR was 24 fewer per 1000 HF hospitalization For surgical atrial fibrillation (AF) ablation vs cardiac surgery alone: Total Stroke (Any Cause): Relative Risk: 0.54 (95% CI, 0.35 - 0.82; Absolute difference: 25 fewer per 1000 (35 fewer to 10 fewer) As I said above there were not significant reductions in HHF or mortality with surgical AF ablation. The authors concluded: 'Catheter ablation reduced the risks for ischemic stroke at more than 30 days, mortality, and HF hospitalization. Surgical ablation had uncertain benefit, except for stroke.' A neutral reader could conclude that total stroke, mortality and HHF all trended lower for catheter ablation. I am quite surprised that the accompanying editorial for Beth Isreal Boston key opinion leaders was quite positive. I am not at all positive about this meta-analysis. And I am surprised by how many key opinion leaders in AF there were as sub-authors. I think the main, perhaps only, value of this meta-analysis is how it displays the weaknesses of meta-analyses and what should not be done. Before I mention the specifics of this analysis, it's a good time to do some basics of meta-analyses, which combine studies to, hopefully…ideally…come to a summed effect size. Meta-analyses in my mind can really shine when individual trials are underpowered because of low event rates. If 2 or 3 or 4 trials are similar, you can combine and increase the power. I think of NOAH and ARTESIA, the trials of DOAC in sub-clinical atrial fibrillation. Each had low stroke rates; each were similar and combining them increases power. Another example is the risk of AF with fish oil. Each trial of fish oil showed an elevated risk of AF. Why, I do not know, but together the signal of AF is stronger. Another area where meta-analyses may be helpful is finding a dose-response relationship, like in the fish oil and AF example: trials with the highest fish oil concentration had the highest risk. Another area of meta-analysis might be when individual trials show conflicting results. Here, if the trials are similar, you might sort out the direction and magnitude of effect. But inherent in deriving any benefit from meta-analyzing trials, you need the combined trials to enroll similar populations who have similar interventions, ideally, with similar outcomes. You want the included studies to be high in quality, and of the same clinical scenario. For instance, it's madness to combine ICD trials from the 2000s to now—as HF therapy has changed so much. This meta-analysis fails in nearly all of these facets. It's so weird that this many smart academics thought it a good idea. First problem…the endpoint is mind-boggling. You don't look at stroke before and after 30 days. You look at stroke overall. One group gets a procedure that could increase short term risk of stroke (manipulation of the left atrium) but might reduce stroke in the long-term, by decreasing AF. You only care about stroke—overall. The example in the left atrial appendage occlusion (LAAO) trials where the only positive result was excluding the week after the procedure. This is ridiculous, because no patient can exclude the time after a procedure. Second problem….the authors combined trials from 20 years ago to trials done now. This is almost equally ridiculous, because modern ablation is very different from the hocus pocus we did in 2004. Third problem…the vast majority of included studies had a handful of patients. Combining small studies is a recipe for overestimating effect size. Combining 10, 20, 30, or 40 single-center studies cannot come close to estimating effect size compared with a 2000-patient strong CABANA trial. It's foolish to combine tiny studies with massive studies. Fourth problem…the authors looked at outcomes that were not primary outcomes of the major trials. Without individual patient level data from each trial, who knows if the results are accurate. Fifth problem…the trials varied too much in trial conduct, endpoints, time of study, to combine them together. Heterogeneity is off the charts. In sum, this massive effort yields exactly zero new information. I mean no malice to the authors, but this was destined to fail. Meta-analyses have a role, but this is not it. Catheter ablation should be studied; we should have proper primary endpoints, such as stroke, death, and total (not heart failure) hospitalizations. If you want to study quality of life, there is only one way: you must have a placebo or sham control arm. Otherwise you fail as hard as the tricuspid valve interventionalists have failed. I think air embolism here is not likely related exclusively to the Watchman device; it sounds more like a physiologic phenomenon wherein patients on conscious sedation can take these huge breaths, which, if timed unfortunately during opening of the valve of the sheath could suck in air. We worry about this a lot during AF ablation, and sheath management is crucial. I always remove catheters from sheaths slowly. And I hate catheter exchanges. It's one of the negatives of pulsed field ablation (PFA) technology now, that we have to use a separate mapping catheter and PFA catheter. That will soon change. What Boston Scientific is recommending is basic procedural hygiene when in the LA. I wonder, though, whether this new warning has to do with the new system or is it just more doctors, many of whom are low-volume operators, doing more cases because of the device's popularity. I mean there have been tens of thousands of cases of LAAO since 2016, and now in 2025, we get an alert on specific catheters. If I were an implanter, I would be curious about this question. We've done this procedure for a long time, but now, with the new systems, we see a problem. Why? Are we sure about those valves? I am asking, I don't know. That said, FDA warnings are common with procedures. We learn things during the iterative process—for all procedures. For instance, we did not know about atrioesophageal fistula after AF ablation until tragedies occurred. Thermal ablation evolved to avoid heat stacking in the area of the esophagus. I am glad companies issue such warnings. Transparency is laudable. The larger lesson here is that procedures can cause harm. Their evidentiary basis should be as strong as a new drug. Often it is not. AF ablation has only one placebo controlled trial. Tricuspid interventions have zero, and you all know how I feel about LAAO procedures: Failure of the seminal Watchman trials to show non-inferiority to warfarin. And no compelling evidence for the device in patients not able to take oral anticoagulants. None. And it's been 9 years. But…But….when we intervene on patients with symptomatic AF, or symptomatic tricuspid regurgitation, or symptomatic myocardial infarction, we intervene on patients with an active problem. When we intervene on the LAA, we are doing prevention. We seek probabilistic benefit in the future. Prevention must always have a higher not lower bar of evidence. It doesn't with LAAO, and that is blemish on our profession. Journal of the American College of Cardiology has a nice paper on the issue of switching oral anticoagulants in older patients who have frailty. This comes up a lot. Anticoagulant- naive patients, at least in my neighborhood, get a direct oral anticoagulant (DOAC). I can hardly recall the last time I started warfarin de novo—in any patient with AF. We do this mostly for convenience, but also for efficacy and safety. The issue at hand is whether a patient on warfarin should be switched to DOAC. I reported in 2023 on the FRAIL-AF study, a Dutch study that randomized 1330 patients who were age ≥75 years, frail, and treated with a vitamin K antagonist (VKA) to either switch from VKA to a DOAC (rivaroxaban 54%, apixaban 19%, edoxaban 18%, or dabigatran 9%) or to continue VKA. The trial was stopped prematurely for futility as there was a significant increase in major or clinically relevant nonmajor (CRNM) bleeding, mainly gastrointestinal bleeding, in patients switched to DOAC (HR: 1.69; 95% CI: 1.23-2.32) This was provocative because it was surprising. You would not have thought bleeding would have gone so much higher when switching. Critical appraisal of FRAIL-AF included the very wide confidence intervals, and low number of events, made wider by the early termination of the trial for futility. The TIMI group, led by Dr Robert Gugliano, has formed a COMBINE-AF collaboration, which is patient-level meta-analysis of the four DOAC vs warfarin trials. RELY, ARISTOTLE, ROCKET and ENGAGE. That's a lot of data, and this is a much better use of meta-analyses than the first paper I discussed on AF ablation. This substudy of COMBINE-AF set out to replicate FRAIL-AF in a larger population of the four trials. It's a neat analysis. Here is what they did: They took patients who were on VKA, the so-called VKA experienced arm, when entering the trial, and elderly (older than 75 years old), and frail. For frailty, the investigators had to make a frailty scale based on a number of factors (which is different from the scale used in FRAIL-AF). Also note: VKA and warfarin are almost interchangeable. This group — warfarin-experienced, old, and frail — were then randomized in the trials to DOAC or warfarin. There were about 6000 of these FRAIL-AF like patients in the four trials. Split equally into DOAC or warfarin arms. The authors called these the test groups. They also looked at patients without these characteristics. These were either VKA naive, or non-elderly or non-frail. There were 52,000 of these, and the authors called these the non-test group. The main outcomes were stroke/systemic embolism, major bleeding, and mortality. They also looked at GI bleeding and ICH, but I think these are not as important as the big categories: stroke, bleeding, mortality. Here were the findings: In the FRAIL-AF like population, over 2.5 years: there was a 17% reduction in stroke and systemic embolism that did not reach statistical significance. Absolute risk reduction (ARR) was 0.4%, no difference in mortality and no difference in major bleeding. In the FRAIL-AF like population, randomization to DOAC vs warfarin was associated with an 83% increase in GI bleeding that was significant, and 1.5% absolute risk increase, but a 54% reduction in fatal bleeding, though the ARR was only 0.3%, of course because there were fewer events. When looking at net clinical outcome in the FRAIL-AF-like group the HR was right at 1.01. When compared to the non-FRAIL-AF population, the 52,000 patients who did not have one of the three criteria of VKA naive, elderly, or frail. These results were exactly similar to what you would expect and what was seen in the main trials: DOAC has statistically significant reductions in the risks of stroke and systemic embolism (SE) vs warfarin (HR, 0.81), death (HR, 0.91), and major bleeding (HR, 0.82). GI bleeding was increased with DOAC but it was only a 23% increase rather than the 83% increase. Net clinical outcome was statistically significant at HR 0.89 for DOACs. The authors did a special analysis based on type of DOAC in the FRAIL-AF like group. Recall that in FRAIL-AF, the main DOAC that patients on warfarin were switched to was rivaroxaban. In COMBINE-AF it was apixaban and edoxaban. When the authors simulated this in their data, they found that when using the 'same DOAC mix as FRAIL-AF (rivaroxaban 54%, apixaban 19%, edoxaban ,18% and dabigatran 9%) they found no statistical differences in stroke/SE but now a statistically significant increase in major bleeding HR 1.21 and even larger 2.2x increase in GI bleeding. But on the other hand, when they did an apixaban and edoxaban-only analysis in this FRAIL-AF group, they found similar stroke/SE rates but now a 17% significant reduction in major bleeding and only a 36% non-significant increase in GI bleeding. Like FRAIL-AF, switching from warfarin to DOAC had no sig effect on stroke or SE. Unlike FRAIL-AF, which had to be terminated early for bleeding, the COMBINE-AF FRAIL-AF-like group did not sustain higher rates of major bleeding when switching. GI bleeding was higher with the switch, but fatal bleeding was less. FRAIL-AF therefore does not replicate in this data set. The authors dispute the Euro guidelines which give a new Class IIb recommendation to maintain warfarin in elderly frail patients based on FRAIL-AF. They write (strongly, I would add): 'The findings from this study suggest that switching to a DOAC is a reasonable strategy for frail, elderly, and VKA-experienced patients, particularly for reducing the risk of stroke, systemic embolism, death, and the most severe bleeding events, such as intracranial and fatal bleeding.' First, I think it's worth thinking about why the results were divergent. One that the authors put a lot of weight on is the different frailty scores used in the two trials. COMBINE authors say their patients might have been frailer, or at least different enough to drive results. I am not sure this is true. To be in a global trial requires a degree of robustness. FRAIL-AF, however, included social isolation, inability to walk around in the home, and cognitive impairment, which were not available in the COMBINE-AF data set. Close your eyes and imagine an isolated Dutch patient vs a patient well enough to come in the office and be randomized in a global RCT. Another possibility is that DOAC mix is important. The subanalysis with apixaban and edoxaban looked a lot better for bleeding than did rivaroxaban heavy analysis. But I would be extremely suspect: this is a sub-analysis of a sub-analysis that is not adjusted for multiplicity. I think invoking specific mixes of DOAC is a stretch. The main reason for the difference, in my opinion, comes in Figure 4 of the supplement where the COMBINE authors provide the numbers of events along with Forest plots in the two studies For FRAIL-AF there were only 29 stroke events vs 201 in the COMBINE-AF study. For FRAIL-AF there were only 40 major bleeds vs 551 in COMBINE-AF. If you have access to the paper, take a look at the width of the error bars. It's remarkable. This is not a criticism of FRAIL-AF; the authors did a nice trial of a very special patient population and were looking for a reduction in bleeding. When they found the opposite —an increase — it made ethical sense to stop the trial early. Yet I think the lessons here from the two trials are that single trials with small numbers of events should be translated carefully. You could argue that the Euro guideline authors choice of a weak IIb recommendation for remaining on warfarin is careful. I was enthusiastic when FRAIL-AF came out because it was so darn provocative. I would not have predicted it. And I think it still is a great trial, but this analysis tells us that a) we should be cautious of small numbers of events, and b) as it so often is in clinical medicine, perhaps there is no exact right answer in these patients. So, how I see the clinical question given this new data is that, in sum, for elderly frail patients on warfarin, I don't think we are mandated to do any one specific thing. FRAIL-AF said don't switch when doing well on warfarin. COMBINE says that if you switch, outcomes are similar. There is not a major advantage or disadvantage. But if an elderly, frail patient wanted to switch, say for convenience, COMBINE results would argue that outcomes would be similar. Hence, switching should neither be proscribed nor recommended. It can be a shared decision with the patient and his or her family. Recall also that this is not about initial choice, which I think remains a DOAC. This is about patients on warfarin and considering switching.
Business Journals
a day ago
- Business Journals
How Los Angeles-based Med-X's Nature-Cide division is making the world safer for all
In an era where sustainability and public health are front and center, Med-X, Inc. is reshaping the future of pest control through its flagship product line, Nature-Cide. What began as a Los Angeles based Eco-Friendly Integrated Pest Management (IPM) pest control service has evolved into a global force for change—offering scientifically validated, plant-based alternatives to chemical pesticides across residential, commercial, and agricultural sectors. For decades, the American public has unknowingly been exposed to harmful chemicals in everything from the food they eat to everyday products and the air they breathe, all of which have contributed to growing concerns about these substances' environmental and health impacts. It wasn't until the onset of the COVID-19 pandemic that many individuals began questioning the systems around them, scrutinizing labels, and demanding transparency from businesses and governments. Recognizing the increasing demand for safer alternatives, the native angelenos and Med-X founders, Matthew and Jennifer Mills took action. With years of experience in product development, CEO Matthew Mills led his Med-X, Inc. team in creating a line of plant-based pest control products called Nature-Cide. These industrial strength, plant-based pest control solutions are designed to replace and augment harmful chemical pesticides in residential and commercial applications. Nature-Cide has quickly gained global recognition as a leading eco-friendly application for professional pest control solutions, now trusted worldwide by professional pest control applicators. Formulated using essential oils like clove, cedar, cottonseed, and cinnamon, Nature-Cide products are non-toxic, non-flammable, and safe to use around humans and pets—without compromising effectiveness or the environment. 'Sometimes nature needs a little science,' said Matthew Mills. 'We're seeing real change take root. Cities in Georgia are already implementing aerial mosquito applications of Nature-Cide with great success, and we're in discussions with the Georgia Emergency Management and Homeland Security Agency (GEMA) and Federal Emergency Management Agency (FEMA) to expand its use in disaster relief, particularly after storms where mosquito-borne illnesses spike.' expand The Origins of Med-X Ironically, Nature-Cide was initially a byproduct of Med-X's other divisions, such as Thermal-Aid and Malibu Brands. However, the company's journey truly took off through its eco-friendly Integrated Pest Management (IPM) services for rattlesnake abatement in Los Angeles county in the cities of Malibu and Calabasas. The market was and still is in desperate need of minimum-risk eco-friendly pest control, and Med-X stepped in to set a new benchmark in environmentally responsible pest management. What began as a niche, local solution is now becoming a standard in the professional pest control industry globally. The Health Credentials of Nature-Cide The company soon began earning national and international recognition for providing effective alternatives to conventional pesticides across residential, commercial, and the agricultural sectors. Proudly produced in the USA under strict quality standards, Nature-Cide reflects Med-X's commitment to sustainable pest management innovation. Its plant-based formulation not only prioritizes safety but delivers industrial-grade results, challenging long-held assumptions about what natural products can achieve in professional settings. 'As parents and professionals, we wanted to create solutions that help families and protect communities,' said Jennifer Mills, President of Med-X. 'Seeing this idea—born right here in Los Angeles—resonate around the globe is beyond rewarding. But our work is far from done.' Verification and Authenticity Ongoing scientific research continues to validate the efficacy of the Nature-Cide brand. A 2019 independent, non-sponsored, peer-reviewed study published in the Journal of the Florida Mosquito Control Association showed that Nature-Cide was more effective than leading synthetic and botanical insecticides in controlling Aedes albopictus mosquitoes—carriers of West Nile virus and dengue fever. The study documented a 90% decrease in adult female mosquitoes four weeks after treatment, highlighting Nature-Cide's superior performance compared to widely used pyrethroid-based solutions. Growing Public Health Role and Global Reach Med-X is also working with policymakers to incorporate safer pest control options into public health programs. In several counties in the state of Georgia, the company promoted the use of Nature-Cide in aerial mosquito control efforts with the hopes of partnering with state agencies like GEMA and federal organizations, including FEMA, to support mosquito-borne disease prevention in high-risk areas. In November 2024, the company earned OMRI certification for one of its Nature-Cide products approved for food production use—solidifying its credibility in the agricultural space. Med-X has also expanded into Mexico, the Caribbean while working in Chile, Argentina, Peru, and Colombia, supported by strategic distribution partnerships. A broader global distribution alliance has extended the ongoing registration process across more than 29 territories in Asia, Oceania, Southern Africa, and the Middle East. Despite early skepticism about using essential oils for industrial pest control, Med-X gained traction by allowing local agencies and pest control operators to run their own evaluations. As consistent results emerged, demand soared and continued. Moving Forward Today, Nature-Cide products are trusted by professional pest control applicators on the global stage. Med-X continues to build partnerships with public health leaders, environmental organizations, and governments. The company's full product line is now available to consumers via Nature-Cide website and Amazon Prime, earning a growing base of positive reviews. Med-X's approach blends scientific integrity, environmental responsibility, with global engagement. What began as a local solution for rattlesnake abatement is now garnering a safer, science-driven future for pest control. With Nature-Cide, Med-X is shaping the future of numerous safe, science-based solutions to build a healthier world for all.
