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Manhattan Laser Spa Continues to Set the Standard for Non-Invasive Aesthetic Care in Sunny Isles Beach

Manhattan Laser Spa Continues to Set the Standard for Non-Invasive Aesthetic Care in Sunny Isles Beach

Globe and Mail4 days ago
Manhattan Laser Spa expands in Sunny Isles Beach, offering expert laser hair removal, Botox, and dermal fillers under Mila Alishaev's leadership.
Sunny Isles Beach, FL - July 24, 2025 - Manhattan Laser Spa, led by Founder and CEO Mila Alishaev, is proud to reaffirm its commitment to cutting-edge, non-invasive aesthetic solutions at its Sunny Isles Beach location.
With a growing reputation for excellence, the spa continues to offer clients in South Florida personalized, high-quality treatments that prioritize safety, innovation, and natural-looking results.
At the heart of this continued success is a focus on clinical expertise, modern technology, and a personalized approach to beauty. Alishaev, a seasoned entrepreneur and visionary in the cosmetic industry, emphasizes that every service offered at Manhattan Laser Spa is guided by a singular goal: helping clients look and feel their best without compromising on safety or comfort.
Expanding Access to Leading Services in Cosmetic Enhancement
With increasing demand for non-surgical beauty procedures, Manhattan Laser Spa has become a trusted name in South Florida.
Its Sunny Isles Beach facility offers a full suite of advanced treatments, including laser hair removal, designed to provide long-lasting results with minimal discomfort.
This location also specializes in FDA-approved injectables like Botox, a solution widely used to minimize the appearance of fine lines and wrinkles. For those seeking more volume or facial contouring, the spa provides expertly administered dermal fillers, customized to complement individual facial structure and aesthetic goals.
These services are performed under the supervision of trained professionals using state-of-the-art equipment, ensuring that every treatment meets the highest standard of care. Alishaev notes, 'Our goal is to make the most trusted aesthetic services accessible to clients in South Florida, while maintaining a strong commitment to medical integrity and visible results.'
A Vision Driven by Excellence and Innovation
Mila Alishaev's leadership is central to the spa's continued success and expansion. Her passion for innovation and dedication to her clients' satisfaction has not only elevated the spa's reputation but has also helped set a new standard in the aesthetic care industry.
By consistently investing in the latest technologies and staff training, she ensures Manhattan Laser Spa remains at the forefront of the cosmetic field.
'Cosmetic enhancements are no longer just about trends; they're about confidence, health, and the power of choice,' says Alishaev. 'At Manhattan Laser Spa, we don't believe in one-size-fits-all. Every client deserves a customized approach based on their individual goals and skin profile.'
As the beauty industry evolves, Manhattan Laser Spa remains a leading example of what modern, client-focused care should look like. With its expanded offerings in Sunny Isles Beach and continued dedication to safety and innovation, the spa is positioned to remain a leader in aesthetic medicine for years to come.
About Manhattan Laser Spa
Founded by Mila Alishaev, Manhattan Laser Spa is a full-service medical spa specializing in non-invasive beauty solutions.
With multiple locations, including its growing presence in Sunny Isles Beach, the spa has earned a strong reputation for quality care and natural results. Services include laser hair removal, Botox, dermal fillers, skin rejuvenation, and more.
For more information or to schedule a consultation, visit https://manhattanlaserspa.com/.
Media Contact
Company Name: Manhattan Laser Spa
Contact Person: Mila Alishaev
Email: Send Email
Phone: 7867514733
Address: 16850, Collins Ave #105
City: Sunny Isles Beach
State: Florida, 33160
Country: United States
Website: https://manhattanlaserspa.com/
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Sarepta Therapeutics Provides Clarifying Statement on ELEVIDYS
Sarepta Therapeutics Provides Clarifying Statement on ELEVIDYS

Globe and Mail

time2 days ago

  • Globe and Mail

Sarepta Therapeutics Provides Clarifying Statement on ELEVIDYS

Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, today issued the following statement: Just before 6:00 p.m. ET today, the U.S. Food and Drug Administration (FDA) issued a press release announcing an investigation into the death of an eight-year-old Duchenne muscular dystrophy (Duchenne) patient who had received ELEVIDYS (delandistrogene moxeparvovec) gene therapy. The death of this patient was deemed unrelated to treatment with ELEVIDYS. As reported yesterday by Naomi Kresge at Bloomberg News: Roche Holding AG says the recent death of a patient in Brazil who had been treated with gene therapy Elevidys for Duchenne muscular dystrophy is unrelated to the treatment. * The boy wasn't a clinical trial participant; reporting physician assessed his death as being unrelated to the gene therapy, Roche says in statement * Death was reported to health authorities * Roche, which markets Sarepta's Duchenne treatment Elevidys outside the US, declines to comment on the boy's age or details of the case Sarepta reported this event to FDA on June 18, 2025, via the FDA's postmarketing electronic database, FAERS. At Sarepta, patient safety and well-being are always our top priority. We are committed to upholding the highest safety standards for all of our therapies, and do so in accordance with applicable law and commitment to full regulatory transparency. ELEVIDYS is the only approved gene therapy for families and children devastated by Duchenne, a rare, progressive and ultimately fatal disease. We remain committed to working closely with the FDA to ensure that all decisions are grounded in science and the best interests of patients, considering the compelling need of these families to access disease-modifying therapy. About ELEVIDYS (delandistrogene moxeparvovec-rokl) ELEVIDYS (delandistrogene moxeparvovec-rokl) is a single-dose, adeno-associated virus (AAV)-based gene transfer therapy for intravenous infusion designed to address the underlying genetic cause of Duchenne muscular dystrophy – mutations or changes in the DMD gene that result in the lack of dystrophin protein – through the delivery of a transgene that codes for the targeted production of ELEVIDYS micro-dystrophin in skeletal muscle. ELEVIDYS is indicated for the treatment of Duchenne muscular dystrophy (DMD) in individuals at least 4 years of age. For patients who are ambulatory and have a confirmed mutation in the DMD gene For patients who are non-ambulatory and have a confirmed mutation in the DMD gene. The DMD indication in non-ambulatory patients is approved under accelerated approval based on expression of ELEVIDYS micro-dystrophin in skeletal muscle. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). IMPORTANT SAFETY INFORMATION CONTRAINDICATION: ELEVIDYS is contraindicated in patients with any deletion in exon 8 and/or exon 9 in the DMD gene. WARNINGS AND PRECAUTIONS: Infusion-related Reactions: Infusion-related reactions, including hypersensitivity reactions and anaphylaxis, have occurred during or up to several hours following ELEVIDYS administration. Closely monitor patients during administration and for at least 3 hours after the end of infusion. If symptoms of infusion-related reactions occur, slow, or stop the infusion and give appropriate treatment. Once symptoms resolve, the infusion may be restarted at a lower rate. ELEVIDYS should be administered in a setting where treatment for infusion-related reactions is immediately available. Discontinue infusion for anaphylaxis. Acute Serious Liver Injury: Acute serious liver injury has been observed with ELEVIDYS, and administration may result in elevations of liver enzymes (such as GGT, GLDH, ALT, AST) or total bilirubin, typically seen within 8 weeks. Patients with preexisting liver impairment, chronic hepatic condition, or acute liver disease (e.g., acute hepatic viral infection) may be at higher risk of acute serious liver injury. Postpone ELEVIDYS administration in patients with acute liver disease until resolved or controlled. Prior to ELEVIDYS administration, perform liver enzyme test and monitor liver function (clinical exam, GGT, and total bilirubin) weekly for the first 3 months following ELEVIDYS infusion. Continue monitoring if clinically indicated, until results are unremarkable (normal clinical exam, GGT, and total bilirubin levels return to near baseline levels). Systemic corticosteroid treatment is recommended for patients before and after ELEVIDYS infusion. Adjust corticosteroid regimen when indicated. If acute serious liver injury is suspected, consultation with a specialist is recommended. Immune-mediated Myositis: In clinical trials, immune-mediated myositis has been observed approximately 1 month following ELEVIDYS infusion in patients with deletion mutations involving exon 8 and/or exon 9 in the DMD gene. Symptoms of severe muscle weakness, including dysphagia, dyspnea, and hypophonia, were observed. Limited data are available for ELEVIDYS treatment in patients with mutations in the DMD gene in exons 1 to 17 and/or exons 59 to 71. Patients with deletions in these regions may be at risk for a severe immune-mediated myositis reaction. Advise patients to contact a physician immediately if they experience any unexplained increased muscle pain, tenderness, or weakness, including dysphagia, dyspnea, or hypophonia, as these may be symptoms of myositis. Consider additional immunomodulatory treatment (immunosuppressants [e.g., calcineurin-inhibitor] in addition to corticosteroids) based on patient's clinical presentation and medical history if these symptoms occur. Myocarditis: Acute serious myocarditis and troponin-I elevations have been observed following ELEVIDYS infusion in clinical trials. If a patient experiences myocarditis, those with pre-existing left ventricle ejection fraction (LVEF) impairment may be at higher risk of adverse outcomes. Monitor troponin-I before ELEVIDYS infusion and weekly for the first month following infusion and continue monitoring if clinically indicated. More frequent monitoring may be warranted in the presence of cardiac symptoms, such as chest pain or shortness of breath. Advise patients to contact a physician immediately if they experience cardiac symptoms. Preexisting Immunity against AAVrh74: In AAV-vector based gene therapies, preexisting anti-AAV antibodies may impede transgene expression at desired therapeutic levels. Following treatment with ELEVIDYS, all patients developed anti-AAVrh74 antibodies. Perform baseline testing for presence of anti-AAVrh74 total binding antibodies prior to ELEVIDYS administration. ELEVIDYS administration is not recommended in patients with elevated anti-AAVrh74 total binding antibody titers greater than or equal to 1:400. Adverse Reactions: The most common adverse reactions (incidence ≥5%) reported in clinical studies were vomiting, nausea, liver injury, pyrexia, and thrombocytopenia. Report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. You may also report side effects to Sarepta Therapeutics at 1-888-SAREPTA (1-888-727-3782). For further information, please see the full Prescribing Information. About Sarepta Therapeutics Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. For more information, please visit or follow us on LinkedIn, X, Instagram and Facebook. Forward-Looking Statements This statement contains 'forward-looking statements.' Any statements that are not statements of historical fact may be deemed to be forward-looking statements. Words such as 'believe,' 'anticipate,' 'plan,' 'expect,' 'will,' 'may,' 'intend,' 'prepare,' 'look,' 'potential,' 'possible' and similar expressions are intended to identify forward-looking statements. These forward-looking statements include, without limitation, statements relating to our future operations, research and development programs, clinical trials and ELEVIDYS. Actual results could materially differ from those stated or implied by these forward-looking statements as a result of such risks and uncertainties. Known risk factors include the following: our products or product candidates may be perceived as insufficiently effective, unsafe or may result in unforeseen adverse events; our products or product candidates may cause undesirable side effects that result in significant negative consequences following any marketing approval; the possible impact of regulations and regulatory decisions by the FDA and other regulatory agencies on our business; and those risks identified under the heading 'Risk Factors' in our most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) as well as other SEC filings made by the Company, which you are encouraged to review. Any of the foregoing risks could materially and adversely affect the Company's business, results of operations and the trading price of Sarepta's common stock. For a detailed description of risks and uncertainties Sarepta faces, you are encouraged to review the SEC filings made by Sarepta. We caution investors not to place considerable reliance on the forward-looking statements contained herein. Sarepta does not undertake any obligation to publicly update its forward-looking statements based on events or circumstances after the date hereof, except as required by law. Source: Sarepta Therapeutics, Inc.

Amyotrophic Lateral Sclerosis Pipeline Insight 2025: 75+ Companies Accelerating Innovation Across Genetic and Neuroinflammatory Targets
Amyotrophic Lateral Sclerosis Pipeline Insight 2025: 75+ Companies Accelerating Innovation Across Genetic and Neuroinflammatory Targets

Globe and Mail

time3 days ago

  • Globe and Mail

Amyotrophic Lateral Sclerosis Pipeline Insight 2025: 75+ Companies Accelerating Innovation Across Genetic and Neuroinflammatory Targets

The ALS pipeline is gaining momentum, with over 75 companies advancing R&D across key targets like SOD1 mutations, TDP-43, C9orf72 expansions, and neuroinflammation. Approaches include ASOs, gene therapies, mitochondrial modulators, neuroprotective agents, and immune biologics. A major milestone was the FDA's 2023 accelerated approval of Biogen and Ionis's Tofersen for SOD1-ALS. DelveInsight's ' Amyotrophic Lateral Sclerosis (ALS) – Pipeline Insight, 2025 ' offers a detailed analysis of the evolving therapeutic landscape for ALS, a fatal neurodegenerative disease characterized by progressive loss of motor neurons, leading to muscle weakness, paralysis, and eventually respiratory failure. With most patients succumbing to the disease within 3–5 years of symptom onset, there remains a critical unmet need for effective disease-modifying treatments. 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ALS is often classified into sporadic (the most common form) and familial types, with the latter being linked to genetic mutations. Although the exact cause of ALS is unknown in most cases, environmental and genetic factors are believed to contribute to its development. Currently, there is no cure for ALS, but several treatment options aim to slow disease progression and manage symptoms. FDA-approved drugs like riluzole and edaravone offer modest benefits in extending survival or preserving function. Ongoing research is focused on gene therapies, neuroprotective agents, and immune-targeting approaches to better address the underlying mechanisms of the disease and improve patient outcomes. Find out more about amyotrophic lateral sclerosis medication at Amyotrophic Lateral Sclerosis Treatment Analysis: Drug Profile MN-166: MediciNova MN-166 is an orally administered small molecule glial attenuator that reduces neuroinflammation by suppressing pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-6, while potentially increasing the anti-inflammatory cytokine IL-10. It also functions as a toll-like receptor 4 (TLR4) antagonist, contributing further to its anti-inflammatory effects. MN-166 is currently in Phase II/III clinical trials for the treatment of ALS. RNS60: Revalesio RNS60 is designed to offer disease-modifying and potentially regenerative effects in neurological disorders. It works by activating signaling pathways that enhance mitochondrial function and reduce inflammation, offering neuroprotection and immune modulation. The FDA has granted RNS60 both Orphan Drug and Fast Track status for ALS. It is currently in Phase II clinical trials. VM202: Helixmith VM202 is a gene therapy aimed at tissue regeneration by promoting the production of hepatocyte growth factor (HGF) at the site of injection along peripheral nerves. HGF supports nerve protection, neuron growth, and muscle atrophy prevention. The FDA has granted VM202 Orphan Drug and Fast Track designations. It is being evaluated in Phase II trials for ALS treatment. Learn more about the novel and emerging amyotrophic lateral sclerosis pipeline therapies. By Product Type • Mono • Combination • Mono/Combination. By Stage • Late-stage products (Phase III) • Mid-stage products (Phase II) • Early-stage product (Phase I) along with the details of • Pre-clinical and Discovery stage candidates • Discontinued & Inactive candidates By Route of Administration • Intravenous • Subcutaneous • Oral • Intramuscular By Molecule Type • Monoclonal antibody • Small molecule • Peptide Scope of the Amyotrophic Lateral Sclerosis Pipeline Report • Coverage: Global • Key Amyotrophic Lateral Sclerosis Companies: Ionis Pharmaceuticals, 1ST Biotherapeutics, Scholar Rock, Revalesio, QurAlis Corporation, Sanofi, MediciNova, Helixmith, Verge Genomics, UCB, and others. • Key Amyotrophic Lateral Sclerosis Pipeline Therapies: ION363, FB418, SRK-015, RNS60, QRL-201, SAR443820, MN-166, VM202, VRG-50635, Zilucoplan, and others. Explore detailed insights on drugs used in the treatment of amyotrophic lateral sclerosis here. Table of Contents 1. Introduction 2. Executive Summary 3. Amyotrophic Lateral Sclerosis Pipeline: Overview 4. Analytical Perspective In-depth Commercial Assessment 5. Amyotrophic Lateral Sclerosis Pipeline Therapeutics 6. Amyotrophic Lateral Sclerosis Pipeline: Late-Stage Products (Phase III) 7. Amyotrophic Lateral Sclerosis Pipeline: Mid-Stage Products (Phase II) 8. Amyotrophic Lateral Sclerosis Pipeline: Early Stage Products (Phase I) 9. Therapeutic Assessment 10. Inactive Products 11. Company-University Collaborations (Licensing/Partnering) Analysis 12. Key Companies 13. Key Products 14. Unmet Needs 15. Market Drivers and Barriers 16. Future Perspectives and Conclusion 17. Analyst Views 18. Appendix About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform, PharmDelve. Media Contact Company Name: DelveInsight Contact Person: Jatin Vimal Email: Send Email Phone: +14699457679 Address: 304 S. Jones Blvd #2432 City: Las Vegas State: Nevada Country: United States Website:

Manhattan Laser Spa Continues to Set the Standard for Non-Invasive Aesthetic Care in Sunny Isles Beach
Manhattan Laser Spa Continues to Set the Standard for Non-Invasive Aesthetic Care in Sunny Isles Beach

Globe and Mail

time4 days ago

  • Globe and Mail

Manhattan Laser Spa Continues to Set the Standard for Non-Invasive Aesthetic Care in Sunny Isles Beach

Manhattan Laser Spa expands in Sunny Isles Beach, offering expert laser hair removal, Botox, and dermal fillers under Mila Alishaev's leadership. Sunny Isles Beach, FL - July 24, 2025 - Manhattan Laser Spa, led by Founder and CEO Mila Alishaev, is proud to reaffirm its commitment to cutting-edge, non-invasive aesthetic solutions at its Sunny Isles Beach location. With a growing reputation for excellence, the spa continues to offer clients in South Florida personalized, high-quality treatments that prioritize safety, innovation, and natural-looking results. At the heart of this continued success is a focus on clinical expertise, modern technology, and a personalized approach to beauty. Alishaev, a seasoned entrepreneur and visionary in the cosmetic industry, emphasizes that every service offered at Manhattan Laser Spa is guided by a singular goal: helping clients look and feel their best without compromising on safety or comfort. Expanding Access to Leading Services in Cosmetic Enhancement With increasing demand for non-surgical beauty procedures, Manhattan Laser Spa has become a trusted name in South Florida. Its Sunny Isles Beach facility offers a full suite of advanced treatments, including laser hair removal, designed to provide long-lasting results with minimal discomfort. This location also specializes in FDA-approved injectables like Botox, a solution widely used to minimize the appearance of fine lines and wrinkles. For those seeking more volume or facial contouring, the spa provides expertly administered dermal fillers, customized to complement individual facial structure and aesthetic goals. These services are performed under the supervision of trained professionals using state-of-the-art equipment, ensuring that every treatment meets the highest standard of care. Alishaev notes, 'Our goal is to make the most trusted aesthetic services accessible to clients in South Florida, while maintaining a strong commitment to medical integrity and visible results.' A Vision Driven by Excellence and Innovation Mila Alishaev's leadership is central to the spa's continued success and expansion. Her passion for innovation and dedication to her clients' satisfaction has not only elevated the spa's reputation but has also helped set a new standard in the aesthetic care industry. By consistently investing in the latest technologies and staff training, she ensures Manhattan Laser Spa remains at the forefront of the cosmetic field. 'Cosmetic enhancements are no longer just about trends; they're about confidence, health, and the power of choice,' says Alishaev. 'At Manhattan Laser Spa, we don't believe in one-size-fits-all. Every client deserves a customized approach based on their individual goals and skin profile.' As the beauty industry evolves, Manhattan Laser Spa remains a leading example of what modern, client-focused care should look like. With its expanded offerings in Sunny Isles Beach and continued dedication to safety and innovation, the spa is positioned to remain a leader in aesthetic medicine for years to come. About Manhattan Laser Spa Founded by Mila Alishaev, Manhattan Laser Spa is a full-service medical spa specializing in non-invasive beauty solutions. With multiple locations, including its growing presence in Sunny Isles Beach, the spa has earned a strong reputation for quality care and natural results. Services include laser hair removal, Botox, dermal fillers, skin rejuvenation, and more. For more information or to schedule a consultation, visit Media Contact Company Name: Manhattan Laser Spa Contact Person: Mila Alishaev Email: Send Email Phone: 7867514733 Address: 16850, Collins Ave #105 City: Sunny Isles Beach State: Florida, 33160 Country: United States Website:

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