Bristol Myers to pay $1.5 billion upfront for BioNTech cancer drug partnership
Bristol said it will co-develop and co-commercialize BioNTech's drug, BNT327, for multiple solid tumour types.
The deal underscores the industry's focus on a new dual mechanism of action in oncology. BNT327 is designed to activate the immune system, similar to an established drug class including Merck & Co's (MRK.N), opens new tab Keytruda, but also to cut a tumour's blood supply.
"We are impressed by the innovation that BioNTech has achieved to date and we look forward to partnering to accelerate existing clinical trials and time to market, while expanding the number of potential indications," Bristol Myers CEO Chris Boerner said in a statement.
Instil Bio, opens new tab(TIL.O), opens new tab and ImmuneOnco (1541.HK), opens new tab are working on a similar compound called SYN-2510. Summit Therapeutics, opens new tab(SMMT.O), opens new tab and Akeso (9926.HK), opens new tab have formed another partnership in the development race with a drug candidate called ivonescimab.
BioNTech took full ownership of BNT327 through the acquisition, opens new tab of China's Biotheus earlier this year for $800 million upfront and up to $150 million contingent on development achievements.
It previously held certain rights in the drug under a 2023 collaboration, opens new tab deal.
In addition to the initial payment, Bristol plans to pay BioNTech up to $2 billion more in non-contingent anniversary payments through 2028. BioNTech may also earn up to $7.6 billion more in development, regulatory and commercial milestones, Bristol said.
The companies will share global profits and losses from the drug equally, and joint development and manufacturing costs will also be shared on a 50/50 basis, subject to some exceptions.
BNT327, part of a drug category known as bispecific antibodies, is currently being tested as a first-line treatment in extensive stage small cell lung cancer and non-small cell lung cancer. More than 1,000 patients have been treated with the drug to date.
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