Overfishing Threatens a Third of Global Fish Stocks, FAO Says
More than a third of global fish stocks are being depleted at a pace that's driving down populations, marking a trend that's been getting worse in recent years, according to a study by the Food and Agriculture Organization.
The Rome-based United Nations agency found that 35.5% of marine stocks are subject to overfishing, based on the most recent catch data, which uses an improved methodology to assess stocks in 2021. The findings, unveiled on Wednesday at the UN Oceans Conference in Nice, make clear that continuing current levels of fishing would have dire consequences, FAO said.
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Yahoo
11 hours ago
- Yahoo
Editas Medicine Reports Proprietary Targeted Lipid Nanoparticle Delivery in Non-Human Primates Enables In Vivo HBG1/2 Promoter Editing for Sickle Cell Disease and Beta Thalassemia at the European Hematology Association 2025 Congress in June
Achieved 58% mean editing at five months after a single dose using high efficiency HSC delivery, demonstrating therapeutically relevant editing levels using a clinically validated strategy. Achievement supports development of a novel, in vivo approach to treating sickle cell disease and beta thalassemia. CAMBRIDGE, Mass., June 12, 2025 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a pioneering gene editing company, today shared new in vivo data demonstrating therapeutically relevant levels of HBG1/2 promoter editing in hematopoietic stem cells (HSCs) with a single dose of proprietary targeted lipid nanoparticle (tLNP) in non-human primates (NHPs). This clinically validated approach targeting HBG1/2 promoters to upregulate fetal hemoglobin (HbF) is in pre-clinical development as a potential transformative in vivo gene editing medicine for the treatment of sickle cell disease and beta thalassemia. The Company reported these data in a presentation available today and will detail the data in a poster session on Saturday, June 14th 6:30 - 7:30 p.m. CEST (12:30 – 1:30 p.m. EDT) at the European Hematology Association (EHA) 2025 Congress in Milan, Italy. In this study, the Company's proprietary tLNP formulation delivered HBG1/2 promoter editing cargo to HSCs in NHPs. Latest data from this ongoing NHP study showed that at five months a single intravenous administration of Editas' tLNP resulted in mean on-target editing levels in the HBG1/2 promoter region of 58% in HSCs: well exceeding the predicted editing threshold of ≥25% required for therapeutic benefit. In addition to achieving therapeutically relevant editing levels, the biodistribution data in NHPs with Editas' tLNP continue to show significant de-targeting of the liver in contrast to standard LNPs. 'These data from our in vivo HSC program confirm our ability to achieve high efficiency delivery, therapeutically relevant editing levels and favorable biodistribution in NHPs. These data validate the further development of Editas' proprietary HSC-tLNP for editing of the HBG1/2 promoters for the treatment of sickle cell disease and beta thalassemia,' said Linda C. Burkly, Ph.D., Executive Vice President and Chief Scientific Officer, Editas Medicine. Editas Medicine's in vivo HSC program targets HBG1/2 promoters to mimic naturally occurring mechanisms of hereditary persistence of fetal hemoglobin (HPFH) and utilizes proprietary AsCas12a to edit with high efficiency and minimize off-target editing. Editing the HBG1/2 promoters with AsCas12a with the investigational medicine reni-cel led to robust increases in HbF and total hemoglobin (Hb) in clinical trials. The presentation details are listed below. Abstracts can be accessed on the EHA website, and the presentation will be posted on the Editas Medicine website during the conference. Poster Presentation Details: Title: Targeted Lipid Nanoparticle Delivery in Non-Human Primates Enables In Vivo HBG1/2 Promoter Editing for β-hemoglobinopathies Date/Time: Saturday, June 14, 2025, 6:30 - 7:30 p.m. CEST/ 12:30 – 1:30 p.m. EDT Location: Allianz MiCo, Milano Convention Centre Session: Poster Session 2 About Editas Medicine As a pioneering gene editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of in vivo medicines for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision in vivo gene editing medicines for a broad class of diseases. Editas Medicine is the exclusive licensee of Broad Institute's Cas12a patent estate and Broad Institute and Harvard University's Cas9 patent estates for human medicines. For the latest information and scientific presentations, please visit CONTACT: Media and Investor Contacts: media@ ir@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Forbes
a day ago
- Forbes
How To Make AI Your Playmate For Life: 4 Easy Steps
Playing is not only for children. It is time to infuse the rest of our existence on earth with joy, ... More curiosity and playful discovery. Ai might help Today marks the UN International Day of Play, a reminder that play is not a luxury but a fundamental human right deserving protection throughout our lives. As we celebrate this recognition, we face a critical question: Will artificial intelligence become the catalyst for reigniting humanity's inherent drive to play, explore, and discover? Or will it inadvertently suffocate the very curiosity that fuels our growth and development? The answer lies not in the technology itself, but in how we choose to integrate it into our learning landscapes. Play is not merely childhood's pastime — it is the fundamental engine of human development that continues throughout our lives. "Play disarms fear, builds connectedness and teaches social skills and competencies for life." This statement from research of the Karyn Purvis Institute of Child Development captures the essence of what neuroscientists and developmental psychologists have long understood: play and curiosity exist in a symbiotic relationship, each feeding and amplifying the other. The science is unequivocal. Research from Harvard's neuroscience and child development experts shows that "allowing a learner to indulge their curiosity allows them to focus their effort on useful information that they do not yet possess." When we play, we create safe spaces for experimentation, failure, and discovery. When we're curious, we seek out playful interactions with our environment. This cycle doesn't diminish with age — it simply transforms, becoming more sophisticated and nuanced as we develop. Yet modern society has increasingly compartmentalized play as something reserved for children, creating artificial boundaries that separate "serious" learning from "frivolous" exploration. This fragmentation has contributed to what many educators describe as a curiosity crisis, where standardized learning environments prioritize conformity over creativity, answers over questions. Enter artificial intelligence with the potential to revolutionize how we approach lifelong learning and play. When thoughtfully implemented, AI can serve as humanity's most powerful ally in rekindling our natural propensity for exploration and discovery. Consider the immense potential of AI-powered learning environments that adapt to individual curiosity patterns. In the words of Harvard researchers, "AI companions that ask questions during activities like reading can improve children's comprehension and vocabulary." But this is merely the beginning. Imagine AI systems that recognize when learners are most curious, that present challenges precisely calibrated to maintain engagement without overwhelming, that create personalized pathways for exploration based on individual interests and learning styles. The beauty of AI lies in its ability to make learning genuinely playful again. Unlike traditional educational tools that often impose rigid structures, AI can create dynamic, responsive environments that mirror the natural patterns of play. It can generate infinite variations of problems, create immersive scenarios that blur the lines between learning and gaming, and provide immediate feedback that encourages experimentation rather than punishment for mistakes. Moreover, AI democratizes access to personalized learning experiences. For neurodivergent children particularly, "AI can be a powerful tool" that adapts to different cognitive styles and learning needs, ensuring that every individual can access the joy of discovery in ways that resonate with their unique neurological makeup. However, the promise of AI comes with profound risks that we must acknowledge and actively guard against. The same technology that could liberate human curiosity could just as easily extinguish it. The most insidious threat lies in AI's potential to provide answers too quickly, too easily, and too completely. When we can simply ask an AI assistant for information, we may lose the motivation to wonder, to question, to explore independently. The messy, uncertain process of discovery — which is where true learning happens — gets bypassed in favor of efficient information delivery. There's also the risk of algorithmic conformity. AI systems trained on existing data may inadvertently promote conventional thinking patterns, subtly discouraging the kind of divergent thinking that leads to breakthrough insights. When AI platforms optimize for "correct" answers rather than creative exploration, they may inadvertently create new forms of educational standardization that are even more powerful than traditional approaches. Perhaps most concerning is the potential for AI to create learned helplessness. If learners become dependent on AI assistance for problem-solving, they may lose confidence in their own ability to navigate uncertainty and ambiguity — skills that are fundamental to both play and curiosity. The surveillance aspects of AI systems also pose risks to the kind of uninhibited exploration that genuine play requires. When every interaction is monitored, analyzed, and optimized, the freedom to make mistakes, to pursue tangential interests, and to engage in purposeless exploration may be compromised. The key to harnessing AI's potential while avoiding its pitfalls lies in intentional design that prioritizes curiosity cultivation over information delivery. This requires a fundamental shift in how we conceptualize AI's role in learning and development. First, AI systems should be designed to ask better questions rather than provide better answers. Research emphasizes that effective learning happens "by harnessing children's natural curiosity and their proclivities to experiment, explore, problem solve, and stay engaged in meaningful activities." AI can amplify this natural tendency by posing intriguing questions, presenting puzzling scenarios, and creating cognitive gaps that learners feel compelled to fill. Second, AI should embrace and encourage productive failure. Instead of immediately correcting mistakes, AI systems should create environments where errors become springboards for deeper exploration. This mirrors the natural pattern of play, where trial and error is not only acceptable but essential. Third, AI should be designed to fade into the background, empowering human agency rather than replacing it. The goal should be to create scaffolding that supports independent exploration rather than dependence on technological assistance. Neuroscience research from the National Institute for Play shows that play experiences rewire neuron connections at the front end of the brain. As a consequence of that mechanism, playful social experiences may provide an opportunity to develop flexible behavioral strategies when novel and uncertain situations arise as an adult. This finding has important implications for how we structure AI-enhanced learning environments throughout the lifespan. Configured deliberately, and with a prosocial intent, AI has the potential to create what we might call "neurological playgrounds" — digital environments that stimulate the same neural pathways activated during physical play. These spaces could provide opportunities for adults to engage in the kind of exploratory behavior that is crucial for neuroplasticity and continued cognitive development. The research on curiosity and cognition suggests that "curiosity play uses existing knowledge and skills, encourages the struggle to master new competences, and is a process of manipulating, exploring, discovering and practicing." AI systems that support this process could help maintain cognitive flexibility and learning capacity throughout the human lifespan. To ensure that AI serves as a catalyst for curiosity rather than its destroyer, we need practical frameworks that guide implementation. The acronym PLAY offers a structure aligned with the four dimensions of human experience: P - Purpose (Aspiration): AI should help learners connect with their deeper sense of purpose and aspiration. Rather than simply delivering content, AI systems should help individuals explore their interests, values, and goals, creating learning pathways that feel personally meaningful and intrinsically motivated. L - Love (Emotion): Emotional engagement is crucial for both play and learning. AI should be designed to evoke positive emotions — wonder, excitement, joy, and the satisfaction of discovery. This means creating experiences that feel delightful rather than merely functional, that celebrate progress and curiosity rather than just achievement. A - Awareness (Thought): AI should enhance metacognitive awareness, helping learners understand their own thinking processes, learning patterns, and curiosity triggers. This involves creating reflection opportunities, making thinking visible, and encouraging learners to question their own assumptions and approaches. Y - Yearning (Sensation): The physical and sensory dimensions of learning should not be forgotten in digital environments. AI can create multisensory experiences that engage the body as well as the mind, recognizing that deep learning often involves physical interaction with the environment. We face an important moment in human history. The artificial intelligence revolution offers us an opportunity to rediscover and cultivate the power of play and curiosity that has driven human progress for millennia. But this outcome is not guaranteed — it requires conscious choice, thoughtful design, and vigilant attention to the values we embed in our technological systems. The question is not whether AI will influence how we learn and grow — it already is. The question is whether we will use this powerful tool to create a world where curiosity flourishes, where play continues throughout the lifespan, and where the joy of discovery remains a fundamental part of the human experience. AI, when properly harnessed, can be our partner in this essential work. The choice — and the responsibility — remains ours.
Associated Press
a day ago
- Associated Press
Janine Benyus on Biomimicry and the Art of Generous Design
From the Spring 2025 Bioneers Conference – In this insight keynote presentation, biomimicry icon Janine Benyus helps us imagine a city that functions like a forest – storing the same amount of water, cleaning and cooling as well as the same amount of air, cycling of nutrients and the nurturing of biodiversity. She also shares inspiring news about Biomimicry 3.8's Project Positive initiatives that reveal that this regenerative vision is indeed achievable and within our reach, if we are able to quiet our human cleverness sufficiently to be able to ask: What would Nature do here? We encourage you to learn more about her work at Biomimicry 3.8 - it begins by watching her video here - ==== Visit 3BL Media to see more multimedia and stories from GreenMoney Journal
