logo
‘Mind diet': Eating right can protect cognitive health as you age

‘Mind diet': Eating right can protect cognitive health as you age

Scroll.ina day ago
There's long been evidence that what we eat can affect our risk of dementia, Alzheimer's disease and cognitive decline as we age. But can any one diet actually keep the brain strong and lower dementia risk? Evidence suggests the so-called 'Mind diet' might.
The Mind diet (which stands for the Mediterranean-Dash intervention for neurocognitive delay) combines the well-established Mediterranean diet with the 'Dash' diet (dietary approaches to stop hypertension). However, it also includes some specific dietary modifications based on their benefits to cognitive health.
Both the Mediterranean diet and Dash diet are based on traditional eating patterns from countries which border the Mediterranean sea.
Both emphasise eating plenty of plant-based foods (such as fruits, vegetables, nuts and seeds), low-fat dairy products (such as milk and yoghurts) and lean proteins including fish and chicken. Both diets include very little red and processed meats. The Dash diet, however, places greater emphasis on consuming low-sodium foods, less added sugar and fewer saturated and trans-fats to reduce blood pressure.
Both diets are well-researched and shown to be effective in preventing lifestyle-related diseases – including cardiovascular disease and hypertension. They're also shown to help protect the brain's neurons from damage and benefit cognitive health.
The Mind diet follows many of the core tenets of both diets but places greater emphasis on consuming more foods that contain nutrients which promote brain health and prevent cognitive decline, including:
flavonoids and polyphenols found in fruit, vegetables, tea and dark chocolate
folate found in leafy greens and legumes
N-3 polyunsaturated fatty acids found in oily fish, nuts and seeds.
Numerous studies have been conducted on the Mind diet, and the evidence for this dietary approach's brain health benefit is pretty convincing.
For instance, one study asked 906 older adults about their usual diet – giving them a 'Mind score' based on the number of foods and nutrients they regularly consumed that are linked with lower dementia risk. The researchers found a link between people who had a higher Mind diet score and slower cognitive decline when followed up almost five years later.
Another study of 581 participants found that people who had closely followed either the Mind diet or the Mediterranean diet for at least a decade had fewer signs of amyloid plaques in their brain when examined post-mortem. Amyloid plaques are a key hallmark of Alzheimer's disease. Higher intake of leafy greens appeared to the most important dietary component.
A systematic review of 13 studies on the Mind diet has also found a positive association between adherence to the Mind diet and cognitive performance and function in older people. One paper included in the review even demonstrated a 53% reduction in Alzheimer's disease risk in those that adhered to the diet.
It's important to note that most of this research is based on observational studies and food frequency questionnaires, which have their limitations in research due to reliability and participant bias. Only one randomised control trial was included in the review. It found that women who were randomly assigned to follow the Mind diet over a control diet for a short period of time showed a slight improvement in memory and attention.
Research in this field is ongoing, so hopefully we'll soon have a better understanding of the diet's benefits – and know exactly why it's so beneficial.
Mind your diet
UK public health guidance recommends people follow a balanced diet to maintain good overall health. But the Mind diet offers a more targeted approach for those hoping to look after their cognitive health.
While public health guidance encourages people to eat at least five portions of fruit and vegetables daily, the Mind diet would recommend choosing leafy green vegetables (such as spinach and kale) and berries for their cognitive benefits.
Similarly, while UK guidance says to choose unsaturated fats over saturated ones, the Mind diet explicitly recommends that these fats come from olive oil. This is due to the potential neuroprotective effects of the fats found in olive oil.
If you want to protect your cognitive function as you age, here are some other small, simple swaps you can make each day to more closely follow the Mind diet:
upgrade your meals by sprinkling nuts and seeds on cereals, salads or yoghurts to increase fibre and healthy fats
eat the rainbow of fruit and vegetables, aiming to fill half your plate with these foods
canned and frozen foods are just as nutrient-rich as fresh fruits and vegetables
bake or airfry vegetables and meats instead of frying to reduce fat intake
opt for poly-unsaturated fats and oils in salads and dressings – such as olive oil
bulk out meat or meat alternatives with pulses, legumes chickpeas or beans. These can easily be added into dishes such as spaghetti bolognese, chilli, shepherd's pie or curry
use tinned salmon, mackerel or sardines in salads or as protein sources for meal planning.
These small changes can have a meaningful impact on your overall health – including your brain's health. With growing evidence linking diet to cognitive function, even little changes to your eating habits may help protect your mind as you age.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Hepatologist explains how gut influences memory, mood and mental wellbeing; unpacks why gut may be the ‘second brain'
Hepatologist explains how gut influences memory, mood and mental wellbeing; unpacks why gut may be the ‘second brain'

Hindustan Times

time6 hours ago

  • Hindustan Times

Hepatologist explains how gut influences memory, mood and mental wellbeing; unpacks why gut may be the ‘second brain'

Several cognitive functions, such as memory, thinking, and concentration, don't just stem from brain activity alone; they are also deeply influenced by gut health. This further demonstrates the importance of gut health in maintaining overall well-being, as it has the ability to influence major functions, including immunity and mental performance. In an interview with HT Lifestyle, Dr Amey Sonavane, consultant hepatology, AHNM, explained how key brain functions are connected to gut health. From memory to concentration, much of the cognitive functions are influenced by gut health. (Shutterstock) ALSO READ: Gastroenterologist shares what your stool's colour, consistency, and frequency tell about your gut health He said, 'Memory and brain function are also closely linked to gut health. The gut sends signals to the brain that affect focus, memory, and even decision-making. When gut bacteria are in poor shape, they can produce chemicals that travel through the bloodstream to the brain, potentially increasing inflammation and contributing to cognitive decline. Some early studies suggest that changes in gut bacteria may appear even before signs of memory loss or Alzheimer's disease show up. This makes the gut an important area to watch, not just for digestion, but for long-term brain health.' Let's take a closer look at the gut-brain axis and explore the fundamentals of this connection, from the microbiome and the chemicals that make the gut the 'second brain' to how your diet can help support this bi-directional relationship. Role of microbiome The microbiome is one of the vital factors at play that form the bedrock of the gut-brain axis, shaping and influencing major cognitive functions and mood regulation. While the gut-brain axis may seem complex, the gut microbiome holds the answers and simplifies it. Dr Amey spoke about the role of microbiome and explained, 'Over the past few years, scientists have discovered something quite remarkable - your gut does a lot more than digest food. Inside your digestive system lives a massive population of bacteria and other tiny organisms, collectively called the gut microbiome. These microorganisms affect how you feel, how your body handles food, and even how your brain works. In simple terms, your gut could be quietly shaping your mood, metabolism, and memory every single day.' Gut is the second brain for mood The roots of your happy moods may be in your gut.(Shutterstock) While cognitive functions like memory, concentration, attention, decision-making, and processing are shaped by gut health, even emotions can be influenced by what's going on in your gut. It signifies the powerful role of gut health, influencing both mind and mood. Dr Amey shed light on the connection to mood regulation and said, 'The gut and the brain are constantly in touch with each other through a network known as the gut-brain axis. In fact, the gut is often called the 'second brain' because it produces many of the same chemicals that your brain does.' 'For example, about 90 percent of your body's serotonin, a chemical that influences mood, is made in the gut. It regulates things like gut motility, secretion, and blood clotting. If the balance of bacteria in your gut is disturbed, it can trigger low moods, anxiety, or even depression. New research shows that improving gut health can actually help some people feel mentally better, giving rise to what are now being called 'psychobiotics', probiotics that support mental health,' he added. Brain-friendly foods Curd in Indian dishes like raita contains good bacteria that help to balance the oral microbiome. (Shutterstock) If the role of gut health in mental wellbeing feels intimidating because it's something that is beyond your conscious control and awareness, but it turns out you can actively take charge and consciously support this gut-brain axis by adding gut-healthy food to your diet. The hepatologist shared some gut-healthy foods and warned against one common habit. Dr Amey suggested, 'Traditional Indian diets actually offer a natural advantage. Fermented foods like curd, buttermilk, dosa, and idli are full of beneficial bacteria. Fruits, vegetables, whole grains, and lentils feed the good microbes in your gut and help keep harmful ones in check. On the other hand, overuse of antibiotics, low-fibre diets, stress, and lack of physical activity can damage the microbiome.' Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

Immune cells' fat blocks brain's ability to clean Alzheimer's plaques
Immune cells' fat blocks brain's ability to clean Alzheimer's plaques

The Hindu

time17 hours ago

  • The Hindu

Immune cells' fat blocks brain's ability to clean Alzheimer's plaques

Alzheimer's disease is a progressive brain disorder and a form of dementia that affects memory, thinking, and behaviour. As symptoms become more severe, the disease can seriously affect a person's ability to perform tasks that would otherwise be deemed routine, like brushing teeth, making a meal or even recognising family members. For many years, the leading theory has been that Alzheimer's is caused when two harmful proteins called amyloid-beta and tau accumulate in the brain. This pile-up sets off a chain of events, eventually damaging nerve cells and leading to memory loss, confusion, and mood changes. This destruction doesn't happen overnight. It begins years, even decades before symptoms appear. In 2021, an estimated 57 million people worldwide were affected by dementia, with Alzheimer's contributing to 60-70% of the cases. Currently, there is no cure for Alzheimer's but there are treatments that can slow symptoms and improve quality of life. It isn't surprising that in the ongoing search for answers, scientists are increasingly turning their attention from neurons to their lesser-known but equally critical neighbours: microglia, the brain's resident immune cells. In a new study published in Immunity, researchers led by Gaurav Chopra at Purdue University have uncovered how fat metabolism in microglia may be a key driver of disease progression. 'This study is pretty interesting and part of a growing body of studies indicating the role of fat metabolism problems in cells around amyloid plaques,' Indian Institute of Science professor Deepak Nair said. The lipid link In healthy brains, microglia serve as surveillance cells, clearing away waste products and toxic proteins like amyloid-beta (Aβ), the sticky molecule that forms the hallmark plaques in Alzheimer's. This clean-up process helps protect neurons from damage. But in Alzheimer's patients this mechanism fails. 'The big question was: how and why are microglia no longer able to eat up or clear these plaques?' said Priya Prakash, a co-lead author of the paper. 'This isn't a new observation. Dr. Alzheimer himself noted fat vacuoles in glial cells over a century ago, but their functional significance has remained unclear until now.' The study identified DGAT2, an enzyme that converts free fatty acids into triacylglycerols (TAGs), the main component of lipid droplets, as a key player. In both mouse models and post-mortem human brain samples from patients with late-stage Alzheimer's, the researchers found that microglia near amyloid plaques have high DGAT2 expression and are bloated with lipid droplets, particularly in the hippocampus, the region responsible for memory. 'We see that the proximity of microglia to plaques correlates with lipid droplet size. The closer they are, the fatter they get,' Prakash noted. What causes the lipid overload? According to the study, Aβ exposure triggers a metabolic chain reaction. Microglia start converting free fatty acids into fats stored inside lipid droplets. Over time, this lipid build-up disrupts their ability to engulf and digest more Aβ, setting up a vicious cycle: more plaques lead to more fat, which leads to more dysfunction. The research team used advanced imaging, lipidomic analysis, and metabolomics to track how microglia's lipid profiles changed over time in response to Aβ exposure. Initially, microglia accumulated toxic free fatty acids. Later, with the help of the DGAT2 enzyme, they converted these fatty acids into triacylglycerols and stored them in lipid droplets. To test whether this lipid build-up could be reversed, the researchers used genetically engineered mice that mimicked human Alzheimer's, known as 5xFAD mice. Two methods were used to reduce DGAT2 activity: a pharmacological inhibitor, currently in clinical trials for non-alcoholic fatty liver disease, and a custom-designed PROTAC-like degrader that targets DGAT2 specifically in microglia. 'When we blocked DGAT2, we saw reduced fat accumulation in microglia and restoration of their ability to clear amyloid plaques. Even a one-week treatment in aged mice with heavy pathology drastically reduced the plaque burden by over 50% and significantly reduced neuronal damage markers,' Prakash said. However, Prof. Nair cautioned that the animal model used in this study is an accelerated Alzheimer's disease model that relies on Aβ pathology, so the findings may not be equally applicable to all forms or stages of the disease. A fat-filled puzzle Lipid droplets are not inherently bad. In fact, they help cells survive stress by safely storing excess fat. But in microglia that are chronically exposed to Aβ, this once-protective response turns harmful. The study's authors suggested that microglia sacrifice their protective immune function in exchange for lipid safety and that this trade-off may be a key step in Alzheimer's progression. The study also uncovered a notable sex-based difference: female mice accumulated more lipid droplets in their microglia and showed more severe microglial impairment than males. This echoed real-world data that show women face a higher risk of developing Alzheimer's. Because DGAT2 is expressed in many cell types throughout the body, targeting it systemically could lead to unwanted side effects. The team's microglia-specific degrader represents an early but promising step towards cell-selective therapy. 'This is a beautiful proof of concept,' Prof. Nair said. 'We've had over 100 drugs in clinical trials for Alzheimer's in the past 20 years, and very few have succeeded. The disease is complex in its origin — it's not caused by one thing.' While the amyloid cascade hypothesis has dominated the field for decades, more recent theories incorporate inflammation, tau protein tangles, metabolic dysfunction, and now, lipid metabolism. 'In brain diseases, homeostasis slowly breaks down until the system is overwhelmed,' Prof. Nair said. 'If we can control just three or four critical pathways, lipid metabolism being one of them, it might be enough to slow down that collapse. 'And slowing down matters. A five-year delay in Alzheimer's onset would significantly reduce the socioeconomic burden of the disease.' Manjeera Gowravaram has a PhD in RNA biochemistry and works as a freelance science writer.

‘Mind diet': Eating right can protect cognitive health as you age
‘Mind diet': Eating right can protect cognitive health as you age

Scroll.in

timea day ago

  • Scroll.in

‘Mind diet': Eating right can protect cognitive health as you age

There's long been evidence that what we eat can affect our risk of dementia, Alzheimer's disease and cognitive decline as we age. But can any one diet actually keep the brain strong and lower dementia risk? Evidence suggests the so-called 'Mind diet' might. The Mind diet (which stands for the Mediterranean-Dash intervention for neurocognitive delay) combines the well-established Mediterranean diet with the 'Dash' diet (dietary approaches to stop hypertension). However, it also includes some specific dietary modifications based on their benefits to cognitive health. Both the Mediterranean diet and Dash diet are based on traditional eating patterns from countries which border the Mediterranean sea. Both emphasise eating plenty of plant-based foods (such as fruits, vegetables, nuts and seeds), low-fat dairy products (such as milk and yoghurts) and lean proteins including fish and chicken. Both diets include very little red and processed meats. The Dash diet, however, places greater emphasis on consuming low-sodium foods, less added sugar and fewer saturated and trans-fats to reduce blood pressure. Both diets are well-researched and shown to be effective in preventing lifestyle-related diseases – including cardiovascular disease and hypertension. They're also shown to help protect the brain's neurons from damage and benefit cognitive health. The Mind diet follows many of the core tenets of both diets but places greater emphasis on consuming more foods that contain nutrients which promote brain health and prevent cognitive decline, including: flavonoids and polyphenols found in fruit, vegetables, tea and dark chocolate folate found in leafy greens and legumes N-3 polyunsaturated fatty acids found in oily fish, nuts and seeds. Numerous studies have been conducted on the Mind diet, and the evidence for this dietary approach's brain health benefit is pretty convincing. For instance, one study asked 906 older adults about their usual diet – giving them a 'Mind score' based on the number of foods and nutrients they regularly consumed that are linked with lower dementia risk. The researchers found a link between people who had a higher Mind diet score and slower cognitive decline when followed up almost five years later. Another study of 581 participants found that people who had closely followed either the Mind diet or the Mediterranean diet for at least a decade had fewer signs of amyloid plaques in their brain when examined post-mortem. Amyloid plaques are a key hallmark of Alzheimer's disease. Higher intake of leafy greens appeared to the most important dietary component. A systematic review of 13 studies on the Mind diet has also found a positive association between adherence to the Mind diet and cognitive performance and function in older people. One paper included in the review even demonstrated a 53% reduction in Alzheimer's disease risk in those that adhered to the diet. It's important to note that most of this research is based on observational studies and food frequency questionnaires, which have their limitations in research due to reliability and participant bias. Only one randomised control trial was included in the review. It found that women who were randomly assigned to follow the Mind diet over a control diet for a short period of time showed a slight improvement in memory and attention. Research in this field is ongoing, so hopefully we'll soon have a better understanding of the diet's benefits – and know exactly why it's so beneficial. Mind your diet UK public health guidance recommends people follow a balanced diet to maintain good overall health. But the Mind diet offers a more targeted approach for those hoping to look after their cognitive health. While public health guidance encourages people to eat at least five portions of fruit and vegetables daily, the Mind diet would recommend choosing leafy green vegetables (such as spinach and kale) and berries for their cognitive benefits. Similarly, while UK guidance says to choose unsaturated fats over saturated ones, the Mind diet explicitly recommends that these fats come from olive oil. This is due to the potential neuroprotective effects of the fats found in olive oil. If you want to protect your cognitive function as you age, here are some other small, simple swaps you can make each day to more closely follow the Mind diet: upgrade your meals by sprinkling nuts and seeds on cereals, salads or yoghurts to increase fibre and healthy fats eat the rainbow of fruit and vegetables, aiming to fill half your plate with these foods canned and frozen foods are just as nutrient-rich as fresh fruits and vegetables bake or airfry vegetables and meats instead of frying to reduce fat intake opt for poly-unsaturated fats and oils in salads and dressings – such as olive oil bulk out meat or meat alternatives with pulses, legumes chickpeas or beans. These can easily be added into dishes such as spaghetti bolognese, chilli, shepherd's pie or curry use tinned salmon, mackerel or sardines in salads or as protein sources for meal planning. These small changes can have a meaningful impact on your overall health – including your brain's health. With growing evidence linking diet to cognitive function, even little changes to your eating habits may help protect your mind as you age.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store