
Nuclear wasps fallout explodes as worker from bomb factory blows the lid on the true threat of the crisis... while battling FIVE cancers
Reif, 76, worked there for 10 years in the 1980s and 1990s and had to retire after being hit by a torrent of different cancers - skin, bladder, kidney, rectal and pancreatic.
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The Independent
23 minutes ago
- The Independent
The best supermarket cakes to bring with you to a Macmillan Coffee Morning
Macmillan Coffee Morning is celebrating 35 years of bringing people together to raise money for those living with cancer. Since 1990, the fundraising event has raised more than £300m for Macmillan Cancer Support. In 2024 alone, the charity provided vital support to around 2.4 million people affected by cancer across the UK. The charity's famous Coffee Morning event is a chance for people to get involved and donate to the cause. The idea is simple: bring baked treats for the group to eat while enjoying a cup of coffee or tea and ask everyone to donate money while having a good time. You can make it as wild or as simple as you like; whether it's organised among teachers and parents at a school, a sober rave with a group of colleagues at work or in your living room with friends. And there's no reason to stick to coffee and cakes, mix things up by organising a Coffee Morning with a difference. Macmillan Cancer Support makes it easy for hosts with information and advice online on how to organise the event, and a fundraising kit that contains everything from balloons and bunting to posters and food labels. Want to be a Coffee Morning Host? Traditionally, people bake their own cakes to take to Macmillan Coffee Mornings. But if you're strapped for time (or skills), then this shouldn't dissuade you from taking part. Requiring minimal effort but often tasting just as nice, supermarket cakes are equally well-received. But with all the biggest supermarkets vying for your attention, which cake should you buy? If you're joining a Macmillan Coffee Morning soon and need some inspiration, the IndyBest team has tried and tasted the best supermarket cakes to enjoy with a cuppa (someone had to do it). How we tested The team sampled these cakes one by one, considering freshness, flavour, ingredients and the concept behind each. From classic carrot cake and tiered extravaganzas to rich red velvet and a spongey take on Eton mess, these are our favourites. The best supermarket cakes for 2025 are: Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland.


The Guardian
24 minutes ago
- The Guardian
Joanna Lyall obituary
During her long journalistic career, my friend Joanna Lyall, who has died aged 76, challenged preconceptions about what people with cancer needed to know about their illness. She also raised awareness about health and social issues such as bereavement, child carers and living with chronic illness. In the mid 1980s, when she proposed a book to enable people with cancer to make informed decisions about their care, patient-focused information was limited. In Living With Cancer (1987), which we co-authored, Joanna dug deep into the emotional, social and financial challenges, and told the human story of cancer through patient experiences with her trademark compassion. Born in Pimlico, central London, to Joan (nee Kenny) and Robert Lyall, an advertising executive, Joanna attended Our Lady of Sion Convent, in Bayswater, and later studied English and French at University College Dublin. After working for the Kensington Post and the Western Daily Press in Bristol, Joanna joined General Practitioner (GP) in 1977, before turning freelance in 1980. By subsequently writing for both healthcare users, in newspapers such as the Guardian and Sunday Times, and care providers in GP, Nursing Times and the Health Service Journal, Joanna took her message about the need for jargon-free communication, shared decision making, and both specialist care, to a wide audience. Joanna had strong French roots; an aunt was in the French Resistance during the second world war, and an uncle helped run an escape line across occupied France. Another uncle, Desmond Knox-Leet, co-founded Diptyque, which Joanna saw grow from a small shop in Paris in the 1960s to a global luxury perfume brand. From 2010 to 2020, Joanna was honorary secretary of the Pugin Society and, through her writing, highlighted the significance of Pugin in 19th-century architecture and design. Her genuine interest in other people's lives led her into obituary writing for the Guardian and the British Medical Journal. When diagnosed with pancreatic cancer earlier this year, Joanna refused to ask: 'Why me?' and said she didn't feel 'shortchanged in the longevity stakes'. Like many of the people she had interviewed nearly four decades earlier, her request was for effective symptom control and her long-held belief in the importance of good palliative care proved justified. Joanna was a much loved friend to a large circle of people. She is survived by her brother, Michael, her nieces, Alexandra and Katharine, her great-niece, Julia, and great-nephews, George and László.


Daily Mail
an hour ago
- Daily Mail
Prescription pills are being laced with synthetic opioid that is 40 times stronger than fentanyl
A synthetic drug more than 40 times stronger than fentanyl has infiltrated the US drug supply, with federal data estimating more than 2,000 Americans have already been killed. Nitazenes are a group of compounds developed in the 1950s as an opioid pain reliever, but they never made it to patients because of the extremely high risk of overdose. In addition to being stronger than fentanyl, it's about 100 times stronger than morphine. However, recently, the illegal lab-made compounds are increasingly being pressed into counterfeit pills that buyers believe are legitimate pharmaceuticals, such as Xanax or oxycodone. What they might not know is that nitazenes have been found in at least 4,300 law enforcement-led drug seizures since 2019. They are often mixed in with other counterfeit or illegal drugs, including opioid pills, heroin, fentanyl and methamphetamine. Earlier this year, 22-year-old Lucci Reyes-McCallister died after taking what he believed was a Xanax pill. The Texas native had no idea the fake medication was laced with a type of nitazene 25 times deadlier than fentanyl. Just six months later, his friend Hunter Clement, 21, suffered the same fate after swallowing a counterfeit Percocet containing nitazenes. In both cases, several doses of Narcan, the opioid overdose reversal agent, were not enough. Nitazenes were never widely used until now, with a surge leaving the CDC and law enforcement at a major disadvantage. They gained popularity rapidly starting in 2019, evading officials' limited testing capabilities, leading to underreported overdoses. There are dozens of analogs, or modified versions of nitazenes, that have varying levels of potency. Potency also varies among batches, depending on the type of nitazene analog lacing the drugs, and uneven mixing means one pill may have a lethal dose while another has barely any. Compared to fentanyl, the analogs butonitazene and etodesnitazene are 25 to 50 percent as strong, while isotonitazene (ISO) is five to 10 times stronger. The most extreme variants, N-pyrrolidino protonitazene and N-pyrrolidino etonitazene, are up to 25 times stronger and up to 43 times stronger, respectively. Nitazenes first appeared in the US as fentanyl, which has killed an average of 70,000 Americans annually over the past three years. At about the same time, nitazenes appeared in Europe and the UK, where they have spread quickly and have killed nearly a thousand people. From 2020 to 2021, Tennessee saw a notable jump in nitazene-related deaths. It was the first cluster of deaths linked to the synthetic drug the country had seen and caught the CDC's attention. Fatal overdoses there jumped from 10 to 42. Most of those deaths involved multiple substances, including fentanyl and meth. ISO drove most of the nitazene-linked deaths. From May 2024 to 2025, Houston, Texas DEA agents reported 15 nitazene overdose deaths in people ranging in age from 17 to 59. William Kimbell, the special agent in charge of the division, said: 'We started seeing it in the Houston area, our first seizure was in 2022. 'And kind of the reason we're talking now is over the last year we have seen a pretty dramatic increase in its usage in Houston and the surrounding area.' Kimbell added that the agency has seen a 15 percent increase in nitazene-related overdoses in Houston and surrounding areas between November 2024 and February 2025. Reyes-McCallister died in the Houston area on January 26. His counterfeit Xanax had been laced with N-pyrrolidino protonitazene. His mother Grey McCallister told the New York Post: 'It was the first time I'd ever heard of it. 'It took them seven rounds of Narcan to try to revive him.' Clement's mother was equally as unacquainted with the drug. She said: 'I told my husband, "I feel like that could be what Hunter died from."' The raw chemicals to make the drugs are believed to come from China and India. Chemical companies there are able to synthesize the compounds at scale in a relatively easy process of three or four steps before the substance is smuggled to the UK, Europe and the US. Compared to countries in Asia, Europe, South America, as well as Australia, New Zealand, and the Pacific islands, the US has the widest range of nitazene analogs and the most fatalities. In the US, drug seizures are ticking up. The Drug Enforcement Administration has reportedly seized nitazenes more than 4,000 times between 2019 and 2024. Andrew Renna, Assistant Port Director for Cargo Operations at JFK Airport in New York City said in May: 'Earlier this month, we seized almost a pound of nitazene that was going to a private residence in South Carolina. It was shipped from the United Kingdom. 'Unfortunately, here at JFK, we're seeing xylazine and nitazenes at least a few times a week in quantities ranging from just a few grams to upwards of a pound or more.' Nitazenes often evade detection in standard toxicology tests, allowing them to fly under the radar of public health officials and medical examiners. Many routine drug screens do not include tests for these synthetic opioids, meaning overdoses and deaths linked to nitazenes may be misclassified or underreported. This lack of visibility delays public health responses, leaving communities unaware of the growing threat on their streets. Nitazene overdose can lead to severe and life-threatening symptoms, including slow or shallow breathing, which indicates respiratory depression, a hallmark of opioid toxicity. If a good Samaritan passing by or a law enforcement officer only has one or two doses on them, it may not be enough to save the person's life.