Cobenfy (xanomeline/trospium chloride) and cost
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
The Guardian
43 minutes ago
- The Guardian
The Guardian view on RFK Jr's vaccine cuts: an assault on science from a politician unfit for his office
Science is not black and white. It's more complicated and more exciting. It's a constant process of exploration. An adventure into the unknown. Scientists come up with theories about what might be going on, and then test them. They don't always get it right. Far from it. But inch by inch, testing, failing and trying again, they make progress. Robert F Kennedy Jr, during Senate confirmation hearings for the role of secretary at the Department of Health and Human Services (HHS), seemed to get that. Those who feared what a vaccine sceptic might do in that role breathed again. 'I'm going to empower the scientists at HHS to do their job and make sure that we have good science that is evidence based … I'm not going to substitute my judgment for science,' he said. Yet now, without good explanation or sound science, he is cutting $500m of research funding for mRNA vaccines, claiming that they 'fail to protect effectively against upper respiratory infections like Covid and flu'. In fact, no Covid vaccine fully protects against infection, but they have been shown to prevent deaths in billions of people. The 22 contracts that will be cancelled include one with Moderna for a vaccine against bird flu, which many fear could trigger the next human pandemic (and there will be one). Instead, federal funds will go to vaccines developed in more traditional ways. Either Mr Kennedy lied to Congress or he has a different understanding of science and evidence from most scientists, unpicking what they thought was uncontestable. The childhood vaccine schedule is being reconsidered, and mandating the measles vaccine is being questioned in spite of fatal outbreaks in the US. He has sacked the Centers for Disease Control vaccine advisory panel and replaced it with many people known to have sceptical views. Mr Kennedy is particularly hostile to the mRNA vaccines against Covid-19, panning them in 2021 as the 'deadliest vaccines in history', wrongly claiming that half those suffering the rare side-effect of myocarditis would die or need heart transplants within five years. The vast majority have quickly recovered. Until 2023, he chaired an anti-vaccine organisation called Children's Health Defense, where he petitioned the Food and Drug Administration to rescind the licence of all Covid-19 vaccines and compared mandating vaccines to Nazi oppression in the second world war. This is the stuff of internet scares; labyrinthine tangles of misinformation dotted with odd inaccurate nuggets of quasi-science. It doesn't compare with the evidence base for mRNA vaccines, which went through clinical trials on hundreds of thousands of people and have since been used to vaccinate billions. Experts agree that the mRNA vaccines were a stunning breakthrough that allowed people to be protected in record time from Covid-19. They contain messenger RNA, a tiny bit of genetic code that teaches the immune system to fight the virus. No need to grow the virus in hen's eggs, which takes months. The 'plug and play' technology can be adapted against other viruses, such as flu, including some that devastate populations in poor countries. The inventors won the Nobel prize in 2023. Mr Kennedy's cancellation of funding not only stymies much research but also feeds worldwide doubt in mRNA vaccines. We are all the losers. Humanity needs these vaccines. Other countries need to step up with money and reassurance to try to heal this latest breach between science and nonsense. And Mr Kennedy is clearly unfit for the job he holds.
Daily Mail
an hour ago
- Daily Mail
I'm taking a drug prescribed to 18M Americans and feel like I'm losing my mind: Top doctors explain what's behind crippling side effects
A common pill prescribed to millions of Americans annually could lead to crippling depression, anxiety and mood swings, experts warn. About 18 million prescriptions are filled every year for prednisone, a corticosteroid used to treat everything from migraines to Crohn's disease to allergic reactions. Your browser does not support iframes.
Daily Mail
an hour ago
- Daily Mail
My baby girl was slightly stiff. Now she's been given just years to live after a devastating diagnosis
A new mom has shared her heartbreak after a subtle symptom in her newborn ended up leading to a horrific diagnosis that has now left her baby with only 10 years to live. Kaitlin Norton, 29, and Gerard Norton, 32, from Massapequa, New York, were enjoying the bliss of new parenthood after welcoming their daughter, Madeline, in December. But the joy of being first-time parents was quickly turned into fear and devastation when their 'completely normal' newborn was diagnosed with an extremely rare neurodegenerative disorder six months after her birth. There was only one warning sign that something was wrong, and it's something that could be easily overlooked by many parents: the youngster was a little stiff. 'She was holding her head up within a week. She wasn't the type of newborn to just cuddle up in your arms. It was also difficult to dress her,' Kaitlin shared exclusively with the Daily Mail. 'We noticed that she always held her arms close to her chest and it was hard to pull them out. But she was completely normal other than the stiffness.' Kaitlin explained that while it didn't seem like a big deal at first, her 'gut' told her that something was wrong, so she brought Madeline in to her pediatrician. Kaitlin Norton, 29, and Gerard Norton, 32, from Massapequa, New York, were enjoying the bliss of new parenthood after welcoming their daughter, Madeline, in December But the joy of being first-time parents quickly turned into devastation when their newborn was diagnosed with an extremely rare neurodegenerative disorder six months after her birth The doctor didn't seem too concerned, but he recommended they go see a neurologist to be sure there was nothing to worry about. The neurologist conducted full genetic testing. That is when the devastating news came in: Madeline had Pantothenate Kinase-Associated Neurodegeneration (PKAN), which is a rare genetic disorder that affects fewer than one in one million children. It causes dystonia (involuntary muscle contractions), significant speech disturbances, dementia, visual impairment and seizures among other things. They were told Madeline likely only had 10 to 15 years to live, and that while her early years may be normal, she will lose her motor functions, speech and ability to walk as she ages. 'It is a genetic mutation that causes an iron build up in her brain over childhood,' Kaitlin explained. 'Due to the iron in her brain, she'll experience a regression in motor skills. She will have dystonia and eventually require the use of a wheelchair and feeding tube... 'We truly only thought she had hypertonia and that physical therapy would help. We were completely blindsided when we received the results.' As expected, Kaitlin said they were 'devastated' over the fatal diagnosis. There was only one warning sign that something was wrong, and it's something that could be easily overlooked by many parents: the youngster was a little stiff Madeline has Pantothenate Kinase-Associated Neurodegeneration (PKAN), which is a rare genetic disorder that affects fewer than one in one million children They were told that Madeline likely only has 10 to 15 years to live, and that while her early years may be normal, she will lose her motor functions, speech and ability to walk as she ages She called that day 'a blur'. 'We couldn't believe we received this diagnosis as we hadn't heard about that disease before,' she said. 'We were devastated. Initially we were in shock. We slowly told our family and friends the news - it was world stopping. 'We spent the next two days as a family just processing the news, then the few weeks after lost in grief.' While Madeline's condition is not curable, Kaitlin explained there is a foundation currently raising money to fund gene therapy research to look for a cure. They have now started a GoFundMe to help contribute to the foundation, where they have brought in over $43,000. 'We are optimistic but also realistic. We are doing everything we can to find a cure for our daughter,' Kaitlin concluded. 'Our goal is to spread awareness and raise funds for the gene therapy. We will do anything for our precious baby.'
