‘We Are Not Programmed to Die,' Says Nobel Laureate Venki Ramakrishnan

WIRED

15-04-2025

Apr 15, 2025 5:00 AM The structural biologist, who has devoted his life to studying the processes behind aging, discusses the surprising things he has learned and the public misunderstandings about longevity. Venkatraman Ramakrishnan at the Milan Longevity Summit in Milan, Italy. Courtesy of the Milan Longevity Summit
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Venkatraman Ramakrishnan, the man of death. Although this does not sound like a good moniker, it is: Ramakrishnan is one of the world's most eminent scientists in the fields of structural biology and cellular processes related to aging and death. He was awarded the Nobel Prize in Chemistry in 2009 for his discovery of the structure of the ribosome, a crucial cellular machine responsible for gene expression.
In addition to being a leading researcher, Ramakrishnan is also a prolific author. After the enormous success of The Gene Machine , a memoir in which he recounts his human and scientific journey, he published the mighty Why We Die , a book—as its name suggests—dedicated precisely to illustrating the dynamics that regulate aging and which, progressively and inexorably, lead to death.
Ramakrishnan was recently in Italy, in Milan, where he gave a lecture at the second edition of the Milan Longevity Summit, the most important Italian event dedicated to longevity and psycho-physical well-being, organized by BrainCircle Italia. It was an opportunity to meet him and ask him a few questions. This interview has been edited for clarity and length.
WIRED: Professor Ramakrishnan, the crucial question in your book is why we die . But exactly what is death?
Venki Ramakrishnan: By death, we mean the irreversible loss of the ability to function as a coherent individual. It is the result of the failure of a critical system or apparatus, for example, heart, brain, lung, or kidney failure. In this sense there is an apparent paradox: When our organism, as a whole, is alive, millions of cells within us are constantly dying, and we do not even realize it. On the other hand, at the time of death, most of the cells in our bodies are still alive, and entire organs are still functioning and can be donated to people in need of transplantation. But at that point the body has lost the ability to function as a whole. In this sense, it is therefore important to distinguish between cell death and death of the individual.
Speaking of death and aging, you say in your most recent book that you 'wanted to offer an objective look at our current understanding of the two phenomena.' What was the biggest surprise or most deeply held belief that you had to reconsider while writing and researching this work?
There have been several surprises, actually. One is that death, contrary to what one might think, is not programmed by our genes. Evolution does not care how long we live, but merely selects the ability to pass on our genes, a process known as 'fitness' in evolutionary biology. Thus, the traits that are selected are those that help us survive childhood and reproduce. And it is these traits, later in life, that cause aging and decline.
Another curious finding was the fact that aging is not simply due to wear and tear on cells. Wear and tear happens constantly in all living things, yet different species have very different lifespans. Instead, lifespan is the result of a balance between the expenditure of resources needed to keep the organism functioning and repairing it and those needed to make it grow, mature, and keep it healthy until it reproduces and nurtures offspring.
Do you think there is an aspect of the biology of aging that is still deeply misunderstood by the general public?
Certainly the indefinite extension of life. Although in principle there are no laws or constraints that prevent us from living much longer than we do currently, great longevity or 'eternal youth' are still far off, and very significant obstacles to increasing our maximum life expectancy remain.
We must also beware of the pseudoscience—and business—around the concepts of 'anti-aging' or the 'reversal of aging.' These are often baseless concepts, unsupported by hard evidence, even though they may use language that sounds scientific. Unfortunately, we are all afraid of growing old and dying, so we are very sensitive to any claim that promises to help us avoid it.
A famous scene in the movie Frankenstein Junior shows a student asking Professor Frankenstein about some experiments with worms, and the lecturer replies that 'a worm, with very few exceptions, is not a human being.' Yet a whole chapter of Why We Die is called 'Lessons from a Humble Worm.' What do we have to learn from worms?
Science has always studied fundamental processes by using model organisms, including worms, fruit flies, and even yeast and bacteria. Of course, the closer these species are to us, the better, which is why drug trials are first conducted on mice and even monkeys and chimpanzees. But we can learn a lot from organisms like the worm. Many things discovered in worms have counterparts in humans. However, we cannot directly extrapolate every result. For example, humans with some of the same mutations that cause the longevity of worms turn out to have serious problems, such as growth defects.
What do you think are the social and ethical implications of our desire to live longer?
Ever since we became aware of our mortality, we have desired to defeat aging and death. However, our individual desires may conflict with what is best for society. A society in which fertility rates are very low and lifespans are very high will be a stagnant society, with very slow generational turnover, and probably much less dynamic and creative. The Nobel Prize-winning South American novelist Mario Vargas Llosa, who recently passed away, expressed it best: 'Old age on the one hand terrifies us, but when we feel anxious, it is important to remember how terrible it would be to live forever. If eternity were guaranteed, all the incentives and illusions of life would vanish. This thought can help us live old age in a better way.'
This story originally appeared on WIRED Italia and has been translated from Italian.