Breast cancer breakthrough as new test could revolutionise treatment
Experts said thousands of breast cancer patients could be spared unnecessary treatment as a result.
The new test has been devised by scientists to detect the likelihood of cancer reoccurring in patients with a type of breast cancer known as oestrogen receptor positive, human epidermal growth factor receptor 2 positive – which accounts for around 200,000 cases of cancer each year around the globe.
Writing in the journal eBioMedicine, experts said the test means that some patients will be able to 'de-escalate' their treatment while it could also help identify those who need 'more intensive therapeutic strategies'.
The test, which was developed by scientists at The Institute for Cancer Research, London, correctly identifies the 6% of patients at highest risk of relapse.
Researchers analysed tumour samples from 213 patients.
They found that two weeks of hormone therapy changes the characteristics of some tumours, causing them to shift their subtype.
The patients with the highest risk of cancer returning had a type of tumour called Luminal B that did not change after this short-term hormone therapy.
Experts said these patients will require more intensive treatment.
They said the findings highlight the benefit of two weeks of hormone therapy before surgery to help guide doctors' decision making.
Corresponding author of the study, Dr Maggie Cheang, from The Institute of Cancer Research, London, said: 'To deliver truly personalised care, we need to refine how we classify breast cancer, so that each patient receives the treatment most likely to benefit them.
'While current classification relies on hormone receptor and HER2 status, we know that patients within these groups can respond very differently to the same therapy.
'Our earlier research identified distinct molecular subtypes within HER2-positive, oestrogen receptor-positive breast cancer. In this new study, we've shown that these subtypes can shift after just two weeks of hormone therapy.
'This insight helps us identify which patients are likely to respond well and which may show early signs of treatment resistance, offering the opportunity to tailor treatment strategies sooner.
'Ultimately, our findings move us closer to more precise, patient-centred care for this overlooked breast cancer subtype.'
Professor Kristian Helin, chief executive of The Institute of Cancer Research, London, added: 'By decoding the underlying biology of tumours, we can tailor treatments to individual patients.'
Dr Simon Vincent, chief scientific officer at Breast Cancer Now, which part-funded the study, said: 'These findings add to the growing evidence that genomic testing can play a powerful role in helping to predict the risk of a woman's breast cancer coming back, particularly in people with ER-positive, HER2-positive breast cancer.
'There's potential for women to benefit hugely from this research in the future, with it ensuring they avoid undergoing unnecessary treatment and leading to more personalised treatment plans, so that women receive the most effective therapy for their specific type of breast cancer.'
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
BBC News
19 minutes ago
- BBC News
Why plane turbulence dey more serious now and dey hapun more and more?
Andrew Davies bin dey go New Zealand to work as project manager for one Doctor Who exhibition. Di first part of im flight from London to Singapore no get wahala but den di plane face serious turbulence. E remember di mata as: "being on a rollercoaster na how I go fit describe am. Afta I bin land ontop my seat very hard, we just drop. My iPad hit me for head, coffee pour me for bodi. Kasala full di cabin and pipo and tins scata evriwia. Pipo bin dey cry and no fit believe wetin just hapun." Oga Davies say e be "one of di lucky ones". Oda passengers collect injuries and broken bones. Geoff Kitchen wey be 73 years die from heart attack. Death sake of turbulence no dey very common. Official numbers no dey but e dey estimated say na only four pipo don die since 1981. But as for di wound, na anoda tori. For just US, since 2009, dem don record 207 serious injuries, injuries wia pesin need to get ova two days admission for hospital for. Dis na according to di official figures from di National Transportation Safety Board show. (166 of dis pipo na crew wey fit no sidon). But as climate change dey affect atmosphere conditions, sabi pipo warn say air travel fit dey bumpier, di temperature change and shift for wind patterns for di upper atmosphere dey expected to increase di frequency and intensity of serious turbulence. Professor Paul Williams wey be atmospheric scientist for di University of Reading tok say, "we dey expect double or triple of di amount of serious turbulence around di world in di next decades. For evri 10 minutes of severe turbulence wey we dey face now, e fit increase to like 20 to 30 minutes." So if di turbulence go become more serious, e fit become more dangerous abi airlines fit find smart ways to make dia planes "turbulence-proof"? Di bumpy North Atlantic route Serious turbulence be wen di up and down movement of plane wen e dey pass disturbed air, release enough force for your bodi to carry you from your seat if you no dey wia seatbelt. E dey estimated say around 5,000 cases of serious or greater turbulence na im dey hapun yearly out of di ova 35 million flights wey dey take off worldwide. Throughout 2023, na turbulence cause almost 40% of all di severe injuries wey passengers catch bicos dem dey fly. Dis na according to di annual safety report by di International Civil Aviation Organization. Between UK and US, Canada and di Caribbean na among di areas wey don dey affected. In di last 40 years, since satellites start to dey observe di atmosphere, dem don be 55% increase for di serious turbulence ova di North Atlantic. But di amount of turbulence don dey projected say e go increase for oda areas too, dat na wetin recent studies tok. E go rise for parts of East Asia, North Africa, North Pacific, North America and di Middle East. See wetin climate change don cause Na three main causes of turbulence dey, dem be convective (clouds or thunderstorms), orographic (air flow around mountainous areas) and clear-air (changes in wind direction or speed). All of dem fit cause severe - serious - turbulence. Pesin fit avoid convective and orographic but you see dat clear air turbulence ehn, you no fit even see am, sometimes e just be like say e dey comot from nowia. Climate change na major reason for di rise of both convective and clear-air turbulence. Even though di relationship between clinate change and thunderstorms dey hard to explain, warmer atmosphere fit get more moisture and dat extreme heat and moisture go mix to make more ogbonge thunderstorms. Back to turbulence, convective turbulence na di physical process of air rising and falling for di atmosphere especially for clouds and you no go find more violent up and down drafts but di ones wey dey thunderstorm clouds. Na wetin cause di severe turbulence for Andre Davies 2024 air trip na. Report from SIngapore Transport Safety Investigation Bureau find out say di plane "bin likely dey fly ova area wey bin get developing convective activity" ova South Myanmar wey cause "19 seconds of extreme turbulence wey include drop of 178 feet in just five seconds." One study from di US wey bin dey published for di Science journal for 2014 show say 1C increase for global temperature dey increase lightning strikes by 12%. Captain Nathan Davies, wey be commercial airline pilot tok say, "I don notice more large storm cells dey spread 80 miles plus in diameter. Dis na sometin wey suppose to be rare." But e add say, di clouds dey very easy to see unless e hide behind oda clouds so dem fit just dodge dem. Clear-air turbulence fit also rise soon. Na disturbed air in and around di jet stream dey cause am. Wind speeds for di jet stream wey dey travel from west to east across di Atlantic fit change from 160mph to 250mph. Colder air dey for di north and warmer air for di south. Di difference in temperature and change in winds dey useful for airliners so dem fit use am as tailwind to take save time and fuels. But e also dey create turbulent air. "Climate change dey warm di air to di south of di jet stream more dan di air to di north so dat temperature difference dey become stronger," Prof Williams explain. "E in turn dey drive a stronger jet stream." 'E suppose worry all of us' Some passengers dey worry bicos di increase wit severe turbulence wey fit lift pesin comot from chair fit potentially bring more incidents of injury or possible death for di most severe cases. Oga Davies dey fear ova di change of more turbulence and e say no be just for am but for im pikin too. E tok say, "I dey pleased say issue wey serious like my own never hapun, but I tink say e suppose worry us". Ova one fifth of UK adults say dem dey fear to fly. Dis na according to recent YouGov survey and if di turbulence go worse, e fit make travel to be more of a nightmare for dis pipo. As Wendy Barker, wey be nervous flyer from Norfolk, tell me: "More turbulence for me mean more chance for sometin to go wrong and less chance of survival." Aircraft wings dey designed to fly through turbulent air. As Chris Keane wey be former pilot and now dey work as ground-school instructor tok, "you no go believe how flexible wing be. For 747 passenger aircraft, under 'destructive' testing, di wings go bend upwards by some 25 degrees before e break wey dey very extreme and sometin wey no go eva hapun, even for di most severe turbulence." For airlines, dem get anoda hidden concern, dat na di economic costs of more turbulence. Di hidden cost of turbulence AVTECH, wey be tech company wey dey monitor climate and temperature changes - and dey work wit di Met Office to help warn pilots of turbulence - suggest say di costs fit start from £180,000 to £1.5 million per airline yearly. Dis include di money to check and maintain di plane afta di serious turbulence, compensation costs if flight don dey diverted or delayed and costs from going to di wrong location. Eurocontrol, wey be civil-military organisation wey dey help European aviation understand di risk of climate change say, to dodge dis turbulence producing storms fit cause crowded airspace for some areas bicos of change to flight paths. E also mean extra fuel and time wey dey cause extra CO2, Di expectation be say di need to doge bad weather go rise more by 2050. How airlines dey do turbulence-proofing Forecasting turbulence don dey beta recenntly as Prof Williams say dem fit correctly forecast like 75% of clean air turbulence correctly wen you compare am to 60% twenty years ago. Capt Davies explain say before flights, most airlines go produce flight plan wey go use computer modelling take chook eye for wia turbulence fit be for di route even though e no dey 100% accurate, na good idea make pesin use oda aircraft and Air Traffic Control reports as dem dey move. Southwest Airlines for US recently decide say dem go dey end cabin service wen di plane dey 18,000ft instead of di 10,000ft dem dey use before, so di crew and passengers go don sidon and ready to land for dis level wey dem suggest say go drop di injuries turbulence dey cause by 20%. Last year sef, Korean Airlines say dem no go give passengers noodles again for economy so passengers no go burn demselves as dem don see times two turbulence since 2019. From owls to AI: extreme measures Some studies don dey look at different ways to build wings. Sabi pipo don study di way owl dey fly for windy area and find out say di wings dey act as suspension and dey stabilise di head and chest as e dey fly dia. So di study wey dem publish for di Royal Society proceedings for 2020 conclude say, dat kain wing design fit dey useful for small scale aircraft. Anoda start up for Austria wey dem dey call Turbulence Solutions claim say dem don build sensor wey go see turbulent air and alarm flap for di wing to dodge am. Di company CEO say e fit reduce moderate turbulence for light aircraft by 80%. Some dey wey dey argue say AI solve am. Fourier Adaptive Learning and Control (FALCON) na one kain technology wey dem dey research for di California Institute of Technology, wey dey learn how turbulent air dey flow across wing in real time. Dat one sef dey sense turbulence den e go come tell di flap of di wing to adjust and dodge am. But some pipo like aerospace engineer, Finlay Asher dey reason say all dis technology no go dey for big commercial planes for di next few decades. But oda sabi pipo dey reason say all dis more frequent turbulence no be big deal, las-las, wetin e mean be say dem go be more sitting down wit di seatbelt on. Top Image credit: Ivan-balvan via GETTY
Telegraph
20 minutes ago
- Telegraph
GP reform is vital to fixing the NHS
Gordon Brown's attempt to introduce polyclinics following the Darzi review ended in quiet failure. Decades before, Nye Bevan, the founder of the NHS, was forced to concede that GPs would remain independent contractors. As family doctors threaten winter strikes over his plans to introduce 'community hubs' alongside a new funding agreement, Wes Streeting might take comfort in the observation that he is not the first Labour politician to clash with GPs over their contractual terms. The first contract between GPs and the health service was based on a principle of 'capitation', with roughly half the income of family doctors derived from the number of patients on their books rather than the amount of work performed. Today, most GPs still receive around half their income based on the 'global sum allocation formula', which pays out according to the demographic characteristics of a practice's books, with some added payments to reflect regional costs, rather than on actual services. The result is a system which lacks proper incentives to actually treat patients, and which gatekeeps specialist care behind appointments which are almost impossible to book. Recent analysis from the House of Commons Library showed millions of GP appointments taking place 28 days or longer after their booking. That over 80 per cent of fully qualified permanent GPs now work part-time is surely a contributing factor. Mr Streeting may or may not have a viable solution to this problem, but he is surely right to conclude, as have many patients, that the status quo is untenable. The hope must now be that he has greater success than his predecessors.
BBC News
20 minutes ago
- BBC News
Pathologist shortage leaves Carwe parents in limbo after son's death
Two heartbroken parents say they are still waiting to find out what happened more than a year after their three-year-old son died suddenly and 2 June 2024 Katie Louise Llewellyn went into Tomos' bedroom to wake him for a family holiday, only to find he had passed away.A cause of death has not been given and, without an explanation, Katie and partner Aled Wyn Jones blame themselves and question what they could have done differently. The delay has been put down to a lack of consultant paediatric and perinatal pathologists, with Royal College of Pathologists figures showing there are just two working in Ministry of Justice said it was working to improve the service. "I'm in self-blame every other day because I don't know why, because it was so unexpected when he passed away," said Katie."It was meant to be a happy day that day because we were going to be leaving the morning I found him on a family holiday."I just hope with everything we've done we can try and get the answers and that no other family after us will have to suffer like we have, but other families are at the moment."Katie and Aled, from Carwe, Carmarthenshire, said the wait to find out how Tomos, who was born with Down's Syndrome and Hirschsprung's disease, died, was having a terrible effect on their mental health. Each time they have asked the authorities, they said they have been told repeatedly there are not enough pathologists. "Every single time, the answer we get is that there is only one pathologist in our area and he is shared with Bristol, Devon, Wiltshire and Cornwall," Katie said. "When a child passes away, surely they should have more professionals to be able to take over case loads - one pathologist can't get the job done quick enough."We're 14 months down the line - we still don't know. We've got a lot to still do when we do finally find out - because we haven't been able to register his death - and that's hard because we haven't got the answer." The Royal College of Pathologists has previously highlighted a "worldwide shortage of pathologists and in particular, paediatric pathologists" following a number of traumatic experiences for highlighted issues including a 10 to 12% vacancy rate for roles in the UK, an ageing workforce with many nearing retirement age, and 60% of consultants who said they felt their department was not adequately resourced to meet 21% of paediatric and perinatal consultants are due to retire in the next five years. Dr Nia Bowen, from Carmarthen, who used to be a pathologist, believes there are other barriers stopping people pursuing a career in the area."I think it's quite historical mostly because it tends to be a traditional apprenticeship that has less autonomy for doctors, and it might be a slight turn off that you aren't able to exercise autonomy within your early years as a trainee because that makes you a confident consultant in later years," she said. "Also because of practical things, the pay is slightly less than most other fields within medicine."In the meantime, in their grief, Aled and Katie are calling on the Welsh government to take action."Grieving has just been difficult. Everyday is different and now I feel bad for being sad. I feel bad for being happy and trying to carry on," added Katie."I think all we want now is the answers and for something to be done, and that other families don't go though what we have."According to the coroner's office, an inquest cannot be held until results are received from the pathologist. The Welsh government said responsibility for paediatric pathology lay with the UK Ministry of Justice said there were significant challenges affecting post-mortem pathology services and that it was working urgently to find a long-term solution to improve the service.
