Zomedica Launches the TRUFORMA(R) Enhanced Endogenous ACTH Assay to aid in Equine PPID Diagnosis

Yahoo

06-02-2025

Zomedica continues to redefine what is possible in point of care diagnostics with the TRUFORMA biosensor platform
ANN ARBOR, MI / / February 6, 2025 / Zomedica Corp. (NYSE American:ZOM), a veterinary health company offering point-of-care diagnostics and therapeutic devices for equine and companion animals, today announced a groundbreaking update to its endogenous ACTH (eACTH) assay for equine plasma on the TRUFORMA biosensor platform. Since it was launched in September of 2024, the TRUFORMA eACTH assay has been widely adopted as the only assay to measure eACTH in horses directly at the point-of-care. Leveraging data gathered from its use in the field, Zomedica R&D scientists have now expanded its capabilities and potential utility.
The enhanced test now provides values for both full-length endogenous ACTH and CLIP (Corticotropin-Like Intermediate Peptide) and calculates a composite value that can be directly compared to results from the traditional chemiluminescent assay used at reference laboratories. CLIP is a breakdown product of ACTH and known to have significant cross-reactivity with the assay commonly used in reference laboratories. Recent data indicate that some horses suspected of suffering from Pituitary Pars Intermedia Dysfunction (PPID) have high circulating levels of CLIP, especially in response to TRH stimulation. While the biological function of CLIP and clinical significance of elevated levels of the molecule are currently unknown, the enhanced TRUFORMA Equine eACTH assay provides veterinarians the ability to quantify this molecule for the first time.
This advancement provides a tool that could lead to a significant leap forward in the diagnosis of Pituitary Pars Intermedia Dysfunction (PPID), a common endocrine disorder affecting horses.
"Point-of-care testing with the TRUFORMA platform has already proven to be a valuable tool for equine veterinarians," states Dr. T. J. Barclay, Senior Professional Services Veterinarian for Zomedica. "The enhancements to the eACTH assay will put it on the cutting edge of PPID diagnosis and research."
Research suggests that imbalances in CLIP, full-length ACTH, and related hormones may all play a role in PPID. By enabling the simultaneous and rapid measurement of these biomarkers in a clinical setting, Zomedica's updated assay provides veterinary practitioners and researchers with a more comprehensive tool to assess and understand this complex disease.
"For the first time, veterinarians will have access to a test that concurrently measures both CLIP and full-length ACTH in a clinical setting," said Kelsey Hart, DVM, PhD, DACVIM (LAIM) Professor and Hodgson Chair of Equine Studies at the University of Georgia College of Veterinary Medicine. "This innovation opens new doors for PPID diagnosis and could lead to a deeper understanding of this important equine health condition."
The TRUFORMA platform utilizes state-of-the-art biosensor technology to deliver precise, point-of-care diagnostics, allowing veterinary professionals to make faster, more informed decisions for their equine patients.
For more information on the TRUFORMA eACTH assay and other Zomedica solutions, visit www.zomedica.com/truforma.
About ZomedicaZomedica is a leading equine and companion animal healthcare company dedicated to improving animal health by providing veterinarians with innovative therapeutic and diagnostic solutions. Our gold standard PulseVet® shock wave system, which accelerates healing in musculoskeletal conditions, has transformed veterinary therapeutics. Our suite of products also includes the Assisi® Loop line of therapeutic devices, the TRUFORMA diagnostic platform, the TRUVIEW® digital cytology system, and the VetGuardian® no-touch monitoring system, all designed to empower veterinarians to provide top-tier care. In the aggregate, their total addressable market in the U.S. exceeds $2 billion. Headquartered in Michigan, Zomedica employs approximately 150 people and manufactures and distributes its products from its world-class facilities in Georgia and Minnesota. An NYSE American company, Zomedica grew revenue 33% in 2023 to $25 million and maintains a strong balance sheet with approximately $78 million in liquidity as of September 30, 2024. Zomedica is advancing its product offerings, leveraging strategic acquisitions, and expanding internationally as we work to enhance the quality of care for pets, increase pet parent satisfaction, and improve the workflow, cash flow and profitability of veterinary practices. For more information about Zomedica and our full range of products visit www.zomedica.com.
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