
To stay sharper while aging, get active, challenge your brain, and eat healthy
That's according to initial results released Monday from a rigorous US study of lifestyle changes in seniors at risk of developing dementia. People following a combination of healthier habits slowed typical age-related cognitive decline — achieving scores on brain tests as if they were a year or two younger, researchers reported in JAMA and at the Alzheimer's Association International Conference.
It's not too late to get started -- study participants were in their 60s and 70s -- and it doesn't require becoming a pickleball champ or swearing off ice cream.
'It was the first time I felt like I was doing something proactive to protect my brain,' said Phyllis Jones, 66, of Aurora, Illinois, who joined the study after caring for her mother with dementia and struggling with her own health problems.
It's too soon to know if stalling age-related decline also could reduce the risk of later Alzheimer's or other forms of dementia. But Jones and other study participants underwent brain scans and blood tests that researchers now are analyzing for clues – such as whether people also saw a reduction in Alzheimer's-related protein buildup.
'We're all on a cognitive aging clock and anything we can do to slow that clock down, to me, that is a significant benefit,' said Laura Baker of Wake Forest University School of Medicine, who led the study.
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Time of India
28 minutes ago
- Time of India
Blame your parents for how food smells to you, your genes play a major role
If you've ever wrinkled your nose at the scent of coriander or found the smell of coffee strangely unappealing, science has a surprising answer, your DNA may be to blame. A groundbreaking genetic study has revealed that how we perceive, and emotionally react to, everyday smells isn't just a matter of taste or memory. Among the most compelling findings is a link to the OR6A2 gene , which influences how people perceive aldehydes, compounds found in coriander. People with a specific variant of this gene often describe the herb as having a soapy or foul taste, an aversion more common among people of East Asian and European ancestry. Explore courses from Top Institutes in Please select course: Select a Course Category Technology Data Analytics Digital Marketing Public Policy Others Management MCA Artificial Intelligence others Project Management Data Science PGDM Healthcare CXO Operations Management healthcare Degree Design Thinking MBA Data Science Cybersecurity Leadership Product Management Skills you'll gain: Duration: 12 Weeks MIT xPRO CERT-MIT XPRO Building AI Prod India Starts on undefined Get Details Researchers from Leipzig University in Germany have uncovered key genetic differences that help explain why certain smells, and the foods associated with them, trigger completely opposite reactions in different people. The study, published in PLOS Biology , is the largest genetic investigation ever conducted on human olfaction, analyzing how over 21,000 people of European descent perceive 12 everyday smells. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Play this game for 3 minutes, if you own a mouse Undo What they found was surprising, ten distinct regions of DNA, seven previously unknown, influence how we experience specific odors like clove, cinnamon, peppermint, orange, and fish. Some of these regions had sex-specific effects, offering insights into why men and women may perceive scents differently, particularly during hormonal changes such as pregnancy or menstruation. Another striking example is the OR10G4 gene, which shapes how people react to guaiacol, the compound that gives wood smoke its distinctive scent. While some described it as nostalgic and cozy, others compared it to burning rubber. These emotional reactions came down to slight differences in just a few olfactory receptor genes. Live Events But this isn't just about coriander or candles. The study uncovered a significant link between smell sensitivity and Alzheimer's disease risk, indicating that smell testing could help detect early neurological decline. Loss of smell has already been observed in conditions like Parkinson's, COVID-19, and dementia. The findings also open up commercial possibilities. With scent personalization now a growing trend, companies may soon use genetic testing to tailor perfumes, household cleaners, or even skincare products to suit an individual's olfactory DNA. So next time someone turns up their nose at your favorite scent, don't take it personally, it might just be genetic.


Time of India
3 hours ago
- Time of India
Your genes might be why you hate coriander: New study explains how DNA and smell preferences are connected
Ever wonder why your friend swoons over lavender but you think it smells like dish soap? Or why does the scent of vanilla make you nostalgic, while someone else gags? Turns out, it might not be snobbery or weird taste, it's your DNA. Tired of too many ads? go ad free now Yep, scientists have been sniffing around (literally) and found that our genes can dramatically influence how we experience smells. Smell is more personal than you think. It's not just about memory or vibes, it's about your genetic blueprint. From the cologne aisle to your reaction to certain foods, your nose's taste is written in your DNA. So before judging someone for hating your favourite candle, maybe blame their olfactory receptors instead. Let's dive into how DNA and smell preferences are surprisingly linked, and what recent research reveals about our love-hate relationship with scent. Massive genetic study maps your scent sensitivity In 2025, a major breakthrough came from , where genetic epidemiologist Markus Scholz led a sweeping genome‑wide association meta‑analysis involving over 21,000 individuals of European descent. This is the largest-ever genetic study on human scent perception. Participants were tested using 12 everyday smells (like clove, orange, cinnamon, peppermint, coffee, and fish) via scent pens. The researchers mapped these responses against genetic data and discovered 10 distinct genetic regions tied to the ability to detect specific odours, seven of which were previously unknown. Intriguingly, three of these regions showed sex‑specific effects, helping explain why smell sensitivity varies between people and even between men and women in different hormonal states. Tired of too many ads? go ad free now Additionally, the study revealed a connection between olfactory ability and Alzheimer's disease risk. DNA and smell preferences: The science behind your nose's favourites and foes According to a major study published in , a single change in your genetic code can dramatically alter how you perceive certain odours. One key example is the gene OR11H7P, which affects sensitivity to isovaleric acid, that notorious 'cheesy foot' smell. People with a functional version of this gene can detect the scent at extremely low concentrations, while those without it barely smell anything at all. In the study, participants were asked to rate various smells, and researchers compared their genetic data to the intensity ratings. What stood out was that hyperosmia (a super-sensitivity to odours) could be directly traced to intact receptor genes. This confirms that smell isn't a learned quirk, it's hardwired into your biology. Your genes don't just change how strong a smell feels, they change whether you like it We often think people dislike a smell just because it's strong. But scientists have discovered that strength and likeability are genetically independent traits. This means someone might find a scent subtle, yet completely revolting or very intense but still enjoyable. In a landmark study published in , researchers found that different variants of the olfactory receptor gene OR10G4 altered how people responded to guaiacol, a smoky, campfire-like compound. Some people described it as cozy, nostalgic, and woody, while others said it smelled like burnt rubber or plastic. Same molecule, totally different vibes, all thanks to DNA. This wasn't limited to one smell. The study found that over 12% of smell perception variation across individuals could be explained by differences in just a handful of genes. And when combined with cultural associations, memory, and environment, it makes sense why smell is the most subjective of all senses. Evolution and survival: Why smell preferences are wired differently in all of us From an evolutionary perspective, this smell-diversity isn't a design flaw, it's a survival mechanism. Different environments demanded different warning signals. A population that evolved near toxic plants would need genes that made those plant smells intensely unpleasant. In contrast, a population exposed to fermented foods might develop tolerance or even preference for sour, funky smells. Researchers have also found that ethnic and geographical variation plays a role in olfactory genes . For example, some populations are genetically less sensitive to certain sulphuric compounds (like in durian or onions), while others are hypersensitive. Your nose isn't just yours, it's inherited from centuries of people whose lives depended on reading the air. Why smell preferences matter beyond perfume preferences This isn't just a fun party fact, understanding the genetic link between DNA and smell preferences has real-world uses. Your sense of smell is often one of the first senses affected by neurological conditions like Alzheimer's, Parkinson's, and even long COVID. Smell tests could soon be part of early diagnostics for brain health. In the tech world, there's increasing interest in 'scent personalisation'. Imagine walking into a store and the room adjusts its fragrance based on your olfactory DNA. Or skincare products that smell amazing to you but neutral to someone else. Fragrance companies are already experimenting with this, using genetic testing to create custom scent profiles. Meanwhile, the notes that individual olfactory receptor differences are widespread. This means even subtle changes in your DNA could affect how you perceive essential oils, foods, household cleaners, or even a partner's natural body odour. Bottom line? Your DNA isn't just shaping how you look or how your body works. It's also guiding how you feel about the invisible, aromatic world around you, one sniff at a time. Whether it's coriander, cigars, or that expensive candle everyone raves about, it's not your fault. Your genes are just doing their thing. Also read|


Time of India
10 hours ago
- Time of India
Gitam institute of medical sciences and research to organise CME on genes, morphology on August 22
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