Top 5 Crucial Reasons Why Men's Health Is Important
When it comes to health and wellness, men often fall behind. Studies show that men are less likely than women to schedule regular checkups, pay attention to warning signs, or seek early medical care. This negligence often leads to the late detection of chronic illnesses such as heart disease, diabetes, and prostate cancer. The truth is, men's health matters more than many realise, and taking proactive steps today can prevent life-threatening conditions tomorrow.
In this article, we'll dive into the five main reasons why men's health is important, focusing on areas like prostate health, cancer prevention, mental well-being, and lifestyle choices. By the end, you'll understand why prioritising men's health is not only essential for longevity but also for living a fulfilling, active, and confident life.
One of the most critical reasons why men must prioritise their health is the power of early detection. Conditions such as prostate cancer, testicular cancer, heart disease, and diabetes often progress silently. By the time symptoms appear, the disease may already be in an advanced stage, making treatment more difficult and riskier. Prostate cancer is the second most common cancer in men worldwide. Regular screenings such as PSA (Prostate-Specific Antigen) tests can help detect it early, when treatment outcomes are far more favourable.
is the second most common cancer in men worldwide. Regular screenings such as can help detect it early, when treatment outcomes are far more favourable. Heart disease , often labelled the 'silent killer,' can be managed effectively if identified early with routine checkups and cholesterol monitoring.
, often labelled the 'silent killer,' can be managed effectively if identified early with routine checkups and cholesterol monitoring. Testicular cancer, though less common, often affects younger men between the ages of 15 to 35. Self-exams and annual checkups are vital for spotting unusual lumps early.
By being proactive, men can reduce the risk of severe complications and enjoy a healthier, longer life.
The prostate gland, though small, plays a massive role in men's health. Unfortunately, prostate problems are extremely common, especially as men age. Conditions such as benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer can affect urination, intimacy or reproductive health, and overall comfort.
Why prostate care is essential: Urinary health : An Enlarged prostate can lead to frequent urination, a weak stream, or incomplete bladder emptying.
: An Enlarged prostate can lead to frequent urination, a weak stream, or incomplete bladder emptying. Intimacy or reproductive function : Prostate issues may cause erectile dysfunction or reduced libido.
: Prostate issues may cause erectile dysfunction or reduced libido. Cancer risk: Men over 50 (or over 40 with a family history) are at higher risk of prostate cancer.
Regular prostate checkups, a balanced diet, and natural supplements like saw palmetto, zinc, or herbal blends (e.g., ProstaVive – I'll talk in another article; till then, you can know more at ProstaVive Official Website) can support prostate function and reduce the risk of complications.
Physical health isn't the only concern. Mental health among men is often overlooked, yet it is just as important. Depression, anxiety, and stress-related illnesses are on the rise, but due to stigma, many men hesitate to seek help. Men are less likely than women to speak openly about mental struggles , leading to higher suicide rates in males worldwide.
, leading to higher suicide rates in males worldwide. Stress from work, financial responsibilities, and family obligations often pushes men toward unhealthy coping mechanisms like smoking, alcohol, or overeating.
like smoking, alcohol, or overeating. Conditions like low testosterone can also affect mood, leading to fatigue, irritability, and depression.
Taking care of both mind and body-through therapy, exercise, mindfulness, and medical consultations-ensures a stronger, more balanced life.
A major factor in why men's health is important lies in lifestyle habits. Small daily choices can either protect or destroy long-term health. Unfortunately, men are more likely to engage in risky behaviours such as excessive drinking, smoking, or a poor diet.
Key lifestyle changes every man should make: Eat nutrient-rich foods : Diets high in vegetables, lean proteins, and omega-3 fatty acids reduce inflammation and promote heart and prostate health.
: Diets high in vegetables, lean proteins, and omega-3 fatty acids reduce inflammation and promote heart and prostate health. Exercise regularly : At least 30 minutes of physical activity daily improves cardiovascular fitness, boosts testosterone, and supports mental health.
: At least 30 minutes of physical activity daily improves cardiovascular fitness, boosts testosterone, and supports mental health. Limit alcohol and quit smoking : Both increase the risk of cancer, heart disease, and liver problems.
: Both increase the risk of cancer, heart disease, and liver problems. Prioritise sleep: Poor sleep is linked to obesity, hormonal imbalances, and reduced immune function.
By adopting these healthy lifestyle practices, men can dramatically reduce their risk of diseases like diabetes, obesity, stroke, and hypertension.
A man's health does not affect only himself-it impacts his family, career, and social environment. Healthy men are better equipped to care for their loved ones, maintain productivity at work, and enjoy fulfilling relationships. Family stability : When men prioritise health, they set a positive example for their children and partners.
: When men prioritise health, they set a positive example for their children and partners. Economic productivity : Healthy men are more likely to perform better at work, reducing sick days and financial strain.
: Healthy men are more likely to perform better at work, reducing sick days and financial strain. Long-term support: By preventing chronic illness, men can enjoy active roles as fathers, grandfathers, and mentors.
Taking care of health is not selfish-it is an act of responsibility toward family and society.
Beyond the five major points above, men must also be aware of several other health risks that are common yet preventable: Diabetes : Regular blood sugar checks and lifestyle management are key.
: Regular blood sugar checks and lifestyle management are key. Hypertension : High blood pressure often shows no symptoms until it's dangerous.
: High blood pressure often shows no symptoms until it's dangerous. Obesity : Linked to heart disease, joint problems, and hormonal imbalance.
: Linked to heart disease, joint problems, and hormonal imbalance. Liver health : Alcohol and a poor diet are major threats.
: Alcohol and a poor diet are major threats. Intimacy or reproductive health: Erectile dysfunction can be an early sign of cardiovascular disease.
By keeping an eye on these risks, men can take charge of their long-term health.
Natural Ways to Improve Men's Health
In addition to medical care, many natural remedies and supplements can help men maintain peak wellness. Some powerful ingredients include: Saw Palmetto : Supports prostate and urinary health.
: Supports prostate and urinary health. Ashwagandha : Boosts testosterone, reduces stress, and enhances energy.
: Boosts testosterone, reduces stress, and enhances energy. Zinc & Magnesium : Essential for hormone balance and immune function.
: Essential for hormone balance and immune function. Omega-3 fatty acids : Support heart, brain, and joint health.
: Support heart, brain, and joint health. Green tea extract: Rich in antioxidants, it helps prevent chronic disease.
These natural remedies, when combined with a healthy diet and regular checkups, can create a holistic approach to men's health.
The Role of Regular Health Screenings
Even the healthiest men need annual health screenings. These routine checkups catch issues before they become severe: Blood pressure, cholesterol, and glucose tests (starting in the 30s).
(starting in the 30s). Prostate cancer screenings (starting at 40-50, depending on family history).
(starting at 40-50, depending on family history). Colon cancer screenings (recommended from age 45 onward).
(recommended from age 45 onward). Mental health assessments are conducted when stress or mood changes are noticeable.
Preventive care is the cornerstone of longevity and vitality.
Why Men Shouldn't Ignore Warning Signs
Too often, men dismiss symptoms like fatigue, chest pain, or urinary problems. Unfortunately, ignoring small signs can lead to big problems. For example: Persistent back pain may indicate kidney or prostate issues.
Shortness of breath could be linked to heart disease.
Erectile dysfunction might signal early cardiovascular problems.
Listening to your body and acting promptly is one of the most powerful health strategies men can adopt.
Men's health is not something to put off until later – it is a lifelong investment. From early detection of diseases to maintaining prostate health, mental wellness, and healthy lifestyle habits, every step matters. A man who prioritises his health not only extends his life but also enhances its quality, ensuring he can be there for his family, career, and personal goals.
By focusing on prevention, regular checkups, and proactive lifestyle choices, men can conquer the silent threats that often go unnoticed. Remember: your health is your greatest wealth – and protecting it today ensures a stronger, healthier tomorrow.
TIME BUSINESS NEWS
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Time Business News
5 hours ago
- Time Business News
Top 5 Crucial Reasons Why Men's Health Is Important
Top 5 Crucial Reasons Why Men's Health Is Important When it comes to health and wellness, men often fall behind. Studies show that men are less likely than women to schedule regular checkups, pay attention to warning signs, or seek early medical care. This negligence often leads to the late detection of chronic illnesses such as heart disease, diabetes, and prostate cancer. The truth is, men's health matters more than many realise, and taking proactive steps today can prevent life-threatening conditions tomorrow. In this article, we'll dive into the five main reasons why men's health is important, focusing on areas like prostate health, cancer prevention, mental well-being, and lifestyle choices. By the end, you'll understand why prioritising men's health is not only essential for longevity but also for living a fulfilling, active, and confident life. One of the most critical reasons why men must prioritise their health is the power of early detection. Conditions such as prostate cancer, testicular cancer, heart disease, and diabetes often progress silently. By the time symptoms appear, the disease may already be in an advanced stage, making treatment more difficult and riskier. Prostate cancer is the second most common cancer in men worldwide. Regular screenings such as PSA (Prostate-Specific Antigen) tests can help detect it early, when treatment outcomes are far more favourable. is the second most common cancer in men worldwide. Regular screenings such as can help detect it early, when treatment outcomes are far more favourable. Heart disease , often labelled the 'silent killer,' can be managed effectively if identified early with routine checkups and cholesterol monitoring. , often labelled the 'silent killer,' can be managed effectively if identified early with routine checkups and cholesterol monitoring. Testicular cancer, though less common, often affects younger men between the ages of 15 to 35. Self-exams and annual checkups are vital for spotting unusual lumps early. By being proactive, men can reduce the risk of severe complications and enjoy a healthier, longer life. The prostate gland, though small, plays a massive role in men's health. Unfortunately, prostate problems are extremely common, especially as men age. Conditions such as benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer can affect urination, intimacy or reproductive health, and overall comfort. Why prostate care is essential: Urinary health : An Enlarged prostate can lead to frequent urination, a weak stream, or incomplete bladder emptying. : An Enlarged prostate can lead to frequent urination, a weak stream, or incomplete bladder emptying. Intimacy or reproductive function : Prostate issues may cause erectile dysfunction or reduced libido. : Prostate issues may cause erectile dysfunction or reduced libido. Cancer risk: Men over 50 (or over 40 with a family history) are at higher risk of prostate cancer. Regular prostate checkups, a balanced diet, and natural supplements like saw palmetto, zinc, or herbal blends (e.g., ProstaVive – I'll talk in another article; till then, you can know more at ProstaVive Official Website) can support prostate function and reduce the risk of complications. Physical health isn't the only concern. Mental health among men is often overlooked, yet it is just as important. Depression, anxiety, and stress-related illnesses are on the rise, but due to stigma, many men hesitate to seek help. Men are less likely than women to speak openly about mental struggles , leading to higher suicide rates in males worldwide. , leading to higher suicide rates in males worldwide. Stress from work, financial responsibilities, and family obligations often pushes men toward unhealthy coping mechanisms like smoking, alcohol, or overeating. like smoking, alcohol, or overeating. Conditions like low testosterone can also affect mood, leading to fatigue, irritability, and depression. Taking care of both mind and body-through therapy, exercise, mindfulness, and medical consultations-ensures a stronger, more balanced life. A major factor in why men's health is important lies in lifestyle habits. Small daily choices can either protect or destroy long-term health. Unfortunately, men are more likely to engage in risky behaviours such as excessive drinking, smoking, or a poor diet. Key lifestyle changes every man should make: Eat nutrient-rich foods : Diets high in vegetables, lean proteins, and omega-3 fatty acids reduce inflammation and promote heart and prostate health. : Diets high in vegetables, lean proteins, and omega-3 fatty acids reduce inflammation and promote heart and prostate health. Exercise regularly : At least 30 minutes of physical activity daily improves cardiovascular fitness, boosts testosterone, and supports mental health. : At least 30 minutes of physical activity daily improves cardiovascular fitness, boosts testosterone, and supports mental health. Limit alcohol and quit smoking : Both increase the risk of cancer, heart disease, and liver problems. : Both increase the risk of cancer, heart disease, and liver problems. Prioritise sleep: Poor sleep is linked to obesity, hormonal imbalances, and reduced immune function. By adopting these healthy lifestyle practices, men can dramatically reduce their risk of diseases like diabetes, obesity, stroke, and hypertension. A man's health does not affect only himself-it impacts his family, career, and social environment. Healthy men are better equipped to care for their loved ones, maintain productivity at work, and enjoy fulfilling relationships. Family stability : When men prioritise health, they set a positive example for their children and partners. : When men prioritise health, they set a positive example for their children and partners. Economic productivity : Healthy men are more likely to perform better at work, reducing sick days and financial strain. : Healthy men are more likely to perform better at work, reducing sick days and financial strain. Long-term support: By preventing chronic illness, men can enjoy active roles as fathers, grandfathers, and mentors. Taking care of health is not selfish-it is an act of responsibility toward family and society. Beyond the five major points above, men must also be aware of several other health risks that are common yet preventable: Diabetes : Regular blood sugar checks and lifestyle management are key. : Regular blood sugar checks and lifestyle management are key. Hypertension : High blood pressure often shows no symptoms until it's dangerous. : High blood pressure often shows no symptoms until it's dangerous. Obesity : Linked to heart disease, joint problems, and hormonal imbalance. : Linked to heart disease, joint problems, and hormonal imbalance. Liver health : Alcohol and a poor diet are major threats. : Alcohol and a poor diet are major threats. Intimacy or reproductive health: Erectile dysfunction can be an early sign of cardiovascular disease. By keeping an eye on these risks, men can take charge of their long-term health. Natural Ways to Improve Men's Health In addition to medical care, many natural remedies and supplements can help men maintain peak wellness. Some powerful ingredients include: Saw Palmetto : Supports prostate and urinary health. : Supports prostate and urinary health. Ashwagandha : Boosts testosterone, reduces stress, and enhances energy. : Boosts testosterone, reduces stress, and enhances energy. Zinc & Magnesium : Essential for hormone balance and immune function. : Essential for hormone balance and immune function. Omega-3 fatty acids : Support heart, brain, and joint health. : Support heart, brain, and joint health. Green tea extract: Rich in antioxidants, it helps prevent chronic disease. These natural remedies, when combined with a healthy diet and regular checkups, can create a holistic approach to men's health. The Role of Regular Health Screenings Even the healthiest men need annual health screenings. These routine checkups catch issues before they become severe: Blood pressure, cholesterol, and glucose tests (starting in the 30s). (starting in the 30s). Prostate cancer screenings (starting at 40-50, depending on family history). (starting at 40-50, depending on family history). Colon cancer screenings (recommended from age 45 onward). (recommended from age 45 onward). Mental health assessments are conducted when stress or mood changes are noticeable. Preventive care is the cornerstone of longevity and vitality. Why Men Shouldn't Ignore Warning Signs Too often, men dismiss symptoms like fatigue, chest pain, or urinary problems. Unfortunately, ignoring small signs can lead to big problems. For example: Persistent back pain may indicate kidney or prostate issues. Shortness of breath could be linked to heart disease. Erectile dysfunction might signal early cardiovascular problems. Listening to your body and acting promptly is one of the most powerful health strategies men can adopt. Men's health is not something to put off until later – it is a lifelong investment. From early detection of diseases to maintaining prostate health, mental wellness, and healthy lifestyle habits, every step matters. A man who prioritises his health not only extends his life but also enhances its quality, ensuring he can be there for his family, career, and personal goals. By focusing on prevention, regular checkups, and proactive lifestyle choices, men can conquer the silent threats that often go unnoticed. Remember: your health is your greatest wealth – and protecting it today ensures a stronger, healthier tomorrow. TIME BUSINESS NEWS
Yahoo
13 hours ago
- Yahoo
I told my son I have cancer. He hugged me like his life depended on it
In June this year, Paul Henderson received test results showing elevated PSA (prostate-specific antigen) levels. In this weekly diary, he will be sharing what life is like in the weeks that follow: the tests, the scans, the fear and what it's like when you have to sit down with your loved ones to discuss the possibility of cancer. It was a warm, sunny day in the middle of June, just after 2.30 pm, and I was sitting with my wife, Marilyn, in a generically nondescript doctor's office at Whipps Cross Hospital. Having spent the previous two months undergoing tests, scans, and biopsies for suspected prostate cancer, we were almost certain the news would be bad. But no matter how prepared we thought we were to hear the words, the formal diagnosis hit us both hard. After the initial shock, I tried to gather as much information as I could. Armed with a notepad and pen, I asked what I hoped were the right questions and tried to process what was coming back. In quick succession, Dr Chowdhury told me I had adenocarcinoma, the most common type of prostate cancer; that it was mid-stage, or stage 2, meaning it had spread beyond the prostate gland but not to the lymph nodes or beyond; and that my Gleason score was 7 (4+3), indicating a medium to high risk of the cancer spreading. 'Your cancer definitely looks treatable, but we will need to book you in for a bone scan to make sure it hasn't metastasised,' Dr Chowdhury said. 'It looks unlikely, but we need to be sure.' And if it has spread to the bones, I asked. 'That makes things more […] complicated.' The conversation lasted only about ten minutes, yet it felt both inconsequential and monumental in equal measure. Undoubtedly, this consultation was one of many the doctor would have, but in that moment, for Marilyn and I, it meant everything. We walked to the car park in silence, then held each other tightly. After all the waiting and anticipation, we finally had the news we had feared. And now I had to face the moment I had been dreading since April – telling our children. Despite living with the possibility of a cancer diagnosis for two months, we decided not to tell Nyah (22) and Fox (19) until we knew what we were dealing with. Nyah was living at home after graduating the previous summer, while Fox was in Durham studying for his first-year university exams, and we didn't want to distract him from his studies. We also felt it was important to break the news to them together. It was the hardest conversation I have ever had. The day after he came home, we sat them both down, and I told them the bad news. When it came to saying the words 'I have cancer', the C-word caught in my throat. After the initial shock, we all ended up in tears. Fox hugged me like his life depended on it. At 6ft 3in and with broad shoulders, he is bigger than his old man, but at that moment he was a little boy again. I held him closer than I had in years. Then it was Nyah's turn; she buried her head in my shoulder and squeezed hard. They then both took turns cuddling Marilyn. I felt incredibly proud of them all for being so brave. Once the initial shock had subsided, we talked. I explained the situation as best I could and tried to be as positive as possible. I didn't sugarcoat it, but I also wanted them to feel optimistic. Although the tumours in my prostate were fairly large, especially on the left side, the prognosis for stage 2 cancer is very good. Most patients, over 97 per cent, survive at least five years, and it is highly treatable. I am relatively young (56), fit, and healthy, so there was no need to panic, I reassured them. They then asked the same question: what happens next? That was a little harder to answer. At the end of my consultation, when the doctor had informed me I had cancer, he explained that I had two options for treatment. I would have to choose between surgery to remove the prostate or radiotherapy to try to kill the cancer cells. To help make that decision, he referred me to St Bartholomew's Hospital, where I would meet specialists from both areas to discuss the best way forward. In the meantime, while I waited for my appointment, there was the small matter of the bone scan that might just change everything… Frequently asked questions Answered by Prostate Cancer UK specialist nurses 1. What are the different types of prostate cancer and is there one type that's 'worse'? Most men diagnosed with prostate cancer have a type known as adenocarcinoma. There are, however, several much rarer forms of the disease. Because these are uncommon, they have not been studied as extensively, and we know far less about them. Some of these rare cancers can be more aggressive, meaning they may grow faster and are more likely to spread to other parts of the body. In many cases, men with a rare form of prostate cancer also have some adenocarcinoma present at the same time. Rare types of prostate cancer include: Neuroendocrine tumours (small cell or large cell) Glandular tumours (ductal, mucinous, or signet ring cell) Basal cell carcinoma Transitional cell carcinoma Prostate sarcoma Some of these rare cancers do not cause a rise in PSA levels. As a result, they may not be detected through a routine PSA blood test. Diagnosis may therefore only occur once the cancer has already spread outside the prostate, often following a biopsy. 2. What's a Gleason score? After a prostate biopsy, the tissue samples are examined under a microscope by a specialist doctor called a histopathologist. They check for the presence of cancer cells and describe their findings in a pathology report. Cancer cells in the prostate can look different depending on how likely they are to grow and spread. This appearance is given a Gleason grade, which ranges from 1 to 5. Grades 1 and 2 resemble normal prostate cells and are not usually reported. Prostate cancer is generally graded as Gleason 3, 4, or 5, the higher the number, the more aggressive the cancer is likely to be. The Gleason score is made up of two numbers: The most common grade seen in all the samples. The highest other grade found in the samples. These two numbers are added together, with the most common grade listed first. For example: If most cancer cells are pattern 4 and the highest other pattern is 3, the score is 4+3 = 7. A score of 3+3 = 6 usually indicates very slow-growing cancer. A score of 7 suggests faster-growing cancer, with 4+3 generally being more aggressive than 3+4. Scores of 8, 9, or 10 indicate faster-growing, more aggressive cancer that is more likely to spread. 3. What does it mean if cancer has metastasised? You might hear the terms metastasised, metastatic or advanced prostate cancer. These all mean the same thing – that the cancer has spread from the prostate to other parts of the body. This occurs when cancer cells travel through the blood or lymphatic system, so the cancer is no longer contained within the prostate. When this happens, prostate cancer is no longer curable, but treatments can be offered to help shrink the cancer and slow its growth or prevent further spread, such as hormone therapy. In recent years, research has developed a number of new treatments for advanced prostate cancer, meaning men are thankfully living longer than ever before. Metastatic prostate cancer can sometimes cause symptoms in the areas it has affected, for example bone pain, anaemia, or issues passing urine. At this stage, additional treatments may be required to address these symptoms, rather than the cancer itself, to improve quality of life and keep the patient as comfortable as possible. 4. How should you talk to your kids about your cancer diagnosis and treatment? Is there support available for them? Breaking the news to loved ones that you've been diagnosed with prostate cancer is never easy. It can be especially challenging when that conversation is with your children. Even when they are young adults, like Paul's children, aged 22 and 19, a parent's illness can shake their world. Men often tell us they feel unsure about the best way to approach the conversation. While there's no single 'right' method, here are some guiding principles to help you navigate it in a way that feels true to your family, remembering that everyone approaches these conversations differently. Choosing the right moment Sometimes it helps to wait until you have a clear treatment plan before talking to your children. That might mean allowing time for tests and consultations to finish. Having answers ready, such as, 'This is what I have, and this is how we're going to deal with it', can make the conversation feel less uncertain for everyone. Pick a time when you won't be interrupted, and allow space afterwards for reflection. It's common for questions to come hours or even days later, so check in with them regularly. Some men also consider what else might be happening in their children's lives – exams, travel, big events – when deciding on timing. Considering their age and experience The way you speak will naturally differ depending on whether your children are young, teenagers, or adults. With young adults, you might be more open about the details of diagnosis and treatment, while still tailoring your words to their emotional readiness. If they've experienced illness in the family before, acknowledge that, but remind them that every situation is different. Above all, be honest. Children, whatever their age, often sense when something is being held back, and uncertainty can fuel anxiety. Keep them updated. Even small updates – 'I had my appointment today; they don't need to see me again for six months' – can help prevent them from imagining the worst. Support for them, and for you It's not just you who needs support. Your children may benefit from speaking with a counsellor, a health professional, a trusted person at school or reading information designed for family members. Organisations like Maggie's, Macmillan and Fruitfly Collective have further information on talking to children about a cancer diagnosis. Encouraging them to seek help is not a sign of weakness; it's a way of strengthening the whole family. Facing cancer is daunting, but talking openly with your children can deepen trust, reduce fear, and help you face the journey together. Acknowledge emotions: yours and theirs Let them know it's OK to feel scared, angry or uncertain. Naming emotions can make them feel less overwhelming. Broaden your horizons with award-winning British journalism. 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Medscape
11-08-2025
- Medscape
Don't Reclassify Grade Group 1 Prostate Cancer: New Data
TOPLINE: Among US men with grade group 1 (GG1) prostate cancer, about 1 in 6 had intermediate- or high-risk disease, along with increased rates of adverse pathology and cancer-specific mortality. This finding suggests that GG1 prostate cancer should not be reclassified as noncancerous, as some experts have proposed. METHODOLOGY: Some experts have pushed to reclassify GG1 prostate cancer as a noncancerous entity to help reduce overtreatment. GG1 status is primarily designated via biopsy, but current guidelines recommend treatment decisions be based on a range of parameters, including prostate-specific antigen (PSA) levels, clinical stage, and tumor volume. Arguing against reclassification, researchers analyzed how localized GG1 prostate cancer varies by National Comprehensive Cancer Network (NCCN) risk groups, treatment, and cancer-specific outcomes. The researchers used the Surveillance, Epidemiology, and End Results database to identify 117,162 men diagnosed with localized GG1 prostate cancer (median age, 64 years) between January 2010 and December 2020. Patients were stratified by NCCN risk groups: low-risk, favorable intermediate-risk (n = 10,440; 9%), unfavorable intermediate-risk (n = 3145; 3%), and high-risk (n = 4539; 4%) — meaning 16% had non-low-risk disease. Outcomes included adverse pathology (> pT3, GG3-5 or pN+) at radical prostatectomy, prostate cancer-specific mortality, and trends in the management of GG1 prostate cancer. Comparisons with SEER patients with GG2 disease were included for context. The median follow-up was 58 months. TAKEAWAY: Rates of adverse pathology at prostatectomy increased from 16% in low-risk GG1 disease to 60% in high-risk GG1 disease. In adjusted analyses, compared with low-risk prostate cancer, favorable intermediate-risk GG1 prostate cancer was associated with 1.42-fold higher odds of adverse pathology, unfavorable intermediate-risk GG1 with 2.31-fold higher odds, and high-risk GG1 with 7.15-fold higher odds. At 10 years, the cumulative incidence of prostate cancer-specific mortality was 1.3% for low-risk GG1, 2.0% for favorable intermediate-risk GG1, 2.4% for unfavorable intermediate-risk GG1, and 4.7% for high-risk GG1. Compared with low-risk GG1 disease, the risk for death from prostate cancer was higher for favorable intermediate-risk (adjusted hazard ratio [aHR], 1.60), unfavorable intermediate-risk (aHR, 2.10), and high-risk (aHR, 3.58) GG1 prostate cancer. Mortality rates among patients with intermediate-risk GG1 cancer were comparable to that of patients with favorable intermediate-risk GG2 disease, at 2.1%. However, mortality among high-risk GG1 patients (4.7%) was significantly higher (P < .001). Regarding trends in the management of GG1 prostate cancer, active surveillance rose from 4% to 19% for unfavorable intermediate-risk disease, and from 9% to 25% for high-risk disease (P < .001). The data suggest high-risk patients are being undertreated, the authors wrote, 'possibly due to conflation of grade and risk.' IN PRACTICE: Prostate cancer-specific mortality for men with GG1 disease 'increases substantially across National Comprehensive Cancer Network risk groups,' the authors concluded. 'Designating GG1 on biopsy as noncancer without considering the prognostic values of adverse clinical features may lead to undertreatment and an increased risk of cancer-specific death in men with non-low-risk disease.' SOURCE: The study, led by Neal A. Patel, MD, Weill Cornell Medicine, New York City, was published online in JAMA Oncology. LIMITATIONS: Analysis lacked data on MRI and targeted biopsy use and did not account for prostate volume, which affects PSA levels. Histologic grading varied across pathologists due to nonstandardized assessments. Additionally, details on active surveillance intensity and watchful-waiting protocols were unavailable. DISCLOSURES: The study received support from the Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust and the Sandra and Edward Meyer Cancer Center of Weill Cornell Medicine. One author reported serving on the advisory board for Lantheus, Lynx Dx, Pacific Edge, and Pfizer/Astellas and receiving grants from the National Cancer Institute outside the submitted work. No other conflicts of interest were reported. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
