
Measles outbreak: how contagious is it and what are the symptoms?
Twenty-five years ago, the US eliminated the measles virus. Measles is extremely contagious, and sporadic cases and outbreaks are expected.
But as of 28 February, 146 people in Texas – the majority of whom are unvaccinated children – have contracted measles. Twenty have been hospitalized, according to the Texas department of state health services. One 'school-aged child' who was not vaccinated died this week, according to a 26 February statement – the first measles death in the US since 2015.
Nine other cases have been reported in a neighboring county in New Mexico, say state health officials.
'This is a significantly sized outbreak,' says Dr Adam Ratner, a pediatric infectious disease physician in New York City and author of the book Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children's Health. The CDC defines an outbreak as three or more related cases; last year, a total of 285 cases were reported across 31 states and Washington DC.
Here's everything to know about measles as the virus spreads.
The last major US measles outbreak occurred in 2019, when nearly 1,300 people caught the virus. According to the CDC, this almost cost the US its elimination status. (Measles is considered eliminated when it hasn't spread in a region for 12 or more consecutive months.)
Dr Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston, says the latest case numbers are 'still the tip of the iceberg' and are on track to reach or surpass those of past outbreaks.
That's largely due to declines in vaccination rates in the US and worldwide that have contributed to a fourfold rise in measles outbreaks from 2023 to 2024 alone. 'I think we're still on that trajectory,' Hotez says. 'I would imagine 2025 is going to be a pretty rough year for measles.'
Measles is a respiratory virus that mostly affects children, but can also affect adults who were never infected or vaccinated against it, says Robert Bednarczyck, an epidemiologist and associate professor of global health at Emory University in Georgia.
Measles is often lumped together with mumps and rubella because there's one vaccine, known as MMR, that protects against all three diseases. But they're each caused by different respiratory viruses.
The measles virus lives in the nose and throat mucus of infected people. When they cough, sneeze or breathe, viral particles slingshot into the air, where they can linger for up to two hours. 'You don't even have to have direct or close contact with an infected individual' to get sick, says Hotez. This is why measles is one of the most contagious viruses we know of.
According to the CDC, if one person has measles, up to 90% of people who are not immune and breathe the contaminated air or touch an infected surface will get sick. Unlike other respiratory bugs, it is not seasonal.
A person infected with measles is contagious for about eight days, including the four days before a rash appears, and the four days after. This is problematic, says Ratner, because it means you can spread the virus without knowing it.
You may not know you have measles right away because symptoms typically emerge one to two weeks after exposure. Around that time, you might develop a cough, runny nose, red and watery eyes, and high fever, according to the CDC. At this point you might assume you have the flu, but in another two to three days you may find tiny white spots inside your mouth, Bednarczyck says, which 'is a clear giveaway' for measles.
Three to five days in, you might develop the classic rash: red patches on the face that dot the hairline, then spread to the neck, trunk, arms, legs and feet, says the CDC. The darker your skin, the more likely you'll see small raised bumps in the same areas without discoloration. Although it looks painful, a measles rash usually isn't itchy.
Overall, you might feel sick for about a week, says the World Health Organization, and the rash could take five to six days to fade away. If you suspect that you or your child has measles, call the doctor's office or hospital before you arrive, says Ratner, so they can reduce your exposure to others in the waiting room.
Most people who catch measles recover with no lingering consequences, say experts. But complications can affect a relatively large number of people who get the virus; some are very serious.
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Ear infections, for example, occur in about one out of every 10 children with measles, according to the CDC. As many as one in 20 will get pneumonia, which is the most common cause of measles-related death in young kids. About one in every 1,000 children will develop brain swelling called encephalitis, which can cause deafness, convulsions or intellectual disability. Data show that about one to three of every 1,000 kids with measles will die from these complications.
A fatal central nervous system disease called subacute sclerosing panencephalitis can happen to very few people about seven to 10 years after they recover from measles; the risk is higher for those who get measles before age two.
Unvaccinated people, children younger than age five, adults over age 20, people with weakened immune systems, and pregnant people face the greatest risks of measles complications, says the CDC. Even so, it's important to remember that anyone, regardless of their health, can get seriously ill and die from measles, says Ratner – especially considering there are no treatments for the virus. Some hospitalized people may receive vitamin A, which may reduce their risks of bad outcomes, says Ratner, but it's not a cure.
Because measles is airborne, face masks can help protect against infection, experts say. But vaccination is by far the best way. Before the US measles vaccination program began in 1963, about 3 to 4 million people caught the virus, 48,000 were hospitalized, 1,000 developed encephalitis, and 400 to 500 died each year in the US, according to CDC data.
There are two doses. The first, which children get aged 12 to 15 months, is about 93% effective, and the second, which kids get between ages four and six, is about 97% effective. That means roughly three out of every 100 people who are fully vaccinated still get measles after exposure to the virus, says the CDC.
Still, the vaccine can lower the odds of severe disease and the likelihood of spreading it to others, says Ratner, including those who can't get vaccinated because they're too young or have weakened immune systems. And research suggests that the virus diminishes the antibodies you've acquired for other germs, says Bednarczyck, leaving you vulnerable to all sorts of infections, especially if you aren't vaccinated.
The measles shot is safe, according to decades of research. One infamous 1998 study of 12 children suggested a link between MMR and autism; it was later retracted for 'scientific fraud'. Several papers have since proved that association wrong.
If you are exposed to measles and have not been vaccinated or have only received one dose, you can receive a measles vaccine within 72 hours of exposure, says Ratner, which could prevent infection or reduce the chances you get really sick. Kids too young for vaccination and people considered high-risk for severe disease could receive an antibody treatment called immunoglobulin within six days of exposure via IV or a shot in their arm.
Infection and vaccination against measles are both thought to offer lifelong immunity – that is, you can't get measles twice. But if you're unvaccinated and have been infected, says Ratner, you should roll up your sleeve anyway to protect against mumps and rubella.
MMR contains a weakened version of the measles virus, which causes a harmless infection that helps people develop immunity. So some people shouldn't get the vaccine, says the CDC, including those who are pregnant, have a weakened immune system due to disease or treatment, or have a parent or sibling with a history of immune system problems.
If you've been vaccinated, you don't have much to worry about. But overall, the CDC says measles is a concern for the US. Fewer children worldwide are getting their measles shots, fueled in part by Covid-related anti-vaccine rhetoric. This means infections could become more common as unvaccinated travelers spread the virus. 'Our control of measles is really a testament to the vaccine and our ability to use it,' says Bednarczyck, 'but we're potentially sitting right on the edge of where we might start seeing more widespread outbreaks.'
From the 2019-20 to 2023-24 school year, vaccinations among US kindergartners dropped from 95% to just below 93%. It's a concerning trend, says Ratner, because we need at least 95% vaccination coverage to achieve herd immunity, which is when enough people are immune to measles to prevent significant spread. Within individual states, rates can be even lower; Idaho, for example, has a 80% vaccination rate.
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The Guardian
20 hours ago
- The Guardian
US experts fear all vaccines at risk as Trump officials target mRNA jabs
As top US health officials turn against some mRNA vaccines, experts fear for the country's preparedness for the next pandemic and worry that other vaccines will be targeted next. Donald Trump's administration recently canceled a $766m award to Moderna on the research and development of H5N1 bird flu vaccines, and officials have announced new restrictions and regulations for Covid mRNA vaccines – actions that signal a move away from the breakthrough technology. These changes add to other vaccine-related shakeups at health agencies, including layoffs and resignations of top vaccine officials and the abrupt termination of HIV vaccine research. On Monday, Robert F Kennedy Jr, secretary of health and human services, announced he was disbanding the independent advisory committee on vaccines for the US Centers for Disease Control and Prevention (CDC). 'I think mRNA vaccines are particularly at risk, although I think all vaccines are at risk,' said Paul Offit, professor of pediatrics at the University of Pennsylvania Perelman School of Medicine. 'I think that this administration will do everything it can to make vaccines less available, less affordable and more feared.' Messenger RNA, or mRNA, vaccines heralded a major breakthrough in battling the Covid pandemic, building on three decades of scientific work and earning a Nobel prize. The Covid vaccines, some of which were co-developed by US government scientists, were taken by millions of people around the globe, and international scientists and officials closely monitored their side effects and effectiveness. mRNA vaccines and therapeutics show promise for treating or preventing certain cancers, rare conditions and infectious diseases – including, potentially, the next pandemic, experts said. 'We don't know what the next pandemic virus is going to be,' said Jennifer Nuzzo, professor of epidemiology and director of the Pandemic Center at Brown University School of Public Health. With mRNA, she said, 'you can pivot faster when you find a new virus to make a vaccine that's tailored to that virus'. The mRNA vaccines also don't need to be incubated in eggs, which is time-consuming and potentially difficult if there are egg shortages from bird flu outbreaks. In 2009, the US didn't have enough vaccines to battle the swine flu pandemic, Nuzzo said. 'It seems like we're determined to repeat those mistakes.' Despite their promise, mRNA vaccines have been plagued by misinformation. Some skeptics believe the vaccines affect fertility or cause birth defects, though research shows no link – and, in fact, studies show that the vaccines reduce these risks by preventing infections with Covid, which can be especially dangerous to pregnant people and newborns. Because mRNA sounds similar to DNA, some people mistakenly think it interferes with their genes. Conspiracy theorists also claim the vaccine causes people to die suddenly, or that the shots implant microchips or impart 5G connectivity. Meghan McCain recently endorsed, in a now-deleted social media post, an unregulated supplement company's 'spike detox' for those who 'regret' getting vaccinated. Kennedy, a longtime anti-vaccine activist, called the mRNA Covid shots the 'deadliest vaccine ever made,' incorrectly claiming the vaccines cause more illnesses and deaths than they prevent. Kennedy rose to greater prominence through the pandemic as previously fringe conspiracies about vaccines began dominating more mainstream narratives. 'Anti-vaccine sentiment goes back to the first days of vaccines in the 1700 and 1800s,' said John Moore, professor of microbiology and immunology at Weill Cornell Medical College. 'It's been a perpetual theme in society for 200-plus years, but it has been turbocharged by the Covid pandemic.' Some states are now considering laws against mRNA vaccines, and US health officials have taken several steps to limit Covid shots in recent weeks. Officials with the Food and Drug Administration (FDA) announced plans to limit boosters to older people and those with certain health conditions, as well as plans to conduct placebo-controlled clinical trials again. The CDC removed the vaccination recommendation for pregnant people and softened the recommendation for children's shots. About 165,000 Americans were hospitalized and 40,000 died in the previous year because of Covid, the CDC said at an April meeting. About 6,700 of those hospitalizations were among children, especially young children, and 152 children died from Covid in that time, the data showed. About 5% of children under five are vaccinated against Covid – rates much lower than other age groups. 'That's why, if you look at the numbers of hospitalizations and deaths for children now, especially young children less than four years old, it's really not much different than the beginning of this pandemic,' Offit said. There's also 'extensive evidence' for benefits to pregnant people and their babies, he said. While the FDA recently approved Moderna's 'next generation' Covid vaccine, which was even more effective that their current shot in clinical trials, the agency limited the new shot only for older adults and for people aged 12 to 64 with health conditions putting them at higher risk. The FDA also announced new requirements for mRNA Covid vaccine makers to add additional warnings about the risks of myocarditis, or heart inflammation, based on data the FDA has not made public. During the Biden administration, Moderna received two awards totaling $766m to develop potential bird flu vaccines. Despite the changeover in administrations, Moderna's work continued as normal – until February, when health officials said in an article that the funding was being reviewed. Moderna hadn't received any notification of this review, which recently culminated in having the funding cancelled. Halting the H5N1 vaccine research, which was in phase 3 trials, leaves the US vulnerable in a potential flu pandemic, Nuzzo said. It also means other countries could build upon US investments to procure the vaccines for themselves. mRNA has shown promise in treating pancreatic cancer and other cancers, as well as rare conditions and hard-to-treat infectious diseases. Moderna, for instance, is working on vaccines for melanoma, lung cancer, norovirus, flu, and CMV, or cytomegalovirus, a fairly common infection that can cause lasting health problems for infants. The company also has an RSV vaccine, currently approved for older adults, that could be expanded for other age groups. But those efforts could be hampered by the administration's moves against mRNA and terminations of vaccine scientists and independent advisors who offer vaccine recommendations. 'We don't want to see kids kicked out of school because a 12-year-old girl is not getting her fifth Covid booster shot,' Marty Makary, head of the FDA, said in a recent interview. Yet no states require Covid vaccination for school attendance. Pushing back against mandates is a common tactic from anti-vaccine activists working to dismantle all vaccine mandates, Offit said. In addition to claiming the Covid vaccines are deadly, Kennedy has 'also said no vaccine is beneficial', he said. Kennedy recently unveiled a sweeping and controversial $50m research project on autism, including an autism research database. If that effort somehow links autism to vaccines – despite decades of studies showing no connection – it could open lawmakers up to lawsuits, Offit said. 'He could manipulate the Vaccine Injury Compensation Program,' Offit said. If Kennedy adds autism to the compensable list of injuries, 'it would break the program'. That would mean the people who experience very rare severe side effects from vaccines may then face challenges getting compensated. And it could prompt vaccine makers to stop producing routine childhood immunizations because of legal liability. 'It's a fragile market,' Offit said. Kennedy 'is an anti-vaccine activist, science denialist and conspiracy theorist', he continued. 'I think that he will continue this onslaught against vaccines.'


The Independent
2 days ago
- The Independent
Bacteria in your mouth might reveal how depressed you are, scientists say
Depression could be linked to a lack of diversity in the bacteria in your mouth, according to new research. As you read this, your mouth contains between 500 billion and 1 trillion bacteria. After the gut microbiome, the orifice is the second-largest community of microorganisms in human bodies. Now, researchers at New York University say the makeup of those microbes could be used to help diagnose and treat depression. In a new study, they found that less diversity of microbes in the mouth is associated with the mental health condition. 'It's possible that the oral microbiome influences depressive symptoms through inflammation or changes to the immune system. Conversely, depression can drive changes including dietary intake, poor oral hygiene, increased smoking and drinking, or the use of medications—all of which have the potential to alter the oral microbiome,' Dr. Bei Wu, vice dean for research at NYU Rory Meyers College of Nursing, said in a statement. 'We need more research to understand the direction and underlying pathways of this relationship.' Wu is the senior author of the study, which was published this week in the journal BMC Oral Health. To reach these conclusions, the authors examined data from the Centers for Disease Control and Prevention's National Health and Nutrition Examination Survey. They used questionnaire data from more than 15,000 adults collected between 2009 and 2012 to compare symptoms of depression with saliva samples. They also used gene sequencing to identify the microbes in the saliva and measure the diversity of the oral microbiome. That's how they found that people with less microbial diversity were more likely to have symptoms of depression. Additional analysis revealed that practices including smoking, drinking, and dental care influenced the relationship between the oral microbiome and depression. They can all change the makeup of bacteria in the mouth. They noted that antidepressants and other psychotropic medications have side effects that can lead to reduced saliva and alter the oral microenvironment. 'Thus, medications not only alleviate depressive symptoms but also have a regulatory effect on oral health,' they said. Still, it remains unclear whether the diversity of microbes in the mouth influences depression, if depression leads to changes in the oral microbiome, or if there's a symbiotic relationship. They noted that a recent study found a potential link between depression and the diversity of bacteria in the gut, and that a growing body of research points to a connection between the oral microbiome and overall health. That's thought to be driven by inflammation and disruptions to the immune system. They hope these findings will support a greater understanding of the issue. In 2021, an estimated 21 million adults had at least one major depressive episode in the past year. 'Having a better understanding of the relationship between the oral microbiome and depression could not only help us learn about the mechanisms underlying depression, but could contribute to the development of new biomarkers or treatments for mood disorders,' said Wu.


Telegraph
2 days ago
- Telegraph
Misinformation, guitar ballads and herbal remedies: A who's who of RFK Jr's vaccine committee
Robert F. Kennedy Jr has unveiled his choices for a critical committee whose job it will be to advise the US government on vaccine use. All 17 members of the Advisory Committee on Immunisation Practices (ACIP) at the Centres for Disease Control and Prevention (CDC) were abruptly sacked earlier this week in the health secretary's latest assault on US vaccine policy. Mr Kennedy, a prominent vaccine sceptic, has now named the eight officials who will take over the job of developing recommendations on how to use vaccines to control diseases in the US. Among them are high-profile critics of the jabs developed to fight Covid-19, an accident and emergency doctor with little or no vaccine expertise, and a former gynaecology professor who advised a supplement company selling healing herbs. Out of the eight – the minimum number of people required to sit on the committee – at least four have actively spoken out against vaccines in the past in some form. The sudden dismissal of the original advisors, along with the swift announcement of their replacements, has sparked concern in the public health community that the usually strict vetting procedures have not been followed. Typically, the ACIP vetting process takes a year and a half. It is not clear how long the new members were vetted for – although Donald Trump took office just five months ago and RFK Jr was only confirmed as health secretary in February. The ACIP was once considered the 'gold standard for vaccine decision making,' said Helen Chu, one of the fired panel members, but now many in the field are concerned that the panel will advance an anti-vaccine agenda. Dr Robert Malone Arguably the most controversial pick is Dr Robert Malone, a medical doctor and biochemist by background who became one of the most vocal critics of mRNA vaccines during the pandemic. Dr Malone actually claims to have invented mRNA technology – the technology first used during the pandemic to manufacture Covid-19 vaccines, which have been credited with saving millions of lives. Though he was involved in some early mRNA research in the late 1980s, his role has been described as minimal at best. But during the pandemic, Dr Malone made several appearances on right-wing media channels to share his views on the jabs and was temporarily banned from using X (formerly Twitter) for spreading misinformation. Dr Malone appeared on the Joe Rogan Experience (JRE) podcast in 2023 which ignited uproar in the medical community. In a three hour episode, Dr Malone and Mr Rogan discussed theories and claims about the pandemic and vaccines. The conversation included a false equivalence between the vaccine and Nazi medical experiments, that the public had been 'hypnotised' into following government Covid guidelines, and that those who are vaccinated after having Covid-19 are at greater risk of harmful side effects. After the episode aired, a group of 270 doctors, scientists, and academics wrote to Spotify, saying that 'Dr Malone used the JRE platform to promote numerous baseless claims, including several falsehoods about Covid-19 vaccines and an unfounded theory that societal leaders have 'hypnotised' the public. Many of these statements have already been discredited'. Dr Malone is closely aligned with Mr Kennedy's Make America Healthy Again movement, and joined both the health secretary and President Trump to celebrate on election night. Dr Martin Kulldorff Dr Kulldorff is a Swedish biostatistician and former professor of medicine at Harvard university. While he has been historically supportive of vaccines – and previously advised the CDC on vaccine safety – he is critical of vaccine mandates. He has argued that those who have been previously infected with Covid-19 – and children – do not need to be vaccinated. 'Study after study have shown that natural immunity after Covid infection is superior to vaccine immunity,' he wrote on X. 'Forcing the vaccine on everyone is a stain on hospitals, universities and public health officials. How can we trust them on other matters?' In October 2020, Kulldorff, along with now US National Institute of Health director Jayanta Bhattacharya, co-authored the highly controversial Great Barrington Declaration. The open letter opposed lockdowns and called for the promotion of herd immunity through infection by lifting all restrictions on lower-risk groups and shielding older people from the virus. Dr Retsef Levi Dr Levi is a professor of operations management at Massachusetts Institute of Technology. He has published multiple research papers on Covid-19, including one that raises concerns about the relationship between vaccines and cardiac arrest in young people. Pinned to the top of Dr Levi's X profile is a post from 2023, in which he said: 'The evidence is mounting and indisputable that MRNA vaccines cause serious harm including death, especially among young people. We have to stop giving them immediately!' Infectious disease experts and scientists say that mRNA vaccines are safe and effective, and saved millions of lives during the pandemic. The technology is particularly useful in outbreaks of novel viruses, because the vaccines can be manufactured quickly and to scale. Dr Joseph Hibbeln Dr Hibbeln is a psychiatrist and neuroscientist. He has previously worked at the US National Institutes of Health, where he focused chiefly on the link between nutrition and mental health disorders. His work has also influenced US public health guidelines on fish consumption during pregnancy. Echoing the rhetoric of RFK Jr's 'Make America Healthy Again' movement, a post on Mr Hibbeln's Linkedin says 21st century diets provide 'inadequate brain nutrients that are likely contributing to the high burden of mental illnesses worldwide.' It is not clear what Dr Hibbeln's views on vaccination are. Dr Michael A Ross Dr Ross is a former professor of obstetrics and gynecology at Virginia Commonwealth university. He has held board, advisory and executive positions at a wide range of private healthcare and life-science firms. He once worked as an advisor to LarreaRX, a supplement manufacturer which produces capsules made from Larrea Tridenta, a desert herb that the company claims 'can be used for immune support.' The US Food and Drug Administration (FDA) has issued warnings about the herb, saying it can be hazardous to health. The agency says it has received multiple reports of hepatitis associated with consumption of the herb, including at least two cases in which consumers had to undergo liver transplants. During the Covid-19 pandemic, Dr Ross signed an open letter criticising a study which found ivermectin was ineffective for treating the disease. Ivermectin, an anti-parasitic used in both humans and livestock, was touted as a 'miracle drug' by vaccine sceptics, despite it being proven to have no effect on Covid-19 infection. 'We oppose this fixation on randomised controlled trials at the expense of other clinical and scientific evidence and urge medical policymakers to restore balance to the practice of medicine,' the letter read. Dr Vicky Pebsworth Dr Pebsworth is an ICU nurse by background, and has previously served on the FDA's Vaccine and Related Biological Products Advisory Committee. She is a board member of the National Vaccine Information Center, formerly called 'Dissatisfied Parents Together', a Virginia-based organisation which has been widely criticised as a leading source of misinformation about vaccines. An online biography of Ms Pebsworth says her interest in vaccine safety was peaked when her son 'experienced serious, long-term health problems following receipt of seven live viruses and killed bacterial vaccines' during a health visit as an infant. Dr Cody Meissner Dr Meissner is a professor of paediatrics at the Geisel School of Medicine at Dartmouth, and previously worked as the Chief of Paediatric Infectious Diseases at Tufts Children's Hospital. He has sat on multiple federal boards, including the ACIP between 2008-2012 and an advisory panel to the US Food and Drug Administration on vaccine safety. In 2021, he was a part of the FDA panel that rejected Joe Biden's plan to offer Pfizer booster jabs to Americans of all age groups, approving only their use in over 65s and those at risk of significant illness. 'I don't think a booster dose is going to significantly contribute to controlling the pandemic and I think it's important that the main message we transmit is that we've got to get everyone two doses,' he said at the time. He has also expressed doubt over whether children should be vaccinated against Covid-19. Dr James Pagano Dr Pagano is a retired emergency medicine doctor from Los Angeles 'with over 40 years of clinical experience', and is a 'strong advocate for evidence-based medicine,' according to Mr Kennedy. He has published two medical fiction books entitled The Bleed and The Drain. The latter is about 'money, medicine, miracles, and a doctor's pursuit of happiness in spite of all that,' according to a description on Amazon. According to his author's biography, Dr Pagano is also an accomplished guitarist who has composed and recorded music for motion pictures. The cover of his album 'Hopeless Romantic' depicts the doctor with a martini in one hand, with his arm around a guitar. What does it mean for vaccination in the US? Since 1964, the ACIP has deliberated on the use of new and existing vaccines and delivered their findings to the CDC, who subsequently implements their recommendations – although has the power to overrule them. The group votes on key questions about jabs, for example who should receive Covid boosters or at what ages children should receive certain vaccinations. All of the vaccines that are discussed already have to be approved by the FDA, although many health insurance companies – including Medicare, the federal insurance program for people aged 65 or older and younger people with disabilities – are required to pay for vaccinations in full if the ACIP recommends them. The Vaccines for Children Program, another federal program which provides free vaccinations for kids whose parents cannot afford them, also covers the cost of immunisations recommended by the ACIP. If the new board decides to stop recommending certain vaccinations, it is possible that insurance companies could stop funding them – meaning individuals would have to pay for the shots themselves. The ACIP's next meeting is set for later this month. A previously released agenda said the committee would discuss vaccination against Covid, HPV, and lyme disease.