Dupilumab Controls Cancer Rx-Related Skin Toxicities
Patients with antibody-drug conjugate (ADC)-related skin reactions had higher response rates and fewer treatment discontinuations when treated with dupilumab than with systemic steroids.
METHODOLOGY:
Researchers evaluated 163 patients at Memorial Sloan Kettering Cancer Center who received an ADC from January 2020 through September 2024, with follow-up until December 2024.
The analysis included 27 adult patients with ADC-induced dermatologic adverse events (dAEs); 11 were treated with dupilumab (63.6% women; 81.8% White) and 16 were treated with systemic steroids alone (37.5% women; 81.2% White).
Researchers analyzed the severity of dAEs, treatment responses, and cancer treatment discontinuation rates.
TAKEAWAY:
In the dupilumab group, 82% of patients received enfortumab vedotin for genitourinary malignancies, and 46% received pembrolizumab. Clinical presentations of dAEs included eczematous eruptions in 54% of patients, morbilliform eruptions in 46%, and vesiculobullous eruptions in 27%.
In the steroid-treated group, all patients received enfortumab vedotin with pembrolizumab for genitourinary malignancies. In the dupilumab group, 70% of patients experienced grade 3 events, whereas 56% in the steroid-only group experienced grade 2 reactions.
In the dupilumab group vs the steroid-only group, 73% vs 56% of patients achieved complete response, and 27% vs 25% achieved partial response of skin reactions, respectively. Among those on dupilumab, the median time to first clinical response was 24 days, and the median time to best clinical response was 52 days.
In the dupilumab group, no patients discontinued treatment because of dAEs vs 43.8% in the steroid-only group (P < .05).
IN PRACTICE:
'Dupilumab appears promising as a steroid-sparing treatment of ADC-induced cutaneous toxicities,' which 'are difficult to manage and can disrupt cancer treatment,' the study authors wrote. 'Further research is essential to explore its broader utility and economic feasibility,' they added.
SOURCE:
The study was led by Ian Nykaza, BS, of the Dermatology Service, Department of Medicine at Memorial Sloan Kettering Cancer Center, New York City. It was published online on July 30 in JAMA Dermatology.
LIMITATIONS:
Limitations included the small study size, retrospective design, treatment heterogeneity, and limited ADC diversity.
DISCLOSURES:
This study was supported by the National Institutes of Health/National Cancer Institute's Cancer Center Support Grant P30 CA008748. Several authors reported receiving personal fees and research funding from various sources.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
8 minutes ago
- Yahoo
7 Things a Trauma-Informed Psychologist Is Begging Parents and Grandparents To Stop Doing ASAP
7 Things a Trauma-Informed Psychologist Is Begging Parents and Grandparents To Stop Doing ASAP originally appeared on Parade. "I turned out fine." "They'll never remember this time, anyway."These lines may offer reassurance to parents and grandparents. However, one psychologist notes it's essential to recognize that what happens in early childhooddoes indeed matter."The brain goes through its most rapid period of development in the first few years of life, and parents play a critical role in shaping the neural pathways that will impact children for the rest of their lives," explains Dr. Emily Guarnotta, Psy.D., a psychologist who uses trauma-informed techniques and is the co-founder of Phoenix Health. "From a trauma-informed perspective, providing a consistent, nurturing and predictable environment and relationship for children helps foster a secure attachment."On the other hand, she warns that environments marked by fear, unpredictability and neglect wire a child's brain for threat and be clear, no one is saying anyone has to be perfect. That's impossible and sets an untenable standard for children to try to emulate. The goal is to raise children who feel safe, even during challenging times, and have the ability to self-regulate their emotions. To help explain this, Dr. Guarnotta shares seven things she wishes parents and grandparents would stop doingso that they don't sabotage these 7 Things Grandparents and Parents Should Stop Doing ASAP, According to a Trauma-Informed Psychologist 1. Dismissing a child's feelings Class dismissed? Not when it comes to teaching emotional regulation, a process that begins early and involves being mindful not to invalidate a child's feelings."This can involve saying things like, 'You're overreacting,' 'Stop crying' or 'It's not that big of a deal,'" explains Dr. Guarnotta. "When we dismiss a child's feelings, we send the message that their emotions are 'wrong.'"Sure, drinking milk from a blue cup instead of a green cup doesn't seem like a big deal to you as an adult. However, kids are not mini-adults, and their disappointment—while not cause to start hitting you—is real to them. Telling them they can't hit is fine, but telling them something is "NBD" is harmful when done constantly."This can cause them to mistrust themselves and impact their emotion regulation skills," she says. "It can also negatively affect the child/caregiver bond, since children feel misunderstood rather than supported."Related: 2. Using punishments to spark fear and shame Some of these punishments may sound familiar and remind you of your childhood. However, Dr. Guarnotta says we know better these days and encourages caregivers to do better by the next generation of humans. "This can involve putting your hands on a child by spanking them, giving them the silent treatment or using hurtful words," she says. "These methods of punishment activate the fight-flight-freeze response. When a child is afraid, they are unable to learn the lesson that you are trying to teach them."Unfortunately, she warns that these punishments can damage your relationship with a child and teach them to use power and intimidation to solve problems with others. 3. Forcing affection If your child or grandchild doesn't want to hug Uncle Joey—or you—that's more than okay."Pushing a child to hug or kiss a family member when they are hesitant or say no teaches them that they should ignore their own feelings in order to please an adult," Dr. Guarnotta says. "Physical touch is one of the earliest and most important lessons in healthy boundaries. Instead of pressuring your child, you can say, 'Would you like to hug your uncle?' If your child says no, respect their decision." 4. Comparing your child When it comes to raising kids, comparison is more than the thief of joy. It can damage the relationship they have with the person you're putting on a pedestal and rob them of self-esteem."Comparing your child to a sibling or someone else can lead to resentment and feelings of inadequacy," Dr. Guarnotta points out. "It can also damage sibling relationships and lead children to seek external validation to prove their worth."Related: 5. Praising the outcome instead of the effort This one is sneaky, and even the most well-meaning grandparents and parents do it. It doesn't make you a bad person, but Dr. Guarnotta suggests taking a mindful approach to praise."When a child comes home with an 'A,' praising the outcome might sound like 'Good job on that A!' while praising the effort might sound like, 'You worked so hard to get that A,'" she what's the issue? Hear her out."While praising the outcome is well-intentioned, it can lead children to tie their self-worth to their performance, fear failure, avoid challenges and seek constant praise," she points out. 6. Overlooking the importance of play Again, even the best parents and grandparents may have this blind spot. Signing kids up for sports, music lessons and other structured activities is often done out of love and an attempt to have them find their "things" or get into a "good" college. "There is a strong push today for children to get involved in structured activities and academics," Dr. Guarnotta structured activities are fine—great even—and a child may adore them. Still, balance is key. Play isn't frivolous."While there is value in these activities, unstructured play is important for helping children process their experiences, learn problem-solving skills and develop social-emotional skills," she says. "When children are stressed, play can help them cope with their emotions and work things out." 7. Not attending to *your* emotional needs Surprised to see this one here? Don't be. You're a parent or a grandparent—not a martyr. Your needs matter too and will help you meet a child's needs."Many caregivers today are stressed, exhausted and even burnt out," Dr. Guarnotta reports. "The problem with this is that children rely on their caregivers to help them co-regulate, or regulate their own emotions."She shares that children can pick up on their caregivers' chronic stress, anxiety and anger."Their nervous system will mirror ours," she reveals. "It's important to model how to recognize and cope with our own emotions." Taking a minute to take a deep breath or tapping out for a quick walk when a partner comes home can offer a reset that helps you better show up for a The Most Impactful Thing You Can Do With Your Kids and Grandkids Today Dr. Guarnotta wants parents and grandparents to understand the importance of repair after rupture. Remember how we said no parent or grandparent is perfect? That's because it's true. You're bound to mess up."We all have moments where we lose our tempers, say the wrong things or dismiss a loved one's feelings," she explains. "These moments are called 'ruptures' in our relationships with our children. While we do want to minimize ruptures, they cannot be avoided entirely."That's where repair comes in."The goal is to repair when they do happen," she says. "Repairing ruptures shows children that relationships are resilient, it's OK to make mistakes and conflicts can be worked out. It also models empathy, accountability and forgiveness, which are important life skills."For instance, apologizing for raising your voice and telling a child to "calm down" about getting the blue cup instead of the green cup is a good example of repair. Then, validate that it must have been disappointing, and that you'll work on taking a deep breath before raising your voice next time—and following Next:Source: Dr Emily Guarnotta, Psy.D., a psychologist who uses trauma-informed techniques and is the co-founder of Phoenix Health. 7 Things a Trauma-Informed Psychologist Is Begging Parents and Grandparents To Stop Doing ASAP first appeared on Parade on Aug 3, 2025 This story was originally reported by Parade on Aug 3, 2025, where it first appeared. Solve the daily Crossword
Digital Trends
9 minutes ago
- Digital Trends
NASA skywatching tips for August include a Jupiter and Venus meetup
There's plenty of planetary action to be enjoyed in August, according to NASA's latest rundown of what to look out for in the sky this month. Highlights include a morning meetup between Jupiter and Venus, a chance to see the Perseid meteor shower, and a glimpse into the destiny of our own sun. Mars Mars is also viewable this month, in fact, it's the only planet that's visible in the early evening sky in August. You'll be able to spot it low in the west for about an hour after daylight starts to fade, though you'll have to look hard, as the glow of its characteristic salmon-pink color is now only about 60% as bright as it was in May. Saturn Later in the evening, at around 10 p.m., you'll be able to spot Saturn, and as the month goes on it'll appear a little earlier each evening. Look out for Saturn in the east after dark with the constellations Cassiopeia and Andromeda. The planet will appear to move toward the western part of the sky by dawn, so if you're an early riser, it's the perfect time to take a look. Jupiter and Venus 'The real highlight of August is the close approach of Jupiter and Venus,' NASA says. 'They shine brightly in the east before sunrise throughout the month.' The two planets appear far apart at the start of August, but as the days pass, they'll move closer together. 'They appear at their closest on the 11th and 12th — only about a degree apart. Their rendezvous happens against a backdrop of bright stars including Orion, Taurus, Gemini, and Sirius. A slim crescent moon joins the pair of planets after they separate again, on the mornings of the 19th and 20th,' NASA says. Perseids meteor shower The Perseids meteor shower is back again, and peaks overnight on August 12 and 13. But this year the moon is nearly full on the peak night, and so its brightness will impact the ability to see the meteors, except for the brightest ones. NASA says that while this is obviously disappointing, another meteor shower, the Geminids, will offer an excellent viewing opportunity — free of any moonlight — in December. Dumbbell Nebula This month is also a wonderful chance to view the Dumbbell Nebula, also known as M27, which is a type known as a 'planetary nebula.' 'A nebula is a giant cloud of gas and dust in space, and planetary nebulas are produced by stars like our sun when they become old and nuclear fusion ceases inside them,' NASA explains. 'They blow off their outer layers, leaving behind a small, hot remnant called a white dwarf. The white dwarf produces lots of bright ultraviolet light that illuminates the nebula from the inside, as the expanding shell of gas absorbs the UV light and re-radiates it as visible light.' Nicknamed for its dumbbell-like shape, the Dumbbell Nebula shows in the night sky as a small, faint patch of light about a quarter of the width of the full moon when viewing through binoculars or a small telescope. The diagram below gives you an idea of where to look — or consult your favorite astronomy app to find its precise location. 'Here's hoping you get a chance to observe this glimpse into the future that awaits our sun about 5 billion years from now,' NASA says. 'It's part of a cycle that seeds the galaxy with the ingredients for new generations of stars and planets — perhaps even some not too different from our own.'
Yahoo
16 minutes ago
- Yahoo
10 bodyweight moves are all you need to build stronger glutes, according to a Pilates instructor
When you buy through links on our articles, Future and its syndication partners may earn a commission. Building stronger glutes isn't a process that's strictly reserved for the heavy weights section in the gym. According to Pilates instructor Rachel, who is the founder of the highly popular Rachel Fit Pilates YouTube channel, it's perfectly possible to build strength and shape in your backside with just your bodyweight. In fact, the certified Pilates instructor and occupational therapist, who has a background in exercise science, says you just need 10 moves and 10 minutes to do so — and the benefits of doing so are tenfold. Carving out stronger glutes can help you avoid ankle sprains and hip injuries, as your gluteus maximus (which is the biggest muscle in the body), alongside your gluteus medius and gluteus minimus, act as shock absorbers for the body. Strong glutes can also boost your posture and reduce lower back pain. So what's not to love? Once you've rolled out your mat, you're good to go. How to do the 10-minute, 10-move workout This workout is part of a five-day no-equipment schedule, which makes this short session (and the rest) ideal for helping you keep up your fitness routine on the go. 'It's good to get in a little movement, whether you're travelling or just short on time,' notes Rachel. Featuring just 10 exercises in total, the workout is easy to follow as each move is split into 40-second intervals, followed by a 20-second rest. Rachel then finishes off with a glute stretch. During these periods of rest, the Pilates instructor demonstrates how to do the next exercise and shares pointers on how to master the move with the correct form. The 10 exercises include: Kneeling glute raise left Kneeling glute raise right Kneeling side raise left Kneeling side raise right V bridge Glute bridge Bridge hold + circle left Bridge hold + circle right Single leg bridge left Single leg bridge right If you have ankle weights available, Rachel says you can always strap these on for some extra resistance. Can Pilates grow your glutes? In short: yes, Pilates can grow your glutes if you're performing some of the best glute exercises, like the ones listed above. That's because the mind-body practice is a form of resistance training, as you are using resistance — in this case, your body weight — against gravity to increase muscle strength and tone. So technically speaking, you're resistance training each time you roll out your mat and perfect your leg circles, planks, and glute bridges. And the same can be said for each time you lift your child or carry bags of heavy shopping to and from your car. You can also utilize resistance equipment, like the humble Pilates ring, resistance bands, or a Reformer machine, to challenge your muscles further. Of course, building muscle doesn't just require you to lift heavy. To pack on muscle, you'll also need to ensure you're getting enough protein in your diet, as this nutrient provides the building blocks (amino acids) needed to help your muscles repair and grow after exercise. How much protein you need to build muscle will vary and will be personal to each and every one of us. In an ideal world, we'd all get enough protein through the meals we put on our plates. But if for any reason you're unable to hit your protein target — be it due to time constraints or motivation — that's where the best protein shakes make keeping on top of your goals easy. Follow Tom's Guide on Google News to get our up-to-date news, how-tos, and reviews in your feeds. Make sure to click the Follow button. More from Tom's Guide Forget push-ups — according to a scientist, these are the only two upper-body exercises you'll ever need Forget pull-ups — you only need 5 moves and a pair of dumbbells to build upper body strength and improve your posture Ditch the gym! This 5-move strength workout sculpts upper body muscle with just a pair of dumbbells
