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Glenmark receives DCGI approval to launch oncology drug BRUKINSA in India
Glenmark receives DCGI approval to launch oncology drug BRUKINSA in India

Business Standard

time3 hours ago

  • Health
  • Business Standard

Glenmark receives DCGI approval to launch oncology drug BRUKINSA in India

Glenmark Pharmaceuticals has announced the upcoming launch of zanubrutinib in India following approval by the Drugs Controller General of India (DCGI). Zanubrutinib will be marketed in India under the brand name BRUKINSA, an innovative therapy developed by BeiGene (now BeOne Medicines), a global oncology leader committed to delivering advanced treatments for cancer patients worldwide. BRUKINSA is the first and only Bruton's tyrosine kinase (BTK) inhibitor approved in India for the treatment of five distinct B-cell malignancies: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), Waldenstr macroglobulinemia (WM), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), and follicular lymphoma (FL). Globally, BRUKINSA is approved in more than 70 countries, supported by compelling clinical evidence from pivotal trials including ALPINE, ASPEN, and SEQUOIA. This extensive clinical program underscores BRUKINSA's proven efficacy, strong safety profile, and broad therapeutic value. The introduction of BRUKINSA brings an innovative treatment option at a time when India continues to face a significant burden from serious and difficult-to-treat haematological malignancies. According to various sources, someone in India is diagnosed with blood cancer every five minutes, and an estimated 70,000 people die from the disease each year. BRUKINSA addresses a critical unmet need with its differentiated pharmacological profile, demonstrating high response rates and durable disease control across multiple B-cell malignancies as shown in pivotal clinical trials. BRUKINSA's flexible dosing regimen (once or twice daily) supports personalized care.1 In the head-to-head ALPINE study in relapsed/refractory chronic lymphocytic leukemia, BRUKINSA demonstrated a lower rate of serious cardiac events (1.9% vs. 7.7%) and fewer treatment discontinuations due to cardiac issues (0.3% vs. 4.3%) compared with ibrutinib.

Glenmark Pharmaceuticals to launch Zanubrutinib (BRUKINSA) in India after DCGI approval
Glenmark Pharmaceuticals to launch Zanubrutinib (BRUKINSA) in India after DCGI approval

Business Upturn

time6 hours ago

  • Business
  • Business Upturn

Glenmark Pharmaceuticals to launch Zanubrutinib (BRUKINSA) in India after DCGI approval

Glenmark Pharmaceuticals has announced the launch of zanubrutinib in India following approval by the Drugs Controller General of India (DCGI). The drug will be marketed under the brand name BRUKINSA®, developed by BeiGene (now BeOne Medicines), a global oncology company. This marks the introduction of the first Bruton's tyrosine kinase (BTK) inhibitor in India approved for the treatment of five B-cell malignancies: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), Waldenström macroglobulinemia (WM), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), and follicular lymphoma (FL). BRUKINSA is approved in over 70 countries, backed by data from clinical studies such as ALPINE, ASPEN, and SEQUOIA. These trials have demonstrated consistent clinical outcomes across various B-cell cancers. The availability of BRUKINSA in India comes at a time when blood cancers continue to impact a large number of individuals. Estimates suggest that someone is diagnosed with blood cancer every five minutes in India, with annual deaths from the disease numbering around 70,000. The treatment has shown high response rates and the ability to maintain disease control in patients with different types of B-cell malignancies. It also offers dosing flexibility, allowing for once or twice-daily administration. In the ALPINE study, BRUKINSA was compared with ibrutinib in relapsed or refractory CLL and showed a lower rate of serious cardiac events and fewer treatment discontinuations due to cardiac-related issues. With its recent regulatory approval, BRUKINSA will now be available to patients in India who are affected by challenging hematological cancers. Aman Shukla is a post-graduate in mass communication . A media enthusiast who has a strong hold on communication ,content writing and copy writing. Aman is currently working as journalist at

India and Pakistan could come to blows over Kashmir
India and Pakistan could come to blows over Kashmir

Hindustan Times

time23-04-2025

  • Politics
  • Hindustan Times

India and Pakistan could come to blows over Kashmir

THE ALPINE meadows and pine forests of Pahalgam have long been a lure for visitors to the Indian region of Jammu & Kashmir. They called it 'mini-Switzerland' and came in greater numbers lately as India's government hailed a downturn in militant violence in the region. Yet on April 22nd, at least 20 people were killed and many more injured after unidentified gunmen opened fire on tourists in Pahalgam. It appears to have been the deadliest militant attack since 2019 in the Himalayan region, which is claimed in full but ruled in part by both India and Pakistan. While Indian police blamed militants fighting Indian rule, a group calling itself the 'Resistance Front' claimed responsibility on social media, citing an influx of 85,000 settlers. But former Indian military and intelligence officials accused Pakistan's armed forces of masterminding the assault and called for a strong and swift response. After the 2019 attack, which killed 40 Indian policemen, India carried out an air strike on Pakistan 12 days later. Pakistan's air force struck back the next day and as Indian jets responded, one crashed in Pakistani territory, although the pilot survived and was quickly returned to India. The Pahalgam attack, which coincided with a visit to India by America's vice-president, J.D. Vance, threatens to trigger another military confrontation between India and Pakistan, which both have nuclear weapons and have fought two wars, plus one more limited conflict, over Kashmir since their independence in 1947. Mr Vance, who is visiting cultural sites in northern India (several hundred miles away), offered his condolences to the victims of what he called a 'devastating terrorist attack'. President Donald Trump said America 'stands strong with India against terrorism'. India's prime minister, Narendra Modi, who is visiting Saudi Arabia, vowed to bring the perpetrators to justice. 'They will not be spared!' he posted on X. 'Our resolve to fight terrorism is unshakable.' Amit Shah, the Indian home minister, rushed to Kashmir to hold a security meeting. 'This attack on our visitors is an abomination,' said Omar Abdullah, the region's top elected official. It was 'much larger than anything we've seen directed at civilians in recent years.' Indian media reports said two of the dead were foreigners of Indian origin but did not give their nationalities. The attack is a blow to the Indian government's claims to have stabilised Kashmir. Tens of thousands of people have been killed there since the start of an anti-Indian insurgency in 1989. But in recent years militant violence appeared to have subsided. India's government credited that to its decision to revoke Kashmir's semi-autonomous status in 2019, splitting what had been an Indian state into two federally administered territories: Jammu & Kashmir, and Ladakh. That allowed tens of thousands of outsiders to get jobs and buy land in the region. Tourist numbers increased. But it also led to a deterioration of ties with Pakistan. In a speech this month Pakistan's army chief, General Asim Munir, described Kashmir as 'our jugular vein'. He continued: 'We will not forget it. And we will not leave our Kashmiri brethren in their heroic struggle.' Former Indian military and security officials suggested that the perpetrators had wanted to draw international attention to Kashmir by planning the attack to coincide with Mr Vance's visit to India and Mr Modi's to Saudi Arabia. They also suggested that the attack was designed to undermine Kashmir's tourist industry, as it came a few weeks before a big Hindu pilgrimage. The last deadly incident in the region was in June 2024 when nine people died after a militant attack caused a bus carrying Hindu pilgrims to plunge into a gorge. India's government then launched a major operation to find the perpetrators and pledged to strengthen security. This time, expect public calls for much firmer action.

India and Pakistan could come to blows over Kashmir
India and Pakistan could come to blows over Kashmir

Economist

time22-04-2025

  • Economist

India and Pakistan could come to blows over Kashmir

THE ALPINE meadows and pine forests of Pahalgam have long been a lure for visitors to the Indian region of Jammu & Kashmir. They called it 'mini-Switzerland' and came in greater numbers lately as India's government hailed a downturn in militant violence in the region. Yet on April 22nd, at least 20 people were killed and many more injured after unidentified gunmen opened fire on tourists in Pahalgam. It appears to have been the deadliest militant attack since 2019 in the Himalayan region, which is claimed in full but ruled in part by both India and Pakistan.

Connections: Sports Edition hints for April 17, 2025, puzzle No. 206
Connections: Sports Edition hints for April 17, 2025, puzzle No. 206

New York Times

time17-04-2025

  • Sport
  • New York Times

Connections: Sports Edition hints for April 17, 2025, puzzle No. 206

Need help with today's Connections: Sports Edition puzzle? You've come to the right place. Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores. A quick public service announcement before we continue: The bottom of this article includes one answer in each of the four categories. So if you want to solve the board hint-free, we recommend you play before continuing. Advertisement You can access Thursday's game here. Game No. 206's difficulty: 3.5 out of 5 Scroll below for one answer in each of the four categories. . . . . . . . . . . . . . . . . . . . . Yellow: SKELETON Green: ALPINE Blue: GREENE Purple: BERRA The next puzzle will be available at midnight in your time zone. Thanks for playing — and share your scores in the comments! (Illustration: Dan Goldfarb / The Athletic)

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