Latest news with #Abstract
Hypebeast
5 hours ago
- Entertainment
- Hypebeast
Things We Loved In Music This Week: June 27
As the week in music comes to a close, Hypebeast has rounded up the most notable music-related headlines – new releases, live performances, merch drops, fashion collaborations and more. After an enigmatic rollout,Kevin Abstracthas formally unveiled his latest studio endeavor:Blush. A homage to his hometown of Houston, the 19-track album features a lineup of local H-town artists as well as Abstract's close collaboratorsJPEGMAFIA,Dominic Fikeand, on executive production, Quadeca. Spotify|Apple Music Virginsummer can properly commence;Lorde's long-awaited fourth studio LP is officially upon us. Preceded by singles 'What Was That,' 'Man of The Year' and 'Hammer,' the anthemic album is here just in time for summer. Spotify|Apple Music At the end ofPharrell's latestLouis Vuittonspectacle in Paris, a new track blared over the speakers – an unreleased collaboration from none other thanTyler, the CreatorandDoechii. With Pharrell on production, the track is entitled 'Get Right.' F1quite possibly just dropped the most star-studded soundtrack of the year. FeaturingPeggy Gou,Tate McRae,Obongjayar,Don Toliver,Doja Cat,Burna Boy, and many more, the album arrives shortly after the movie, out in theaters everywhere now. Spotify|Apple Music For the first time since lock-up,Young Thugtook the stage for a live performance. Headlining the final day ofLyrical Lemonade'sSummer Smash, Thugger brought outTravis Scott,T.I. andKen Carson, debuting new music with the latter. Almost a decade afterInvasion of Privacy,Cardi Bis plotting her return to the scene. The rapper has announced her first studio endeavor in over seven years,Am I The Drama?, which is confirmed to drop everywhere on September 19. Pusha TandMalicewere bound to show up and show out in Paris. The duo performed an intimate outdoor show during sunset ahead of the Louis Vuitton show, following it up a few days later with aClipseCOLORSperformance. Fresh offFanatics Fest,Oakleyrevealed Travis Scott would join the brand as its first-ever Chief Visionary, kicking off a multi-year partnership withCactus Jack. Marking their first live performance together in seven years,Beyoncébrought outJay-Zfor her third and final Parisian show. They performed 'Crazy in Love', 'N***as in Paris', and 'Drunk in Love.' Mac DeMarcohas finally detailed his imminent new album. EntitledGuitar, the album is set to drop on August 22. What he believes to be a highly authentic release at this point in his life, DeMarco handled all of the production, mixing, and video shooting, also sharing the project's lead single, 'Home.' Spotify|Apple Music The first-ever collaboration fromMAVIandSminohas landed. Dubbed 'Potluck,' the smooth new single arrives on the heels of MAVI's other recent big-name link-up withEarl Sweatshirton 'Landgrab.' Spotify|Apple Music For the first time ever,Frank Oceanis releasing a channel ORANGEvinyl – 13 years after his debut project's release. A new cover art features a grid of photos of Ocean donning his iconic bandana. On the heels of high-octane singles 'DELILAH,' 'BBGIRLGOSLOW,' and 'DUMB SHIT,'Bktherulahas delivered her latest studio endeavor:LUCY. Spotify|Apple Music On Don Toliver's birthday, he debuted a brief snippet of 'FWU (GEMINI SZN).' Now, two weeks later, we're getting an official release for the track. Spotify|Apple Music ForPi'erre Bourne's first new album since 2021'sThe Life of Pi'erre 5,the producer/rapper has presented the primarily solo effort entitledMade in 17 tracks – including singles 'Pop' and 'Blocs,' the album's sole feature comes from Yung Nudy on 'JBH.' Spotify|Apple Music The424Paris Fashion Week runway was another captivating convergence of high fashion and music. Not only didRemaandRoddy Ricchwalk the runway, but the entire runway soundtrack was created by Tommy Richman. Before theChannel Orangevinyl drop, Ocean revealed hisHomerjewelry brand would be dropping soon, complemented by a handful of brick-and-mortar stores globally. Dev Hynes, akaBlood Orange, has unveiled his first song since dropping a four-song EPFour Songsin 2022. 'The Field' is a collaborative effort, with assistance fromDaniel Caesar,Caroline Polachekand more. Spotify|Apple Music As revealed on his @worldaffairsincorporated Instagram account,Yung Leanhas lifted the curtain on his first book. 256 GB compiles 256 GB worth of photos, notes and screenshots split into nine color-themed chapters. Another duo of first-time collaborators linked up this week:IDKandCordae. The pair dropped off the first-ever studio track 'Prince George.' Spotify|Apple Music
Hypebeast
14 hours ago
- Entertainment
- Hypebeast
Kevin Abstract's 'Blush' Is a Heartfelt Homage to Houston
Kevin Abstractwas born in Corpus Christi, Texas, a few hours outside of Houston, where he spent the majority of his adolescence before moving to Georgia. For his fourth solo studio album, Abstract is harkening to the spirit of his hometown for another genre-blurring, needle-pushing album with some of his sharpest storytelling yet. Blushsounds homegrown, Abstract calling the genre 'Texas Pop,' but ultimately defining it as 'just music that sounds like home.' With that sentiment stringing through each of the 18 tracks, features come from a handful of local Houston artists like Love Spells, along with a collection of Abstract's close friends and creative collaborators, includingJPEGMAFIA,Danny Brown,Dominic Fike, Ameer Van, and top-to-bottom executive production from Quadeca. '2024: I was dealing with heartbreak, addiction, and feeling completely lost. Felt myself erasing myself from me. I ain't even look like me when I looked in the mirror,' Abstract wrote on his alternate Instagram account, @clifford___73, which he began using to roll out the album, sort of acting as a growing moodboard for the project. 'So I left the city I've been in since 19 and went back home. Just to see some n*ggas who know me honestly,' he continued, travelling back home to Houston and setting up shop at his friend Boyer's, where he recorded when he first started making music in middle school. 'No fancy hardware or nothing like that. Just me, a mic, and some feelings I hadn't said out loud in a while. Outside of the ones I wrote most this record bout. Kiko sent me some beats [...] and somehow, although it is haunting, it turned into something I love. And helped me start to find myself again. We kept making sh*t. That turned intoBlush.' 1. Introduction2. H-Town3. Copy4. Danny's Track5. Yoko Ono6. NOLA7. Post Break Up Beauty8. 97 Jag9. Text Me10. Geezer11. I Wasn't There12. Blush Interlude13. Maroon14. Pop Out15. Doggystyle16. Girlfriend17. Bloom18. Abandon Me19. Red Light StreamBLUSHnow on all major streaming platforms.
Hypebeast
06-06-2025
- Entertainment
- Hypebeast
Kevin Abstract x Dominic Fike Release First 'BLUSH' Single, "Geezer"
Summary After first linking up forARIZONA BABYcut 'Peach' back in 2019,Kevin AbstractandDominic Fikeare back on their second studio track. Dubbed 'Geezer,' the track signals the first glimpse into Abstract's still-quite-ominousBLUSHproject. A press release describesBLUSHto be 'Abstract firing on all cylinders, sitting down again in his rightful place in the producer's chair to make one of the most dynamic, sonically adventurous, and just plain fun albums of his career.' 'To create the record, Abstract relied on one of his greatest superpowers as an artist, the thing that has made him one of the most unstoppable creators of the last decade: his unmatched ability to find, work with, and get the best out of incredible artists across all genres,' the release continues, noting that Abstract tapped 'an amazing coterie of collaborators to makeBLUSHthe genius record that it is,' including Fike, Quadeca,JPEGMAFIA, Sekou,Danny Brownand Truly Young and 'placing them next to rising voices from Houston he discovered after returning to live back home in Texas last year.' While 'Geezer' isn't on streaming platforms at the time of writing, listen to the song in the music video above. ExpectBLUSHto drop everywhere on June 27.
Yahoo
05-06-2025
- Business
- Yahoo
Akeso's PD-1/CTLA-4 Bispecific Antibody Cadonilimab Approved for First-Line Treatment of Cervical Cancer in All-Comer Populations--Third Approved Indication for Cadonilimab
HONG KONG, June 4, 2025 /PRNewswire/ -- Akeso, Inc. ( ("Akeso" or the "Company") is pleased to announce that the National Medical Products Administration (NMPA) has approved the company's first- in-class PD-1/CTLA-4 bispecific antibody, cadonilimab, for the first-line treatment of persistent, recurrent, or metastatic cervical cancer, in combination with platinum-based chemotherapy, with or without bevacizumab. The NMPA approval marks the third approved indication for cadonilimab. With the approval for first-line cervical cancer, cadonilimab has achieved comprehensive coverage for the treatment of advanced cervical cancer, offering an innovative treatment option for patients across all stages of advanced cervical cancer. This approval addresses the critical unmet need for immune-based therapies for first-line cervical cancer patients in China and represents a significant step forward in the treatment of this disease. In addition to the treatment for first-line cervical cancer, cadonilimab is also approved for first-line treatment of advanced gastric cancer, and for the treatment of relapsed or metastatic cervical cancer who progressed on or after platinum-based chemotherapy. The approval for cadonilimab's use in combination with chemotherapy (with or without bevacizumab) in first-line cervical cancer is based on the clinical data from the Phase III COMPASSION-16 (AK104-303) study. In COMPASSION-16, the cadonilimab combination regimen showed a notable efficacy benefit in patients with tumors that have a negative PD-L1 expression (CPS <1), comprising 27.9% of the population in the treatment group, compared to 24.2% in the control group. The study met both progression-free survival (PFS) and overall survival (OS) endpoints, demonstrating significant improvements in both endpoints for patients treated with the cadonilimab regimen compared to standard therapies in the first-line setting for cervical cancer. Subgroup analyses from COMPASSION-16 study indicated that both PD-L1-positive and PD-L1-negative populations, regardless of bevacizumab inclusion, benefited from the treatment. The results of the COMPASSION-16 trial were presented as a Late-Breaking Abstract (LBA) at the 2024 International Gynecologic Cancer Society (IGCS) Global Meeting, and were subsequently published in The Lancet and later reported again in Nature Reviews Clinical Oncology. Cervical cancer remains one of the most prevalent and deadly cancers among women, with a 5-year survival rate of approximately 17.0% for patients in the advanced stages. In 2022, China reported 150,700 new cervical cancer cases, resulting in the second-largest burden of cervical cancer worldwide. Professor Wu Xiaohua, the principal investigator of COMPASSION-16 and a professor at the Fudan University Shanghai Cancer Center, stated, "COMPASSION-16 is the first Phase III study focused on first-line cervical cancer patients in China, with internationally recognized data. We've seen cadonilimab's breakthrough efficacy in both recurrent and metastatic cervical cancer, showing high effectiveness, low toxicity, and strong anti-tumor activity regardless of PD-L1 expression. This first-line combination therapy sets a new standard in cancer treatment and is expected to accelerate the clinical adoption of cadonilimab, benefiting more patients." Dr. Xia Yu, founder, chairwoman, president, and CEO of Akeso, commented, "Cadonilimab has demonstrated significant survival benefit for cervical cancer patients across all-comer populations in both clinical trials and real-world settings. For patients who respond to PD-1/L1 monotherapy, cadonilimab offers superior therapeutic outcomes over PD-1/PD-L1 therapies. For patients with low PD-L1 expression or those who are resistant to PD-1 monotherapy, cadonilimab provides significant clinical benefits over current treatment options. Cadonilimab takes advantage of the synergistic anti-tumor effect of two immune checkpoint targets, PD-1 and CTLA-4, while producing a meaningfully lower immune side effects than the combination of PD-1 and CTLA-4 antibody therapies. This approval represents another advancement of immunotherapy 2.0 in cervical cancer therapy, offering clinically meaningful improvements in disease treatment and in patient quality of life. This achievement reflects Akeso's robust innovation capabilities and commitment to cancer patient outcomes, and it also aligns with our corporate vision to become a global leader in developing next-generation therapeutic antibodies for patients worldwide. " Currently, cadonilimab is included in 16 authoritative clinical treatment guidelines and consensus documents across multiple oncology indications, including gastric cancer, gynecological cancers, liver cancer, esophageal cancer, and nasopharyngeal cancer. Beyond the three approved indications, cadonilimab is also currently in over 30 Phase II and III clinical trials for other cancer types, which includes different stages of disease progression as well as different cancer sub-types. These include clinical studies on gastric cancer, lung cancer, liver cancer, cervical cancer, and pancreatic cancer. Forward-Looking Statement of Akeso, Inc. This announcement by Akeso, Inc. ( "Akeso") contains "forward-looking statements" . These statements reflect the current beliefs and expectations of Akeso's management and are subject to significant risks and uncertainties. These statements are not intended to form the basis of any investment decision or any decision to purchase securities of Akeso. There can be no assurance that the drug candidate(s) indicated in this announcement or Akeso's other pipeline candidates will obtain the required regulatory approvals or achieve commercial success. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Akeso's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Akeso's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. Akeso does not undertake any obligation to publicly revise these forward-looking statements to reflect events or circumstances after the date hereof, except as required by law. View original content: SOURCE Akeso, Inc. Sign in to access your portfolio
Business Mayor
23-05-2025
- Entertainment
- Business Mayor
YGG expands into Web3 game publishing with launch of LOL Land
Yield Guild Games announced that it has expanded into Web3 game publishing with the launch of the Casual Degen game LOL Land. With the launch of its first title, LOL Land, Yield Guild Games (YGG) has announced YGG Play, a new game publishing unit dedicated to lighthearted, addictive games that embrace the chaos and culture of crypto degeneracy. With YGG Play, the association aims to define a new genre in gaming: Casual Degen. The debut game — a browser-based casual board game featuring members of the Pudgy Penguins community as playable characters — with 116,000 pre-registrations prior to its exclusive launch on Abstract Chain. By playing, collecting points, and unlocking NFTs in LOL Land, players have the chance to win part of a prize pool funded on May 1, valued at $10 million in YGG token rewards. 'Over the past four years, we've seen and played hundreds of games, and Yield Guild has invested in many of them. Through that experience, we've come to know what's fun, what works and what doesn't, and that's led us to develop some very strong opinions on how to best serve the crypto market,' said Gabby Dizon, cofounder of Yield Guild, in a statement. 'YGG Play, which is specifically targeting the Casual Degen market, is our expression of everything we've learned, starting with our first game, LOL Land.' LOL Land features four thematic boards, each with a unique mechanic: YGG City, Beach Day, Carnival, and Ice World Wonderland — the latter being home to the Pudgy Penguins IP, where players can choose to playable characters based on notable members from Pudgy's community, including Aaron Teng, Rusk0f, KP, Burnasso, and Orange. Dizon is also a playable game character, and other themes are under development, including Pirate Cove and Parkside Story. Read More Steam's top 10 games captured over 60% of revenue in 2023 The Abstract Chain, the exclusive platform for LOL Land, was created by Igloo Inc., the parent company of Pudgy Penguins. Its consumer-first approach makes it easier for players to get into Web3 games by using chain abstraction and integrating friendlier onboarding mechanisms such as social logins and passkeys. The platform has already succeeded with several launches, including Myriad, Roach Racing Club, and Gacha. The launch also coincides with the YGG token being available on Abstract. 'LOL Land is a game built by degens for degens,' said Luca Netz, CEO of Pudgy Penguins, in a statement. 'It takes everything we've come to love about playing Web3 games and puts it into a casual pick-up-and-play experience. We're really excited to be a part of YGG's first game and its exclusive launch on Abstract.' LOL Land offers two gameplay modes to suit different player preferences. The free mode allows players to enjoy unlimited rolls at no cost, though it does not include YGG token rewards. In the premium mode, players can purchase premium rolls, with points earned through gameplay eligible for redemption in YGG tokens. LOL Land is only available to players 18 years or older and in certain countries. The game is available to play now at I asked Dizon a few questions. In a message to GamesBeat, Dizon said YGG is a guild protocol that provides guilds with a suite of tools to organize onchain. 'Our core community's Discord currently has over 112,000 members and our Guild Advancement Program (GAP) has seen over 300,000 community members use our questing platform,' Dizon said. 'Since launching on Base in November last year, we've had more than 75 Onchain Guilds sign up for our platform's pilot. We also have a global network of guilds spanning 11 regions, represented by our guild partners YGG Pilipinas (Philippines), W3GG (Southeast Asia), OLA GG (Latin America), KGeN (India, Brazil, Saudi Arabia), SKYGG (South Korea), YGG Japan, YGG China, AMG DAO (Europe), and NYXL (North America).' Asked why YGG decided to make a game, Dizon said, 'We decided to launch our game publishing arm because we want to establish the 'Casual Degen' category in Web3 games. With our history and our deep connection to the community and its crypto-native, grassroots, play-first culture, game publishing felt like a natural expansion.' Gabby Dizon is cofounder of YGG. YGG has grown into a hub for players to discover new games and contribute their skills to different projects and ecosystems. Dizon added, 'We represent highly skilled communities that can bootstrap the launch of a game by connecting them with dedicated players as well as groups that can provide the services these early-stage projects need like community management, marketing and local events, content creation, education, esports, game testing, and more.' And he said, 'YGG is uniquely positioned as a publisher because we know what the community looks for in games and we know where these games need help at launch—we hear it directly from the players. So, expanding into publishing and making the first game ourselves made sense.' I asked Dizon how YGG chose the game. He noted that before he got into crypto and cofounded YGG, he was a game developer for over 20 years. 'I was actually building casual games for much of my career. It's nearly five years since we founded YGG, and we've played hundreds of Web3 games and invested in many of them,' Dizon said. 'Building our ecosystem and running events like the YGG Play Summit has kept us closely aligned with our community's interests. We understand what the YGG community wants: playing fun games and enjoying the rewards together.' And he added, 'Based on our experience, we also knew that the Web3-native game market is still very underserved. These are the people who aren't necessarily hardcore gamers but are in crypto for fun — or what we call degens. Hardcore Web3 gamers are actually a very small portion of the total Web3 user base. But the 'Casual Degens' — that's people trading memecoins, minting NFTs, or trading on exchanges — they're a much larger market. And we know exactly how to target these markets.' Yield Guild Games (YGG) is a global collective of gamers, creators, and builders turning play into opportunity. Known for pioneering the Web3 guild model with the rise of the play-to-earn movement in 2020, YGG laid the foundation for a new kind of digital coordination: a network of onchain groups, each organized around their own purpose, and united by shared values of collaboration, progression, and ownership. Pre-registration is currently ongoing at
