Latest news with #Accutane
Yahoo
15-05-2025
- Business
- Yahoo
Journey Medical Corp (DERM) Q1 2025 Earnings Call Highlights: Amrosi Launch Boosts Margins ...
Net Revenue: $13.1 million for Q1 2025, compared to $13 million for Q1 2024. Amrosi Revenue: $2 million from the initial launch included in Q1 2025 net product sales. Gross Margin: Increased to 64% in Q1 2025 from 54% in Q1 2024. R&D Costs: Nil in Q1 2025, compared to $7.9 million in Q1 2024. SG&A Expenses: Increased to $10.6 million in Q1 2025 from $8.4 million in Q1 2024. Net Loss: $4.1 million or $0.18 per share for Q1 2025, compared to $10.4 million or $0.53 per share for Q1 2024. Cash Position: $21.1 million at the end of Q1 2025, compared to $20.3 million at December 31, 2024. Commercial Payer Access: Approximately 30% of covered commercial insured lives now have access to Amrosi. Warning! GuruFocus has detected 8 Warning Signs with DERM. Release Date: May 14, 2025 For the complete transcript of the earnings call, please refer to the full earnings call transcript. Journey Medical Corp (NASDAQ:DERM) successfully launched Amrosi, a new oral rosacea treatment, contributing $2 million to the first quarter 2025 net product sales. The company reported a gross margin increase to 64% in Q1 2025, up from 54% in the prior year, due to a favorable product sales mix and reduced product costs. Amrosi's market introduction has been well-received, with positive feedback from healthcare providers and strong initial prescription volumes. Approximately 30% of commercially insured lives now have access to Amrosi, up from 20% in the previous quarter, indicating progress in payer coverage. The inclusion of Amrosi in the National Rosacea Society's treatment algorithms and its publication in JAMA Dermatology are expected to drive further clinical adoption and market uptake. Net revenue for Q1 2025 was only slightly higher at $13.1 million compared to $13 million in Q1 2024, indicating limited overall revenue growth. Legacy products experienced a decline, with a noted decrease in prescriptions for Accutane due to increased competition and aggressive pricing by new market entrants. SG&A expenses increased by $2.1 million to $10.6 million in Q1 2025, reflecting higher investments in commercial infrastructure for the Amrosi launch. The company reported a net loss to common shareholders of $4.1 million for Q1 2025, although this was an improvement from the $10.4 million loss in Q1 2024. There is uncertainty regarding the sustainability of initial Amrosi sales, as the Q1 revenue included significant stocking, and future revenues will need to reflect actual demand. Q: Can you provide insights on the Q1 revenues for Amrosi and expectations for future quarters? A: Claude Maraoui, President and CEO, explained that the $2 million in Q1 revenues was largely due to stocking the distribution channel. The salesforce began actively promoting Amrosi in April, and while no specific revenue expectations for Q2 were provided, the company is optimistic about continued growth and will share updates at the end of Q2. Q: How is the legacy business performing, particularly with products like Cubrexa and Accutane? A: Claude Maraoui noted a decline in legacy brands due to generic competition. However, Cubrexa is performing well, with a 15% increase in prescriptions year-over-year, despite new competition. Accutane faced challenges from new competitors but showed a 10% growth from Q4 2024 to Q1 2025, indicating stabilization. Q: What is the current inventory level in the distribution channel, and how do you anticipate it changing? A: Claude Maraoui stated that the inventory level is typically between 2 to 4 weeks, depending on the ramp-up. The company is focusing on specialty pharmacies that dermatologists frequently use, and the inventory level will adjust as demand grows. Q: What feedback have you received from prescribers about Amrosi, and who are the primary prescribers? A: Claude Maraoui shared that feedback has been positive, with prescribers impressed by Amrosi's efficacy and tolerability. The initial focus is on new patients, with expectations that prescribers will switch existing patients to Amrosi as they gain confidence in the product. Q: Is there any feedback from doctors regarding Amrosi's impact on erythema, even though it's not in the label? A: Claude Maraoui mentioned anecdotal feedback from doctors noting significant erythema reduction, which is supported by data published in JAMA Dermatology. The company plans to build on this data to inform providers about Amrosi's impact on erythema. For the complete transcript of the earnings call, please refer to the full earnings call transcript. This article first appeared on GuruFocus. Sign in to access your portfolio
7NEWS
08-05-2025
- Health
- 7NEWS
‘Life-changing' Sydney-based clinic is transforming the skin of thousands of shoppers with common skin concerns
Seasonal change can cause havoc on our skin, increasing dryness, irritation, sensitivity, and even acne. While switching up a skincare routine can help boost your skin barrier, seeking a long-term solution is going to be your best bet for keeping a complexion looking happy and healthy. That's why hundreds of shoppers are rushing to book an appointment at renowned Sydney-based skin clinic, SDL (Sydney Dermal Lounge). With three salons across the city, SDL is 'leading the bare skin movement,' providing a wide range of effective skin treatments that can help to improve the appearance of many common skin concerns. Because let's face it; a difficult skin journey can leave you feeling exhausted, overwhelmed, and low on confidence. Whether you're battling acne, redness, a dry or irritated complexion, SDL founder Savannah Lee made it her mission to create a clinic that offers effective, medical-grade solutions. 'I opened my first clinic when I was 26, with an 18-month-old on my hip and a vision that felt so much bigger than me,' Savannah tells Best Picks. 'At the time, everyone was opening laser hair removal clinics. It was the safe bet. The easy sell. But I wasn't interested in shortcuts or trends. I had already spent over a decade in the industry managing some of Australia's leading laser and cosmetic clinics and I had seen the gaps up close.' Instead, SDL provides a range of 'life-changing' treatments across skin health, skin correction, maintenance and hair restoration for 'real results'. Combined with expert-lead guidance from a team who have gone through their own skin struggles, the Sydney-based clinic ensures that each and every shopper leaves feeling comfortable and confident with their skin. Offering more than just a 'quick fix,' SDL is home to many popular treatments including HydraFacial and AviClear laser. Savannah says that 'if something doesn't deliver results — we don't offer it. We're known for skin correction that works.' If you're ready to kickstart your skincare journey, SDL offers an in-depth 60 minute skin consultation to discuss any skin concerns and indentify which result-driven products and treatments are best suited. 'I wanted to focus on skin. Not just treating it. But correcting it properly and with full certainty,' she adds. With nearly 80,000 followers on Instagram and dozens of in credible before and after shots, it's no surprise that shoppers are rushing to book an appointment. SDL is one of the few clinics in Sydney to offer AviClear, a laser treatment for treating acne. It has minimal downtime with 30-minute sessions, done in series of three, spaced four to six weeks apart. 'It's not just about clearing skin — it's about doing it safely and long-term.' 'We see so many clients who've been through harsh medications, antibiotics, and even multiple rounds of Accutane — only for the acne to return. And the side effects? Gut issues. Mood swings. Hormonal imbalance.' 'The full course is around $3,000 — and while that might sound like a big number up front, it's often less than what people spend over the years trying to control acne through skincare, prescriptions, supplements, and coverups.' Shoppers who have visited SDL have given the clinic rave reviews. 'The ladies at Sydney Dermal Lounge are so friendly and professional. They always make me feel gorgeous and relaxed after my treatments. Love their work and totally recommend,' one shopper commented. 'THIS IS THE PLACE TO VISIT! I am a mature aged person and I visit for ant-aging laser skin tightening and I undergo pigmentation treatment. I feel and look 20 years younger,' another wrote.
Buzz Feed
04-05-2025
- Health
- Buzz Feed
11 Clinique Products That'll Leave Your Skin Feeling Very Loved
We hope you love our recommendations! Some may have been sent as samples, but all were independently selected by our editors. Just FYI, BuzzFeed and its publishing partners may collect a share of sales and/or other compensation from the links on this page. Like a moisturizer that'll feel like a soothing hug for your face. What could be better? 1. Dramatically Different Moisturizing Lotion+ receives top marks from thousands of reviewers for its cult-favorite formula of pure glycerin and urea (a humectant that draws in moisture and halts dry-skin triggers). It enriches the skin with up to eight hours of hydration, so your skin can look refreshed even during your afternoon slump. Promising review:"I have used this moisturizer for literally decades. I used it through my teenage years and countless acne treatments, including Accutane. I use it now during the dreaded changes of perimenopause, drying my skin. This product gently moisturizes without making you feel greasy or sticky and never causes breakouts. It's wonderful for my current combination skin, and I could never recommend it enough!" — Dana Price: $7+ (available in four sizes) This is also available in a lightweight moisturizing ge l for combination and oilier skin types. 2. All About Clean Liquid Facial Soap rinses away impurities with a mild cleanser available in formulas suitable for dry, combination, very dry to dry, and combination to oily skin. This tailored approach to a cleanser is favored by thousands of reviewers who say that after the first use, their skin feels clean and refreshed. Clinique 3. Redness Solutions Daily Relief Cream soothes and comforts irritation when applied to clean, makeup-free skin. Reviewers say they notice redness toned down, and the brand notes it is safe to use on skin with rosacea. 4. Take The Day Off Cleansing Balm melts makeup away in a dream-like silky balm that's packed with safflower seed oil. This natural emollient helps to nourish skin, lashes, and brows and won't leave your face feeling tight. Promising review:"This is the best makeup remover I've ever used. It easily removes water-resistant full coverage foundation and waterproof makeup, lipstick, etc. After I rub the product around my face (sometimes add a little warm water to the mix), I then run a clean washcloth under warm water to wipe everything off. I have sensitive skin and am prone to breakouts with certain products. This product doesn't cause breakouts and my skin feels hydrated and silky smooth when I'm done." — Teresa 5. Acne Solutions Cleansing Foam pumps out a blend of salicylic acid and other oil-prevention ingredients to unclog pores and help prevent breakouts. This combo exfoliates dead skin and assists in calming redness and inflammation. Clinique 6. Pep-Start Daily UV Protector Broad Spectrum SPF 50 comes with compliments *and* sun protection built into its ultra-lightweight formula, because the moment you sweep this over your skin, your radiance won't go unnoticed. Clinique Promising reviews:"This is the best mineral sunscreen! It has a nice tint that evens out my complexion and tones down redness. Doesn't settle into fine lines or wrinkles. My super sensitive skin can wear this and reapply without any breakouts or oily buildup! Also does great under primer and foundation or under tinted moisturizer. I am so happy I found this!" — Happy Susan "'You look so good!' 'You look happy and healthy!' 'Your coloring is so fresh!!' Without fail, this is how my family responds when I wear Pep Start sun protector. My skin looks glowy and dewy." — Besidesthelaundry 7. All About Eyes Brightening Serum Concentrate reduces the appearance of tired-looking eyes with a cooling metal-tip applicator and a serum formulated with a gentle retinoid (perfect for accelerating cell turnover). It's also packed with vitamin C for brightening and hyaluronic acid to moisturize delicate skin. Start by using this at night three times a week and work your way up to daily use to see how your skin responds. Promising review:"I've been using the All About Eyes Brightening Serum Concentrate for a few weeks now, and I'm really impressed with the results! This serum is lightweight and absorbs quickly into the skin, leaving my under-eye area feeling refreshed and hydrated. It's made a noticeable difference in reducing dark circles and puffiness, which I've struggled with for years. The brightening effect is subtle yet effective, and my under-eye area looks much more awake and rejuvenated. I also love that it's gentle on the skin and doesn't cause any irritation. Overall, it's become a staple in my skincare routine! Highly recommend it for anyone looking for a boost of brightness and hydration around the eyes." — Jaspreet 8. Or All About Eyes Eye Cream dabs on caffeine and vitamin C to help brighten and reduce puffiness — if you'd rather skip on a retinoid-based formula. You can apply this twice daily from the get-go and gently pat it into the skin using your ring finger for less pressure. Plus, reviewers mention that it pairs well under makeup. Clinique Promising review:"I have been using this eye cream for about four months now and can see visible improvement to the lines around my eyes. The cream feels very nice and silky to put on and is not greasy." — Rachelle "I put this on before any under-eye makeup. It really helps with keeping it hydrated and prevents creasing." — Dayna 9. Clinical Repair AM/PM Retinoid Balm targets fine lines and dry skin in a handy applicator. Best used after a serum and before a moisturizer, you can apply the 1% advanced retinoid + hyaluronic acid formula right to the source of your creases. Clinique Promising reviews:"Such a little skin-saver in a stick form. Useful to have handy as needed. Only need to remember to apply SPF after using. Far prefer to have this as a spot-treatment for areas of concern, rather than applying so many serums and creams all the time!" — Clinique Customer "From the first day, my wrinkles have decreased! I highly recommend it." — Iryna 10. Moisture Surge Broad Spectrum SPF 28 Sheer Hydrator boosts your skin's hydration and glow with a cloud-like cream that goes on opaque and turns sheer — no white cast, no pilling. Plus, it has UV protection and won't leave your skin shiny. Clinique Promising review:"I have extremely sensitive skin and this is the best moisturizer/sunscreen I've found! I started using the moisture surge line a year ago and fell in love with the products. I had been putting off trying this one because SPF sometimes breaks me out. That, however, has not been a problem with this product! So glad I can wear SPF now and not be afraid of what will happen to my skin after. Hoping this product and the moisture surge line are around for years to come! — Beo99 11. Smart Clinical Repair Overnight Recovery Cream + Mask repairs your skin barrier as you sleep. It optimizes the restoration process with hydrating peptides, hyaluronic acid, and adenosine, which is known for its skin-soothing properties. The result? In one week, you can expect fine lines and crepiness to be reduced. Clinique
NBC News
28-04-2025
- Health
- NBC News
We asked, derms answered: The 11 best sunscreens for acne-prone skin
You've likely heard it time and time again: Don't skip sunscreen if you want to prevent dark spots, sun damage and signs of aging. But there's one caveat: thick formulas can congest your pores, which may lead to pimples. Still, wearing sunscreen daily is essential, especially if you use products that treat acne, like retinol, Accutane and alpha-hydroxy acids. 'Many acne medications make your skin sensitive to sunburn,' says Dr. Joshua Zeichner, a board-certified dermatologist and director of cosmetic and clinical research at Mount Sinai Hospital. 'The right sunscreen can give a mattifying effect and protect the skin without worsening breakouts.' I talked to dermatologists about how to buy the best sunscreen for acne-prone skin and their favorite options from brands like EltaMD, Neutrogena and La Roche-Posay. I also rounded up sunscreens NBC Select staff swear by while dealing with breakouts. How I picked the best sunscreen for acne-prone skin If you have acne-prone skin, experts told me to prioritize the following while shopping for sunscreen. Formula: The best sunscreens for acne-prone skin have noncomedogenic formulas, meaning they won't clog pores, says Dr. Robyn Gmyrek, a board-certified dermatologist at UnionDerm in New York City. Also, look for oil-free and fragrance-free options. Ingredients: Pay attention to the active and inactive ingredients in sunscreen, both of which can contribute to breakouts and clogged pores. Those with acne-prone skin should avoid mineral and soybean oils, as well as emollient-rich ingredients like coconut, beeswax, lanolin and cocoa butter, says Dr. Jane Yoo, a board-certified dermatologist and Mohs surgeon based in New York City. Stay away from silicones and sodium lauryl sulfates, too, says Dr. Patricia Wexler, a board-certified dermatologist at Wexler Dermatology in New York City. Type: If you have acne-prone skin, using a mineral sunscreen can help avoid breakouts and exacerbating active pimples, says Yoo. Mineral sunscreen contains zinc oxide and/or titanium dioxide, and it sits on top of the skin to act like a shield against UV rays. This makes mineral sunscreen less likely to irritate those with acne-prone skin compared to chemical sunscreen, which contains synthetic ingredients like oxybenzone, avobenzone and octinoxate that the skin absorbs, says Yoo. These chemicals help turn UV rays into heat that's dissipated from the skin. That doesn't mean you can't wear chemical sunscreen if you have acne-prone skin — you can, but look for options that are specifically designed for those who deal with breakouts. Some sunscreens are mineral-based, which means they contain mineral and chemical active ingredients. Overall, as far as acne-prone skin goes, mineral is best, mineral-based is second best and chemical is at the bottom of the list, dermatologists told me. Protection level: The face sunscreen you apply daily should have a SPF rating of at least 30 and offer broad-spectrum protection, meaning it shields you from UVA and UVB rays, says Dr. Dina Strachan, a board-certified dermatologist at Aglow Dermatology in New York City. This is in line with the American Academy of Dermatology Association and the Skin Cancer Foundation 's recommendations. Water resistance: Wearing a water-resistant sunscreen is especially important if you're sweating or spending time in water. You can find out whether a sunscreen is water-resistant, and if so, how long it's water-resistant for, by reading its label. Want more from NBC Select? Sign up for our newsletter, The Selection, and shop smarter. The best sunscreens for acne-prone skin in 2025 All of the sunscreens below have a SPF rating of at least 30 and offer broad-spectrum protection. They're either recommended by dermatologists or NBC Select staff who have acne-prone skin. EltaMD's fragrance-free, oil-free sunscreen is a top pick among many of the dermatologists I spoke to, including Zeichner, Yoo and Wexler. It contains zinc oxide, a mineral UV blocker that offers a soothing effect on the skin, says Zeichner. It's also made with niacinamide and hyaluronic acid, two hydrating ingredients. The sunscreen leaves a transparent finish on skin and is safe for those with acne-prone skin, sensitive skin, rosacea and dark spots, according to the brand. In addition to its clear formula, EltaMD sells a tinted version of this sunscreen, which offers SPF 40. Cory Fernandez, NBC Select commerce editor, uses it daily. I've struggled with cystic acne for my entire adult life and have been using prescription acne medication for about four years. Tower 28's reef-safe, fragrance-free tinted sunscreen is my go-to for daily UV protection. It offers light to medium coverage, which tones down redness and reduces how noticeable my acne and acne scars are. The SPF has also never irritated my sensitive, combination skin or worsened breakouts. The sunscreen (from one of our favorite AAPI-owned brands) is made with non-nano zinc oxide and soothing aloe vera, plus it's approved by the National Eczema Association. It comes in 17 shades and has a natural finish — it's not too dewy that it makes me look oily, and it's not too matte either. One tube lasts me months since I only need to use a little sunscreen at a time. Certain acne medications can be drying, so using a sunscreen that doubles as a moisturizer helps combat flaky, dull skin and cut down on your skin care routine. Strachan recommends CeraVe's moisturizing SPF for daily use. It's made with ceramides, hyaluronic acid and niacinamide, and is oil-free and fragrance-free. The sunscreen offers a clear finish. I give my skin a break from makeup a few days a week, and instead of applying my tinted sunscreen, I use this one from Supergoop. It's so lightweight that I forget I'm wearing it and it has a matte finish. The sunscreen is white when it comes out of the tube, but it's blendable and becomes totally sheer as I rub it into my skin. It also has a light smell due to the zinc oxide and titanium dioxide it's made with — the smell goes away quickly, in my experience, and its formula is fragrance-free overall. While I don't wear makeup on top of this sunscreen, it doubles as a grippy primer. SPF powder is a great option for those with acne-prone, oily skin, says Dr. Hadley King, a board-certified dermatologist. 'It absorbs excess oil, so it serves a dual purpose as a finishing powder, actually extending the life of your makeup and providing sun protection,' she says. This SPF from Brush on Block is available as a translucent powder or in a Touch of Tan shade. The built-in brush has a twist-open feature that ensures powder is only released when you want to use it. The brush is also refillable — when it runs out of powder, you can purchase refills online. In addition to a face sunscreen, Brush on Block's powder makes a great scalp sunscreen. Cetaphil's mineral sunscreen is another one of Strachan's favorites for acne-prone skin. It's a basic, no-frills option you can wear on its own or under makeup. The reef-safe, fragrance-free sunscreen is made with zinc oxide and titanium dioxide. It offers a lightweight matte finish — the brand describes the SPF's texture as serum-like. The sunscreen also has vitamin E in its formula to moisturize skin. Ashley Morris, NBC Select associate SEO reporter, says this sunscreen doesn't make her acne-prone skin greasy. 'The texture is so lightweight that it blends in well without giving me any added shine,' she says. 'It also gives me a chance to use some of my more dewy moisturizers underneath.' The formula contains silica, a powder that absorbs excess oil. Morris also appreciates that the bottle is a portable size so she can bring it with her for constant reapplication. Zeichner recommends this chemical sunscreen from Neutrogena because it's specifically formulated for acne-prone skin. It's made with avobenzone, an organic sunscreen filter that's 'extremely' effective in providing broad-spectrum UV protection, he says. The sunscreen has a matte finish, and it's oil-free and fragrance-free. SPF: 30, 50 and 55 | Type: chemical | Water-resistant: up to 80 min. 'This sunscreen keeps skin dry, even in heat and humidity, making it great for oily, acne-prone skin,' says Wexler. It's made with perlite and silica, lightweight powders that help absorb excess oil on skin and reduce shine, according to La Roche-Posay. The oil-free, fragrance-free sunscreen has a non-greasy, dry touch texture. Morris initially tried this sunscreen while on vacation in Jamaica last year, and loves how well it holds up in hotter, sunnier climates. 'It applies without any white cast, and doesn't get super oily even after spending hours on the beach,' she says. It has a non-comedogenic formula and broad-spectrum protection, according to the brand. Morris also likes the sunscreen's lightweight texture, and how it doesn't leave any sticky or stuff residue after applying. Frequently asked questions Can sunscreen cause acne? Yes, sunscreen can cause breakouts in those with acne-prone skin. There are two main reasons why sunscreen-related acne occurs. Heavy, oily sunscreens can clog pores, which often leads to acne. Your skin may be sensitive to some UV-blocking ingredients in sunscreen, which can show up as a rash or as small bumps, says King. That said, wearing sunscreen every day is non-negotiable — you must wear it to protect your skin from UV rays. That's why it's important to find a sunscreen that works with your skin type. Does acne medication make you more sensitive to the sun? Yes, some prescription and over-the-counter acne medications can make your skin photosensitive, meaning sensitive to sunlight and more likely to burn, says Strachan. This includes products that contain chemical exfoliants like alpha-hydroxy acids (including glycolic acid) and beta-hydroxy acids (including salicylic acid), as well as topical and oral retinoids like adapalene, Accutane (isotretinoin) and Tretinoin. Antibiotics used to treat bacterial acne like Tetracycline, particularly doxycycline, can also cause photosensitivity, says Strachan. How should you apply sunscreen to acne-prone skin? The first time you use a new type of sunscreen, spot test it on a small patch of skin before applying it to your entire face, says Yoo. Wear it for a few hours indoors — if you don't notice any redness, stinging or small red bumps pop up, your skin likely won't react to it long term. Before applying sunscreen to your face, cleanse with a gentle face wash to remove excess oils and dirt, which can contribute to clogging pores, says Yoo. Then apply sunscreen and let it dry for about 15 minutes before you spend time outside. Note that sunscreen should always be the last step in your daily skin care routine. At the end of the day, thoroughly wash your face to remove sunscreen before following the rest of your nightly skin care routine, says Yoo. How much sunscreen should you wear every day? Regardless of which type you purchase, sunscreen is important to wear daily — Zeichner recommends applying a quarter-sized dollop of SPF to your face. If you're spending time in the sun, you should reapply every two hours or immediately after heavy sweating or swimming. Meet our experts At NBC Select, we work with experts who have specialized knowledge and authority based on relevant training and/or experience. We also take steps to ensure all expert advice and recommendations are made independently and without undisclosed financial conflicts of interest. Dr. Joshua Zeichner is the director of cosmetic and clinical research in dermatology and an associate professor of dermatology at Mount Sinai Hospital. Dr. Hadley King is a board-certified dermatologist based in New York. Dr. Patricia Wexler is a board-certified dermatologist at Wexler Dermatology in New York City. Dr. Robyn Gmyrek is a board-certified dermatologist at UnionDerm in New York City. Dr. Jane Yoo is a board-certified dermatologist and Mohs surgeon based in New York City. Dr. Dina Strachan is a board-certified dermatologist at Aglow Dermatology in New York City. Why trust NBC Select? Zoe Malin is an associate updates editor at NBC Select who writes about skin care, including articles on ingrown hair, razor burn, tinted sunscreen and sunburns. Ashley Morris is an associate SEO reporter at NBC Select covering wellness who's written on topics like acne spot treatments and hyperpigmentation. For this article, Malin interviewed six experts about the best sunscreen for acne-prone skin. Using their guidance, she put together a list of products dermatologists recommend and those NBC Select staff have tested.
USA Today
11-04-2025
- Health
- USA Today
Before starting isotretinoin, here's what dermatologists need you to consider
Before starting isotretinoin, here's what dermatologists need you to consider Show Caption Hide Caption Carcinogenic chemical found in popular acne creams The safety of skin care has come under scrutiny as elevated levels of the carcinogen benzene have been found in acne creams. unbranded - Newsworthy If you're someone who's experienced recurring bouts of cystic acne, you'll know there's no one-size-fits-all approach to keeping acne flares at bay. Clearing your skin can feel like a bit of a waiting game, and if you've cycled through rounds of hormonal therapies, oral antibiotics and topical retinoids to no avail, you've likely considered isotretinoin as a possible acne treatment. Isotretinoin is a powerful oral retinoid that can be prescribed to treat resistant cystic acne. The medication's acne-fighting benefits have been backed by science for decades, but it's important to be aware of a few serious risks. Here's what dermatologists need you to know. What is isotretinoin? What is Accutane? Isotretinoin is a potent derivative of vitamin A that shrinks oil glands in the face, chest, back, shoulders and upper arms, says Dr. Richard Antaya, director of pediatric dermatology for Yale Medicine. The medication was first approved by the U.S. Food & Drug Administration in 1982 under its original brand name, Accutane. Accutane itself isn't actually sold in the U.S. anymore, and has since been replaced by different generic formulations of isotretinoin, explains Antaya. Isotretinoin lowers sebum production in the skin; sebum is a waxy, oily substance that's meant to protect the skin from moisture loss. The sebaceous glands that live under our hair follicles secrete sebum. When we produce too much sebum, and the sebaceous glands become infected, acne may develop, says Dr. Andrew Wong, a primary care physician in Westport, Connecticut, and Fairfield County regional medical director for Hartford Healthcare. By removing the underlying mechanism of acne (sebum production), isotretinoin unclogs pores and quells skin inflammation. 'I always tell my patients, decreasing the oil (or sebum) takes the wind out of the sails of acne,' says Antaya. The results are palpable: With just one course of isotretinoin, the majority of patients will see a great improvement, and in many cases, a near-complete clearing of acne, Antaya says. How isotretinoin works, plus who is a good candidate? Isotretinoin could be a great option for those in search of a long-lasting solution to their cystic acne. That said, the medication does have severe potential side effects, which is why it's not for everyone. There's a few reasons why a dermatologist may prescribe isotretinoin: Your acne is persistent. You've tried multiple treatments for acne—from topical retinoids to benzoyl peroxide to oral antibiotics—and your acne still isn't clearing up. You've tried multiple treatments for acne—from topical retinoids to benzoyl peroxide to oral antibiotics—and your acne still isn't clearing up. You have severe, nodular cystic acne. Topical medication is rarely, if ever, effective for treating nodular cystic acne. If you haven't responded well to other oral acne treatments, including oral antibiotics or hormonal therapies, that's when a dermatologist may consider prescribing isotretinoin, Antaya says. Topical medication is rarely, if ever, effective for treating nodular cystic acne. If you haven't responded well to other oral acne treatments, including oral antibiotics or hormonal therapies, that's when a dermatologist may consider prescribing isotretinoin, Antaya says. You have severe acne scarring: Severe acne can be disfiguring, leaving permanent scars, says Wong. Isotretinoin can't get rid of scarring, but as your skin clears, it may improve the appearance of scars, and help prevent new ones from forming. More on cystic acne: Cystic acne can cause pain, shame and lasting scars. Here's what causes it. What are the risks of isotretinoin? The decision to start isotretinoin isn't one that should be taken lightly—it's a medicine that carries significant risks. Isotretinoin shrinks the oil glands and thins the epidermal barrier, which could cause dryness of the skin, lips and nose. Other potential side effects include joint and muscle pain, eye irritation, elevated blood fat levels and in rare cases, liver damage. Isotretinoin is known to cause severe birth defects and miscarriages in people who are pregnant, says Wong. For this reason, isotretinoin isn't the kind of medication that can be prescribed on a yearly basis; it has to be renewed every month. 'We have strict safeguards in place to make sure we get positive feedback that someone is doing well with the medicine, and that they performed a pregnancy test during that month,' Wong explains. Patients must enroll and adhere to the iPLEDGE program, an FDA-mandated registry to help prevent pregnancy in patients taking isotretinoin. Isotretinoin has also been associated with depression and suicidal thoughts, though the American Academy of Dermatology says there currently isn't enough evidence to determine a clear link. Patients will be screened for possible signs of depression or suicidal ideation before isotretinoin is prescribed. 'So, I strongly recommend that if an acne patient suffers from depression, the dermatologist works with the mental health professional to ensure the patient can undergo a course of isotretinoin,' says Antaya. In case you missed: How do antibiotics work, what happens to your body when you take them? We've got answers. Can isotretinoin cure acne? If your dermatologist has determined you're a good candidate for isotretinoin, know that it could take two to three months before you start to see a significant improvement in your acne, and four to six months (or potentially longer!) for it to clear—though the results are long-lasting. After completing a single course of isotretinoin, around 85% of patients will experience a long-term clearing of skin, says Wong. Today, isotretinoin still stands to be the most clinically effective treatment for severe acne. 'Even though isotretinoin has been available for over 40 years, if you ask most dermatologists, we will still list (isotretinoin) as one of our favorite medications, because it is consistently effective and therefore provides significant benefit, both physically and emotionally, to our patients,' Antaya says.
