Latest news with #CISH
Hindustan Times
30-05-2025
- Business
- Hindustan Times
Famed UP mangoes set to fly out, tickle taste buds across globe
Uttar Pradesh is likely to make a mark on the global fruit export map as its famed mangoes head to international markets including Singapore, Dubai, Saudi Arabia, United States, and the United Kingdom. This year, UP will target to export 100-150 tonnes of mangoes grown in the state, an official said. 'Last year, UP mango production was 6 million metric tonnes, against India's total 22 to 23 million metric tonnes. In 2024, overall UP export was pegged at 0.013%. This number is very likely to increase in 2025,' says T Damodaran, director, ICAR-Central Institute for Subtropical Horticulture (CISH). Damodaran said, 'We plan to export mangoes to Singapore and UAE by sea so that a large quantity can be exported. Mangoes will be sent to the US and Japan by air from the West UP region like Bulandshahr and Meerut.' Divisional commissioner, Lucknow, Roshan Jacob, on Friday interacted with exporters and mango growers, and directed state officials to extend all necessary facilities for mango exports using CISH-developed post-harvest and sea-route export technologies. To accelerate this initiative, ICAR-Central Institute for Subtropical Horticulture (CISH), Lucknow held a high-level Exporters-Growers Business Meet-2025 at its Rehmankheda campus where Jacob emphasised the importance of tapping into the domestic market potential across various states in India. Additionally, she instructed divisional officials to establish a nodal centre for export promotion at the state level. She asked the Mandi Parishad, Lucknow, to set up a one-stop centre to assist farmers with registration on APEDA's Hort-Net Portal. Damodaran highlighted that the institute will provide technical and logistical support for the export of premium Dussheri and Chausa mango varieties to Singapore, Dubai, and other international destinations during their respective seasons. He informed that CISH has developed dedicated clusters for Dussheri mangoes in Lucknow and Chausa in Siana (Bulandshahr), where farmers are now producing export-quality fruits under the Institute's technical guidance, using CISH-developed technologies to ensure superior quality and compliance with export standards. Vinita Sudhanshu, general manager, APEDA (New Delhi), elaborated on the vital role APEDA plays in promoting the export of North Indian mangoes. She emphasised the importance of quality compliance, international certifications, and logistics readiness for successful exports. Ajay Jain (IAS), the chief development officer (CDO) of Lucknow informed that packing houses in Lucknow, Amroha, and Saharanpur are fully operational and equipped for mango processing and export handling. He was also tasked with coordinating with Indian Railways for train halts and facilitating marketing opportunities through hotel chains, railway outlets, and online platforms such as Zepto, BigBasket, Blinkit, and others.
Time of India
16-05-2025
- General
- Time of India
Pest attack hits mango crop in UP, quality at risk
1 2 3 Lucknow: A sour deal awaits mango lovers this season as a widespread pest attack has affected crops in various parts of Uttar Pradesh. The rising temperatures are believed to be contributing to the pest issue, which can lead to scarring, reduced market value and compromised taste. The attack comes at a critical time when mangoes are growing in size, making them more vulnerable to damage. Despite the fruit size being better than previous years, the pests — including the 'dudwa' or paired fruit borer and 'cutter' (humpback caterpillar or semilooper) — are affecting mangoes in Malihabad and other parts of the state, potentially impacting the fruit's quality and yield. Director, Central Institute for Subtropical Horticulture (CISH), T Damodaran, said that while mango leaves have hardened by now, insects are laying eggs on fruits, which are still developing, or on their stalks. "These pests thrive when temperatures rise. It was the trend last year also," he said, adding that fruits covered with protective bags are at a lower risk. For farmers who cannot afford bagging of fruits, as a single piece may cost around Rs 20, scientists recommend insecticides and sprays, but at specific spots where pests are active, or they may scatter for a while and come back again. Like semilooper, which releases a fine thread from its mouth and hangs down from the tree when disturbed by strong winds, rain or pesticides. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Мъжки сандали, създадени за комфорт и издръжливост. ZAROTRAVEL® КУПИ СЕГА Undo While the larvae may die in the process, the larger insects may crawl back. There is, therefore, the need to spray on tree trunks as well. The paired fruit borer is active between two mangoes or within fruit clusters, laying eggs and multiplying at the junction where two fruits touch each other, while semilooper is laying eggs on fruits which have tender skin and stalks. The larvae scrape and feed on the skin of the fruit, leaving it scarred and with holes, said the director. The infestation grows with a rise in temperature, and if not controlled early, it becomes difficult to manage, he added. However, some precautions can keep them away, like bagging the fruits, light but frequent irrigation, mulching the tree basin with dried leaves and 'canopy management' of old trees so that their height is reduced and they are easier to manage.
Hindustan Times
16-05-2025
- Health
- Hindustan Times
Insect attack: Pest infestation threatens this year's bumper, juicy mango crop
Days after reports of a bountiful and luscious mango crop in the state this year, experts at the Central Institute of Subtropical Horticulture (CISH) have said that the crop is under threat from not just one but two insect species. Experts have confirmed a growing infestation of two dangerous pests, the fruit borer (joda keet) and the leaf-cutting semilooper which could spoil the flavour and beauty of this year's mango harvest. According to Dr T Damodaran, director of the ICAR-Central Institute of Subtropical Horticulture (ICAR-CISH) in Rehmankheda, the insects are damaging mangoes from the inside out. 'These pests bore holes in ripening mangoes, causing them to rot, fall prematurely, and lose market value. Meanwhile, semilooper insects are attacking the leaves, reducing the tree's health and fruit quality,' he explained. The situation is particularly worrying for farmers who rely on mango sales for their livelihood. 'This year, the fruit size is promising due to fewer mangoes per tree. But if these pests are not controlled immediately, they could ruin an otherwise excellent harvest,' warned entomologist Dr VS Singh. According to the horticulture scientists, there's still time to save the crop this season. Scientists recommend spraying safe and export-approved insecticides like Emamectin Benzoate to control the pest infestation. 'Special instructions were issued to target young fruits, lower tree branches, and areas where insects are visible,' said the institute. For farmers planning to export mangoes, experts advise using only certified pesticides to maintain international quality standards.
Hindustan Times
08-05-2025
- Climate
- Hindustan Times
Bigger, juicier, sweeter: Expect an XL mango crop, say experts
In the midst of strife comes news that will gladden most hearts! Experts believe that a combination of timely rains and ideal weather conditions is going to boost the quality of the 'king of fruit', leading to a sweeter and larger yield this season, in Uttar Pradesh. Farmers from the mango belts of the state report that the favourable heat during February and March supported excellent flowering. Now, the recent spell of rain is expected to enhance both the taste and size of the mangoes, making this year's harvest one of the best in recent times. Upendra Kumar Singh, a Malihabad-based farmer and general secretary of the Awadh Mango Producer Horticulture Committee, said, 'Rain at this time enhances the weight of mango fruit and gives it a natural taste.' Expressing similar sentiments, Insram Ali, president of the All India Mango Growers' Association, noted, 'Over the years, fake pest control measures have ruined mango produce. The combination of poor weather and pest treatment impact has reduced yields. But this year, farmers in Malihabad are expecting better results and higher prices.' According to scientists at the ICAR-Central Institute for Subtropical Horticulture (CISH) in Rehmankheda, rain in parts of western Uttar Pradesh has affected mango production positively to some extent. However, they assured that there will be no shortage in supply. 'In the Mal-Malihabad region, there was only rainfall without thunderstorms, which is beneficial for mangoes until they ripen,' said T Damodaran, director, CISH. However, experts warn that prolonged rainfall could damage the mango crop, as harvesting is still a few weeks away. Former ICAR-Lucknow director, Dr Shailendra Rajan, explained, 'One or two spells of rain are beneficial for the fruit, but excessive frequent rain can be harmful. It increases the risk of pest and disease attacks, and the fruit's surface may turn black due to water-induced stress.' Mangoes coming in June Expecting better produce Singh said, 'the mango will start hitting the market from the first week of June as harvesting will begin from June 1 in the Mal-Malihabad region.' He further added that the most popular varieties like Dussehri will hit the market on June 10, while others such as Chausa and Langra will be seen by June 15. However, Dr Rajan said, 'Harvesting in the first week of June will be too early for the mangoes and it should be harvested after June 15 for better results.
Yahoo
03-05-2025
- Health
- Yahoo
Data from First-in-Human Trial targeting CISH, a Novel Immune Checkpoint, in Patients with Metastatic Colorectal Cancer Presented at 2025 American Association for Cancer Research (AACR) Annual Meeting
Study Administered CRISPR genetically engineered CISH-knockout Tumor Infiltrating Lymphocytes as a Model System to Evaluate the Safety and Efficacy of this Classically Undruggable Intracellular Target Ongoing and Durable Complete Response of Two Years Observed in Patient with Young Adult Colorectal Cancer Refractory to Multiple Lines of Chemotherapy and Immunotherapy Given these findings, Next-generation Small Molecule Drugging Strategies are Structurally Enabled in Advanced Development NEW YORK and CAMBRIDGE, England, May 1, 2025 /PRNewswire/ -- Intima Bioscience, a clinical stage oncology company focused on curative intent in solid tumor cancers, presented data from a first-in-human study using CRISPR knockout of the intracellular immune checkpoint CISH in T cells administered to patients with metastatic colorectal cancer at the 2025 American Association for Cancer Research (AACR) Annual Meeting. "Over the last decade, the fast-growing field of Immuno-Oncology has nearly entirely focused on neutralizing cell surface targets. Inhibiting promising intracellular checkpoint targets like CISH have dramatic anti-cancer potential, but have traditionally been thought to be undruggable," said Emil Lou, M.D., Ph.D., Principal Investigator of the clinical trial and Professor of Hematology and Oncology at the University of Minnesota. "This first-in-human study used CRISPR/Cas9 deletion of CISH as a model system to evaluate the viability of CISH checkpoint inhibition as a novel strategy for solid tumor immunotherapy." In a featured oral presentation at the AACR Meeting, Dr. Lou provided the first report of the effects of administering neoantigen reactive TILs with knockout of CISH, a gene which encodes cytokine-inducible SH2-containing protein, in patients with metastatic colorectal cancer. The study's results were contemporaneously published in The Lancet Oncology. This dataset consisted of 12 patients who had received multiple lines of therapy, including standard-of-care chemotherapy and biologic agents. "This is the first clinical trial to test genetic disruption of CISH as a harbinger of a new class of immune checkpoints that have pan cancer activity and are not limited by any given tumor's surface PD-L1 expression. Multiple genomic screens have converged on nominating these intracellular immune checkpoints as highly promising therapeutic targets to advance immunotherapy beyond the current limits of the PD1/PD-L1 paradigm," said Christopher A. Klebanoff, M.D., a senior advisor to the study and immunotherapy expert at Memorial Sloan Kettering Cancer Center (MSK), Associate Attending, Laboratory Head, and Member, Immuno-Oncology Program (IOP). Key points from this proof-of-concept clinical trial: The most common severe adverse events included expected hematological events attributable to the preparative lymphodepleting chemotherapy regimen or expected effects of IL-2 (12 patients [100%]). No episodes of high-grade cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome were observed. No serious adverse events or patient deaths resulted from targeting the CISH checkpoint. A patient with young adult/early onset Stage IV colorectal cancer resistant to multiple lines of chemotherapy and immunotherapy was treated on this trial and developed a clinical complete response which is ongoing after more than two years. Detailed molecular and genetic analysis of this patient demonstrated ongoing persistence of CISH inhibited T cells synchronous with the ongoing complete response to this treatment. As a testament to the end stage nature of the treated patient population, the median progression-free survival on this trial was 57 days, and median overall survival was 129 days. A companion scientific paper entitled "CISH, a novel intracellular immune checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints" comprehensively evaluates the intrinsic single agent and combination anti-cancer activity of CISH relative to other prevailing immune checkpoints. This preprint has been submitted for peer review. Dr. Lou added: "In metastatic colorectal cancer, where treatment options are limited and survival outcomes are uniformly fatal, CISH represents a promising new target that may overcome the limitations of current immunotherapies. We believe these data, including an exceptional complete response attributed to CISH knockout, resoundingly support the potential role of CISH checkpoint inhibition in addressing this significant unmet need and underline the possibility of small molecule drugging of CISH to democratize access to patients beyond this proof-of-concept cell therapy clinical trial." NB: The National Cancer Institute of the NIH formally defines an exceptional response as a complete response in which less than 10% of patients respond overall. About CISHThe cytokine-inducible SH2-containing protein CISH is an intracellular cancer immune checkpoint that functions as a negative modulator of T-cell receptor (TCR) signaling and cancer neoantigen recognition. CISH negatively regulates antigen-specific cytokine release and T cell expansion via its capacity to bind PLC-γ1, a proximal mediator of TCR complex signaling. Inhibition of CISH in T cells is believed to help overcome immune evasion regardless of tumor type or PD-L1 expression. About Intima BioscienceIntima Bioscience is a clinical stage oncology company focused on curative intent in solid tumor cancer. Intima is developing a novel small molecule and cell therapy platform for targeting the immune checkpoint CISH in patients with solid tumor cancers. By advancing a mechanism of action for a promising, yet traditionally undruggable target, Intima seeks to democratize the promise of immunotherapy to patients suffering from cancer. Company Contactinfo@ Media ContactRosie Gillam, Edelman View original content to download multimedia: SOURCE Intima Bioscience Sign in to access your portfolio
