Latest news with #EmilyRichardson
Business Wire
2 days ago
- Health
- Business Wire
CN Bio introduces cross-species DILI services to enhance
CAMBRIDGE, England--(BUSINESS WIRE)--CN Bio, a leading provider of Organ-on-a-chip (OOC) systems and solutions that accelerate drug discovery and development workflows, has introduced two new animal microphysiological system (MPS) models that enhance translatability in preclinical drug safety and toxicology assessments to its Contract Research Services (CRS). Building upon the Company's FDA-recognized drug induced liver injury (DILI) assay, the expanded offering enables rapid, comparative studies between commonly used animal and human models to flag interspecies differences early, and better informs in vivo study design. Traditional human in vitro methods have limited capacity to accurately determine drug toxicity. Added to this, the discrepancies between these methods and in vivo animal studies make it challenging to accurately predict safety risks for humans during preclinical testing. Often, unsafe drug candidates are wrongly progressed, and potentially life-saving ones are misclassified and abandoned, ultimately impacting clinical progression. In response to growing market demand for tools that address these concerns, CN Bio has expanded the in vitro to in vivo extrapolation (IVIVE) capabilities of its established PhysioMimix ® DILI assay, adding the ability to easily compare results across human-, rat-, and dog-derived Liver-on-a-chip models. These assays offer a modernized workflow to generate predictive and actionable insights that mitigate the risk of costly, late-stage conflicting data, and reduce unnecessary animal use by providing early warning of hepatotoxicity/DILI prior to in vivo studies. Accessible through the Company's CRS, the new offering harnesses the longstanding expertise of CN Bio's scientific team to provide detailed data analysis, optimized outcomes, and data-driven conclusions beyond what is achievable using existing in vitro models. The assay enables a broad range of longitudinal and endpoint testing for DILI-specific biomarkers from single- or repeat-dosing studies over a 14-day experimental window. This provides a more comprehensive overview of underlying mechanisms of hepatotoxicity or latent effects of drug candidates to improve IVIVE assessment and streamline clinical progression. Dr Emily Richardson, Lead Scientist, Safety and Toxicology, CN Bio, said: 'Understanding safety risks is critical to successful drug development, however, fundamental physiological and biological differences between species can lead to inaccuracies in predictions, often causing drug candidates to be wrongfully abandoned as toxic, or worse, mistakenly classified as safe.' She added: 'Having established our DILI assay as an industry leading option to garner more valuable insights across the development pipeline, we were in an ideal position to expand its capabilities and address this crucial gap in understanding hepatotoxicity using the most commonly used animal models. Partnering with us to utilize this powerful service not only ensures robust and reliable results but also provides access to a team of Organ-on-a-chip experts, who are invested in your success; to de-risk your pipeline and move it forward with confidence.'
Associated Press
09-04-2025
- Business
- Associated Press
Solix Raises $29.5M to Revolutionize Decentralized Internet Infrastructure
MUNICH, Germany, April 09, 2025 (GLOBE NEWSWIRE) -- Solix DePIN, a pioneer in decentralized physical infrastructure networks, has secured $29.5 million in funding from Eclip Foundation. This investment will accelerate the development of Solix's groundbreaking MODEL CONTEXT PROTOCOL (MCP) technology, which enables intelligent bandwidth sharing without affecting users' internet experience. Founded with the mission to transform how internet bandwidth is shared and monetized, Solix has created a platform where users can contribute their unused bandwidth and earn rewards through a simple browser extension. This approach addresses critical challenges in today's internet landscape, including bandwidth inequality and inefficient resource allocation. 'We designed Solix with simplicity and accessibility as core principles,' said David Rodriguez, CEO of Solix DePIN. 'By removing technical barriers to entry, we're enabling anyone with an internet connection to participate in the decentralized economy and be rewarded for sharing resources they already have.' The MODEL CONTEXT PROTOCOL at the heart of Solix's technology represents a significant advancement in the DePIN space. This innovative protocol connects AI models to real-time contextual data about internet usage, allowing for dynamic, intelligent decision-making on bandwidth allocation. Unlike traditional bandwidth sharing solutions that operate on fixed rules, MCP ensures that users' internet experience remains uncompromised. Our MODEL CONTEXT PROTOCOL implementation is what truly sets Solix apart in the DePIN ecosystem,' explained Emily Richardson, Chief Technology Officer at Solix. 'MCP allows for sophisticated real-time analysis of bandwidth availability, creating an optimal balance between sharing resources and maintaining exceptional user experience.' The company's user-friendly approach has driven impressive adoption metrics. Solix currently boasts over 100,000 active users across more than 63 countries, processing approximately 275 TB of data daily. These figures demonstrate both the robust infrastructure and growing demand for decentralized bandwidth solutions. Eclip Foundation, known for backing transformative Web3 technologies, recognized Solix's potential to reshape internet resource distribution. 'Solix represents exactly the kind of innovation we aim to support – solutions that combine technical excellence with practical utility and broad market potential,' said James Wilson, Managing Partner at Eclip Foundation. The $29.5 million investment will fund several key initiatives on Solix's roadmap. These include enhancing the core technology, expanding global reach, and introducing advanced features such as smart bandwidth allocation and AI-powered network optimization. The company also plans to establish strategic partnerships with cloud service providers and content delivery networks to create broader use cases for its decentralized bandwidth marketplace. As internet bandwidth demands continue to grow exponentially with the rise of AI, streaming services, and IoT devices, Solix's decentralized approach offers a scalable and sustainable alternative to traditional bandwidth provisioning. The platform's ability to dynamically adjust to network demands ensures optimal performance while maximizing rewards for contributors. Participating in the Solix network is straightforward – users simply download and activate the Solix browser extension. Once running, the extension intelligently allocates a portion of the user's unused bandwidth to the network, automatically earning them SLIX Points for their contribution. With this significant funding round, Solix is positioned to lead the next wave of innovation in decentralized infrastructure, creating a more accessible, efficient, and equitable internet experience for users worldwide. About Solix DePIN Solix DePIN is a decentralized physical infrastructure network enabling users to share and monetize their excess bandwidth. As the first DePIN project implementing MODEL CONTEXT PROTOCOL (MCP), Solix creates a more accessible, efficient, and equitable internet experience. Solix is committed to building a user-centric sharing economy for digital resources. Media Contact: Company Name: Solix DePIN
Yahoo
26-02-2025
- Climate
- Yahoo
Potholes on I-70 near Deer Trail exposing rebar below
DEER TRAIL, Colo. (KDVR) — Between the recent cold snap and the warm weather this week, significant potholes have formed on Interstate 70 between Byers and Deer Trail. 'Our maintenance crews make temporary repairs to potholes until permanent repairs can be made. Depending on the extreme change in temperatures and traffic volumes, the temporary patches can loosen and other potholes can form,' CDOT spokesperson Tamara Rollison said. Fluctuating weather can increase fire risk in Colorado Multiple people who live in Deer Trail tell FOX31 their vehicles have taken a beating from the poor road conditions. 'A pothole is one thing but showing actual rebar structure of the road is a serious, serious safety hazard,' Deer Trail resident Emily Richardson said. The metal structure of the road is visible in a small section of the westbound lanes of I-70 near Peoria Road. Richardson says it is part of a bigger problem with the integrity of I-70 on the eastern plains. 'It's every bridge on I-70. There's even a decent gap in the road they just keep filling with asphalt outside of Bennet. It's awful. It needs a whole revamp in my opinion,' Deer Trail resident Emily Richardson said. According to Richardson, potholes are such a problem that locals have special driving techniques to avoid them. See the latest traffic conditions in Denver on FOX31 'They'll drive in the middle lane because on the outside of both lanes are potholes so we as 'I-70 corridorians' we know just to kind of ride the middle, which is definitely illegal,' she said. Another Deer Trail resident, Jennifer Atencio-Stokes, says the potholes have become an ongoing problem over the last five years. 'When you drive this drive every day you learn how to play Frogger, kind of dodging all the potholes. You know where the bad ones are and when to get over,' she said. However, Tuesday morning Richardson was unable to avoid a problem spot on I-70 westbound near Peoria Road due to a semi-truck driving next to her. 'I did ride the shoulder as much as I could because there's kind of one on each. You can't really straddle them both unless you're a race car driver so I still straddle the left side as much as I could without hitting the barrier but I still hit my left side and the weight of my car just completely popped the tire,' she said. Teen drives 46 mph over limit with minor in the car Richardson says replacing her tires and repairing the damage will cost about $1,100. She is hoping CDOT can fix the problem spots before more vehicles are damaged. 'We don't even have a grocery store. We have two gas stations and a post office. I have to take that stretch to get milk eggs butter for my family. It's not that I just get to stay home and avoid the roads,' she said. Drivers can report potholes to CDOT online or by phone. In areas where potholes are prevalent, drivers are encouraged to slow down to minimize damage to vehicles. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
