Latest news with #FSCDR
Yahoo
2 days ago
- Sport
- Yahoo
Deion Sanders Cancels Speaking Engagement as Rumors Swirl
Deion Sanders Cancels Speaking Engagement as Rumors Swirl originally appeared on Athlon Sports. Deion Sanders was originally scheduled to be the keynote speaker for The Foundation for Sickle Cell Disease Research (FSCDR) in Fort Lauderdale, Fla. this weekend. However, he was replaced by NBA legend Earvin "Magic" Johnson. Advertisement "Due to an unavoidable last-minute scheduling change, our originally scheduled Foundation Keynote Speaker, Deion Sanders 'Coach Prime,' is unable to attend," the foundation's website read. "We are grateful for his support and look forward to future opportunities to welcome him." The sudden drop out from the conference in his home state has many wondering if Sanders' current health issues might've played a factor. While nothing has been confirmed by Sanders or Colorado, rumors are swirling about his future. Ten days ago, the Colorado Buffaloes coach made his first public appearance in weeks on Asante Samuel's 'Say What Needs to Be Said' podcast and explained why he's been away. "I've done no media. I've done nothing for a minute, Sanders said. "So coming on with you is something. I ain't been in front of nobody for a minute. I lost about 14 pounds. I'm coming back, but I needed this." When Samuel asked if fasting was involved, Sanders replied by saying it was more serious. Related: Former Colorado Defensive Coordinator Reveals Travis Hunter's Ideal NFL Role Sanders' health challenges have been widely reported over the past four years. He previously underwent multiple surgeries related to blood clots, resulting in the amputation of two toes on his left foot while at Jackson State. In late 2024, Sanders said doctors advised removing the remaining toes, which he declined. Advertisement Related: Where Shedeur Sanders Stands in Browns' QB Depth Chart Today Sanders signed a five-year, $54 million extension with Colorado in March. He became the highest-paid coach in the Big 12 conference and currently ranks within the top ten nationally. The Buffaloes open the 2025 season against Georgia Tech on Friday, August 29 (8 p.m. ET, ESPN). This story was originally reported by Athlon Sports on Jun 9, 2025, where it first appeared.
Associated Press
15-04-2025
- Health
- Associated Press
Vascarta commences Proof of Concept Phase 1 clinical study of VAS-101 in sickle cell disease in the United States
SUMMIT, N.J. , April 15, 2025 /PRNewswire/ -- A first in human proof of concept phase I clinical study of VAS-101 (Vasceptor®; topical curcumin gel) in sickle cell disease (SCD) is underway. The study is being conducted by the Foundation for Sickle Cell Disease Research (FSCDR) in Hollywood, Florida, under the supervision of the principal investigator, Dr. Gershwin Blyden. Ten (10) patients with sickle cell disease will be treated with VAS-101 twice per week over 4 weeks for a total of 8 treatments; their blood will be drawn weekly. Five (5) patients will be treated topically on their forearm and five (5) patients will be treated sublingually (under the tongue), the duration of treatment is 29 days. The primary study objectives are: (1) assess the safety and tolerability of VAS-101; and (2) assess its effects on impaired blood flow dynamics, including adhesion molecule expression and erythrocyte fragility parameters. The objective assessment of VAS-101 impact on red blood cell health will be performed by Functional Fluidics utilizing their proprietary assays at their specialty laboratory in Detroit, Michigan. Secondary study objectives include (1) an evaluation of the effect of VAS-101 on inflammatory markers associated with the activation of sterile inflammation over 28 days; (2) determination of the mean change in red blood cell sickling kinetics and oxygen dissociation curves will be assessed by The Biophysical Chemistry Section, Laboratory of Chemical Physics at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in Bethesda, Maryland; and (3) assessment of the pain-relieving benefit and opioid-sparing effect of VAS-101. Dr. Lanetta Bronté-Hall, President of FSCDR, stated, 'I'm proud that we are taking part in Vascarta's pilot study, which explores a new transdermal approach to pain management for individuals living with Sickle Cell Disease (SCD). Pain remains one of the most challenging and life-disrupting aspects of this disease, and new approaches are urgently needed. While early in development, this research represents an important step toward finding new options that could one day help ease that burden. At FSCDR, we are committed to advancing care and bringing hope to the SCD community through innovation and collaboration.' About VAS101 VAS-101 (developed by Vascarta Inc., Summit, NJ) is a topical curcumin formulation that employs a patented transdermal delivery technology designed to increase bioavailability. A published study in the PNAS Nexus Journal indicated that VAS-101 'has the potential to ameliorate chronic pain, improve RBC stability, and reduce inflammatory consequences of SCD.' * While Curcumin possesses many beneficial attributes such as safety, anti-sickling, anti-inflammatory, and antioxidant properties, its clinical translational potential has been constrained due to limited bioavailability from oral administration. About Sickle Cell Disease Sickle cell disease is the most common inherited genetic disorder that affects primarily African American and non – Hispanic Black individuals in the United States. SCD associated complications include anemia, acute and chronic pain, infections, pneumonia and acute chest syndrome, stroke, kidney, liver, and heart disease. Current estimates indicate there are >165,000 cases of SCD in the USA and 45,000 in European Union countries. The estimated life expectancy of those with sickle cell disease in the USA is more than 20 years shorter than the average expected lifespan. SCD is caused by a single point mutation in the globin gene leading to sickling of red blood cells. It is characterized by severe pain, inflammation, oxidative stress, and organ damage, which contribute to the poor quality of life and reduced survival. Recently approved SCD therapies do not mitigate pain, and patients are often on multiple drugs which often have undesirable side effects. The unmet medical need for most SCD sufferers is significant. Better therapies that improve outcomes, optimize compliance for patients of all ages, minimize the need for blood transfusions, and reduce the need for chronic administration of potentially harmful pain medications are needed. Dr. Joel Friedman, Professor, Department of Microbiology & Immunology, Albert Einstein College of Medicine, and Vascarta Scientific Founder & Head, Scientific Advisory Board, stated, 'The preclinical results to date showing pain reduction and therapeutic efficacy resulting from our novel approach of targeting red blood cell instability, neuro-inflammation and vascular inflammation bodes well for the development of a widely accessible therapy that prevents and treats many if not most of the clinical consequences of SCD.' Dr. Friedman is the inventor of VAS-101 which is exclusively licensed to Vascarta from the Albert Einstein College of Medicine (Bronx, New York, USA). Dr. Richard Prince, Vascarta Chairman, CEO & President commented, 'We are excited at the prospect of bringing relief to SCD sufferers who have limited therapeutic options. VAS-101 has the potential to become the new standard of care in the management of SCD.' * 'Targeting sickle cell pathobiology and pain with novel transdermal curcumin' About Vascarta Vascarta is a clinical stage pharmaceutical company exploring efficient transdermal delivery of pharmaceuticals to address inflammatory conditions with an initial focus on sickle cell disease and osteoarthritis. To learn more, contact Vascarta Chairman, CEO & President, Dr. Richard Prince, at [email protected]. Media requests should be directed to David Hymson at [email protected]. View original content to download multimedia: SOURCE Vascarta Inc
