Latest news with #McDonnell
Yahoo
11 hours ago
- Business
- Yahoo
Agilent Tech looks to double investments in India, eyes high-teen growth, CEO says
By Rishika Sadam HYDERABAD (Reuters) -U.S.-based laboratory equipment maker Agilent Technologies plans to double its investments in India to expand in one of its fastest-growing markets, a top executive said. The company anticipates the Indian market to grow in the high teens and beyond, CEO Padraig McDonnell told Reuters, during the inauguration of its center in Hyderabad, a city in southern India. CEO McDonnell said the company plans to double its investments in India over the next three years, without specifying the amount, and added, "Before the end of the year, we're going to have new announcements about investments in India." Agilent generated revenue of $6.51 billion in the previous fiscal year, with the U.S. being its largest market. It produces laboratory equipment used in research, production and testing by pharmaceutical, chemical and food companies. "We're evenly split across markets, like one-third from the U.S., Europe and Asia," McDonnell said. However, he declined to provide details on India's contribution to total revenue, noting only that it is growing in double digits. The soaring demand for weight-loss drugs and drugmakers racing to develop their own versions is expected to boost demand for Agilent's services, McDonnell said. Indian drugmakers are working on developing cheaper versions of Novo Nordisk's blockbuster obesity drug Wegovy. Agilent has already observed such demand in other markets, and anticipates growth in its order book as more Indian pharmaceutical companies develop drugs for complex diseases, and work on cell and gene therapies, according to McDonnell. "All these spaces are very fast-growing markets. So we expect these drivers to continue to grow. And that's why we want to kind of invest ahead of the curve," he said, adding that India is expected to be a bigger growth driver of overall revenue in the coming years. Sign in to access your portfolio
Mercury
2 days ago
- Business
- Mercury
Prescient advances cancer drug to unlock value
Prescient at critical stage of development with phase 2a trial underway for PTX-100 PTX-100 granted orphan drug and fast track designations by the US FDA, unlocking benefits Focus on advancing PTX-100 to potential registrational phase 2b trial to open commercial opportunities Special Report: Prescient Therapeutics has entered a critical stage where clinical data, regulatory support, and commercial potential begin to converge in a defining moment for a biotech company aiming to bring a new therapy to market. Prescient Therapeutics (ASX:PTX) is in phase 2a trial for its lead compound PTX-100 in patients with rare blood cancer relapsed/refractory Cutaneous T-Cell Lymphoma (r/r CTCL) with the potential for its phase 2b arm to be registrational. PTX-100 is a first-in-class compound with the ability to block an important cancer growth enzyme geranylgeranyl transferase-1 (GGT-1). It is believed to be the only GGT-1 inhibitor in the world in clinical development. The US Food and Drug Administration (FDA) has granted PTX-100 orphan drug designation (ODD) for all T-cell lymphomas and fast-track designation for treatment of adults with relapsed or refractory mycosis fungoides, the most common subtype of CTCL. Fast Track designation provides an expedited pathway to approval, with orphan drug designation offering market exclusivity for a period of seven years in the US. 'The aim is to improve the quality of life for people suffering from this terrible form of cancer and getting them the therapy they need as fast as possible,' CEO James McDonnell said. 'It's also an incentive for larger pharmaceuticals who are looking to add to their portfolio as the drug progresses through clinical development.' Potential regulatory trial for PTX-100 McDonnell is focused on getting PTX-100 through the phase 2a trial with the potential to make the second phase 2b arm a registration study. 'Fast Track designation opens a dialogue with the FDA for companies to provide ongoing trial updates, instead of a lengthy review at the end, to expedite therapies to patients who desperately need them,' he said. 'All we need to do is replicate the Phase 1b results, if the FDA agrees, they could potentially authorise Phase 2b as a registration study.' In the phase 1b trial PTX-100 delivered a 45% overall response rate and 64% clinical benefit in T-cell lymphoma, with just 4% serious side effects – well below the 30% benchmark. 'The first step now is to progress Phase 2a where we can define a dose which will also have some efficacy and safety data,' McDonnell said 'The registrational study means we are closer to approval and the momentum for PTX-100 really starts to accelerate and excitement grows on the commercial front.' Watch: James McDonnell discusses the first US site for the Phase 2a trial of PTX-100. Eyes on the commercialisation prize With over 27,000 new TCL cases every year, in eight major centres, PTX is targeting a market worth ~US$1.8 billion. Commercialisation of PTX-100 will become a key focus for Prescient if it advances to a registrational study, with all options on the table – including partnership, licensing, or taking the drug to market independently. 'We are confident in how PTX-100 could change the lives of thousands, we need the data now to back that confidence and provide the market a clear indication of the value the therapy can provide,' he said. 'PTX-100 is a first-in-class therapy with a unique mechanism of action which has shown very good results in the Phase 1b study. 'These results have exceeded our benchmarks and compare well to the available therapies on efficacy, duration and a safety perspective.' McDonnell said that Dimerix (ASX:DXB) was a great example of what a potential commercial pathway could look like for Prescient if Phase 2b became a registrational trial. Dimerix is advancing its lead candidate DMX-200 through the ACTION3 phase 3 trial for the rare kidney disease FSGS and has secured four regional licensing agreements to drive commercialisation. 'They were able to take orphan drug designated therapy DMX-200, which is currently in a phase 3 registration study, into significant licensing agreements worth approximately $1.4 billion,' he said. 'Dimerix have highlighted how these milestones, FDA designation and registrational study, can open commercialisation opportunities and drive value creation.' McDonnell said in biotech it often comes down to two questions with the first being: can you get a product to market? The second is: what kind of market is waiting at the end? Phase 2 trials usually provide clearer insights into a drug's potential, with data readouts serving as critical indicators that can drive value inflection points. Source: Prescient Therapeutics A series of upcoming catalyst Investors have plenty to watch out for in H2 CY25, with Prescient advancing its phase 2a study. 'We are excited for the release, once we reach 20 patients, of the initial data from the dose optimisation committee review, which will be a key event in determining the next steps for development of PTX-100,' McDonnell said. A share purchase plan aimed at raising $7 million to support Prescient's clinical program closed on July 25. 'There are several milestones we are looking to hit in the coming months and if we can potentially get that Phase 2b into a registration study we can start to shift our focus toward commercialisation opportunities,' McDonnell said. This article was developed in collaboration with Prescient Therapeutics, a Stockhead advertiser at the time of publishing. This article does not constitute financial product advice. You should consider obtaining independent advice before making any financial decisions. Originally published as Prescient focuses on advancing lead cancer drug toward pivotal trial
Miami Herald
22-07-2025
- Politics
- Miami Herald
LAPD undergoes first major leadership shake-up with McDonnell as chief
LOS ANGELES - In his first major shake-up since taking over the Los Angeles Police Department in November, Chief Jim McDonnell has given new assignments to more than a dozen officials from the upper ranks. Faced with ongoing struggles to woo new recruits and uncertainty around his plans to overhaul the LAPD, McDonnell gave the first indications about how he intends to reorganize by elevating three deputy chiefs - Emada Tingirides, Michael Rimkunas and Scott Harrelson - to top positions and resurrecting a long-dormant bureau. The moves were announced in a departmentwide email last week but aren't expected to take effect until later this month. Tingirides, who lost out to McDonnell in a bid to become chief last fall, becomes assistant chief in charge of the Office of Operations, which oversees patrol functions. She was recently announced as a finalist for the same job in Fort Worth, according to local news reports. Her recent promotion is seen by some inside the department as a move to convince her to stay. She becomes the highest-ranking Black woman in the department's history. Harrelson will now be in charge of the department's training and recruitment efforts as the head of the Office of Support Services, replacing Assistant Chief Daniel Randolph, who is expected to retire in the coming weeks. Filling out McDonnell's inner circle are two other holdovers from the administration of former Chief Michel Moore: Rimkunas and Dominic Choi, who served as interim chief until McDonnell took over in November. Choi remained an assistant chief but was named McDonnell's chief of staff - in effect the department's No. 2. The head of the bureau that includes internal affairs, Rimkunas will now run the Office of Special Operations. McDonnell also resurrected the department's Human Resources Bureau, which was shut down in 2004 when McDonnell he was a senior official under former Chief William J. Bratton. He didn't immediately say what the new bureau's responsibilities will be. It's unclear whether McDonnell will have to submit parts of his reorganization plan to the City Council, which in the past has had to sign off on changes to the department's structure. When he took the job last year, McDonnell initially said he wanted to spend at least three months studying the LAPD to understand how it had changed since he came up through the ranks. He left in 2010 to become the top cop in Long Beach, then served a term as L.A. County sheriff. His early review timeline was thrown off, he told reporters at a news conference last week, because of the fires in January and the recent protests over federal immigration raids. The series of major incidents, McDonnell said, presented an unexpected opportunity to evaluate his senior staff to see how they performed "in crisis mode." The chief added that he had delayed his realignment for the "outcome of the budget to see where we were" and the completion of a monthslong study of the department by Rand Corp., a global policy think tank brought in last year to conduct a top-down review. The study was recently finished, and McDonnell said he was reviewing its recommendations, as well as those made by the numerous internal working groups he had convened to look at recruitment, discipline and other workplace issues. Without offering details, McDonnell hinted that another one of his priorities will be beefing up the department's detective ranks and overhauling the system that handles misconduct complaints against officers, long a source of controversy and frustration. "I have in rough form what I think it could look like, but I certainly want to get the input from those who are dealing with it on a day-to-day basis on how do we best deal with the nuances of doing the job today with the number of resources that we have," he told reporters. McDonnell has come under growing pressure from critics who have said he is moving too slowly to make changes, with more urgency required as the city gets ready to host events such as the next year's World Cup and the 2028 Olympic Games. In other personnel moves announced last week, McDonnell moved Deputy Chief Marc Reina from the Training Bureau to South Bureau, where he previously worked as captain, and promoted German Hurtado, the department's immigration coordinator, to deputy chief over Central Bureau, which has been the epicenter of recent protests. Hurtado has been named in at least two pending lawsuits by LAPD officials accusing him of covering up unjustified uses of force by officers during the 2020 protests. The city has denied wrongdoing and is fighting the cases in court. "As far as I know, I'm only named as a witness in those cases, and I'm not at liberty to talk about ongoing lawsuits," Hurtado said when reached Monday by The Times. McDonnell also demoted Assistant Chief Blake Chow to his civil service rank of commander - a similar trajectory to McDonnell, who was made to drop a rank during the tenure of former Chief Charlie Beck. Capt. Ray Valois, who helped oversee the department's response to the Palisades fire, was elevated to commander in the Valley Bureau. Copyright (C) 2025, Tribune Content Agency, LLC. Portions copyrighted by the respective providers.
Los Angeles Times
22-07-2025
- Politics
- Los Angeles Times
LAPD undergoes first major leadership shake-up with McDonnell as chief
In his first major shake-up since taking over the Los Angeles Police Department in November, Chief Jim McDonnell has given new assignments to more than a dozen officials from the upper ranks. Faced with ongoing struggles to woo new recruits and uncertainty around his plans to overhaul the LAPD, McDonnell gave the first indications about how he intends to reorganize by elevating three deputy chiefs — Emada Tingirides, Michael Rimkunas and Scott Harrelson — to top positions and resurrecting a long-dormant bureau. The moves were announced in a departmentwide email last week but aren't expected to take effect until later this month. Tingirides, who lost out to McDonnell in a bid to become chief last fall, becomes assistant chief in charge of the Office of Operations, which oversees patrol functions. She was recently announced as a finalist for the same job in Fort Worth, according to local news reports. Her recent promotion is seen by some inside the department as a move to convince her to stay. She becomes the highest-ranking Black woman in the department's history. Harrelson will now be in charge of the department's training and recruitment efforts as the head of the Office of Support Services, replacing Assistant Chief Daniel Randolph, who is expected to retire in the coming weeks. Filling out McDonnell's inner circle are two other holdovers from the administration of former Chief Michel Moore: Rimkunas and Dominic Choi, who served as interim chief until McDonnell took over in November. Choi remained an assistant chief but was named McDonnell's chief of staff — in effect the department's No. 2. The head of the bureau that includes internal affairs, Rimkunas will now run the Office of Special Operations. McDonnell also resurrected the department's Human Resources Bureau, which was shut down in 2004 when McDonnell he was a senior official under former Chief William J. Bratton. He didn't immediately say what the new bureau's responsibilities will be. It's unclear whether McDonnell will have to submit parts of his reorganization plan to the City Council, which in the past has had to sign off on changes to the department's structure. When he took the job last year, McDonnell initially said he wanted to spend at least three months studying the LAPD to understand how it had changed since he came up through the ranks. He left in 2010 to become the top cop in Long Beach, then served a term as L.A. County sheriff. His early review timeline was thrown off, he told reporters at a news conference last week, because of the fires in January and the recent protests over federal immigration raids. The series of major incidents, McDonnell said, presented an unexpected opportunity to evaluate his senior staff to see how they performed 'in crisis mode.' The chief added that he had delayed his realignment for the 'outcome of the budget to see where we were' and the completion of a monthslong study of the department by Rand Corp., a global policy think tank brought in last year to conduct a top-down review. The study was recently finished, and McDonnell said he was reviewing its recommendations, as well as those made by the numerous internal working groups he had convened to look at recruitment, discipline and other workplace issues. Without offering details, McDonnell hinted that another one of his priorities will be beefing up the department's detective ranks and overhauling the system that handles misconduct complaints against officers, long a source of controversy and frustration. 'I have in rough form what I think it could look like, but I certainly want to get the input from those who are dealing with it on a day-to-day basis on how do we best deal with the nuances of doing the job today with the number of resources that we have,' he told reporters. McDonnell has come under growing pressure from critics who have said he is moving too slowly to make changes, with more urgency required as the city gets ready to host events such as the next year's World Cup and the 2028 Olympic Games. In other personnel moves announced last week, McDonnell moved Deputy Chief Marc Reina from the Training Bureau to South Bureau, where he previously worked as captain, and promoted German Hurtado, the department's immigration coordinator, to deputy chief over Central Bureau, which has been the epicenter of recent protests. Hurtado has been named in at least two pending lawsuits by LAPD officials accusing him of covering up unjustified uses of force by officers during the 2020 protests. The city has denied wrongdoing and is fighting the cases in court. 'As far as I know, I'm only named as a witness in those cases, and I'm not at liberty to talk about ongoing lawsuits,' Hurtado said when reached Monday by The Times. McDonnell also demoted Assistant Chief Blake Chow to his civil service rank of commander — a similar trajectory to McDonnell, who was made to drop a rank during the tenure of former Chief Charlie Beck. Capt. Ray Valois, who helped oversee the department's response to the Palisades fire, was elevated to commander in the Valley Bureau.
Belfast Telegraph
18-07-2025
- Sport
- Belfast Telegraph
Northern Ireland young gun ready to make most of ‘family environment' after sealing loan move to League One club
The 21-year-old midfielder is the third Forest youngster to join the Stags in the summer of 2025 following Joe Gardner and Kyle McAdam. He spent the 2024/25 season on loan at Colchester United, making 32 appearances in League Two. 'There seems like a real family environment here with a strong bond amongst the players and staff. I feel like this is a club where I can really contribute and develop,' McDonnell said. 'I've previously spoken to Kyle and Joe and they've said nothing but great things about the club.' McDonnell scooped Colchester's Young Player of the Season accolade and also made it into the Sky Bet League Two Team of the Season. He captained Forest's Under-18s in their first-ever FA Youth Cup Final in 2022 against Manchester United at Old Trafford and has also featured five times in his nation's Uefa European Under-21 Championship qualifying campaign. The Stags start the 2025/26 season with a trip to boss Nigel Clough's former club Burton Albion on August 2. Meanwhile, League One side Blackpool are reportedly interested in Forest and Northern Ireland striker Dale Taylor. The 21-year-old spent the 2024/25 season on loan at Wigan Athletic in the third-tier of English football.
