Latest news with #Metformin
Yahoo
3 days ago
- Business
- Yahoo
NY man alleges vision loss after taking Ozempic: Details
The Brief A 48-year-old man from Suffolk County blames Ozempic for partial vision loss in both eyes. He, along with over 30 others who are suffering from the same side effect, are suing Ozempic's manufacturer. The manufacturer, Novo Nordisk, states they believe "the benefit-risk profile of semaglutide remains unchanged." LONG ISLAND - Michael, a 48-year-old from Suffolk County, is suing Ozempic's manufacturer for partial loss of vision. What we know Michael, who opted out of sharing his surname, says that the loss of sight began after his endocrinologist recommended he switch from Metformin to Ozempic to manage his type 2 diabetes. Michael told FOX 5 NY's Jodi Goldberg that he lost 10 pounds, but also some vision in both eyes. "From the bottom right side of my eye… if I close the left eye, faces get blurry, I can't read my cell phone." He claims he had 20/20 vision before taking Ozempic. Michael was diagnosed with NAION (Non-arteritic Anterior Ischemic Optic Neuropathy), which is essentially a stroke of the eye – it presents as an acute but painless loss of vision in one eye. No treatment for NAION currently exists. One of the most recognized risk factors for NAION is diabetes. However, two recent studies – one from the JAMA Network and the other out of Denmark – suggest there could be a link between the condition and taking semaglutide, which is the active ingredient in Ozempic. Jason Goldstein of Parker Waichman LLP, a personal injury, mass tort and environmental law firm, has filed a multimillion dollar lawsuit against Novo Nordisk, the manufacturer of Ozempic and Wegovy, a similar medication. Goldstein is representing more than 30 clients from 10 states suffering from the same side effect, including Michael. "This lawsuit is about holding Novo Nordisk responsible for not warning doctors and their patients this condition could develop," Goldstein said. Dig deeper Over the past decade, the U.S. Food and Drug Administration (FDA) has recalled over 14,000 drugs; rare side effects can be missed during clinical trials and may not be discovered until later on. Goldberg spoke to Dr. Chetna Bakshi about how common reactions to medications like Ozempic could be. Bakshi's take is that more research is necessary. "These medications come out, people take them, and it's not until 10 or 15 years later that we find other complications that weren't apparent in the initial clinical trials." The other side A spokesperson for Novo Nordisk gave FOX 5 this statement: "Patient safety is a top priority for Novo Nordisk, and we take all reports about adverse events from use of our medicines very seriously. After a thorough evaluation of studies from the University of Southern Denmark and Novo Nordisk's internal safety assessment, Novo Nordisk is of the opinion that the benefit-risk profile of semaglutide remains unchanged." Goldstein's response: "It was a drug you were taking, that there were other options on the market, and no one warned you this could happen." The Source This article includes reporting from FOX 5 NY's Jodi Goldberg, as well as two medical studies from the JAMA Network and a Danish-Norwegian cohort.
Indian Express
3 days ago
- Health
- Indian Express
Metformin: Miracle aging drug or overhyped hope?
What is Metformin? Metformin is an FDA-approved drug for Type 2 diabetes, also used for weight loss and PCOS. Some doctors believe it may prevent chronic diseases and support longevity. Source: Canva
Time Business News
24-05-2025
- Health
- Time Business News
Metformin Weight Loss Before and After: Real Transformations and What You Need to Know
In recent years, the conversation around metformin has shifted from its primary use as a treatment for type 2 diabetes to its surprising role in aiding weight loss. The topic of 'metformin weight loss before and after' has captured the curiosity of many who are seeking effective and medically supported solutions to manage their weight. With numerous testimonials and studies surfacing, it's clear that this humble prescription drug is gaining traction beyond its traditional boundaries. But how does it really work, and what should individuals know before considering it for weight loss? In today's fast-paced world, the healthcare landscape is rapidly evolving, and ordering blood tests online has emerged as a game-changer, offering unparalleled convenience and accessibility to users across the globe—a trend explored in detail here. As more individuals embrace this shift, many are curious about what to expect from a home blood test, from sample collection to result interpretation—an experience outlined comprehensively in this guide. The growing popularity of these at-home services can be attributed to various factors, including privacy, time-saving, and proactive health management, all of which are key reasons behind the surge in demand for home health testing. Understanding Metformin: More Than Just a Diabetes Medication Metformin is commonly prescribed to manage blood sugar levels in individuals with type 2 diabetes. It works by improving insulin sensitivity, decreasing glucose production in the liver, and enhancing the body's ability to process sugar. However, during its use, many patients reported a modest but noticeable reduction in weight. This unexpected benefit sparked scientific interest and led to more comprehensive studies investigating its impact on body mass. Though not originally designed for weight loss, the mechanism by which metformin works may indirectly support weight reduction. It suppresses appetite in some individuals, improves metabolic efficiency, and alters the gut microbiome in ways that might contribute to decreased body fat. These effects, while not universal, provide a scientific basis for the growing number of metformin weight loss before and after success stories. What the Before and After Stories Reveal When exploring real-life experiences, one common thread among individuals who have used metformin for weight loss is the gradual nature of their transformation. Unlike crash diets or extreme fitness regimens that promise rapid changes, metformin typically contributes to slow, steady weight reduction. Many users have reported losing anywhere from 5 to 15 pounds over a few months, depending on lifestyle factors like diet, exercise, and consistency with the medication. The 'before' phase often begins with individuals feeling frustrated by their inability to lose weight through traditional means. For some, underlying insulin resistance or polycystic ovary syndrome (PCOS) had made weight management difficult. After starting metformin under medical supervision, many noticed subtle changes: clothes fitting better, a decrease in cravings, and more energy throughout the day. Over time, these improvements compound, leading to the 'after' phase marked by renewed confidence and improved health metrics. The Science Behind Metformin-Induced Weight Loss While anecdotal evidence is compelling, understanding the scientific framework behind these transformations adds credibility. Metformin reduces hepatic glucose production and improves insulin sensitivity, which are key factors in managing obesity-related conditions. Furthermore, some research suggests that metformin may influence certain hormones related to appetite and satiety, such as leptin and ghrelin, potentially reducing the urge to overeat. Another intriguing aspect is how metformin interacts with the gut microbiome. Emerging studies indicate that this drug alters the composition of gut bacteria in a way that favors weight loss. While this area of research is still developing, the connection between gut health and weight regulation is becoming increasingly clear. Important Considerations Before Starting Metformin for Weight Loss Despite its promising benefits, metformin is not a magic pill. The most compelling metformin weight loss before and after journeys often come from those who combined the medication with meaningful lifestyle changes. Diet modifications, regular physical activity, and mindful eating habits significantly enhance metformin's weight loss potential. Additionally, metformin is a prescription drug that should only be taken under the guidance of a healthcare provider. Side effects like gastrointestinal discomfort, nausea, or diarrhea are not uncommon, especially when beginning treatment. Moreover, long-term use requires regular monitoring of kidney function and vitamin B12 levels to ensure safety. It's also important to understand that results can vary greatly between individuals. Some may experience dramatic changes, while others might find little to no impact on their weight. Genetics, baseline insulin sensitivity, and overall metabolic health all play a role in determining outcomes. Realistic Expectations and Sustainable Outcomes Perhaps one of the most valuable lessons from metformin weight loss before and after experiences is the importance of setting realistic goals. Unlike fad diets or aggressive supplements, metformin fosters sustainable changes by working with the body's existing metabolic processes. Users who approach the journey with patience and a long-term mindset are more likely to maintain their progress and develop healthier habits along the way. Moreover, the psychological shift reported by many is worth noting. The gradual weight loss often leads to improved self-esteem, increased motivation to stay active, and a more balanced relationship with food. These benefits can reinforce a cycle of positive change that extends beyond the physical transformation. Conclusion: Is Metformin the Right Tool for You? The growing number of metformin weight loss before and after stories speaks to its potential as a helpful ally in the journey toward better health. While it may not deliver overnight results or work for everyone, metformin offers a science-backed option that supports gradual, sustainable weight loss when combined with healthy lifestyle choices. As with any medication, consultation with a healthcare professional is essential to determine its suitability and ensure a safe and effective approach. Whether you're struggling with insulin resistance, managing PCOS, or simply exploring medically-supported weight loss strategies, metformin could be a step in the right direction. Ultimately, the most inspiring transformations are those grounded in education, commitment, and a deep understanding of how your body responds to change. TIME BUSINESS NEWS
Yahoo
13-05-2025
- Health
- Yahoo
Type 5 diabetes is a newly recognised disease – here's how it compares
Type 5 diabetes has just been recognised as a distinct form of diabetes by the International Diabetes Federation. Despite the name, there are more than a dozen different types of diabetes. The classification isn't quite as tidy as the numbering suggests. Here's a clear guide to the different types, including some that you may not have heard of, along with information about what causes them and how they are treated. Type 1 diabetes is caused by the body's immune system mistakenly attacking the insulin-producing cells in the pancreas. This autoimmune reaction can occur at any age, from infancy through to old age. It is not linked to diet or lifestyle. Instead, it probably results from a combination of genetic predisposition and environmental triggers, such as viral infections. Treatment involves lifelong insulin therapy, delivered through injections or pumps. A small number of people who struggle with low blood sugars, called hypoglycaemia, can receive new cells in the pancreas that produce insulin from deceased donors. For many, this reduces the number of insulin injections needed. Some can stop taking their insulin altogether. What's more, dozens of people have now received stem-cell-derived transplants to effectively 'cure' their diabetes, although people still need to take strong immune-suppressing drugs. This treatment is not yet widely available. Type 2 diabetes is the most common form of the condition and is often linked to having a high BMI (body mass index). However, it can also affect people of normal weight, particularly those with a strong genetic predisposition. Certain ethnic groups, including South Asians and people of African and Caribbean descent, are at higher risk, even at lower body weights. Boosting the body's production of insulin can help to control blood sugar levels. Some drugs boost insulin production from the pancreas, while others improve insulin sensitivity. Metformin, for example, is taken by hundreds of millions of people worldwide. This drug improves insulin sensitivity and switches off sugar production by the liver. There are dozens of different drugs to help control blood sugar in type 2 diabetes. Tailoring treatment to the individual has been shown to improve health outcomes significantly. Lifestyle changes can also reverse diabetes. This can be done by keeping a low-calorie diet of 800 calories a day. In a research trial, maintaining this diet for 12 months reversed diabetes in 46 per cent of people. This type of diabetes develops during pregnancy, typically between weeks 24 and 28. It is triggered by hormonal changes that reduce the body's sensitivity to insulin. Risk factors include being overweight or obese, having a family history of diabetes, and giving birth to a large baby in a previous pregnancy. Those from Middle Eastern, south Asian, black and African Caribbean backgrounds are also at higher risk of gestational diabetes. Age is also a factor, as insulin sensitivity declines with age. This can be treated with diet and exercise, tablets or insulin injections. There are at least nine subtypes of diabetes that include rare genetic forms, sometimes caused by a single genetic change. Others can be caused by treatment, such as surgery or drugs, such as steroids. Neonatal Diabetes appears early in life. Some of the genetic changes affect how insulin is released from the pancreas. Some people still make their own insulin, so can be treated with tablets that help pancreas cells to push out insulin. Maturity-onset diabetes of the young, or Mody, occurs later in life and is linked to genetic changes. There are several gene changes, with some affecting how pancreas cells sense sugar and others affecting how the pancreas develops. Type 3c diabetes is different. It is caused by damage to the pancreas. People with pancreatic cancer, for example, can develop diabetes after parts of the pancreas are removed. It can also develop after pancreatitis (inflammation of the pancreas). Those with cystic fibrosis are also at a higher risk of developing diabetes. This is called cystic fibrosis-related diabetes. The risk increases with age and is very common, with around a third of people with cystic fibrosis developing diabetes by the age of 40. This newly designated form is linked to malnutrition during early life. Type 5 diabetes is more common in poorer countries. It affects around 20-25 million people worldwide. People have low body weight and lack insulin. But the lack of insulin is not caused by the immune system. Instead, the body may not have received the correct nutrition during childhood to help the pancreas develop normally. Studies with rodents have shown that a low-protein diet during pregnancy or adolescence leads to poor pancreas development. This has been known for many years. Having a smaller pancreas is a risk factor for different forms of diabetes. Essentially, having fewer reserves of insulin-producing cells. feeling very thirsty peeing more frequently than usual, particularly at night feeling very tired weight loss and loss of muscle bulk itching around the penis or vagina, or frequent episodes of thrush blurred vision Diabetes is an umbrella term for a range of conditions that result in raised blood sugar levels, but the underlying causes vary widely. Understanding the specific types of diabetes someone has is crucial to providing the right treatment. As medical science evolves, so does the classification of diabetes. Recognising malnutrition-related diabetes as type 5 will stimulate discussion. This is a step towards better global understanding and care – especially in low-income countries. Craig Beall is a Senior Lecturer in the Neuroscience of Energy Homeostasis at the University of Exeter. This article is republished from The Conversation under a Creative Commons license. Read the original article.
Yahoo
12-05-2025
- Health
- Yahoo
Global longevity competition for $101 million names semifinalists—here are their ideas for extending life by 10 years or more
The contestants in a race to extend life are on their second lap. In a seven-year global competition, teams are rushing to discover novel therapeutics and interventions that can extend human life by a decade and help people age well. In 2023, Peter Diamandis, an entrepreneur, self-proclaimed futurist, and founder and executive chairman of the XPRIZE Foundation, launched the $101 million healthspan competition. Since then, over 600 teams from 58 countries have put their ideas in the ring, including medical devices, lifestyle interventions, and biological therapies. Today, the competition awarded each of the top 40 teams $250,000 to help them test their hypotheses in clinical trials. 'We're really pushing at a global scale for people to accelerate the process, so we can get real solutions in the hands of people who need them,' Jamie Justice, PhD, executive director of XPRIZE Healthspan, tells Fortune. Teams from all over the globe, composed of students, university researchers, and even a Nobel Prize winner, are competing for the coveted prize, which will amount to $81 million. One team of high schoolers from Malaysia pitched a community-based solution that includes facilitating drum circles with older adults. Another team is testing the potential life-extending benefits of popular diabetes and weight-loss drugs, GLP-1s. Still another is examining whether the drug Metformin can help prevent cognitive decline. By 2030, the winner will have shown that their therapy can restore muscle, cognitive, and immune function in a one-year clinical trial of older adults. "The next breakthrough in aging could come from scientists and entrepreneurs, anywhere. With this prize, we're igniting a global healthspan revolution, and these semifinalists are leading the charge," said Diamandis, in a press release. "This competition isn't just accelerating progress, it's challenging our society's beliefs in what's possible when it comes to aging." Judges made up of leading researchers and scientists in the field assessed teams based on whether they illustrated 'really solid innovation [on a] potential breakthrough that could affect all of the processes that underlie how we age,' says Justice. Teams had to show a readiness for clinical trials with strong evidence of an intervention that can be scaled to the broader population. While people are living longer, there is still a decade-long gap, on average, between how well people live and how well they live in good health. This competition is hoping to reduce the gap and extend how long people live in good health. 'We're looking at solutions that can be proactive and can be generalized to a greater population, so that we can begin to address that gap at a population level,' Justice says. Teams will submit data from their clinical trials by April of next year, ahead of XPRIZE selecting the top ten finalists in July of 2026, followed by the grand prize winner selected in 2030. This story was originally featured on
