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Weight loss drugs could improve polycystic ovary syndrome: All you need to know

Weight loss drugs could improve polycystic ovary syndrome: All you need to know

Time of India20-07-2025
Image credits: Getty Images
According to the Endocrine Society, an estimated 5-6 million women of reproductive age in the U.S. are affected by PCOS, which is frequently underdiagnosed. Caused by high levels of testosterone and androgens, polycystic ovary syndrome leads to symptoms such as irregular periods, excess hair growth, acne, insulin resistance and more.
It is one of the leading causes of infertility and is strongly linked to metabolic issues, leading to weight gain and hormonal imbalance.
One would think a condition affecting such a huge number of women would have a treatment and medicine ready by now. However, when it comes to PCOS, a condition which also leads to other damaging conditions such as obesity and Type 2 diabetes, there's no standard treatment. Mostly, women opt for birth control, lifestyle changes and a diabetes drug, Metformin, which helps with some symptoms.
However, now, a ray of light has come around in the form of popular weight loss drugs that are shockingly helping with improving PCOS. One of the many women who have experienced a positive result is Grace Hamilton, 27, who earlier had to battle problems like hair loss, heavy periods, inconsistent menstrual cycles, mental health problems and sudden weight loss.
After getting diagnosed with PCOS, she tried birth control and lifestyle changes, only to see limited improvements.
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It was in 2024 when Hamilton joined a trial examining the effects of GLP-1 drugs in PCOS patients. In October, she received her first dose of semaglutide, the active ingredient in Wegovy and Ozempic.
The results, as she said to CNBC were almost immediate with resumed periods, hair regrowth and improvement in depression and anxiety. 'I'm so glad that I stuck with it because it was just clear as day that it was the missing link for me,' said Hamilton, adding that she also maintained a diet and exercise regimen.
Are weight loss drugs really the answer?
Image credits: Getty Images
Some health experts see huge potential in GLP-1, particularly in their effect on improving weight loss and insulin sensitivity. 'The unmet need is massive,' said Dr. Melanie Cree, a pediatric endocrinologist at Children's Hospital Colorado, to CNBC. 'Primary therapies used for PCOS symptoms haven't changed in nearly 50 years.'
Cree has been studying the effects of GLP-1 in adolescents with PCOS for more than 10 years.
She previously studied the oral form of semaglutide and now has an ongoing clinical trial with the injectable version, which worked well for patients like Hamilton.
Her trial began in 2023 with girls and women between the ages of 12-35 with obesity and PCOS who are on or off Metformin. Semaglutide was administered to the patients for 10 months to analyse their weight loss, metabolic changes and reproductive functions.
The initial data included 11 women who completed the 10-month trial and were not on Metformin. 8 of these lost more than 10% of their body weight and saw a reduction in their hormone levels. Six of the 8 women even reported more regular periods.
However, her study group is much smaller compared to the studies done on the popular weight loss drugs, and the results did not show similar effects on everyone. Here, the importance of conducting larger and longer trials on the same is important.
This is because the potential for GLP-1 to cause relief in various PCOS symptoms remains. In previous studies, it has been found that in adults with PCOS, losing even 5% of body weight can improve insulin sensitivity. Thus, the body can respond better to insulin, and the pancreas doesn't need to pump out more insulin to keep the blood sugar in check. This will lower insulin levels, in turn lowering the production of testosterone and reducing symptoms of irregular period, acne and excess hair growth.
Semaglutide not only improves insulin sensitivity but also reduces appetite by slowing how quickly the food leaves the stomach, prompting the pancreas to release insulin when the blood sugar is high and suppressing the release of a hormone that elevates blood sugar.
Not only trials, a recent survey of 1700 people by the birth control app Natural Cycles, revealed that 64% of women with PCOS who took GLP-1 reported more predictable periods, and 20% reported that their bleeding days were shorter.
Now, what is needed is a much larger research study on the subject to analyse its effects and see if it can be administered to all women with PCOS.
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Delhi hounded by strays, kids pay price: Girl (6) dies of rabies after dog attack, family alleges official apathy
Delhi hounded by strays, kids pay price: Girl (6) dies of rabies after dog attack, family alleges official apathy

Time of India

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  • Time of India

Delhi hounded by strays, kids pay price: Girl (6) dies of rabies after dog attack, family alleges official apathy

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Liver can heal naturally if you follow these 3 Ayurvedic habits recommended by doctor
Liver can heal naturally if you follow these 3 Ayurvedic habits recommended by doctor

Time of India

timean hour ago

  • Time of India

Liver can heal naturally if you follow these 3 Ayurvedic habits recommended by doctor

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Aritha, Sidr or Shikakai: Which one's actually best for hair growth?
Aritha, Sidr or Shikakai: Which one's actually best for hair growth?

Time of India

timean hour ago

  • Time of India

Aritha, Sidr or Shikakai: Which one's actually best for hair growth?

Aritha, Sidr, and Shikakai, time-tested natural ingredients, offer unique benefits for hair care. Aritha deep cleanses oily scalps, Sidr soothes dry and sensitive ones while promoting growth, and Shikakai strengthens weak hair. Combining these powders creates a potent DIY cleanser, addressing various hair concerns for healthier, revitalized strands. These herbal remedies provide a natural alternative for achieving dream hair. Okay, let's be real, most of us are always chasing that one thing that'll finally fix our hair. Whether it's hair fall, slow growth, or just dull, lifeless strands, we've all had our fair share of hair problems. And while we've tried everything from fancy serums to expensive salon treatments, the good old desi nuskhas never really fail us, right? Enter: Aritha (aka Reetha), Sidr, and Shikakai, three natural ingredients that have been used for haircare for ages. But if you're wondering which one of these magical powders actually helps your hair grow faster, don't worry, we have done the homework for you. Let's dive in. Aritha: The OG natural shampoo Aritha, also called soapnut, is basically the shampoo your dadi swore by. It's this little brown fruit that foams up when you soak it in water. That foam? All-natural, chemical-free goodness that actually cleans your hair without drying it out like regular shampoo. Now, Aritha isn't just about washing your hair, it also helps with scalp health, improves blood flow to your roots, and gives your hair the kind of clean feeling that lasts days. The potent mix of all three herbs prevents dandruff and reduces radical damage, ensuring that your hair does not lose its original colour. This hair mask also improves hair length and keeps your scalp safe from itching and unnecessary hair loss. Brimming with anti-inflammatory herbs, it is a total saviour and can be used on all scalp types. Take two tablespoons of amla juice and shikakai powder, with one tablespoon of reetha powder and one spoon of rose water. Blend them all and see their power.(Image Credits: Pinterest) Why your hair might love Aritha: Deep cleans your scalp, which means no dandruff and no blocked follicles Helps with itchy, oily scalps Encourages new hair to grow by keeping everything clean and fresh Heads up though: It can be a bit drying if your hair's already on the dry side. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Up to 70% off | Libas Purple Days Sale Libas Undo And be careful with your eyes, it stings like crazy if it gets in. Perfect for: People with oily scalps, buildup, or dandruff issues who still want hair growth. Sidr: The chill, soothing one Not as popular in India but totally loved in places like the Middle East, Sidr (from the Lote tree) is like the cool, underrated cousin of Aritha and Shikakai. It's super gentle, full of nutrients, and doesn't foam at all, but don't let that fool you. It packs a punch when it comes to strengthening hair and calming down cranky scalps. Why Sidr is great: Very gentle, great if your scalp is sensitive or gets flaky Nourishes your hair from the roots, making it stronger over time Helps reduce hair fall and promotes thick growth The catch? It doesn't lather, so if you're someone who needs foam to feel clean, this might feel weird at first. Perfect for: Dry, sensitive scalps or curly-haired folks who want growth without losing moisture. Shikakai: The strength builder Shikakai's been in Indian households forever and with good reason. The name literally means 'fruit for hair' and that's pretty much what it is. It doesn't make too much lather, but it strengthens your strands from the root, reduces breakage, and adds a soft natural shine. Why it works: Strengthens weak hair and helps reduce hair fall Adds shine without weighing your hair down Gently cleanses while promoting growth Only downside? It can be drying if you use it alone, so mix it with something moisturising or oil your hair before washing. Perfect for: People dealing with breakage, thinning, or dullness. Basically anyone who wants thicker, stronger strands. Which one is actually the best? Honestly, there's no clear winner. It really depends on what your hair needs the most. But if we had to simplify: Go for Aritha if your scalp is oily and you want something to deep-clean and refresh. Try Sidr if your scalp is dry, itchy, or sensitive. It's super soothing and also helps with growth. Use Shikakai if your hair breaks easily and feels lifeless. It'll toughen up your strands and bring back that bounce. Can you use all three together? Oh, absolutely! A lot of people love mixing all three into one amazing DIY hair cleanser. It gives you the best of all worlds -cleansing, soothing, strengthening, and growth. Here's a super simple recipe: 1 spoon Aritha powder 1 spoon Shikakai powder 1 spoon Sidr powder Mix with warm water (or aloe vera gel if your scalp's dry) Apply to your scalp and hair, leave on for 10-15 mins, and rinse off It'll leave your hair soft, bouncy, and clean without stripping it dry. At the end of the day, all three - Aritha, Sidr, and Shikakai are absolute gems when it comes to natural hair care. They have been trusted for generations, and for good reason. Whether you use them alone or mix them together, your hair's definitely going to thank you. 5 best yoga poses for hair growth So if you are tired of reading 50-ingredient labels on hair products and watching your hair fall in chunks every time you shower, maybe it's time to go back to basics. Whip up a little herbal magic, be patient, and let nature do its thing. Your dream hair? It might just be one spoon of powder away.

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