Latest news with #ProspectiveLynchSyndromeDatabase
Time of India
28-04-2025
- Health
- Time of India
Extended surgery could help lower risk of second cancer in patients with genetic condition: Study
New Delhi: In patients of Lynch syndrome -- an inherited condition -- risk of developing a second tumour could be lower among those having an extended resection, involving a removal of organs and tissues adjacent to the affected ones, compared to segmental resection , according to a study. The inherited condition increases one's risk of cancer, especially that of colon and rectum. An international collaboration, including researchers from the Institute of Human Genetics, Ahmedabad, compared the incidence of metachronous colorectal cancer -- the second cancer develops distinct from and at least six months following diagnosis of the first -- after segmental versus extended surgical resection in patients with Lynch syndrome. The analysis looked at data taken from the 'Prospective Lynch Syndrome Database', involving 8,500 patients from 25 different countries. Findings are published in the British Journal of Surgery . Once colon cancer is identified, European and American guidelines recommend considering an extended colorectal surgery for patients of Lynch syndrome carrying the 'path_MLH1' and 'path_MSH2' gene variants, and a segmental resection for those carrying the 'path_MSH6' and 'path_PMS2' gene variants. All these gene variants are associated with a higher lifetime risk of developing colorectal, gynaecological and urinary tract cancers, among others. Overall, a higher risk of metachronous colorectal cancer was found to be higher among patients who underwent segmental resection, compared to those who underwent extended surgery . For example, path_MLH1 carriers had a higher risk of metachronous (colorectal cancer) by the age of 75 years after segmental colorectal resection (69.1 per cent), compared with extended surgery (25.1 per cent), the team said. "This study has found that path_MLH1 and path_MSH2 carriers who undergo segmental resection for a first colorectal cancer were at increased risk of metachronous colorectal cancer, compared with those with no prior colorectal cancer," the authors wrote. They said the study's findings contributes to the ongoing discussion on surgical strategies for patients with Lynch syndrome. The research team also included members from the US, Europe and Australia.
Time of India
27-04-2025
- Health
- Time of India
‘Extended resection lowers Lynch-related cancer risk'
Ahmedabad: A global research comprising of 8,438 patients suffering from colorectal cancer caused by Lynch Syndrome has indicated pathways for ensuring less chances recurrence. Tired of too many ads? go ad free now A cohort from Ahmedabad represented India in the study. Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is the most common hereditary cancer condition that significantly increases the risk of developing colorectal cancer and other cancers. The condition often affects multiple generations, and in the Indian context, some studies estimate the prevalence to be one in 300 persons. More importantly, about 10-15% of colorectal cancers in India are caused by the condition compared to 2-10% in Western countries. The cancer has a high relapse rate of 17-50% in later stages. The study, ' Metachronous Colorectal Cancer Risks After Extended or Segmental Resection in MLH1, MSH2, and MSH6 Lynch Syndrome: Multicentre Study from the Prospective Lynch Syndrome Database,' was recently published in the British Journal of Surgery (BJS) by Oxford Academic. One of the authors of the study is Dr Harsh Sheth from FRIGE Institute of Human Genetics, Ahmedabad. "It is one of the biggest studies in connection with Lynch Syndrome, comprising over 65,000 person-year follow-ups and surgical data of 908 patients. The study started with the question of what is the best surgical approach after the first tumour – should the onco surgeons go for segmental resection or extended colectomy to reduce chances of relapse," said Dr Sheth. Tired of too many ads? go ad free now He added that the study's findings indicate an equal or higher risk of developing metachronous colorectal cancer for those who already have a history. It challenges the earlier notion that screening and resection are enough. " Extended resection significantly reduces the risk of metachronous cancer (across all Lynch Syndrome genes) compared to segmental resection. There is no survival benefit in either surgery group, but there are benefits in fewer operative procedures, reduced surveillance burden, and better quality of life," said Dr Sheth. The take-home message, said experts, for the surgical guidelines is to ensure that if Lynch Syndrome is detected pre-operatively, the chances of metachronous cancer should be discussed.
